Article
Oncology
Liqun Wei, Yuanqi He, Shuhong Bi, Xiaoxiao Li, Jianzhong Zhang, Shihong Zhang
Summary: miRNA-199b-3p and ZEB1 expression are increased in patients with ovarian cancer, high miRNA-199b-3p expression is associated with better prognosis, and miRNA-199b-3p overexpression suppresses ovarian cancer progression.
Article
Oncology
Rohan R. Katipally, Sean P. Pitroda, Ralph R. Weichselbaum, Samuel Hellman
Summary: The oligometastasis hypothesis suggests that metastases exist on a spectrum and are not always disseminated. Identifying patients most likely to have an oligometastatic phenotype is difficult. Recent research on epigenetic regulators of epithelial-mesenchymal transition (EMT) has shed light on the emergence of a spectrum of metastatic behavior.
CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Fernanda Lopez-Moncada, Maria Jose Torres, Boris Lavanderos, Oscar Cerda, Enrique A. Castellon, Hector R. Contreras
Summary: SPARC is a protein that modulates interactions between cells and their microenvironment, and it is abundantly expressed in bone marrow and high-grade prostate cancer. In prostate cancer, SPARC induces the repression of E-cadherin and enhances cell migration through the integrin alpha v beta 3/ZEB1 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Gaili An, Ying Liu, Yinyin Hou, Yu Lei, Jun Bai, Li He, Yi Liu
Summary: This study found that RRP12 is highly expressed in colorectal cancer (CRC) and is associated with poor prognosis in CRC patients. Knockdown of RRP12 suppresses migration and invasion of CRC cells and can reverse metastasis of CRC cells. RRP12 is involved in the tumorigenesis and metastasis of CRC by regulating the epithelial-mesenchymal transition (EMT) process through ZEB1. Bioinformatic-based analyses suggest that RRP12 could serve as a potential biomarker for prognostic assessment of CRC patients.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qianwen Zhao, Tinghui Shao, Yuwen Zhu, Gengjie Zong, Junjie Zhang, Shifan Tang, Yanshan Lin, Hongzhen Ma, Zhifan Jiang, Yong Xu, Xiaoyan Wu, Tao Zhang
Summary: This study found that myofibroblasts play an important role in renal fibrosis. By deleting myocardin-related transcription factor A (MRTF-A), the researchers discovered that MRTF-A promotes renal fibrosis by activating the transcription of Zeb1 and IRF9. These findings reveal a potential pathway for treating renal fibrosis.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Oncology
Qing Li, Zhi-Wei Zhou, Wei Duan, Cheng-Yuan Qian, Shu-Nan Wang, Meng-Sheng Deng, Dan Zi, Jian-Min Wang, Cheng-Yi Mao, Guanbin Song, Dong Wang, Kenneth D. Westover, Cheng-Xiong Xu
Summary: High APE1 expression is associated with lymph node metastasis in cervical cancer and linked to epithelial to mesenchymal transition (EMT). APE1 promotes invasion and metastasis of cervical cancer cells, while inhibiting APE1 may suppress EMT. Targeting APE1 redox function could be a novel strategy for inhibiting cervical cancer metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Yuxiang Lin, Xuan Jin, Qian Nie, Minyan Chen, Wenhui Guo, Lili Chen, Yan Li, Xiaobin Chen, Wenzhe Zhang, Hanxi Chen, Meichen Jiang, Han Xiao, Jie Zhang, Fangmeng Fu, Chuan Wang
Summary: YTHDF3 plays an important role in triple-negative breast cancer, and is associated with disease progression and metastasis. It can serve as a potential therapeutic target and prognostic biomarker.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Leyla Soleymani, Ali Zarrabi, Farid Hashemi, Fardin Hashemi, Amirhossein Zabolian, Seyed Mohammad Banihashemi, Shirin Sabouhi Moghadam, Kiavash Hushmandi, Saeed Samarghandian, Milad Ashrafizadeh, Haroon Khan
Summary: Prostate cancer (PCa) is a major cause of death globally, with treatments like surgery, chemotherapy, radiotherapy, and immunotherapy. PCa cells initially respond to therapy but can develop resistance later on. The ZEB family, particularly ZEB1 and ZEB2, play a significant role in promoting cancer progression through EMT induction, impacting proliferation and therapy resistance in PCa. Their upregulation is associated with poor prognosis and can enhance migration and invasion of PCa cells.
