Article
Biotechnology & Applied Microbiology
Matteo Frigelli, Philippe Buchler, Sabine Kling
Summary: In this study, optical coherence elastography was used to investigate the effects of corneal cross-linking on refractive power and corneal biomechanics. The results showed that different cross-linking treatment patterns and energy densities resulted in different refractive corrections and axial strains. Based on the findings, personalized cross-linking treatment plans can be proposed in the future to achieve customized refractive corrections.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ruiliu Wang, Chaoji Chen, Zhenqian Pang, Xizheng Wang, Yubing Zhou, Qi Dong, Miao Guo, Jinlong Gao, Upamanyu Ray, Qinqin Xia, Zhiwei Lin, Shuaiming He, Bob Foster, Teng Li, Liangbing Hu
Summary: Conventional plastic foams made from fossil-fuel-derived polymers are difficult to biodegrade in nature. This study presents a fast and scalable method to prepare cellulose-graphite foams by cross-linking cellulose fibrils in a metal ions-containing solution, followed by ambient drying. The resulting foams exhibit low density, high compressive strength, and excellent water stability. The cross-linking effect of different metal ions is revealed through density functional theory, showing good agreement with experimental observations. This approach offers a sustainable route for low-cost, environmentally friendly, and scalable foam production for various applications.
Article
Engineering, Biomedical
Yahua Wang, Wei-Ning Lee
Summary: The study established a mathematical model and conducted experiments to demonstrate the relationship among arterial wall deformation, stiffness, and luminal pressure, showing the effectiveness and accuracy of the proposed method for estimating dynamic luminal pressure changes.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Biochemical Research Methods
Gary R. Ge, Behrouz Tavakol, David B. Usher, Desmond C. Adler, Jannick P. Rolland, Kevin J. Parker
Summary: In this study, a high-resolution elastography method in combination with a custom optical coherence tomography system was used to track the biomechanical changes in individual corneal layers. The results showed that the reverberant three-dimensional optical coherence elastography (OCE) technique can identify the elasticity changes associated with CXL treatments and provide insights into the nonlinearity of the elasticity changes.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Omran Al Dandan, Ali Hassan, Malak Al Shammari, Mahdi Al Jawad, Hind S. Alsaif, Khalid Alarfaj
Summary: This study found that digital eye strain is prevalent among radiologists, especially among radiology residents. Female radiologists and those who do not take frequent breaks are at higher risk of digital eye strain.
ACADEMIC RADIOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Michael B. Prime, Athanasios Arsenlis, Ryan A. Austin, Nathan R. Barton, Corbett C. Battaile, Justin L. Brown, Leonid Burakovsky, William T. Buttler, Shuh-Rong Chen, Dana M. Dattelbaum, Saryu J. Fensin, Dawn G. Flicker, George T. Gray, Carl Greeff, David R. Jones, J. Matthew D. Lane, Hojun Lim, D. J. Luscher, Thomas R. Mattsson, James M. McNaney, Hye-Sook Park, Philip D. Powell, Shon T. Prisbrey, Bruce A. Remington, Robert E. Rudd, Sky K. Sjue, Damian C. Swift
Summary: By combining experiments and modeling, this study investigates the compressive strength of tantalum under different pressures, strain rates, and temperatures. The findings suggest that strength is more influenced by pressure than strain rate. Simulation experiments provide further insights into strength models and mechanisms.
Article
Ophthalmology
N. Venkatesh Prajna, Naveen Radhakrishnan, Prajna Lalitha, Zijun Liu, Jeremy D. Keenan, Benjamin F. Arnold, Jennifer Rose-Nussbaumer
Summary: The purpose of this study was to determine whether astigmatism or corneal scarring is mediating the reduced visual acuity among patients with fungal keratitis randomized to corneal cross-linking (CXL). The results showed that astigmatism, scar size, scar depth, and corneal density may affect the effectiveness of corneal cross-linking treatment on visual acuity.
Article
Chemistry, Applied
Chen Yang, Manya Wang, Wei Wang, Hongyu Liu, Hongbing Deng, Yumin Du, Xiaowen Shi
Summary: A novel electrofabrication methodology using electrodeposition is developed for the fabrication of hydrogel contact lenses. This method allows for covalent cross-linking between chitosan and epichlorohydrin, improving the transmittance and toughness of hydrogels without affecting their oxygen permeability. The geometry and characteristics of the contact lenses can be customized through electrical signals and electrochemical cross-linking.
