Review
Cell Biology
Shenghao Zhang, Xiaodan Li, Siyu Liu, Wanting Zhang, Meinuo Li, Chen Qiao
Summary: Diabetic kidney disease (DKD) is a common complication of diabetes mellitus, leading to end-stage renal disease and severe health damage. ET-1, closely associated with DKD progression, is elevated in response to high glucose stimulation and contributes to hemodynamic changes, inflammation, and renal dysfunction, ultimately causing proteinuria and decreased glomerular filtration. This review aims to summarize the molecular changes, regulatory mechanisms, and actions of ET-1 in DKD, recent clinical trials of ET-1 receptor antagonists, and current challenges, providing valuable information and research directions for DKD treatment and ET-1-related studies.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Immunology
Ke-qian Chen, Bo-yi Ke, Lu Cheng, Xiao-qing Yu, Zong-bao Wang, Shu-zhi Wang
Summary: With the development of the social economy, unhealthy living habits and eating styles are gradually affecting people's health in recent years. NAFLD, as a chronic liver disease, has become an increasingly serious public health problem due to these factors. Inflammasomes, as a protein complex, play a crucial role in the development of NAFLD and other diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
You Wu, Yan Chen
Summary: This article provides a comprehensive review of the regulatory mechanism of ferroptosis and its relationship with diabetic kidney disease, highlighting its potential as an intervention and treatment method.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Han Li, Li Lin, Yun-Long Xia, Yunpeng Xie, Xiaolei Yang
Summary: The pathogenesis of cardiovascular disease is complex and poses a serious threat to human health. Cardiomyocyte death, including ferroptosis, plays a significant role in the occurrence and development of cardiovascular diseases. The regulation of lipid, amino acid, and iron metabolism can inhibit the ferroptosis pathway and potentially alleviate or prevent cardiovascular diseases. Inhibiting ferroptosis in cardiomyocytes is expected to become a feasible treatment method for cardiovascular diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Endocrinology & Metabolism
Shengjie Li, Shanshan Zheng, Jiao Li, Sen Lin, Hao Li, Ping Wang, Ping Chen, Chaoqun Ma, Yipeng Liu
Summary: Diabetic kidney disease (DKD) is a severe complication of diabetes and a common cause of end-stage renal disease (ESRD). Renal tubules are vulnerable to metabolic disturbances, leading to inflammation and fibrosis. Recent studies have shown the significant role of extracellular vesicles in tubular injury in DKD.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Jiao Li, Shanshan Zheng, Chaoqun Ma, Xuexun Chen, Xuan Li, Shengjie Li, Ping Wang, Ping Chen, Zunsong Wang, Wenbin Li, Yipeng Liu
Summary: Diabetic kidney disease (DKD) is a common end-stage renal disease caused by chronic diabetes. It is characterized by persistent proteinuria and a decline in the glomerular filtration rate. Recent studies have shown that podocyte injury is a central factor in the development of DKD, and research on exosomes in podocyte injury associated with DKD has made significant progress.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Urology & Nephrology
Xuejiao Wei, Xiaoyu Zhu, Lili Jiang, Mengtuan Long, Yujun Du
Summary: With the rise in living standards and aging population, the prevalence of chronic kidney disease (CKD) has increased, making prevention and treatment important worldwide. Ulinastatin, a serine protease inhibitor found in human blood and urine, has shown potential in treating CKD by inhibiting inflammation, regulating immunity, and improving microcirculation.
Review
Neurosciences
Zhengzhe Li, Xiaoling Wang, Xiaoxing Wang, Xiaomei Yi, Yin Kwan Wong, Jiyang Wu, Fangfang Xie, Die Hu, Qi Wang, Jigang Wang, Tianyu Zhong
Summary: Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease, affect millions of people worldwide. Extracellular vesicles (EVs) have been shown to play a role in the pathogenic processes of these diseases and have potential as therapeutic targets or biomarkers. This review summarizes the research progress on EVs in neurodegenerative diseases and discusses their roles and therapeutic potential.
TRANSLATIONAL NEURODEGENERATION
(2023)
Review
Immunology
Yulin Wang, Dongxu Song, Lin Tang
Summary: Mitophagy is a crucial mechanism involved in the regulation of mitochondrial quality control and cell damage. Inflammasomes, newly discovered inflammation-related factors, play an important role in kidney diseases. This review focuses on the progress of mitophagy, inflammasomes, and their interaction in kidney diseases.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Immunology
Shuyuan Huang, Lu Liu, Xiaodong Tang, Shulan Xie, Xinrui Li, Xianhui Kang, Shengmei Zhu
Summary: Ischemic stroke is a leading factor in global mortality and disability. Understanding the pathophysiological mechanisms of brain injury following ischemic stroke is crucial for treatment and prevention. Hormones play a significant role in ischemic stroke by regulating neuronal plasticity and influencing inflammation, oxidative stress, and brain edema.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Paula Anton-Pampols, Clara Diaz-Requena, Laura Martinez-Valenzuela, Francisco Gomez-Preciado, Xavier Fulladosa, Anna Vidal-Alabro, Joan Torras, Nuria Lloberas, Juliana Draibe
Summary: This review describes the characteristics, activation mechanisms, regulation, and functions of different inflammasomes, and discusses the latest findings on the role of the inflammasome in several glomerulonephritis from in vitro, animal, and human studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Siyi You, Xiaojuan Su, Junjie Ying, Shiping Li, Yi Qu, Dezhi Mu
Summary: This review summarizes the roles of glial cells in maintaining cerebral homeostasis and regulating neurological diseases, as well as the relationship and mechanisms between glial cells and RNA m6A modification, providing new insights for understanding and treating neurological diseases.
