Article
Plant Sciences
Aftab Amin, Muhammad Jahangir Hossen, Xiu-Qiong Fu, Ji-Yao Chou, Jia-Ying Wu, Xiao-Qi Wang, Ying-Jie Chen, Ying Wu, Cheng-Le Yin, Xiao-Bing Dou, Chun Liang, Gui-Xin Chou, Zhi-Ling Yu
Summary: The ethanolic extract of Atractylodes macrocephala Koidz. (Asteraceae) suppresses inflammation by inhibiting the Akt/I kappa B alpha/NF-kappa B pathway. These findings provide a pharmacological basis for the clinical use of A. macrocephala rhizome in the treatment and prevention of gastritis and gastric cancer.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Muhammad Jahangir Hossen, Aftab Amin, Xiu-Qiong Fu, Ji-Yao Chou, Jia-Ying Wu, Xiao-Qi Wang, Ying-Jie Chen, Ying Wu, Junkui Li, Cheng-Le Yin, Chun Liang, Gui-Xin Chou, Zhi-Ling Yu
Summary: The ethanolic extract of Atractylodes lancea rhizome showed significant anti-gastritis effects both in vivo and in vitro, potentially through the inhibition of the Akt/I kappa B alpha/NF-kappa B signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Xinyi Cheng, Zhanyou Cao, Junrong Luo, Ruiming Hu, Huabin Cao, Xiaoquan Guo, Chenghong Xing, Fan Yang, Yu Zhuang, Guoliang Hu
Summary: Baicalin (BA) pretreatment can protect against avian colibacillosis-induced intestinal injury by improving intestinal barrier function, reducing inflammation, and inhibiting the PI3K/AKT-mediated NF-kappa B pathway.
Article
Biochemistry & Molecular Biology
Bingyu Shen, Haoqing Zhang, Zhengjin Zhu, Zixi Ling, Fangyuan Zeng, Yazhou Wang, Jianguo Wang
Summary: Baicalin, extracted from Scutellaria, has anti-inflammatory effects and can reduce pulmonary edema caused by ALI. It inhibits the expression of TLR4 and MyD88, leading to a decrease in inflammatory molecules. Baicalin also promotes an increase in white blood cells and improves lung pathology, indicating its potential as a treatment for ALI.
Article
Medicine, Research & Experimental
Randa A. A. Zaghloul, Ahmed M. M. Zaghloul, Dalia H. H. El-Kashef
Summary: This study found that baicalin has the potential to reduce liver fibrosis by inhibiting oxidative stress and inflammation, providing anti-oxidant and anti-inflammatory effects.
Article
Plant Sciences
Ki Woong Kwon, Won Young Jang, Ji Won Kim, Jin Kyoung Noh, Dong-Keun Yi, Jae Youl Cho
Summary: The study found that Meriania hexamera Sprague has anti-inflammatory effects, inhibiting inflammatory responses and improving acute gastritis. It mainly acts by targeting Syk kinase in the NF-kappa B pathway, suggesting it could be used as an anti-inflammatory herbal medicine.
Article
Urology & Nephrology
Ziyuan Liu, Huilong Xiang, Qin Deng, Wanting Fu, Yang Li, Zejun Yu, Yinsheng Qiu, Zhinan Mei, Lingyun Xu
Summary: The aim of this study is to investigate the potential of baicalin (BA) and baicalein (BAI) in alleviating hyperuricemic nephropathy (HN) through the PI3K/AKT/NF-kappa B pathway. The results showed that BA and BAI attenuated renal inflammation and apoptosis by inhibiting the PI3K/AKT/NF-kappa B pathway, providing evidence for their potential use as new anti-HN drugs.
