Article
Chemistry, Multidisciplinary
Yinghui Shang, Qinghai Wang, Jian Li, Haiting Liu, Qiangqiang Zhao, Xueyuan Huang, Hang Dong, Wansong Chen, Rong Gui, Xinmin Nie
Summary: ZrO2 NPs induce cell death in HeLa cells through elevation of intracellular ROS, mitochondrial damage, promotion of autophagy and apoptosis.
FRONTIERS IN CHEMISTRY
(2021)
Article
Oncology
Makoto Takeuchi, Toshihiko Nishisho, Shunichi Toki, Shinji Kawaguchi, Shunsuke Tamaki, Takeshi Oya, Yoshihiro Uto, Toyomasa Katagiri, Koichi Sairyo
Summary: In this study, the antitumor effect of blue light (BL) on synovial sarcoma (SS) was investigated. BL was found to inhibit the growth of SS cells and induce apoptosis. This suggests that BL could be a promising therapeutic strategy for SS.
Article
Biochemistry & Molecular Biology
Dongyang Gao, Runchang Wang, Yuwen Gong, Xiaoquan Yu, Qian Niu, Enguang Yang, Guangrui Fan, Junhai Ma, Chaohu Chen, Yan Tao, Jianzhong Lu, Zhiping Wang
Summary: This study demonstrates that CAB39 enhances autophagy in muscle-invasive bladder cancer cells, protecting mitochondria and other organelles to reduce cell damage caused by cisplatin and other harmful substances, thus influencing cisplatin resistance.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Endocrinology & Metabolism
Mi Jeong Heo, Ji Ho Suh, Sung Ho Lee, Kyle L. Poulsen, Yu A. An, Bhagavatula Moorthy, Sean M. Hartig, David D. Moore, Kang Ho Kim
Summary: This study identifies a new role of the aryl hydrocarbon receptor (AhR) in regulating mitophagy and maintaining hepatic energy homeostasis. AhR inhibition leads to decreased mitochondrial respiration and impaired fasting response of autophagy genes and mitophagy process. The mitophagy receptor BNIP3 is identified as an AhR target gene and its overexpression restores functional mitophagy.
MOLECULAR METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Zhaojuan Guo, Pin Li, Chunguo Wang, Qianjun Kang, Can Tu, Bingqian Jiang, Jingxuan Zhang, Weiling Wang, Ting Wang
Summary: This study found that the ethanol extraction process aggravated the hepatotoxicity of Psoraleae Fructus, with bavachin, psoralidin, bavachinin, neobavaisoflavone, and bakuchiol identified as the main toxic ingredients. These constituents induced cell apoptosis, increased lipid accumulation and reactive oxygen species levels, while decreasing mitochondrial membrane potential. The mechanism may be associated with oxidative stress and mitochondrial damage-mediated apoptosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chao Zhang, Hong-Ying Yang, Long Gao, Ming-Zhen Bai, Wen-Kang Fu, Chong-Fei Huang, Ning-Ning Mi, Hai-Dong Ma, Ya-Wen Lu, Ning-Zu Jiang, Liang Tian, Teng Cai, Yan-Yan Lin, Xing-Xing Zheng, Kun Gao, Jian-Jun Chen, Wen-Bo Meng
Summary: In this study, five cardiac glycosides were extracted from natural plants, and Lan C was identified as the most potent anti-cholangiocarcinoma compound. Lan C inhibited the growth and induced apoptosis of cholangiocarcinoma cells, without toxic effects on normal cells. Mechanistically, Lan C downregulated the expression of STAT3, leading to apoptosis. Therefore, Lan C may serve as a promising candidate for the treatment of cholangiocarcinoma.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jonathan M. Memme, Mikhaela Slavin, Neushaw Moradi, David A. Hood
Summary: Periods of muscle disuse can lead to mitochondrial changes that affect muscle health and atrophy. Research has shown that abnormalities in mitochondrial quality control pathways can cause muscle atrophy due to inactivity, highlighting the need for further investigation into how mitochondria contribute to disuse-induced muscle atrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Tingting Chen, Chenggong Zeng, Zhuoran Li, Juan Wang, Feifei Sun, Junting Huang, Suying Lu, Jia Zhu, Yizhuo Zhang, Xiaofei Sun, Zijun Zhen
Summary: This study aimed to analyze the incidence of chemoresistance in high-risk neuroblastoma patients and investigate the role of autophagy in chemoresistance. The results showed that inhibiting autophagy can increase the sensitivity of neuroblastoma to chemotherapy agents, thus improving the treatment outcome.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyun-Jung Park, Sun-Young Yoon, Jung-Nam Park, Jae-Hee Suh, Hye-Seon Choi
Summary: This study found that doxorubicin-induced bone loss is partly caused by the upregulation of autophagy in osteoclasts (OCs). Doxorubicin induces autophagy in OCs through the mitochondrial reactive oxygen species (mROS)/transient receptor potential mucolipin 1 (TRPML1)/transcription factor EB (TFEB) axis pathway. The results show that doxorubicin-induced autophagy increases the area of OCs and bone resorption activity, while decreasing the number of OCs through apoptosis, resulting in bone loss. The autophagy inhibitor 3-methyladenine (3-MA) reverses the effects of doxorubicin by reducing the area of OCs, thus reversing doxorubicin-induced bone loss.
