Article
Engineering, Multidisciplinary
Ping Song, Mingxin Li, Boqing Zhang, Xingyu Gui, Yanlong Han, Li Wang, Wenzheng Zhou, Likun Guo, Zhenyu Zhang, Zhengyong Li, Changchun Zhou, Yujiang Fan, Xingdong Zhang
Summary: This study aimed to prepare high-precision GelMA/HAp composite scaffolds using digital light processing (DLP) printing for bone repair. GelMA hydrogels with adjustable properties were synthesized, and suitable dispersants were selected to reduce the agglomeration of HAp. The printed composite scaffolds with excellent mechanical strength showed promotion of osteoblast adhesion, proliferation, and differentiation in vitro. In vivo experiments on rabbit skull defects demonstrated the ability of the composite scaffolds to accelerate new bone formation. The GelMA/HAp porous composite scaffolds fabricated by composite inks with good printability, mechanical properties, and osteogenic activity have great potential in bone repair applications.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Materials Science, Ceramics
Francesco Baino, Giulia Magnaterra, Elisa Fiume, Alessandro Schiavi, Luciana-Patricia Tofan, Martin Schwentenwein, Enrica Verne
Summary: This study focuses on the additive manufacturing and characterization of hydroxyapatite scaffolds mimicking the trabecular architecture of cancellous bone. A novel approach using stereolithographic technology and 3D reconstructions of polymeric sponges as templates was proposed. The fabricated scaffolds showed promising mechanical properties and mass transport behaviors, making them suitable for bone tissue engineering applications.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Review
Engineering, Biomedical
Yanhao Hou, Weiguang Wang, Paulo Bartolo
Summary: Bone cancer is a global health problem with increasing clinical and economic burdens. Current treatment methods have limitations, but advanced materials and additive manufacturing offer promising solutions for both treatment and bone regeneration.
BIO-DESIGN AND MANUFACTURING
(2022)
Article
Materials Science, Ceramics
Amit Kumar, Kartikeya Dixit, Niraj Sinha
Summary: During the fabrication process of bone regeneration scaffolds, it is challenging to achieve bioactivity, mechanical performance, and ease of fabrication simultaneously. This study reports on the development of additively manufactured (AM) 45S5 Bioglass scaffolds reinforced with functionalized multi-walled carbon nanotubes (CNTs) coated with cellulose nanowhiskers (CNWs). The fabricated scaffolds were characterized using various techniques and exhibited improved compressive strength and toughness. Moreover, the scaffolds showed suitable porosity, pore size, pore throat size, and interconnectivity, and the coating increased the surface roughness for enhanced bone cell attachment. In vitro studies also demonstrated the bioactivity of the scaffolds in simulated body fluid (SBF). These findings highlight the potential for efficient fabrication of hybrid scaffolds with controlled structure, bioactivity, and required toughness and strength for bone tissue engineering.
CERAMICS INTERNATIONAL
(2023)
Article
Biophysics
Minufar Abdollahi Khabisi, Farhad Shirini, Kasra Shirini, Hamid Khorsand, Max Marian, Andreas Rosenkranz
Summary: Human bones can suffer from various injuries, leading to the need for bone replacement using advanced bio-materials. MAX-phases and MXenes have gained attention for their unique properties and potential in bone tissue engineering. Additive manufacturing allows for the fabrication of bio-scaffolds with controlled porosity and complex shapes. However, there is a lack of comprehensive articles summarizing the use of MAX-phases and MXenes in bone scaffolds. Our article addresses this gap and discusses the importance of material choice, recent developments, and future potential.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Harshavardhan Budharaju, Shruthy Suresh, Muthu Parkkavi Sekar, Brigita De Vega, Swaminathan Sethuraman, Dhakshinamoorthy Sundaramurthi, Deepak M. Kalaskar
Summary: Ceramic bone implants have potential properties ideal for long-term implantation applications, and they have advantages including biocompatibility, low cost, and the ability to be made into various shapes. Bone transplantation is the second largest transplantation surgery globally, indicating hope for potential treatment options for bone diseases.
