Journal
JOURNAL OF VIROLOGY
Volume 94, Issue 9, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01101-19
Keywords
caspase-8; MLKL; RIPK3; ZBP1; apoptosis; influenza; necroptosis
Categories
Funding
- NIH [NS060701, NS099788, AI135025, AI144400]
- Cancer Center Support grant [P30CA006927]
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Influenza A viruses (IAV) are lytic viruses that have recently been found to activate necroptosis in many of the cell types they infect. Necroptotic cell death is potently immunogenic and limits IAV spread by directly eliminating infected cells and by mobilizing both innate and adaptive immune responses. The benefits of necroptosis to the host, however, may sometimes be outweighed by the potentially deleterious hyperinflammatory consequences of activating this death modality in pulmonary and other tissues.
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