High mutational burden in colorectal carcinomas with monoallelic POLE mutations: absence of allelic loss and gene promoter methylation

Genomic heterogeneity in primary colorectal carcinomas and their metastases: born bad or brought up a villain?

(2018) Maja Hühns et al.   HUMAN PATHOLOGY

Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair

(2018) Karl P Hodel et al.   eLife

The PD-1 expressing immune phenotype of T cell exhaustion is prominent in the ‘immunoreactive’ microenvironment of colorectal carcinoma

(2017) Friedrich Prall et al.   HISTOPATHOLOGY

QuPath: Open source software for digital pathology image analysis

(2017) Peter Bankhead et al.   Scientific Reports

Clinical exome sequencing: results from 2819 samples reflecting 1000 families

(2016) Daniel Trujillano et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Combined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancers

(2015) Anne ML Jansen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A Common Cancer-Associated DNA Polymerase   Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading

(2014) D. P. Kane et al.   CANCER RESEARCH

Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations

(2014) Yaser R Hussein et al.   MODERN PATHOLOGY

DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer

(2013) David N. Church et al.   HUMAN MOLECULAR GENETICS

Germline and somatic polymerase ϵ and δ mutations define a new class of hypermutated colorectal and endometrial cancers

(2013) Sarah Briggs et al.   JOURNAL OF PATHOLOGY

The “North German Tumor Bank of Colorectal Cancer”: status report after the first 2 years of support by the German Cancer Aid Foundation

(2013) Martina Oberländer et al.   LANGENBECKS ARCHIVES OF SURGERY

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

(2012) Claire Palles et al.   NATURE GENETICS

A cancer-associated DNA polymerase   variant modeled in yeast causes a catastrophic increase in genomic instability

(2009) D. L. Daee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA