Article
Multidisciplinary Sciences
Yueh-Hua Chung, Yuan-Tso Cheng, Ying-Hsien Kao, Wan-Chi Tsai, Gong-Kai Huang, Yen-Ta Chen, Yuan-Chi Shen, Ming-Hong Tai, Po-Hui Chiang
Summary: This study investigates the expression of miR-26a-5p in upper tract urothelial carcinoma (UTUC) and its associated signaling network. The results demonstrate significant down-regulation of miR-26a-5p in UTUC tumors and its ability to inhibit cell proliferation and migration by reversing epithelial-to-mesenchymal transition (EMT) process.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Hallgeir Selven, Sigve Andersen, Mona Pedersen, Ana Paola Giometti Lombardi, Lill-Tove Rasmussen Busund, Thomas Karsten Kilvaer
Summary: This study investigated the prognostic impact of miR-17-5p and miR-20a-5p in colon cancer. The results showed that high expression of both miR-17-5p and miR-20a-5p is associated with a favorable prognosis and inhibits cell migration.
SCIENTIFIC REPORTS
(2022)
Article
Reproductive Biology
Joanna Szuszkiewicz, Anna Nitkiewicz, Klaudia Drzewiecka, Monika M. Kaczmarek
Summary: Embryo implantation is the most critical stage of pregnancy, dependent on the synchronized developmental capacity of the embryo and uterine receptivity. In early pregnancy, both the conceptus and uterus release various factors to facilitate successful implantation and placenta formation. MicroRNAs, which regulate gene expression, are considered important regulators of early pregnancy events.
BIOLOGY OF REPRODUCTION
(2022)
Article
Cell Biology
Binlin Cai, Xiu Qu, Dan Kan, Yi Luo
Summary: This study found that miR-26a-5p can regulate the growth and invasion ability of nasopharyngeal carcinoma cells by inhibiting PTGS2. This is of great significance for a better understanding of the pathogenesis and development of nasopharyngeal carcinoma.
Article
Cell Biology
Jinnan Zhong, Min Liu, Shi Chen, Shuang Liu, Fajiu Li, Chenghong Li
Summary: The experiment aimed to investigate the effects of miR-26a-5p on cellular fibrosis and airway remodeling in asthmatic mice through regulating target genes. The results showed that interfering with miR-26a-5p improved bronchial histopathology and reduced peribronchial collagen deposition. Additionally, overexpression of miR-26a-5p decreased apoptosis in mouse bronchial tissues. In conclusion, miR-26a-5p affects cellular fibrosis and airway remodeling in asthmatic mice by regulating target genes.
Article
Fisheries
Thi Hao Vu, Jubi Heo, Suyeon Kang, Chaeeun Kim, Hyun S. Lillehoj, Yeong Ho Hong
Summary: This study investigates the role and mechanism of the chicken miRNA gga-miR-26a-5p in the immune response to HPAIV H5N1 infection. The results show that gga-miR-26a-5p acts as a translational repressor of MDA5 and negatively regulates the expression of signaling molecules and proinflammatory cytokines in the MDA5 signaling pathway. These findings contribute to a better understanding of the biological functions of gga-miR-26a-5p and the antiviral response in chickens.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Haein Ji, Tae Won Kim, Woo Joo Lee, Seong Dong Jeong, Yong Beom Cho, Hyeon Ho Kim
Summary: This study demonstrates that circular RNA (circRNA) circPPFIA1 inhibits liver metastasis of colorectal cancer (CRC) through the miR-155-5p/CDX1 and HuR/RAB36 pathways.
Article
Environmental Sciences
Yifei Qin, Jing Zhang, Ricardo David Avellan-Llaguno, Xu Zhang, Qiansheng Huang
Summary: DEHP exposure promotes the secretion of miR-26a-5p in sEV, subsequently enhancing the EMT, migration, and invasion ability in neighboring normal cells.
ENVIRONMENTAL POLLUTION
(2021)
Article
Medical Laboratory Technology
Xing Chen, Guixiang Wu, Jing Qing, Chunlin Li, Xudong Chen, Jian Shen
Summary: This study reveals the regulatory functions of LINC00240 on nasopharyngeal carcinoma (NPC). Silencing LINC00240 can inhibit cell proliferation, invasion, migration, and angiogenesis, while promoting apoptosis via miR-26a-5p and EZH2 inhibition in NPC cells. These findings demonstrate the significant role of LINC00240 in the development of NPC.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Review
Biochemistry & Molecular Biology
Miao Da, Jing Zhuang, Yani Zhou, Quan Qi, Shuwen Han
Summary: The abnormally expressed long non-coding RNA (lncRNA) TUG1 plays a critical role in regulating gene expression in malignant tumors, making it a potential clinical biomarker or therapeutic target for cancer. This review provides a basis for new research directions in cancer prevention, diagnosis, and treatment involving lncRNA TUG1.
MOLECULAR MEDICINE
(2021)
Article
Oncology
Fei Li, Hong-Xiang Jiang, Hui-Kai Zhang, Qian-Xue Chen
Summary: The long non-coding RNA TUG1 plays a crucial role in angiogenesis during neural repair after intracerebral hemorrhage (ICH). Overexpression of TUG1 worsens neurologic function and inhibits cerebral angiogenesis, while overexpression of miR-26a alleviates neurologic damage and promotes cerebral angiogenesis in ICH. TUG1 directly binds to miR-26a and suppresses its expression, resulting in the inhibition of VEGF expression. Targeting TUG1/miR-26a could be a potential therapy for ICH.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Xiaodong Yin, Xilan Gu, Fenjun Li, Fei Ye, Fang Liu, Wenbin Wang
Summary: This study aimed to investigate the molecular mechanism of lncRNA SNHG6 in nasopharyngeal carcinoma (NPC) progression. The findings demonstrated that SNHG6 expression was increased in NPC tissues and cells, and its depletion attenuated NPC cell viability and metastasis. SNHG6 was found to regulate NPC progression by modulating the miR-26a-5p/ARPP19 axis.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Neurosciences
Yitian Lu, Maozhu Liu, Xiangna Guo, Peng Wang, Fanning Zeng, Haitao Wang, Jing Tang, Zaisheng Qin, Tao Tao
Summary: The study found that miR-26a-5p can alleviate pain caused by inflammation and exert its effects by inhibiting inflammatory responses. After the inflammatory pain model was established, intrathecal or subcutaneous injection of miR-26a-5p reversed mechanical hypersensitivity and thermal latency in the left hind paw of mice. The study also found that miR-26a-5p regulates the noncanonical Wnt signaling pathway, contributing to its analgesic effect.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Shingo Kishi, Shiori Mori, Rina Fujiwara-Tani, Ruiko Ogata, Rika Sasaki, Ayaka Ikemoto, Kei Goto, Takamitsu Sasaki, Makito Miyake, Satoru Sasagawa, Masashi Kawaichi, Yi Luo, Ujjal Kumar Bhawal, Kiyohide Fujimoto, Hidemitsu Nakagawa, Hiroki Kuniyasu
Summary: N-methyl-glycine (sarcosine) promotes the metastasis and malignant phenotype of bladder cancer cells through GNMT and miR-873-5p related mechanisms. Urinary sarcosine concentration may serve as a marker for muscle invasion in bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Hongtao Shi, Hao Li, Fan Zhang, Honghong Xue, Yanan Zhang, Qinghua Han
Summary: In this study, miR-26a-5p was found to play an inhibitory role in cardiac hypertrophy by targeting ADAM17. The miR-26a-5p-ADAM17 cardiac hypertrophy axis presents a new molecular mechanism for understanding and potentially treating cardiac hypertrophy.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.