Article
Chemistry, Medicinal
Yuyan Bai, Jin Zhou, Han Zhu, Yanlin Tao, Lupeng Wang, Liu Yang, Hui Wu, Fei Huang, Hailian Shi, Xiaojun Wu
Summary: This study found that Isoliquiritigenin (ISL) can inhibit microglia-mediated neuroinflammation in Parkinson's disease (PD) by deactivating JNK/AKT/NFκB signaling pathways. These findings suggest the therapeutic potential of ISL for microglia-mediated neuroinflammation in PD.
PHYTOTHERAPY RESEARCH
(2023)
Article
Food Science & Technology
Haiyan Wen, Siqi Zhou, Jianping Li, Fei Peng, Xiaotao Han, Haohuan Li
Summary: The study highlights the protective effect of Nuciferine (Nuf) against osteoarthritis (OA) by reducing extracellular matrix degradation and inhibiting the production of inflammatory cytokines. Nuf attenuates OA progression by targeting the PI3K/Akt/NF-kappa B signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Plant Sciences
Tian Xu, Xueqian Wang, Chongyang Ma, Jing Ji, Wenxiu Xu, Qi Shao, Xuejing Liao, Ying Li, Fafeng Cheng, Qingguo Wang
Summary: Baicalin has potential therapeutic effects in preventing cerebral ischemia by reducing neurological injury and inhibiting inflammatory responses through multiple pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Qi Zhang, Guowan Su, Qing Yang, Zhengpeng Wei, Jinmei Wang, Lin Zheng, Mouming Zhao
Summary: The study revealed that WCPFSRSF could ameliorate oxidative stress, promote the Nrf2-mediated defense system, and potentially reduce ROS generation by inhibiting NF kappa B. Additionally, WCPFSRSF showed potential as a radical scavenger and Nrf2 activator, with its antioxidant and anti-inflammatory effects possibly related to the presence of Cys and Trp. Furthermore, WCPFSRSF exhibited memory-improving effects in sleep-deprived mice, highlighting its potential as a candidate against neurotoxicity and memory deficits.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Environmental Sciences
Hao-Min Wu, Chen-Yu Chiang, Wen-Ying Chen, Chun-Jung Chen, Ching-Chi Tseng, Yu-Chi Chang, Wen-Min Cheng, Yu-Hsiang Kuan
Summary: Cyclizine exhibits sedation and treatment of nausea, vomiting, and motion sickness due to its antihistaminic and antimuscarinic effects. However, it has the potential for abuse due to its hallucinogenic and euphoric effects. Overdose and illegal abuse of Cyclizine can result in confusion, tremors, chest pain, ataxia, seizures, and even suicide.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Immunology
Linjie He, Yinan Pan, Jiapei Yu, Ben Wang, Gaole Dai, Xiaozhou Ying
Summary: This study found that DE could inhibit inflammatory responses mediated by IL-1 beta by reducing the secretion of inflammatory factors and preventing extracellular matrix collapse. Molecular docking analysis indicated strong binding affinity of DE with PI3K inhibitory targets. In an animal model of OA, DE treatment improved articular cartilage destruction and reduced serum inflammatory factors, suggesting potential for osteoarthritis treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Xingguan Yang, Jiahui Han, Zhirong Huan, Ce Xu, Qiubo Wang, Xin Ge
Summary: The study suggests that baicalin can protect against hemorrhagic shock-induced lung injury by suppressing the activation of NLRP3 inflammasome via the NF-kappa B pathway.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Cell Biology
Yan-Lin Chen, De-Yi Yan, Chen-Yu Wu, Jiang-Wei Xuan, Chen-Qiang Jin, Xin-Li Hu, Guo-Dong Bao, Yu-Jie Bian, Zhi-Chao Hu, Zhong-Hai Shen, Wen-Fei Ni
Summary: OA is characterized by destruction of articular cartilage and inflammation plays a key role in its progression. Maslinic acid (MA) from olive fruit has been shown to have anti-inflammatory effects. In in vitro and in vivo experiments, MA was found to attenuate inflammatory mediators and inhibit the progression of OA disease.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.