CARBOHYDRATE POLYMERS
(2022)
Article
Ophthalmology
Dawn Meyer, Martin Rickert, Pete Kollbaum
Summary: The study found that both soft contact lens wearers and non-contact lens wearers commonly experience eye fatigue symptoms when using digital devices, with differences in frequency and severity of certain symptoms between the two groups. Principal component analysis revealed distinct patterns of eye fatigue symptoms.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Ophthalmology
Quan Hoang, Quan Wen, David C. Paik, Yong Yao Chun, Ronald Silverman, Takayuki Nagasaki, Stephen L. Trokel, Mariya Zyablitskaya
Summary: This study evaluated the efficacy of scleral cross-linking using sodium hydroxymethylglycinate (SMG) to inhibit eye growth in an in vivo rabbit model. The results showed that SMG treatment significantly limited axial growth and increased heat resistance, suggesting that sub-Tenon injection of cross-linking solutions could be a potential treatment for myopia.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ping Tong, Xiaoqian Xu, Ke Liu, Hongbing Chen, Jinyan Gao
Summary: In this study, the impact of denatured pre-treatments on OVA cross-linking and the combined effect of pre-treatment and cross-linking on OVA structure, allergenicity, and functional properties were evaluated. It was found that heating at 100 degrees C for 5 min or using 0.5% SDS as pre-treatment significantly promoted the cross-linking reaction and altered the properties of OVA. Comparatively, heating at 100 degrees C for 5 min was more effective in reducing the potential allergenicity of OVA when assisted with enzymatic cross-linking.
Article
Polymer Science
Jake A. Muldoon, Michael D. Garrison, Markku A. Savolainen, Benjamin G. Harvey
Summary: Cardanol, a low-cost component of cashew nut shell oil, was converted to a cyanate ester resin and blended with a trifunctional thiol. UV light irradiation allowed for ambient temperature cure and enhanced cross-linking. This material may have potential applications as a toughener for rigid cyanate esters or self-healing materials.
Article
Acoustics
Linfeng Zhao, Haoming Lin, Yaxin Hu, Xin Chen, Siping Chen, Xinyu Zhang
Summary: A corneal viscoelasticity imaging method based on comb-push ultrasound shear elastography (CUSE) was developed in this study to quantitatively assess the mechanical properties of the cornea before and after CXL treatments. The method was shown to provide high-resolution 2D Lamb wave velocity images and quantitative viscoelasticity estimations, demonstrating potential for studying corneal biomechanics. The study also validated the accuracy of elasticity estimation using ex vivo porcine corneas.
Article
Physics, Multidisciplinary
Martin Silhavik, Prabhat Kumar, Zahid Ali Zafar, Martin Misek, Martin Cicala, Marek Piliarik, Jiri Cervenka
Summary: Graphene aerogel exhibits anomalous superelastic behavior and can withstand high compressive and tensile strains. A quantitative origami model is developed to describe its stress-strain behavior.
COMMUNICATIONS PHYSICS
(2022)
Article
Biochemical Research Methods
Fernando Zvietcovich, Achuth Nair, Manmohan Singh, Salavat R. Aglyamov, Michael D. Twa, Kirill V. Larin
Summary: Utilizing ACUS-OCE technology, this study explored the local changes of corneal elasticity in untreated, half-CXL-treated, and full-CXL-treated rabbit corneas, revealing significant increases in shear modulus in the treated regions. This indicates the potential of ACUS-OCE technology in detecting spatially-dependent mechanical properties of the cornea.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Biotechnology & Applied Microbiology
Sabine Kling, Hossein Khodadadi, Orcun Goksel
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Ophthalmology
Sabine Kling, Fong Siang Hufschmid, Emilio A. Torres-Netto, J. Bradley Randleman, Mark Willcox, Reinhard Zbinden, Farhad Hafezi
Article
Psychiatry
Johannes Kirchebner, Steffen Lau, Sabine Kling, Martina Sonnweber, Moritz Philipp Guenther
Summary: Through latent class analysis, the study identified three subtypes of offenders with schizophrenia - early starters, late starters, and all-course starters, showing different levels of symptom remission during inpatient treatment. Tailored psychiatric treatment may be necessary to provide more equal benefits to offender patient subgroups.
INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH
(2021)
Article
Ophthalmology
Emilio A. Torres-Netto, Farhad Hafezi, Bogdan Spiru, Francesca Gilardoni, Nikki L. Hafezi, Jose Alvaro P. Gomes, J. Bradley Randleman, Walter Sekundo, Sabine Kling
Summary: The presence or absence of Bowman layer did not show a measurable difference in corneal stiffness in healthy ex vivo human corneal lamellas. Therefore, removing Bowman layer during photorefractive keratectomy may not have a negative impact on corneal biomechanics.
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2021)
Article
Psychiatry
Moritz Philipp Guenther, Steffen Lau, Sabine Kling, Martina Sonnweber, Elmar Habermeyer, Johannes Kirchebner
Summary: This study identified two homogenous subgroups among forensic patients with schizophrenia, with differences attributed to gender. Female patients were more likely to receive longer prison terms, equally high antipsychotic dosages, and were less likely to benefit from inpatient treatment. Further research is needed to develop tailored approaches for female offender patients with schizophrenia to address potential inequities.
