Article
Nutrition & Dietetics
Bruce Y. Lee, Jose M. Ordovas, Elizabeth J. Parks, Cheryl A. M. Anderson, Albert-Laszlo Barabasi, Steven K. Clinton, Kayla de la Haye, Valerie B. Duffy, Paul W. Franks, Elizabeth M. Ginexi, Kristian J. Hammond, Erin C. Hanlon, Michael Hittle, Emily Ho, Abigail L. Horn, Richard S. Isaacson, Patricia L. Mabry, Susan Malone, Corby K. Martin, Josiemer Mattei, Simin Nikbin Meydani, Lorene M. Nelson, Marian L. Neuhouser, Brendan Parent, Nicolaas P. Pronk, Helen M. Roche, Suchi Saria, Frank A. J. L. Scheer, Eran Segal, Mary Ann Sevick, Tim D. Spector, Linda B. Van Horn, Krista A. Varady, Venkata Saroja Voruganti, Marie F. Martinez
Summary: Precision nutrition is an emerging concept that aims to develop personalized nutrition recommendations based on individual circumstances and biological characteristics. The response to dietary changes and the resulting health outcomes may vary significantly among individuals due to interactions between genetics, physiology, microbiome, health status, behavior, social influences, and environmental exposures. The workshop highlighted the need for further research to achieve more precise nutrition recommendations while considering variables such as age, sex, ethnicity, medical history, genetics, and social and environmental factors.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Genetics & Heredity
George Lagoumintzis, George P. Patrinos
Summary: The physiological and genetic characteristics of individuals influence their reactions to dietary constituents and nutrients, leading to the development of personalized nutrition. Nutrigenetics has made significant progress in understanding the impact of genetic variants on nutrient levels and responsiveness to diet. However, the polygenic nature of nutrition-related pathologies presents obstacles to implementing individualized nutrition. Advanced omic technologies have the potential to uncover hidden genetic elements and gene-environment interactions. This review provides up-to-date information on personalized nutrition, emphasizing the interplay between microbiota, dietary metabolites, and genes, and explores the potential applications of genotyping and microbiomics in tailored dietary plans.
Review
Nutrition & Dietetics
Sangeetha Shyam, Ke Xin Lee, Angeline Shu Wei Tan, Tien An Khoo, Shivani Harikrishnan, Shehzeen Alnoor Lalani, Amutha Ramadas
Summary: Personalized nutrition is an approach that tailors nutrition advice based on individuals' genetic information. Despite interest among scholars, the impact of this approach on lifestyle habits and health has not been adequately explored. A systematic review of randomized trials suggests that there is limited evidence supporting the consistent benefits of personalized nutrition in improving dietary, behavioral, or health outcomes. Future trials should focus on improving methodological quality and expanding the generalizability of the results.
Article
Food Science & Technology
Katherine M. Livingstone, Omar Ramos-Lopez, Louis Perusse, Hisanori Kato, Jose M. Ordovas, J. Alfredo Martinez
Summary: Precision nutrition is a method that utilizes human variability to design personalized dietary interventions. By integrating various technologies, including nutritional genetics, epigenetics, genomics, metabolomics, and metagenomics, it aims to understand metabolism and human wellbeing for implementing health actions. In recent years, significant progress has been made in these research fields, supporting the development of personalized and precision nutrition interventions. Furthermore, advancements in big data and machine learning have opened up new possibilities for the application of precision nutrition in research, industry, and healthcare.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
F. C. Malcomson, J. C. Mathers
Summary: Personalised and precision nutrition uses individual characteristics and responses to nutrients, foods, and dietary patterns to develop targeted nutritional advice for improving health. This approach is moving away from the 'one size fits all' model and may have potential for better population health and disease prevention. While most efforts have focused on obesity and cardiovascular diseases, there is a need to apply personalised and precision nutrition approaches in cancer prevention and for cancer survivors, taking advantage of the understanding of dietary factors, genetics, and the microbiome.
Review
Food Science & Technology
Katherine M. Livingstone, Omar Ramos-Lopez, Louis Perusse, Hisanori Kato, Jose M. Ordovas, J. Alfredo Martinez
Summary: Precision nutrition integrates various factors, such as genetics, metagenomics, metabolomics, physiopathology, behavior, and sociocultural cues, to understand metabolism and human wellbeing and implement health actions. Advances in high-throughput multi-omics techniques and integrative big data systems are necessary for such comprehensive measures. Research in nutritional genetics, epigenetics, genomics, metabolomics, and metagenomics has exponentially accelerated, providing insights into genetic and phenotypic variations in response to diet and paving the way for personalized and precision nutrition interventions. Additionally, developments in big data and machine learning enable integrated precision nutrition applications in research, industry, and healthcare. This review aims to provide an understanding of the latest developments and future trends in precision nutrition by exploring each of these areas.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Giada Bianchetti, Flavio De Maio, Alessio Abeltino, Cassandra Serantoni, Alessia Riente, Giulia Santarelli, Maurizio Sanguinetti, Giovanni Delogu, Roberta Martinoli, Silvia Barbaresi, Marco De Spirito, Giuseppe Maulucci
Summary: The human gut microbiome plays a significant role in human health and disease development. Recent advancements in technology have allowed for a better understanding of its composition and functions. Diet, specifically, has been found to shape the gut microbiome, affecting its diversity, population size, and metabolism. Personalized nutrition, based on individual characteristics, has shown promise in directly impacting the gut microbiome. Longitudinal studies are necessary to fully comprehend the long-term effects of specific diets and food components on the gut microbiome, as well as the variations between individuals. Accurate methods of collecting dietary data and the application of machine learning techniques hold immense potential in understanding the gut microbiome's response to diet and providing tailored lifestyle recommendations.