Article
Biochemistry & Molecular Biology
Jianrong Zheng, Liao Zeng, Mingqing Tang, Hongjun Lin, Chao Pi, Ruian Xu, Xiuling Cui
Summary: Compound 1 exhibited potent anti-HCC activity by inducing cell cycle arrest and apoptosis through mitochondrial pathway, suggesting it as a promising candidate for HCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Hafiz Muhammad Ahmad Javaid, Hwayeon Lim, Sooim Shin, Joo Young Huh
Summary: Chloroquine inhibits autophagy and affects mitochondrial quality and respiratory function. Additionally, chloroquine treatment induces oxidative stress, apoptosis, and metabolic dysregulation.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Review
Toxicology
Bingqing Wang, Yue Wang, Jing Zhang, Chang Hu, Jun Jiang, Yiming Li, ZhiYong Peng
Summary: Reactive oxygen species (ROS) play a crucial role in cell death processes such as apoptosis, autophagy, and ferroptosis through lipid peroxidation. The oxidation of phospholipid bilayers can trigger mitochondrial apoptosis and endoplasmic reticulum stress, while also affecting autophagy. Additionally, ROS and lipid peroxides are involved in ferroptosis, and the nuclear factor erythroid 2-related factor 2 regulates ferroptosis under oxidative conditions. This review provides insights into the interplay among apoptosis, autophagy, and ferroptosis mediated by ROS and lipid peroxidation, offering new directions for studying diseases related to pathological cell death.
ARCHIVES OF TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chenbin Bian, Zhuangzhuang Zheng, Jing Su, Huanhuan Wang, Sitong Chang, Ying Xin, Xin Jiang
Summary: Radiotherapy failure and poor tumor prognosis are mainly caused by radioresistance. The relationship and mechanisms between mitochondrial metabolism and cancer radioresistance are not fully understood. However, mitochondria play a crucial role in regulating various biological reactions and influencing the radiation effects of malignancies. Therefore, targeting mitochondrial signaling pathways for the development of novel anticancer drugs holds promise.
Article
Engineering, Environmental
Guoliang Chen, Mingxing Wang, Panpan Zhu, Guixue Wang, Tingzhang Hu
Summary: Pyraoxystrobin (SYP-3343), a newly-invented strobilurin fungicide, exhibits high toxicity to aquatic organisms, particularly in zebrafish embryos, through affecting cell cycle, mitochondrial membrane potential, and reactive oxygen species generation. This toxicity is dose- and time-dependent, inducing apoptosis in zebrafish embryos.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Oncology
Huynh Diem Thi Ngoc, Yujin Jin, Chang-Seon Myung, Kyung-Sun Heo
Summary: Breast cancer is the most common cause of cancer-related deaths among women globally. Ginsenoside Rh1 exhibits potential anticancer effects on breast cancer cells by inducing cell cycle arrest, apoptosis, and autophagy via inhibition of the ROS-mediated PI3K/Akt pathway.
