Article
Surgery
Liise K. Kayler, Jing Nie, Katia Noyes
Summary: The study found that the hardest-to-place kidneys accepted later in the match run were associated with higher rates of delayed graft function and graft failure.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Yuangao Liu, Fernando A. Padilla, Edward A. Graviss, Duc T. Nguyen, Harveen K. Lamba, Swami Gnanashanmugam, Subhasis Chatterjee, Erik Suarez, Arvind Bhimaraj
Summary: The study examined the outcomes of heart transplant recipients with different body mass index (BMI) ranges. The results showed that recipients with a BMI of 35 to 39.9 kg/m(2) had lower survival rates compared to those with a BMI <35 kg/m(2), but better outcomes than recipients with a BMI >= 40 kg/m(2). This suggests that selected patients with class II obesity should be considered for transplantation, contrary to current guidelines.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Urology & Nephrology
Miko Yu, Kristen L. King, S. Ali Husain, Anne M. Huml, Rachel E. Patzer, Jesse D. Schold, Sumit Mohan
Summary: This study examined differences in reported deaths among kidney transplant candidates and recipients in three transplant datasets. The results showed large discrepancies in patient outcomes reported across datasets, raising questions about their completeness.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Taylor Nordan, Andre C. Critsinelis, Shant H. Mahrokhian, Navin K. Kapur, Katherine L. Thayer, Frederick Y. Chen, Gregory S. Couper, Masashi Kawabori
Summary: The new donor heart allocation system has a positive impact on patients undergoing heart transplantation with extracorporeal membrane oxygenation, leading to shorter waitlist times, reduced preoperative comorbidities, and improved 180-day survival rates compared to the old system.
CIRCULATION-HEART FAILURE
(2021)
Article
Pediatrics
Safaa M. Abdelrahman, Basma Samir, Eman Abobakr Abd Alazem, Noha Musa
Summary: Obesity is an independent risk factor for graft function and survival in pediatric kidney transplantation. Pre-transplant weight reduction is crucial in improving post-transplant outcomes.
Article
Surgery
Scott G. Westphal, Eric D. Langewisch, Amanda M. Robinson, Amber R. Wilk, Jianghu J. Dong, Troy J. Plumb, Ryan Mullane, Shaheed Merani, Arika L. Hoffman, Alexander Maskin, Clifford D. Miles
Summary: This study found that Kidney-alone transplant (KAT) candidates may face disadvantages due to the allocation priority given to multi-organ transplant (MOT) candidates. The analysis showed that next-sequential KAT candidates who missed out on receiving kidney offers were typically younger, more likely to be racial/ethnic minorities, and had higher sensitivities, leading to some candidates experiencing higher mortality rates and delays in transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Nicholas G. Larkins, Lloyd D'Orsogna, Anne Taverniti, Ankit Sharma, Aron Chakera, Doris Chan, Anoushka Krishnan, Germaine Wong, Wai H. Lim
Summary: High resolution HLA typing is crucial for eplet compatibility and specificity of DSA. NGS and LD typing show high concordance but significant differences. Inaccurate DSA assignment from LD typing may inappropriately exclude candidates.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maryne Lepoittevin, Sebastien Giraud, Thomas Kerforne, Benoit Barrou, Lionel Badet, Petru Bucur, Ephrem Salame, Claire Goumard, Eric Savier, Julien Branchereau, Pascal Battistella, Olaf Mercier, Sacha Mussot, Thierry Hauet, Raphael Thuillier
Summary: Organ transplantation is the last resort for treating organ failure, but the shortage of organs remains a challenge. To address this issue, there is a need to expand the donor pool and optimize preservation conditions to improve the quality of transplanted organs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Hillary J. Braun, Dominic Amara, Amy M. Shui, Peter G. Stock, Ryutaro Hirose, Francis L. Delmonico, Nancy L. Ascher
Summary: This study assesses the outcomes of international liver transplant patients based on their citizenship status, revealing significant disparities in access to and outcomes of liver transplantation.
