Three Ingredients of Safflower Alleviate Acute Lung Injury and Inhibit NET Release Induced by Lipopolysaccharide

XueBiJing Injection Versus Placebo for Critically Ill Patients With Severe Community-Acquired Pneumonia

(2019) Yuanlin Song et al.   CRITICAL CARE MEDICINE

Investigating the effects and possible mechanisms of danshen- honghua herb pair on acute myocardial ischemia induced by isoproterenol in rats

(2019) Xiao-Ping Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Protective effect of hydroxysafflor yellow A alone or in combination with acetylglutamine on cerebral ischemia reperfusion injury in rat: A PET study using 18 F-fuorodeoxyglucose

(2018) Ling Deng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The influence of agents differentiating HL-60 cells toward granulocyte-like cells on their ability to release neutrophil extracellular traps

(2018) Aneta Manda-Handzlik et al.   IMMUNOLOGY AND CELL BIOLOGY

Nucleolin mediated pro-angiogenic role of Hydroxysafflor Yellow A in ischaemic cardiac dysfunction: Post-transcriptional regulation of VEGF-A and MMP-9

(2018) Jiang Zou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Efficacy and safety of Xuebijing injection (a Chinese patent) for sepsis: A meta-analysis of randomized controlled trials

(2018) Chengyu Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Neutrophil Extracellular Traps in the Second Decade

(2018) Volker Brinkmann   Journal of Innate Immunity

Neutrophil extracellular traps in ischemic AKI: new way to kill

(2018) Jing Liu et al.   KIDNEY INTERNATIONAL

Excessive neutrophil extracellular trap formation in ANCA-associated vasculitis is independent of ANCA

(2018) Tineke Kraaij et al.   KIDNEY INTERNATIONAL

Curative efficacy and safety of traditional Chinese medicine xuebijing injections combined with ulinastatin for treating sepsis in the Chinese population

(2018) Shi-Hui Xiao et al.   MEDICINE

Oral hydroxysafflor yellow A reduces obesity in mice by modulating the gut microbiota and serum metabolism

(2018) Juan Liu et al.   PHARMACOLOGICAL RESEARCH

Neutrophil extracellular traps in fungal infection

(2018) Constantin F. Urban et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Effects of HSYA on the proliferation and apoptosis of MSCs exposed to hypoxic and serum deprivation conditions

(2018) Xiaoqing Song et al.   Experimental and Therapeutic Medicine

Hydroxysafflor-Yellow A Induces Human Gastric Carcinoma BGC-823 Cell Apoptosis by Activating Peroxisome Proliferator-Activated Receptor Gamma (PPARγ)

(2018) Li Liu et al.   MEDICAL SCIENCE MONITOR

Thrombin and Plasmin Alter the Proteome of Neutrophil Extracellular Traps

(2018) Chun Hwee Lim et al.   Frontiers in Immunology

Hydroxysafflor Yellow A: A Promising Therapeutic Agent for a Broad Spectrum of Diseases

(2018) Hui Ao et al.   Evidence-based Complementary and Alternative Medicine

Hydroxysafflor yellow A suppresses angiogenesis of hepatocellular carcinoma through inhibition of p38 MAPK phosphorylation

(2018) Jingyu Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Host DNases prevent vascular occlusion by neutrophil extracellular traps

(2017) Miguel Jiménez-Alcázar et al.   SCIENCE

A Nuclease from Streptococcus mutans Facilitates Biofilm Dispersal and Escape from Killing by Neutrophil Extracellular Traps

(2017) Jia Liu et al.   Frontiers in Cellular and Infection Microbiology

Synergistic cardioprotective effects of Danshensu and hydroxysafflor yellow A against myocardial ischemia-reperfusion injury are mediated through the Akt/Nrf2/HO-1 pathway

(2016) TIANXIN HU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury

(2016) Yang Wang et al.   Molecular Medicine Reports

Caspase inhibitor zVAD-fmk protects against acute pancreatitis-associated lung injury via inhibiting inflammation and apoptosis