Review
Agriculture, Dairy & Animal Science
Mohamed Abdelrahman, Wei Wang, Aftab Shaukat, Muhammad Fakhar-e-Alam Kulyar, Haimiao Lv, Adili Abulaiti, Zhiqiu Yao, Muhammad Jamil Ahmad, Aixin Liang, Liguo Yang
Summary: In the past decade, animal nutrition science has made significant progress, thanks to advances in molecular technologies. Nutrigenomics and feedomics have provided a new perspective on the interaction between nutrition and genes, integrating comprehensive findings in animal physiology, molecular genetics, and biochemistry. They have also contributed to a better understanding of the diet-gut interaction in ruminants by considering the role of rumen microbes. This review highlights the potential contributions of nutrigenomics and feedomics in closing the knowledge gap about the cellular activities of different nutrients and discusses how nutritional management can impact ruminant health and production through genomics.
Review
Nutrition & Dietetics
Justine Keathley, Veronique Garneau, Daniela Zavala-Mora, Robyn R. Heister, Ellie Gauthier, Josiane Morin-Bernier, Robert Green, Marie-Claude Vohl
Summary: This study conducted a systematic review to examine existing frameworks for determining scientific validity in nutrition and genetics, with the aim of identifying the most appropriate framework for evaluating scientific validity in nutrigenetics. The analysis included 49 articles representing 41 frameworks, highlighting key factors important for evaluating nutrigenetic evidence. A single existing framework was recommended as optimal for the rigorous evaluation of scientific validity in nutritional genomics, with proposed modifications to strengthen its applicability.
FRONTIERS IN NUTRITION
(2021)
Review
Nutrition & Dietetics
Anto Cordelia T. A. Dhanapal, Ramatu Wuni, Eduard F. F. Ventura, Teh Kuan Chiet, Eddy S. G. Cheah, Annaletchumy Loganathan, Phoon Lee Quen, Mahenderan Appukutty, Mohd F. M. Noh, Ian Givens, Karani Santhanakrishnan Vimaleswaran
Summary: This study aims to address malnutrition in Malaysia and proposes a conceptual framework for implementing precision nutrition strategies. The framework includes research in the fields of genetics, genomics, transcriptomics, and more, as well as training and resource development for stakeholders.
Article
Health Care Sciences & Services
Sapna Batheja, Emma M. Schopp, Samantha Pappas, Siri Ravuri, Susan Persky
Summary: This study aims to characterize the landscape of precision nutrition content on Twitter, focusing on nutrigenetics and nutrigenomics. Tweet authors, content types, and the presence of misinformation were examined.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Review
Nutrition & Dietetics
Giacomo Caio, Lisa Lungaro, Fabio Caputo, Eleonora Zoli, Fiorella Giancola, Giuseppe Chiarioni, Roberto De Giorgio, Giorgio Zoli
Summary: Crohn's disease is a chronic inflammatory bowel disease that can cause malnutrition in a significant percentage of patients, highlighting the importance of diet in managing the condition. This review aims to cover recent findings in nutrition for CD treatment, including established diets, new nutritional theories, and advancements in areas like nutrigenomics.
Review
Nutrition & Dietetics
Margaret Allman-Farinelli, Brianna Boljevac, Tiffany Vuong, Eric Hekler
Summary: N-of-1 trials offer better evidence than randomized controlled trials in determining personalized treatment, with a specific focus on personalized nutrition. This systematic review aimed to examine nutrition-related N-of-1 studies. Out of 211 screened articles, 7 studies conducted in 5 countries with a total of 83 participants were included. The quality of reporting varied, but overall, the evidence served to highlight the characteristics and considerations of N-of-1 study designs in personalized medical nutrition therapy.
Review
Nutrition & Dietetics
Chiara Murgia, Ankush Dehlia, Mark A. Guthridge
Summary: Riboflavin is an essential nutrient that plays a critical role in regulating various biochemical pathways, and it has shown remarkable effectiveness in treating adult-onset metabolic disorders.
NUTRITION & METABOLISM
(2023)
Review
Nutrition & Dietetics
Minoru Arakaki, Li Li, Toshiyuki Kaneko, Hiromi Arakaki, Hiromi Fukumura, Chihiro Osaki, Maki Yonamine, Yoshitaka Fukuzawa
Summary: This study introduces a personalized nutritional therapy based on blood data analysis, which has the potential to help patients with pre-disease conditions or undiagnosed malaise recover from their symptoms.