Review
Immunology
Chunyan Liu, Chenchen Liu, Rong Fu
Summary: This review examines the role and contribution of pyruvate kinase M2 (PKM2) in the human immune response, as well as its potential application value in the treatment of autoimmune responses and inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Can Yang, Zhen Zhang, Jieting Liu, Peijian Chen, Jialing Li, Haiying Shu, Yanhui Chu, Luxin Li
Summary: This paper discusses the pathologic research and drug therapy of diabetic kidney disease (DKD), focusing on the death processes and mechanisms of glomerular podocytes in DKD. The complexity and potential crosstalk between various modes of cell death are also examined, providing insights into podocyte death and laying the foundation for future targeted therapy strategies for DKD treatment.
MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Li Peng, Qi Yan, Zhaolin Chen, Ying Hu, Yuansong Sun, Yu Miao, Yincui Wu, Yan Yao, Liangsong Tao, Fei Chen, He Li, Tao Xu
Summary: Hepatocellular carcinoma (HCC) is a complex disease with limited treatment options. The main cause of its incidence has shifted from viral to non-viral. High cholesterol levels can contribute to the development of HCC, but conflicting studies have shown a negative correlation between serum cholesterol levels and morbidity and mortality. Cholesterol plays a vital role in both the body and tumors, and while research on its function in tumors is progressing, the use of cholesterol-lowering drugs in treating HCC is still limited.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Critical Care Medicine
Hongyu Yi, Xiaoming Li, Zhi Mao, Chao Liu, Xin Hu, Rengjie Song, Shuang Qi, Feihu Zhou
Summary: The study shows that high PEEP can reduce the incidence of ARDS and hypoxemia, and improve the PaO2/FIO2 level. While no significant advantages were found in terms of major secondary outcomes, subgroup analysis yielded different results, suggesting the need for more randomized controlled trials to validate the conclusions.
JOURNAL OF CRITICAL CARE
(2022)
Article
Medicine, General & Internal
Xiaoming Li, Chao Liu, Xiaoli Wang, Zhi Mao, Hongyu Yi, Feihu Zhou
Summary: This study developed a nomogram model and a simple risk scoring model to predict sepsis in critically ill patients by combining five commonly available inflammatory markers. Although the prediction performance of the two models is comparable, the simple risk scoring model may be simpler and more practical for clinicians to identify potential sepsis in critically ill patients at an early stage and strategize treatments.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Zheyi Dong, Qian Wang, Yujing Ke, Weiguang Zhang, Quan Hong, Chao Liu, Xiaomin Liu, Jian Yang, Yue Xi, Jinlong Shi, Li Zhang, Ying Zheng, Qiang Lv, Yong Wang, Jie Wu, Xuefeng Sun, Guangyan Cai, Shen Qiao, Chengliang Yin, Shibin Su, Xiangmei Chen
Summary: This study constructed a 3-year diabetic kidney disease risk prediction model in patients with type 2 diabetes mellitus using machine learning and electronic medical records. The study found that older patients with high homocysteine levels, poor glycemic control, low serum albumin levels, low estimated glomerular filtration rate, and high bicarbonate levels had an increased risk of developing DKD over the next 3 years.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Yi Ren, Shaoyuan Cui, Quan Hong, Wanjun Shen, Qinggang Li, Lingling Wu, Bo Fu, Xu Wang, Qian Ma, Jiaona Liu, Xueyuan Bai, Xiangmei Chen
Summary: Activation of NOD-like receptors (NLRs) can lead to renal metabolic injury. In a diabetic minipig model, the expression of NLRs was significantly upregulated, along with activation of the NF-κB signaling pathway and increased levels of inflammatory cytokines.
MEDIATORS OF INFLAMMATION
(2022)
Article
Cell Biology
Chengcheng Song, Shuqiang Wang, Zhangning Fu, Kun Chi, Xiaodong Geng, Chao Liu, Guangyan Cai, Xiangmei Chen, Di Wu, Quan Hong
Summary: Renal inflammation is a critical characteristic of diabetic kidney disease (DKD), but effective treatments are limited. This study found that insulin-like growth factor-binding protein 5 (IGFBP5) is significantly increased in the kidneys of diabetic mice. Elimination of IGFBP5 alleviated kidney inflammation in DKD mice. Mechanistically, IGFBP5 increased glycolysis in endothelial cells through the activation of the transcription factor EGR1 and enhanced expression of PFKFB3, which in turn enhanced renal inflammation.
