Article
Materials Science, Multidisciplinary
Xiao Fu, Yulin Zhang, Gaorui Zhang, Xingang Li, Shilei Ni, Jiwei Cui
Summary: This study reports the synthesis of targeted nanoparticles encapsulated with multiple therapeutics for catalyzing cascade reactions in tumor microenvironments, providing a promising approach for combinational therapy.
APPLIED MATERIALS TODAY
(2022)
Review
Chemistry, Inorganic & Nuclear
Shadpour Mallakpour, Elham Nikkhoo, Chaudhery Mustansar Hussain
Summary: Metal-organic frameworks (MOFs) have gained attention for their adjustable pore sizes, large surface area, and various functionalities, making them suitable for applications in energy storage, CO2 adsorption, catalysis, drug storage, and release.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Vy Anh Tran, Van Thuan Le, Van Dat Doan, Giang N. L. Vo
Summary: Cancer is a multifaceted disease that arises from the interaction between genetic and environmental factors. It has significant clinical, societal, and economic impact. Advancements in material science have led to the development of metal-organic frameworks (MOFs) which show promise as delivery platforms and target vehicles for cancer therapy.
Article
Engineering, Biomedical
Wenyu Chen, Huixin He, Pengfei Jiao, Lefei Han, Jianchun Li, Xiu Wang, Xuliang Guo
Summary: A triple-responsive metal-organic framework is designed to release photosensitizers under low oxygen, reactive oxygen species, and low pH conditions, enhancing the efficacy of photodynamic therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Tanveer A. Tabish, Mian Zahid Hussain, Roland A. Fischer, Angela Casini
Summary: Much progress has been made in subcellular targeted therapy of cancer by attacking disease cell's mitochondria. Mitochondrial dysfunction controls key metabolic changes and is related to tumor invasion, proliferation, tumorigenesis, and metastasis. Supramolecular metal-organic frameworks (MOFs) can be targeted to the tumor's mitochondria selectively and disrupt cancer cells' metabolic processes. Mitochondria-targeted MOFs (mitoMOFs) have the potential to revolutionize targeted therapy and improve therapeutic outcomes with minimal side-effects.
Review
Pharmacology & Pharmacy
Xuechao Cai, Xiaogang Bao, Yelin Wu
Summary: Metal-organic frameworks (MOFs) are versatile materials with tunable properties that have been widely used for the delivery and protection of bioactive agents. Recent research has focused on loading biomacromolecules and utilizing MOFs as intelligent nanocarriers that can be activated in different microenvironments.
Article
Chemistry, Medicinal
Gang Wang, Jingsheng Lu, Xiaoxuan Zeng, Yanwei Cheng, Zhenwei Zhang, Ning Lin, Qing Chen
Summary: Recent studies have shown that combination therapies are more effective in cancer treatment than monotherapies. The combination of metal-organic frameworks (MOFs) and multi-mode therapy offers a realistic possibility to improve the shortcomings of cancer treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Shu Sheng, Lin Lin, Feng Liu, Ying Zhang, Caina Xu, Kai Hao, Dianwei Wang, Huayu Tian, Xuesi Chen
Summary: This study developed a strategy for tumor-specific imaging-guided enhanced combination tumor therapy by introducing endogenous biocatalytic reaction. The reaction produced endogenous melanin with the capabilities of photoacoustic imaging and photothermal therapy. The nanocarrier MIL-100 played dual roles in the reaction, coordinating with the catechol moieties and promoting biocatalysis, and also converting overexpressed H2O2 to O-2, which enhanced the therapeutic outcomes.
CHEMISTRY OF MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Masashi Fujimura, Shinpei Kusaka, Ayaka Masuda, Akihiro Hori, Yuh Hijikata, Jenny Pirillo, Yunsheng Ma, Ryotaro Matsuda
Summary: This study demonstrates a metal-organic framework material capable of reversibly trapping and releasing dissolved oxygen through photosensitization and chemical capturing abilities. The material shows excellent water resistance and can remove oxygen in ppm concentrations in water.