Review
Chemistry, Medicinal
Dinesh Kumar, Rajeev Kumar Singla, Pooja Sharma, Lutesh Kumar, Navdeep Kaur, Ravi Kumar Dhawan, Shailesh Sharma, Kamal Dua, Rohit Sharma
Summary: This study investigated the pharmacological and phytochemical properties of Colebrookea oppositifolia Smith., a traditional medicinal plant. The plant has been widely used for the treatment of various diseases, including nervous system disorders. The results showed that the plant contains abundant compounds with antioxidant, antimicrobial, and antifungal activities. Further evaluation of the plant is warranted to uncover its potential health benefits.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2023)
Article
Plant Sciences
Archit Sood, Kanika Thakur, Robin Joshi, Dinesh Kumar, Ashish R. Warghat
Summary: Dactylorhiza hatagirea, an orchid endemic to North-Western Himalayas, has significant medicinal value due to its active compound dactylorhin. However, the quantification of dactylorhin in this orchid and conservation methods through in vitro approaches are lacking. This study found that flowers and tubers of D. hatagirea contained higher levels of dactylorhin compared to other parts of the plant. Regeneration of shoots with tubers/roots and callus initiation in D. hatagirea were optimized using specific culture media. In vitro cultures showed lower enrichment of dactylorhins compared to naturally grown plant parts.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Immunology
Archana Bharti Sonkar, Pranesh Kumar, Anand Kumar, Anurag Kumar Gautam, Abhishek Verma, Amita Singh, Umesh Kumar, Dinesh Kumar, Tarun Mahata, Bolay Bhattacharya, Amit K. Keshari, Biswanath Maity, Sudipta Saha
Summary: This study reveals the role of vinpocetine, a synthetic derivative of vincamine, in DMH-induced colon carcinogenesis. Rats were induced with DMH for four weeks and then treated with vinpocetine for 15 days. The results show that vinpocetine can attenuate altered plasma parameters, suppress COX-2 stimulation, and decrease IL-10, IL-2, IL-6, and IL-10 levels. Vinpocetine has anti-inflammatory and antioxidant potential, making it a potential anticancer agent for CRC treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anuradha Yadava, Mahfuzur Rahman Bhuyan, Debalina Mukherjee, Dinesh Kumar, Manish Dwivedi
Summary: In this study, in silico approaches were used to identify plant-based natural compounds that can interfere with sodium-proton antiporter activity in E. coli. The simulation results showed that flavonoid compounds (Luteolin, Apigenin, and Rhamnocitrin) had good affinity and stable interaction with the target protein. This study proposed potential natural compounds as interfering agents against sodium-proton transport activity, which may affect the survival of various pathogenic bacteria.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Manish Dwivedi, Sandra Jose, Megha Gupta, Sreevidya S. Devi, Ritu Raj, Dinesh Kumar
Summary: This study used in-silico methods to identify potential inhibitors for the Mycobacterial copper transport protein (Mctb) in order to modulate its function. Four chemical compounds were found to have stable interactions and favorable binding energies with the target protein, making them potential candidates for reducing the growth of M. tuberculosis and providing a novel therapeutic approach for Tuberculosis.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Ajayrajsinh R. Zala, Dinesh Kumar, Uvais Razakhan, Dhanji P. Rajani, Iqrar Ahmad, Harun Patel, Premlata Kumari
Summary: A novel series of s-triazine linked benzothiazole and coumarin hybrids were synthesized and characterized. In vitro antimicrobial analysis showed remarkable antibacterial and antifungal activities of these compounds. Molecular docking studies indicated that the synthesized hybrids maintained their molecular interaction and structural integrity inside the active pocket of S. aureus dihydropteroate synthetase. The in silico analyses supported the outstanding antibacterial efficacy of compound 6d.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Analytical
Vandana Kumari, Dinesh Kumar, Rishabh Bhardwaj, Dinesh Kumar
Summary: Ajuga parviflora is a traditionally important herb used to treat fever, diarrhoea, obesity, and diabetes. Metabolome analysis, nutritional and antioxidant activities were performed to understand its health benefits. The study identified 60 metabolites and found significant nutritional components and antioxidant activities, supporting the health benefits of Ajuga parviflora.
MICROCHEMICAL JOURNAL
(2023)
Article
Agronomy
Swati Walia, Pawan Kumar, Dinesh Kumar, Rakesh Kumar
Summary: This study investigates the growth characteristics and ginsenoside content in the roots of Panax ginseng cultivated in Lahaul & Spiti, Himachal Pradesh, India. The results show that plant growth parameters increase with crop age and reach maximum maturity at five years, along with increased production of seeds and roots. The HPLC analysis reveals 14 compounds representing a total ginsenoside content of 31.81 +/- 2.89 mg/g, with Rb1, Rg2, and Re identified as major ginsenosides. The soil and climate of the Lahaul and Spiti district in Himachal Pradesh are found to be suitable for cultivating P. ginseng with high ginsenoside content in five-year-old roots.