CELL DEATH & DISEASE
(2022)
Review
Pharmacology & Pharmacy
Zhangning Fu, Xiaodong Geng, Kun Chi, Chengcheng Song, Di Wu, Chao Liu, Quan Hong
Summary: This meta-analysis investigated the efficacy and safety of daprodustat, a novel HIF-PHI, in the treatment of chronic kidney disease (CKD)-related anemia. The results showed that daprodustat was noninferior to rhEPO in correcting anemia in both nondialysis-dependent and dialysis-dependent CKD patients. It also had a better effect on optimizing iron metabolism in dialysis-dependent CKD patients. However, further research is needed to evaluate the therapeutic effect of daprodustat due to the limited number of included studies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Zhi Mao, Tao Wen, Xiaoli Liu, Jinsong Chen, Pan Hu, Chao Liu, Hui Liu, Hongjun Kang, Zhengbo Zhang, Feihu Zhou
Summary: The nutritional status of elderly patients with MODS during hospitalization is related to their risk of death, especially when the GNRI value is below 92. Male patients have a lower risk of death compared to female patients.
FRONTIERS IN NUTRITION
(2022)
Article
Critical Care Medicine
Tao Wen, Zhi Mao, Chao Liu, Xiaoli Wang, Shufen Tian, Feihu Zhou
Summary: This study aimed to assess the independent association between serum phosphate levels at ICU admission and the subsequent risk of AKI in hospitalized patients. The results showed that elevated serum phosphate levels were associated with an increased risk of AKI.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Cell Biology
Si-Yang Wang, Yue Xu, Quan Hong, Xiang-Mei Chen, Guang-Yan Cai
Summary: This study demonstrated that aged mice are more susceptible to AKI injury and identified an important role for the upregulation of the senescence-associated DNA damage/p53 pathway in this susceptibility. MSC treatment can reduce the degree of DNA damage and apoptosis. Furthermore, downregulation of let-7b-5p may lead to increased renal AKI susceptibility, and the presence of let-7b-5p in MSC-derived Exos can alleviate tubular epithelial cell apoptosis by inhibiting p53.
CELL AND TISSUE RESEARCH
(2022)
Review
Cell & Tissue Engineering
Zhangning Fu, Yifan Zhang, Xiaodong Geng, Kun Chi, Chao Liu, Chengcheng Song, Guangyan Cai, Xiangmei Chen, Quan Hong
Summary: Considering the high prevalence and lack of targeted pharmacological management, new therapeutic approaches for acute kidney injury (AKI) are urgently needed. Mesenchymal stem cells (MSCs) have shown promise in the treatment of AKI, but the clinical translation of MSCs-based therapies is hindered by poor retention and survival rates, as well as impaired paracrine ability. Various strategies, including local administration, three-dimensional culture, and preconditioning, have been proposed to address these challenges and improve the effectiveness of MSCs in AKI models.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Medicine, General & Internal
Ping Li, Xuefeng Sun, Dinghua Chen, Hong-li Lin, Li Zhang, Yiqing Wu, Shuting Pan, Guangyan Cai, Xiangmei Chen
Summary: This study aims to evaluate the efficacy and safety of Roxadustat in Chinese adults with chronic kidney disease anemia. The study will include 250 Chinese participants with stage 3-5 non-dialysis dependent chronic kidney disease. The primary endpoint is the change in hemoglobin level, and secondary endpoints include the proportion of subjects achieving a target hemoglobin level and safety evaluation.
Article
Public, Environmental & Occupational Health
Ping Li, Xueying Cao, Weicen Liu, Delong Zhao, Sai Pan, Xuefeng Sun, Guangyan Cai, Jianhui Zhou, Xiangmei Chen
Summary: A large-scale survey was conducted to investigate the infrastructure and management of peritoneal dialysis (PD) care in hospitals of different tiers in mainland China. The survey revealed disparities in PD care between secondary and tertiary hospitals, highlighting the need for improved accessibility and quality management in secondary hospitals. The study results have important implications for enhancing PD care in mainland China.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Urology & Nephrology
Shuang Liang, Yong Wang, Wen-Ling Wang, Xin-Ru Guo, Chun Zhang, Chen Yang, Che Wang, Guang-Yan Cai, Xiang-Mei Chen
Summary: A multicenter epidemiological survey was conducted to study chronic kidney disease (CKD) among hospitalized patients, aiming to compare the characteristics of elderly CKD with non-elderly CKD. The study found that diabetic nephropathy and hypertension-related renal impairment were the main causes of CKD among elderly patients, who had a higher burden of comorbidities and worse in-hospital outcomes compared to younger patients. The length of stay and hospitalization costs increased with the number of coexisting diseases in elderly CKD patients.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Urology & Nephrology
Chao Liu, Wuhong Zhou, Zhi Mao, Xiaoming Li, Qing Meng, Rui Fan, Yibo Zhou, Li Zhang, Quan Hong, Xuefeng Sun, Feihu Zhou
Summary: Acute kidney injury (AKI) is a global disease with high morbidity and mortality. Ferroptosis, a form of regulated cell death, plays an essential role in the initiation and progression of AKI. Targeting ferroptosis is considered a potential strategy to cure AKI.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