MATERIALS & DESIGN
(2023)
Article
Biotechnology & Applied Microbiology
Gustavo A. Higuera, Tiago Ramos, Antonio Gloria, Luigi Ambrosio, Andrea Di Luca, Nicholas Pechkov, Joost R. de Wijn, Clemens A. van Blitterswijk, Lorenzo Moroni
Summary: Additively manufactured scaffolds have custom-shaped structures with completely interconnected pore networks, and the surface properties of scaffolds greatly impact the success of engineered tissue structures. By combining microspheres with additive manufacturing technologies, 3D scaffolds with adjustable surface roughness can enhance cell adhesion and metabolic activity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Elham Davoodi, Hossein Montazerian, Anooshe Sadat Mirhakimi, Masoud Zhianmanesh, Osezua Ibhadode, Shahriar Imani Shahabad, Reza Esmaeilizadeh, Einollah Sarikhani, Sahar Toorandaz, Shima A. Sarabi, Rohollah Nasiri, Yangzhi Zhu, Javad Kadkhodapour, Bingbing Li, Ali Khademhosseini, Ehsan Toyserkani
Summary: Metal additive manufacturing has revolutionized the design and fabrication of hard tissue substitutes, allowing for personalized implants and improved tissue integration. This review highlights the latest advances in the design and manufacturing of metallic biomaterials through additive manufacturing processes, as well as the potential applications for tissue regeneration.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Manufacturing
Yousef Abdelgaber, Cole Klemstine, Roozbeh (Ross) Salary
Summary: Bone tissue engineering is a promising strategy for the treatment of various bone diseases. A robust image-based method for identifying and characterizing the porosity and dimensional accuracy of bone tissue scaffolds was introduced. The proposed method showed better performance in pore detection and filling compared to the standard method. These outcomes pave the way for high-resolution fabrication of patient-specific bone scaffolds for the treatment of bone pathologies.
JOURNAL OF MANUFACTURING SCIENCE AND ENGINEERING-TRANSACTIONS OF THE ASME
(2023)
Article
Engineering, Manufacturing
Fabian Guenther, Stefan Pilz, Franz Hirsch, Markus Wagner, Markus Kaestner, Annett Gebert, Martina Zimmermann
Summary: This study focuses on shape optimization of bone substitutes based on triply periodic minimal surfaces (TPMS) and demonstrates the potential of coupling TPMS lattices and shape optimization in additive manufacturing. The optimized lattices show significant increases in stiffness and strength while maintaining the TPMS morphology. The presented shape optimization procedure could be a key factor in enhancing the biomimetic design of biocompatible implant materials.
ADDITIVE MANUFACTURING
(2023)
Article
Engineering, Biomedical
Qingyang Liu, Fei Wei, Melanie Coathup, Wen Shen, Dazhong Wu
Summary: This study investigates the effect of porosity and pore shape on the biological and mechanical behavior of additively manufactured bone scaffolds with porosity levels ranging from 15% to 78% and different pore shapes including triply periodic minimal surfaces. The scaffolds were seeded with murine-derived macrophages and human bone marrow-derived mesenchymal stromal cells and the compressive behavior and surface morphology were characterized. The study found that scaffolds with 15%, 30%, and 45% porosity had the highest rate of cell growth and that gyroid and diamond scaffolds exhibited better compressive behavior compared to regular scaffolds. The study provides valuable insights for the selection of porosity and pore shape in additively manufactured bone scaffolds.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Piyachat Chuysinuan, Patcharakamon Nooeaid, Thanyaluck Thanyacharoen, Supanna Techasakul, Prasit Pavasant, Kavita Kanjanamekanant
Summary: The study demonstrates the potential use of synthetic HA-incorporated fibroin-alginate hydrogel as a scaffold for bone regeneration in dentistry, showing good biocompatibility. The hydrogel exhibits high swelling ratio and degradation properties in vitro, but further in vivo studies are needed to validate its clinical application potential.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Lizhe He, Xiaoling Liu, Chris Rudd
Summary: The addition of MgO in composite materials of biodegradable phosphate glass fiber and polylactic acid (PGF/PLA) can neutralize the acidic degradation products, maintaining a neutral pH environment during degradation. The resulting (MgO + PGF)/PLA composite scaffold shows potential for bone tissue engineering applications.
Article
Polymer Science
Sara Biscaia, Joao C. Silva, Carla Moura, Tania Viana, Ana Tojeira, Geoffrey R. Mitchell, Paula Pascoal-Faria, Frederico Castelo Ferreira, Nuno Alves
Summary: Understanding the coupling mechanisms between mechanics and biology in biomaterials is crucial for tissue engineering. This study investigates the effects of adding graphene nanoparticles on the mechanical and biological properties of a poly(epsilon-caprolactone) scaffold. The results show that adding 0.5% graphene nanoparticles significantly improves the compressive modulus of the scaffold and supports cell adhesion, proliferation, and migration.
Review
Polymer Science
Codruta Victoria Tigmeanu, Lavinia Cosmina Ardelean, Laura-Cristina Rusu, Meda-Lavinia Negrutiu
Summary: 3D printing in dentistry allows for patient-specific devices, mass customization, and digital workflow with lower cost and quick turnaround time. Additionally, 4D printing has shown promising effects in dentistry by producing dynamic and adaptable materials that are effective in the oral environment. Future research aims to produce a fully integrated tooth with the surrounding periodontium using 4D printing technology. The use of additive manufacturing in dentistry primarily focuses on producing polymeric constructs due to the wide selection of available materials and their versatility.
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