PLANT SOIL AND ENVIRONMENT
(2023)
Article
Chemistry, Multidisciplinary
Dinesh Kumar, Narayan Prasad, Nikhil Gupta, Deependra Kumar Yadav, Sonam Gautam, Ashish Kumar
Summary: Chronic kidney disease (CKD) is a common condition caused by various chronic diseases. The use of complementary and alternative medicines (CAMs) in CKD patients is prevalent, and there is a need to understand the differences in metabolic profiles between CKD and CAM-CKD patients. This study used NMR-based metabolomics to explore the serum metabolic disparities and found significant differences in metabolites between CKD and CAM-CKD patients.
Article
Biochemistry & Molecular Biology
Anand Kumar, Chaitany Jayprakash Raorane, Deepak Rawat, Priyanka Prajapati, Ritu Raj, Dinesh Kumar, Seong-Cheol Kim, Vinit Raj, Sapana Kushwaha
Summary: This study aimed to investigate the effect of atenolol on cast immobilization-induced skeletal muscle loss. The results demonstrated that atenolol can effectively prevent muscle loss caused by cast immobilization and protect against the deleterious effects of prolonged bed rest.
Review
Pharmacology & Pharmacy
Anurag Kumar Srivastav, Supriya Karpathak, Mohit Kumar Rai, Dinesh Kumar, Durga Prasanna Misra, Vikas Agarwal
Summary: Lipid based drug delivery systems (LBDDS) are valuable nano-carriers for delivering hydrophilic, hydrophobic, or amphiphilic compounds. They have the advantage of targeted drug delivery and can be modified with various entities for improved efficacy. The use of lipid nanoparticles, vesicles, and other lipid carriers is advancing the field of targeted drug delivery. This review summarizes the types of lipid formulations and their applications, as well as strategies for enhancing disease targeting.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Vandana Singh, Deepak Kumar Tripathi, Vivek Kumar Sharma, Devika Srivastava, Umesh Kumar, Krishna Mohan Poluri, Brahma Nand Singh, Dinesh Kumar, R. Venkatesh Kumar
Summary: Researchers prepared silk fibroin (SF) hydrogel and a composite of vancomycin (VANCO) - loaded SF hydrogel, characterized them using various methods, and conducted in vitro, in vivo, and serum analyses. The results showed that the VANCO-loaded SF hydrogel composite had controlled drug release and antibacterial ability, and performed better in diabetic wound healing than SF hydrogel and povidone. Serum analysis confirmed the increase of metabolites directly correlated to wound healing in the composite treated group.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Tulika Srivastava, Divya Tyagi, Siraj Fatima, Malur Thirumalesh Vishnu Sathyan, Ritu Raj, Aniket Sharma, Minal Chaturvedi, Meetali Sinha, Sonia Kumari Shishodia, Dinesh Kumar, Sandeep K. Sharma, Jata Shankar, Aruna Satish, Smriti Priya
Summary: Small molecules have shown promise as therapeutic molecules for metabolic and neurological disorders. In this study, the natural small molecule Shikonin was found to inhibit protein aggregation and protect against neurodegenerative diseases in Caenorhabditis elegans. Shikonin significantly reduced the aggregation of a-synuclein, improved locomotor activity, and prevented neuronal degeneration. These findings highlight the potential of natural small molecules in the treatment of protein aggregation and neurodegenerative diseases.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Anand Kumar, Priyanka Prajapati, Gurvinder Singh, Dinesh Kumar, Vikas Mishra, Seong-Cheol Kim, Chaitany Jayprakash Raorane, Vinit Raj, Sapana Kushwaha
Summary: This study aimed to evaluate the effect of salbutamol on skeletal muscle atrophy in diabetic rats. The findings demonstrated that salbutamol treatment improved muscle strength, muscle coordination, and lean muscle mass in diabetic rats. By impacting metabolites related to muscle inflammation and oxidative stress, salbutamol could be explored as an intervention in diabetic-associated skeletal muscle atrophy.
Article
Endocrinology & Metabolism
Sachin Yadav, Abhai Kumar, Smita Singh, Shahnawaz Ahmad, Gurvinder Singh, Abdul Rahman Khan, Rameshwar Nath Chaurasia, Dinesh Kumar
Summary: Brain stroke is a serious global health crisis that leads to permanent disability and fatalities. This study used metabolomics to analyze the changes in metabolic pathways following a stroke and discovered potential targets for intervention. The results showed that stroke patients had altered serum metabolite levels, indicating mitochondrial dysfunction. Several metabolic features were found to be highly sensitive and specific in differentiating stroke patients from normal subjects.
METABOLIC BRAIN DISEASE
(2023)