CURRENT CANCER DRUG TARGETS
(2021)
Article
Biochemistry & Molecular Biology
Sergey E. Parfenyev, Sergey V. Shabelnikov, Elena N. Tolkunova, Nickolai A. Barlev, Alexey G. Mittenberg
Summary: P53 plays a critical role in protecting the genome and preventing tumor formation, including metastases. The interaction between p53 and the transcription factor Zeb1 is important in carcinogenesis, particularly in the process of epithelial to mesenchymal transition (EMT). Additionally, the composition of Zeb1 interactome is affected by the presence of cancer stem cells and the level of Oct4/Sox2 expression, indicating that stemness influences the specificity of Zeb1 interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sergey E. Parfenyev, Sergey V. Shabelnikov, Danila Y. Pozdnyakov, Olga O. Gnedina, Leonid S. Adonin, Nickolai A. Barlev, Alexey G. Mittenberg
Summary: The Zeb1 transcription factor plays a crucial role in malignant transformation in breast cancer, interacting with proteins involved in cancer formation. Co-expression of Zeb1 and CTBP2 in breast cancer patients is associated with poor survival prognosis, indicating the functional interaction between them.
Article
Oncology
Wang Zeng, Shuchen Gu, Yi Yu, Yili Feng, Mu Xiao, Xin-Hua Feng
Summary: EMT is a crucial biological process, and ZNF451 plays a role in promoting EMT by regulating TWIST2 through SUMOylation to increase TWIST2 protein levels in cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Environmental Sciences
Sepideh Mirzaei, Mohammad Hossein Gholami, Hamid Asadzadeh Aghdaei, Mehrdad Hashemi, Kazem Parivar, Amin Karamian, Ali Zarrabi, Milad Ashrafizadeh, Jianlin Lu
Summary: This study aimed to explore the role of exosomes in the delivery of miR-200a to suppress EMT-mediated GC metastasis. The findings showed that exosomes could efficiently deliver miR-200a and inhibit EMT in GC cells, suggesting a new strategy for miR-200a delivery.
ENVIRONMENTAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Sara Thornby Bak, Eva Bang Harvald, Ditte Gry Ellman, Sabrina Bech Mathiesen, Ting Chen, Shu Fang, Kristian Skriver Andersen, Christina Duhring Fenger, Mark Burton, Mads Thomassen, Ditte Caroline Andersen
Summary: While fetal heart CMs divide, postnatal CMs become binucleated or polyploid due to the lack of karyokinesis and/or cytokinesis, hindering heart regeneration. This study uses scRNA-seq to identify TFs involved in CM proliferation and terminal differentiation. By combining FACS and scRNA-seq, the researchers generate high-resolution transcriptomic maps of diploid and tetraploid CMs, revealing ZEB1 as a key regulator of CM proliferation and endoreplication.
BASIC RESEARCH IN CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jenna Kitz, Cory Lefebvre, Joselia Carlos, Lori E. Lowes, Alison L. Allan
Summary: This study revealed that inducible knockdown of Zeb1 can lead to an aggressive p-EMT phenotype in prostate cancer cells, which can be mitigated by treatment with the 5-azacytidine drug. DNA methylation chip analysis also identified potential targets for identifying and targeting aggressive p-EMT prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Anastasios Goulioumis, Kostis Gyftopoulos
Summary: Epithelial-to-mesenchymal transition (EMT) is a molecular phenomenon that occurs in epithelial neoplasms, such as laryngeal carcinoma. EMT leads to the loss of epithelial traits and acquisition of mesenchymal traits by tumor cells, enhancing their migratory capacity. EMT is mediated by complex molecular pathways and involves various changes, including loss of adhesion, cytoskeleton remodeling, evasion of apoptosis and immune surveillance, upregulation of metalloproteinases, etc. Partial EMT models have been accepted to explain the cell plasticity associated with invasion and metastasis of tumors.