Article
Medicine, General & Internal
Napat Leeaphorn, Charat Thongprayoon, Pradeep Vaitla, Panupong Hansrivijit, Caroline C. Jadlowiec, Shennen A. Mao, Api Chewcharat, Sreelatha Katari, Pattharawin Pattharanitima, Boonphiphop Boonpheng, Wisit Kaewput, Michael A. Mao, Matthew Cooper, Wisit Cheungpasitporn
Summary: The study found that patient and allograft survival in SCD kidney transplant recipients were lower compared to recipients with other diagnoses. Despite no improvement in outcomes for SCD recipients in the recent era compared to the early era, kidney transplantation for ESKD patients with SCD still provides a survival benefit when compared to remaining on dialysis. Further urgent research is needed to improve outcomes and potentially consider risk adjustment for SCD patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Urology & Nephrology
Calyani Ganesan, Malorie Holmes, Sai Liu, Maria Montez-Rath, Simon Conti, Timothy C. C. Chang, Colin R. Lenihan, Xingxing S. S. Cheng, Glenn M. Chertow, John T. Leppert, Alan C. C. Pao
Summary: Background: Kidney stone disease is common and can lead to complications in kidney transplant recipients. This study found that approximately 2% of kidney transplant recipients were diagnosed with a kidney stone in the first 3 years after transplantation. Risk factors for kidney stone events included a history of kidney stones and longer dialysis vintage.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Surgery
David P. Al-Adra, Laura Hammel, John Roberts, E. Steve Woodle, Deborah Levine, Didier Mandelbrot, Elizabeth Verna, Jayme Locke, Jonathan D'Cunha, Maryjane Farr, Deirdre Sawinski, Piyush K. Agarwal, Jennifer Plichta, Sandhya Pruthi, Deborah Farr, Richard Carvajal, John Walker, Fiona Zwald, Thomas Habermann, Morie Gertz, Philip Bierman, Don S. Dizon, Carrie Langstraat, Talal Al-Qaoud, Scott Eggener, John P. Richgels, George J. Chang, Cristina Geltzeiler, Gonzalo Sapisochin, Rocco Ricciardi, Alexander S. Krupnick, Cassie Kennedy, Nisha Mohindra, David P. Foley, Kymberly D. Watt
Summary: This article discusses the evaluation of solid organ transplantation for patients with a history of malignancy, emphasizing the need to balance the benefits of transplantation and the risk of tumor recurrence. It also points out that previous guidelines do not fully consider current staging, disease biology, and advances in cancer treatments.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Arianne C. Agdamag, Samy Riad, Valmiki Maharaj, Scott Jackson, Meg Fraser, Victoria Charpentier, Bellony Nzemenoh, Cindy M. Martin, Tamas Alexy
Summary: This study examined the use of temporary mechanical circulatory support devices and its impact on survival rates in heart-kidney transplant recipients. The study found that despite the increased use of tMCS devices, the one-year survival rate after heart-kidney transplantation remained unchanged.
Article
Cardiac & Cardiovascular Systems
Jaya Batra, Ersilia M. DeFilippis, Stephanie Golob, Kevin Clerkin, Veli K. Topkara, Marlena Habal, Susan Restaino, Jan Griffin, Sun Hi Lee, Farhana Latif, Maryjane A. Farr, Gabriel Sayer, Jayant Raikelkar, Nir Uriel
Summary: The prevalence of pretransplant malignancy in heart transplant recipients has nearly tripled over the past 20 years. Patients with hematologic pretransplant malignancy are at increased risk of early mortality after heart transplantation. Patients with pretransplant malignancy are also more likely to develop posttransplant malignancies.
CIRCULATION-HEART FAILURE
(2022)
Article
Medicine, General & Internal
Mengmeng Ji, Amanda J. Vinson, Su-Hsin Chang, Massini Merzkani, Krista L. Lentine, Yasar Caliskan, Kristin Progar, Nicole Nesselhauf, Casey Dubrawka, Tarek Alhamad
Summary: This study evaluated kidney use and transplant outcomes from deceased donors with active or resolved COVID-19, showing a decreasing likelihood of nonuse over time and no worse outcomes within 2 years post-transplant.