(2016) Mingdong Liu et al.   PANCREATOLOGY

Neutrophil extracellular traps are indirectly triggered by lipopolysaccharide and contribute to acute lung injury

(2016) Shuai Liu et al.   Scientific Reports

Xuebijing Ameliorates Sepsis-Induced Lung Injury by Downregulating HMGB1 and RAGE Expressions in Mice

(2015) Qiao Wang et al.   Evidence-based Complementary and Alternative Medicine

Xuebijing Injection Promotes M2 Polarization of Macrophages and Improves Survival Rate in Septic Mice

(2015) Yan-Cun Liu et al.   Evidence-based Complementary and Alternative Medicine

Safflower Yellow regulates microglial polarization and inhibits inflammatory response in LPS-stimulated Bv2 cells

(2015) Xing-Wang Yang et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Mediators and molecular pathways involved in the regulation of neutrophil extracellular trap formation mediated by activated platelets

(2015) Agostina Carestia et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Protective effects of hydroxysafflor yellow A (HSYA) on alcohol-induced liver injury in rats

(2015) Yanhao He et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Neutrophil extracellular traps in patients with sepsis

(2015) Masamitsu Hashiba et al.   JOURNAL OF SURGICAL RESEARCH

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

(2015) A. Warnatsch et al.   SCIENCE

Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2

(2014) Carmelo Carmona-Rivera et al.   ANNALS OF THE RHEUMATIC DISEASES

Neutrophil Extracellular Traps Promote Thrombin Generation Through Platelet-Dependent and Platelet-Independent Mechanisms

(2014) Travis J. Gould et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Periodontal bacteria in human carotid atherothrombosis as a potential trigger for neutrophil activation

(2014) Hélène Rangé et al.   ATHEROSCLEROSIS

Hydroxysafflor Yellow A Attenuates Small Airway Remodeling in a Rat Model of Chronic Obstructive Pulmonary Disease

(2014) Yu Wang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Hydroxysafflor yellow A ameliorates lipopolysaccharide-induced acute lung injury in mice via modulating toll-like receptor 4 signaling pathways

(2014) Ya-Li Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis

(2014) MING-WEI LIU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Xuebijing injection improves the respiratory function in rabbits with oleic acid-induced acute lung injury by inhibiting IL-6 expression and promoting IL-10 expression at the protein and mRNA levels

(2014) YUXIA WANG et al.   Experimental and Therapeutic Medicine

Safflor yellow A protects neonatal rat cardiomyocytes against anoxia/reoxygenation injury in vitro

(2013) Jia-lin Duan et al.   ACTA PHARMACOLOGICA SINICA

Resolution of Acute Inflammation in the Lung

(2013) Bruce D. Levy et al.   Annual Review of Physiology

Identification of NF-κB Inhibitors in Xuebijing injection for sepsis treatment based on bioactivity-integrated UPLC-Q/TOF

(2013) Min Jiang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Hydroxysafflor yellow A suppresses inflammatory responses of BV2 microglia after oxygen–glucose deprivation

(2013) Jie Li et al.   NEUROSCIENCE LETTERS

Hydroxysafflor yellow A attenuates left ventricular remodeling after pressure overload-induced cardiac hypertrophy in rats

(2013) Jianping Wang et al.   PHARMACEUTICAL BIOLOGY

Effect of safflor yellow injection on inhibiting lipopolysaccharide-induced pulmonary inflammatory injury in mice

(2012) Ming Jin et al.   Chinese Journal of Integrative Medicine

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Lyn is a redox sensor that mediates leukocyte wound attraction in vivo

(2011) Sa Kan Yoo et al.   NATURE

Identification of the major constituents in Xuebijing injection by HPLC-ESI-MS

(2011) Hao Huang et al.   PHYTOCHEMICAL ANALYSIS

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

Pharmacokinetic properties of hydroxysafflor yellow A in healthy Chinese female volunteers

(2009) Zhifu Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Penehyclidine hydrochloride attenuates LPS-induced acute lung injury involvement of NF-κB pathway

(2009) Weifeng Shen et al.   PHARMACOLOGICAL RESEARCH

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens