Article
Endocrinology & Metabolism
Chin-Hsiao Tseng, Choon-Khim Chong, Jau-Jiuan Sheu
Summary: The study revealed that female sex, diabetes duration, hemoglobin A(1c), and hypertension are associated with sensory symptoms in Taiwanese diabetes patients. Numbness or tingling pain is the most common symptom, with fingers and toes being the most commonly affected anatomical sites.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Abdoulaye Diawara, Djibril Mamadou Coulibaly, Talib Yusuf Abbas Hussain, Cheickna Cisse, Jian Li, Mamadou Wele, Mahamadou Diakite, Kassim Traore, Seydou O. Doumbia, Jeffrey G. Shaffer
Summary: The prevalence of T2D in the Niena community was 7.5%, with rates of 8.6% for females and 5.6% for males. Age, family history of diabetes, hypertension, waist circumference, and fetal macrosomia were significantly associated with T2D. 61.3% of T2D subjects were unaware of their diabetic status before the study.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Grammata Kotzaeridi, Julia Blaetter, Daniel Eppel, Ingo Rosicky, Veronica Falcone, Gabriela Adamczyk, Tina Linder, Guelen Yerlikaya-Schatten, Karen Weisshaupt, Wolfgang Henrich, Andrea Tura, Christian S. Goebl
Summary: Women with a history of gestational diabetes mellitus show alterations in glucose metabolism at the beginning of a subsequent pregnancy, increasing the risk of gestational diabetes recurrence.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Kimberly A. Bertrand, Katie M. O'Brien, Lauren B. Wright, Julie R. Palmer, William J. Blot, A. Heather Eliassen, Lynn Rosenberg, Sven Sandin, Deirdre Tobias, Elisabete Weiderpass, Wei Zheng, Anthony J. Swerdlow, Minouk J. Schoemaker, Hazel B. Nichols, Dale P. Sandler
Summary: The history of gestational diabetes mellitus (GDM) is not a risk factor for breast cancer in young women. The well-established protective effect of parity on the risk of ER-positive breast cancer persists even for pregnancies complicated by GDM.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Endocrinology & Metabolism
Dong-Hwa Lee, Bumhee Yang, Seonhye Gu, Eung-Gook Kim, Youlim Kim, Hyung Koo Kang, Yeong Hun Choe, Hyun Jeong Jeon, Seungyong Park, Hyun Lee
Summary: This study investigated the yearly trend of influenza vaccination and factors associated with being unvaccinated for influenza in subjects with diabetes over the past decade. The results showed that the prevalence of influenza vaccination in subjects with diabetes tended to increase every year, reaching almost 60% in 2019. Younger age, males, smoking, low-income status, high education level, and poor glycemic control were associated with being unvaccinated.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Rachel G. Miller, Trevor J. Orchard, Tina Costacou
Summary: This study investigates the association between long-term glycemic control patterns and cardiovascular disease development in type 1 diabetes patients. Two distinct HbA1c trajectories were identified and shown to be associated with differential cardiovascular disease risk.
Article
Dentistry, Oral Surgery & Medicine
Jung-Hyun Park, Sun-Hyun Kim, Sun-Jong Kim, Jin-Woo Kim
Summary: This study investigated the association between the recovery from or development of periodontal disease (PD) and the risk of incident diabetes in a population. The results showed that individuals who recovered from PD had a lower risk of diabetes compared to those who had consistent PD, while individuals who developed PD had a higher risk of diabetes.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Endocrinology & Metabolism
Saeid Safiri, Nahid Karamzad, Jay S. Kaufman, Arielle Wilder Bell, Seyed Aria Nejadghaderi, Mark J. M. Sullman, Maziar Moradi-Lakeh, Gary Collins, Ali-Asghar Kolahi
Summary: This study reported the prevalence, deaths, and DALYs of type 2 diabetes and its risk factors in 204 countries and territories from 1990 to 2019. The findings showed an increase in the global prevalence and death rates of type 2 diabetes since 1990, with low and middle-income countries carrying the highest burden.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Jingyu Guo, Zhenzhen Wan, Guanglin Cui, An Pan, Gang Liu
Summary: The study found that higher levels of HbEO were significantly associated with an increased prevalence of diabetes mellitus in a nationally representative sample of US adults. After multivariate adjustment including demographics, lifestyle factors, and body mass index (BMI), higher HbEO levels were significantly associated with an increased prevalence of diabetes mellitus.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Medicine, General & Internal
Patricia Chu, Arya Patel, Vicki Helgeson, Andrea B. Goldschmidt, Mary Katherine Ray, Mary Ellen Vajravelu
Summary: This cross-sectional study found no direct association between diabetes risk perception and health behaviors in youth. It suggests the need to address barriers to engagement in lifestyle change, including economic disadvantage.
Article
Nutrition & Dietetics
Hayoung Choi, Jung Eun Yoo, Kyungdo Han, Wonsuk Choi, Sang Youl Rhee, Hyun Lee, Dong Wook Shin
Summary: The study found that being underweight or having diabetes increases the risk of tuberculosis. In individuals under 65, smokers, and heavy drinkers, there is a synergistic effect between underweight and diabetes in relation to tuberculosis risk.
FRONTIERS IN NUTRITION
(2021)
Review
Cardiac & Cardiovascular Systems
Antonio Ceriello, Francesco Prattichizzo
Summary: Studies suggest that variability of risk factors such as blood pressure, plasma lipids, and weight may play a role in diabetes complications, with potential additive effects. While causality of variability is uncertain, monitoring risk factor variability in clinical practice could improve quality of care.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Medicine, General & Internal
Surapaneni Lakshmi Sravya, Jayshree Swain, Abhay Kumar Sahoo, Swayamsidha Mangaraj, Jayabhanu Kanwar, Pooja Jadhao, Srijit Das
Summary: This study aims to determine the prevalence and predictors of sarcopenia among individuals with type 2 diabetes mellitus (T2DM). The study found that the prevalence of sarcopenia was significantly higher among T2DM individuals compared to non-diabetics. Body mass index, physical activity, serum calcium levels, hypertension, and neuropathy were identified as significant predictors of sarcopenia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Christine Gyldenkerne, Martin Bodtker Mortensen, Johnny Kahlert, Pernille Gro Thrane, Kevin Kris Warnakula Olesen, Henrik Toft Sorensen, Reimar Wernich Thomsen, Michael Maeng
Summary: Newly diagnosed type 2 diabetes mellitus significantly increases the risk of cardiovascular disease in patients, especially among younger individuals. Compared to the general population, individuals with type 2 diabetes have a significantly higher 10-year risk of developing cardiovascular events, occurring at least 12 years earlier.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Lingwang An, Yanlei Wang, Chenxiang Cao, Tao Chen, Yonghong Zhang, Linhui Chen, Shuhong Ren, Manni Tang, Fenglian Ma, Xianglan Li, Shuang Yuan, Wenhui Zhao, Yaujiunn Lee, Jianzhong Xiao
Summary: This study evaluated ASCVD risk factors in type 2 diabetes patients from primary diabetes clinics in China and found low control rates, indicating a need for comprehensive intervention and management of ASCVD risk factors, with a focus on global management, weight loss, and smoking cessation.
Article
Endocrinology & Metabolism
Emilie Karense Lykking, Heidi Kammerlander, Fleur S. van Dijk, Daniel Prieto-Alhambra, Bo Abrahamsen, Lars Folkestad
Summary: This study found that there was no increased risk of fractures during pregnancy and 12 or 19 months postpartum compared to 12 or 19 months prior to conception.
Article
Endocrinology & Metabolism
Morten S. Hansen, Kent Soe, Line L. Christensen, Paula Fernandez-Guerra, Nina W. Hansen, Rachael A. Wyatt, Claire Martin, Rowan S. Hardy, Thomas L. Andersen, Jacob B. Olesen, Bolette Hartmann, Mette M. Rosenkilde, Moustapha Kassem, Alexander Rauch, Caroline M. Gorvin, Morten Frost
Summary: Drugs targeting the GIP receptor have potential as treatments for type-2 diabetes and obesity. GIP can directly act on human bone cells to inhibit bone resorption, increase bone formation, and improve osteoblast survival. Therefore, these drugs may reduce bone resorption while preserving bone formation.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Mohamad Nasser, Jacob Stidsen, Kurt Hojlund, Jens Steen Nielsen, Richard Eastell, Morten Frost
Summary: The study found that bone turnover markers are lower in individuals with type 2 diabetes, and their levels are associated with insulin sensitivity. Among the three phenotypes of type 2 diabetes, individuals with the insulinopenic phenotype have higher levels of bone turnover markers. The conclusion is that bone turnover markers are lower in newly diagnosed individuals with type 2 diabetes characterized by low insulin sensitivity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, General & Internal
Suzanne M. Jan de Beur, Salvatore Minisola, Wei-Bo Xia, Bo Abrahamsen, Jean-Jacques Body, Maria Luisa Brandi, Roderick Clifton-Bligh, Michael Collins, Pablo Florenzano, Pascal Houillier, Yasuo Imanishi, Erik A. Imel, Aliya A. Khan, M. Carola Zillikens, Seiji Fukumoto
Summary: Tumor-induced osteomalacia (TIO) is a rare condition caused by tumors that secrete fibroblast growth factor 23 (FGF23), leading to bone pain, muscle weakness, and low levels of vitamin D. Limited awareness of TIO among the medical community often leads to delayed diagnosis and poor outcomes. A global guidance document has been developed to improve knowledge and facilitate appropriate diagnosis, referral, and treatment of TIO. Key recommendations include measuring phosphate levels, conducting physical examinations to identify potential tumors, and utilizing functional imaging for tumor localization.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
John A. Kanis, Nicholas C. Harvey, Enwu Liu, Liesbeth Vandenput, Mattias Lorentzon, Eugene McCloskey, Roger Bouillon, Bo Abrahamsen, Lars Rejnmark, Helena Johansson
Summary: Patients with primary hyperparathyroidism have increased incidence of hip and major osteoporotic fractures, even if not referred for parathyroidectomy. The risk of death is also increased, which affects fracture probability. These findings support the need to widen the indications for parathyroidectomy in mild primary hyperparathyroidism.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Michael Kriegbaum Skjodt, Joeri Nicolaes, Christopher Dyer Smith, Cesar Libanati, Cyrus Cooper, Kim Rose Olsen, Bo Abrahamsen
Summary: This study examines the direct healthcare costs of subjects with vertebral fractures available for identification on routine CT scans. The results show that patients with vertebral fractures incur significantly higher healthcare costs compared to those without fractures. The study also found that the healthcare costs per day at risk were higher in the short term for patients with vertebral fractures, although this difference was not statistically significant, and the long-term healthcare costs were similar to the general population.
Review
Endocrinology & Metabolism
Michael Kriegbaum Skjodt, Bo Abrahamsen
Summary: This article summarizes the recent advances in the understanding of vertebral fractures, with a focus on endocrine diseases, prevention, and treatment. It highlights the increased risk of vertebral fractures in patients with endocrine diseases and the current focus on invasive treatments. It also mentions that licensed treatments are effective in reducing the occurrence of vertebral fractures in osteoporosis patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, General & Internal
Mina Nicole Handel, Isabel Cardoso, Cecilie von Bulow, Jeanett Friis Rohde, Anja Ussing, Sabrina Mai Nielsen, Robin Christensen, Jean-Jacques Body, Maria Luisa Brandi, Adolfo Diez-Perez, Peyman Hadji, Muhammad Kassim Javaid, Willem Frederik Lems, Xavier Nogues, Christian Roux, Salvatore Minisola, Andreas Kurth, Thierry Thomas, Daniel Prieto-Alhambra, Serge Livio Ferrari, Bente Langdahl, Bo Abrahamsen
Summary: This study aimed to review the comparative effectiveness of osteoporosis treatments, including the bone anabolic agents, abaloparatide and romosozumab, on reducing the risk of fractures in postmenopausal women, and to characterize the effect of antiosteoporosis drug treatments on the risk of fractures according to baseline risk factors. The results showed that osteoporosis treatments had a protective effect on reducing fracture risk, and bone anabolic agents were more effective than bisphosphonates.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Biology
Thach Tran, Thao Ho-Le, Dana Bliuc, Bo Abrahamsen, Louise Hansen, Peter Vestergaard, Jacqueline R. Center, Tuan Nguyen
Summary: The concept of "Skeletal Age" is introduced to convey the combined risk of fracture and fracture-associated mortality. Skeletal Age is defined as the sum of chronological age and the number of years of life lost associated with a fragility fracture. The study found that men tend to lose more years of life after a fragility fracture than women, and hip fractures result in the greatest loss of life years.
Article
Clinical Neurology
Carrinna Aviaja Hansen, Martin Thomsen Ernst, Christopher Dyer Smith, Bo Abrahamsen
Summary: This study aimed to characterize the epidemiological risk factors associated with long-term non-cancer opioid use among Danish citizens. The findings revealed that factors such as age, marital status, residence, and medication usage were associated with long-term opioid use. These findings are crucial for future revisions of treatment recommendations.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Endocrinology & Metabolism
Michael Kriegbaum Skjodt, Joeri Nicolaes, Christopher Dyer Smith, Kim Rose Olsen, Cyrus Cooper, Cesar Libanati, Bo Abrahamsen
Summary: We evaluated the risk of subsequent fractures in individuals with vertebral fractures (VFs) identified on routine computed tomography (CT) scans. We found that subjects with VF had a higher risk of major osteoporotic fractures, especially hip fractures, compared to those without VF. This highlights the importance of systematic opportunistic screening and fracture risk management for this high-risk population.
Article
Endocrinology & Metabolism
Joeri Nicolaes, Michael Kriegbaum Skjodt, Steven Raeymaeckers, Christopher Dyer Smith, Bo Abrahamsen, Thomas Fuerst, Marc Debois, Dirk Vandermeulen, Cesar Libanati
Summary: This study developed a machine learning algorithm to identify vertebral fractures in abdominal/chest CT scans and demonstrated its strong performance on an external validation set. It has the potential to support healthcare professionals with the early identification of vertebral fractures and prevention of future fragility fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Sebastian Zanner, Elliott Goff, Samuel Ghatan, Eva Maria Woelfel, Charlotte Ejersted, Gisela Kuhn, Ralph Mueller, Morten Frost
Summary: Clinical studies have shown that microvascular disease (MVD) can affect bone microstructure and decrease bone strength in patients with type 2 diabetes mellitus (T2D). This study collected bone biopsies from T2D patients and found that MVD may alter the morphometric parameters of osteocyte lacunae. Additionally, the study revealed that trabecular bone lacunar density was associated with glycated hemoglobin (HbA1c), independent of MVD.
Article
Endocrinology & Metabolism
Mohamad Nasser, Annika Vestergaard Kvist, Peter Vestergaard, Richard Eastell, Andrea M. Burden, Morten Frost
Summary: The study investigated the trends in fracture incidence rates among men and women with type 1 and type 2 diabetes. The results showed a decrease in fracture incidence rates in men with both types of diabetes and in women with type 2 diabetes, highlighting the need for further attention to the stable trend observed in women with type 1 diabetes.
Article
Health Care Sciences & Services
Helena Kames Kjeldgaard, Kristin Holvik, Bo Abrahamsen, Grethe S. Tell, Haakon E. Meyer, Martin O'Flaherty
Summary: Although the age-standardised hip fracture incidence has declined in many countries, the number of fractures is expected to increase due to population aging. This study found that 91% of the decline in hip fractures can be explained by changes in risk factors and the promotion of osteoporosis treatment.
LANCET REGIONAL HEALTH-EUROPE
(2023)