ANNALS OF GENERAL PSYCHIATRY
(2021)
Article
Psychiatry
Steffen Lau, Johannes Kirchebner, Sabine Kling, Sebastian Euler, Moritz Philipp Guenther
Summary: Research shows differences exist between offender patients with schizophrenia spectrum disorder and childhood maltreatment compared to those without maltreatment, with variations even within the maltreatment group. While some maltreated patients may benefit from inpatient treatment, others may not.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Ophthalmology
Hormoz Abdshahzadeh, Reyhaneh Abrishamchi, Emilio A. Torres-Netto, Sabine Kling, Nikki L. Hafezi, Mark Hillen, Farhad Hafezi
Summary: The study evaluated the potential effect of reducing corneal temperature during CXL on increasing oxygen availability and enhancing the biomechanical stiffening effect in ex vivo porcine corneas, finding that hypothermic conditions did not significantly impact the biomechanical strengthening effect in this model.
Article
Ophthalmology
Farhad Hafezi, Sabine Kling, Francesca Gilardoni, Nikki Hafezi, Mark Hillen, Reyhaneh Abrishamchi, Jose Alvaro P. Gomes, Cosimo Mazzotta, J. Bradley Randleman, Emilio A. Torres-Netto
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Multidisciplinary Sciences
Gonzalo Garcia de Oteyza, Juan Alvarez de Toledo, Rafael Barraquer, Sabine Kling
Summary: The study evaluated the local geometric effects of a unilateral intrastromal ring segment with combined variation of ring thickness and base width in a finite element simulation. Results showed that increasing ring thickness and base width along the arc of the asymmetric ring segment produced a more pronounced flattening, suggesting that intracorneal asymmetric ring segments with varying thickness and base width can be a good alternative for corneas with asymmetric keratoconus phenotypes.
Article
Multidisciplinary Sciences
Sabine Kling, Emilio A. Torres-Netto, Hormoz Abdshahzadeh, Edgar M. Espana, Farhad Hafezi
Summary: The study quantified corneal biomechanical properties in an adult classic EDS mouse model and found that Col5a1(+/-) corneas were thinner but had increased short-term elastic modulus and stronger relaxation compared to wild-type corneas. Differences in collagen fibril structure were observed, suggesting a link between disturbed collagen fibril structure and viscoelastic properties.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Bogdan Spiru, Emilio A. Torres-Netto, Sabine Kling, Farhad Hafezi, Walter Sekundo
Summary: This study investigated the biomechanical properties of ex vivo human paired corneas after hyperopic correction using different surgical techniques. The results showed that the cap-based procedure (SMILE) and flap-based technique (FS-LASIK) may be considered equivalent in terms of biomechanical stability in human corneas.
JOURNAL OF REFRACTIVE SURGERY
(2021)
Article
Biotechnology & Applied Microbiology
Sabine Kling
Summary: A novel approach using OCT system combined with swimming goggles and pressure control unit was presented for non-invasive quantification of axial displacement and strain in response to ambient pressure change in eye tissue. The study showed that pressure modulation induced tissue displacement and strain, potentially relevant for clinical follow-up and pre-surgical screening. More optimization is needed to overcome the limitation of involuntary eye motions for better spatial resolution.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Ophthalmology
Emilio A. Torres-Netto, Sabine Kling
Summary: This study directly records the strain field in the cornea after stromal tunnel creation and implantation of an intracorneal ring segment. The results show that implantation of the ring segment induces localized strains in the regions subjected to refractive changes, which suggests a direct relationship between corneal strain and curvature. Understanding corneal strain in response to surgical intervention may provide new insights on underlying working principles.
JOURNAL OF REFRACTIVE SURGERY
(2022)
Article
Oncology
Felice Simnacher, Anna Gotz, Sabine Kling, Jan Ben Schulze, Roland von Kanel, Sebastian Euler, Moritz Philipp Gunther
Summary: International guidelines recommend screening for cancer patients’ distress, but rates are insufficient. This study developed a survey to assess systemic barriers to distress screening. Through a three-step approach, an initial survey with 53 questions was reduced to a final set of 14 validated questions using qualitative content analysis and factor analysis. Major barriers identified include timing of screening, lack of capacity, patient and staff overload, and refusal of patients to be referred to support services. The validated questions enable quick identification and improvement of screening programs.
Article
Biotechnology & Applied Microbiology
Gonzalo Garcia de Oteyza, Juan alvarez de Toledo, Rafael I. Barraquer, Sabine Kling
Summary: A hyperelastic shell finite element model was developed to investigate the optical changes induced by different intracorneal ring segment (ICRS) geometries. The results showed that customized ICRS designs have the potential to achieve more tailored refractive corrections, particularly in asymmetric keratoconus patterns.
BIOENGINEERING-BASEL
(2023)