Review
Pharmacology & Pharmacy
Nabab Khan, Garima Slathia, Kajal Kaliya, Ankit Saneja
Summary: Covalent organic frameworks (COFs) have emerged as promising nanoplatforms for cancer therapeutics due to their biocompatibility, tunable cavities, excellent crystallinity, ease of modification, and high flexibility. In this review, recent advances in utilizing COFs for chemotherapeutic agents, photodynamic therapy (PDT), photothermal therapy (PTT), sonodynamic therapy (SDT), cancer diagnostics, and combinatorial therapy are outlined. The current challenges and future directions of this unique research field are also summarized.
DRUG DISCOVERY TODAY
(2023)
Review
Chemistry, Multidisciplinary
Yang Liu, Pengfei Lei, Xuewei Liao, Chen Wang
Summary: This review article summarizes recent advances in nanoscale metal-organic frameworks (nMOFs) as nanoplatforms for drug delivery and cancer therapy. Different techniques using nMOFs are systematically summarized, and their advantages in biomedical applications are highlighted.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2022)
Article
Chemistry, Applied
Zhihui Zong, Wen Xie, Fangxin Gao, Jingyi Shen, Zhicheng Pan, Lili Liang
Summary: In this study, a folic acid-functionalized Fe-MOF was designed as a drug carrier to efficiently deliver Oridonin to cancer cells. The synthesized Fe-MOF-FA@Ori showed promising anticancer effects, inhibiting cell proliferation and inducing apoptosis in SMMC-7721 cells. It also exhibited good anti-metastatic ability. Overall, Fe-MOF-FA is a potent drug carrier for targeted cancer therapy.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Yinjie Wang, Yi Cao, Zhenqi Jiang, Yanying Li, Bo Yuan, Jie Xing, Mingli Li, Qianqian Gao, Kaiwei Xu, Ozioma Udochukwu Akakuru, Aiguo Wu, Juan Li
Summary: This study developed a neuropeptide Y1 receptor ligand-modified cell membrane camouflaged bioresponsive ZIF system for targeted photodynamic therapy of breast cancer, showing good biocompatibility and enhanced tumor accumulation. The ZIF-based nanocarrier combines targeted guidance and long-term stability, providing a platform for safer and more efficient photodynamic therapy for Y1R-overexpressed breast cancer.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Review
Pharmacology & Pharmacy
Roman A. A. Verkhovskii, Alexey N. N. Ivanov, Ekaterina V. V. Lengert, Ksenia A. A. Tulyakova, Natalia Yu. Shilyagina, Alexey V. V. Ermakov
Summary: The paradigm of drug delivery via particulate formulations enables overcoming limitations of traditional chemotherapeutic agents. Stimuli-responsive systems capable of controlled cargo release are widely accepted, with endogenous pH being the most common trigger. However, challenges such as accumulation in off-target tissues, immunogenicity, and complexity of drug delivery hinder the implementation of this idea. This article discusses fundamental strategies for pH-responsive drug delivery, limitations, main problems, weaknesses, and reasons for poor clinical results.
Review
Chemistry, Multidisciplinary
Ling Meng, Na Ren, Mengwei Dong, Shengmin Zhang, Aizhu Wang, Zhong Zhuang, Jie Wang, Chunhui Sun, Hong Liu
Summary: Metal-organic frameworks (MOFs) hold great potential for nerve repair and neural stem cell therapy. This review summarizes the recent advancements in utilizing MOFs for the treatment of neurological diseases, including endogenous stimulation, magnetic response therapy, phototherapy, ultrasound therapy, and drug delivery systems. Furthermore, the use of MOFs-based stem cell therapy can promote nerve regeneration, inhibit neuroinflammation and oxidative stress. The paper also provides an outlook on the future development and challenges in the field of neuroscience concerning MOFs.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)