Article
Chemistry, Multidisciplinary
Seongheon Baek, Sanggyun Jeong, Hyeong Woo Ban, Jiyeon Ryu, Yoonkyum Kim, Da Hwi Gu, Changil Son, Tae-Sik Yoon, Jiseok Lee, Jae Sung Son
Summary: Direct optical printing of functional inorganics has great potential for creating intricate patterns and affordable devices. However, precise control of vertical thickness in 3D structures has been overlooked. In this study, a generalized optical 3D printing process using maskless digital light processing is presented, enabling high-resolution and cost-effective fabrication of inorganic nanoparticle ink.
Article
Physics, Multidisciplinary
Jonas Meinel, Minsik Kwon, Rouven Maier, Durga Dasari, Hitoshi Sumiya, Shinobu Onoda, Junichi Isoya, Vadim Vorobyov, Joerg Wrachtrup
Summary: In this study, a new method for detecting nuclear magnetic resonance (NMR) signals at high magnetic fields using heterodyne detection is introduced. By utilizing a series of phase coherent electron nuclear double resonance sensing blocks, the limitations of heterodyne detection at high magnetic fields are overcome, allowing for chemical shift resolution in NMR experiments.
COMMUNICATIONS PHYSICS
(2023)
Article
Chemistry, Analytical
Jeffrey J. Schwartz, Georges Pavlidis, Andrea Centrone
Summary: Photothermal induced resonance (PTIR), also known as AFM-IR, enables nanoscale infrared (IR) imaging and spectroscopy by utilizing an atomic force microscope's tip to measure the local photothermal expansion and contraction of a sample. This research focuses on understanding the factors that affect the signal transduction efficiency and spatial resolution of PTIR, including laser pulse parameters, sample thermalization time, interfacial thermal conductance, and cantilever detection frequency. The study reveals that shorter laser pulses and higher cantilever detection frequencies can improve the performance of PTIR. These insights can inform experimental designs and measurement strategies, and potentially lead to advancements in PTIR technology.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ilya Milekhin, Kirill Anikin, Nina N. Kurus, Vladimir G. Mansurov, Timur V. Malin, Konstantin S. Zhuravlev, Alexander V. Latyshev, Alexander V. Latyshev, Dietrich R. T. Zahn
Summary: We carried out local phonon analysis on single AlN nanocrystals using two complementary imaging spectroscopic techniques: tip-enhanced Raman scattering (TERS) and nano-Fourier transform infrared (nano-FTIR) spectroscopy. The TERS spectra showed strong surface optical (SO) phonon modes, with their intensities having a weak polarization dependence. The electric field enhancement from the plasmon mode of the TERS tip altered the phonon response of the sample, causing the dominance of the SO mode over other phonon modes. TERS imaging allowed for the visualization of the spatial localization of the SO mode. We successfully observed the angle anisotropy of the SO phonon modes in AlN nanocrystals with nanoscale spatial resolution. The frequency position of the SO modes in nano-FTIR spectra was determined by the excitation geometry and the local nanostructure surface profile, as demonstrated by analytical calculations.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Physical
Meng Wang, Xiaofeng Wang, Zhican Zhou, Feng Xia, Haoran Zhang, Artem Shelaev, Xinzheng Zhang, Chuanfei Guo, Jingjun Xu, Qian Liu
Summary: This study presents a method for large-scale composition analysis with nanoscale spatial resolution using Raman spectroscopy. The capability and practicality of this method are experimentally verified.
Article
Chemistry, Multidisciplinary
Meitong Nie, Yuming Zhao, Wonil Nam, Junyeob Song, Wenqi Zhu, Henri J. Lezec, Amit Agrawal, Wei Zhou
Summary: The research introduces nanolaminate plasmonic nanocavities on 3D vertical nanopillar arrays for broadband SERS operation with large enhancement factors. It shows uniform SERS performance and demonstrates nanoscale broadband SERS operation at the single MIM nanocavity level. Numerical studies reveal that the nanolaminate plasmonic nanocavities can support multiple hybridized plasmonic modes for concentrating optical fields across a broadband wavelength range.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Nuan Lin, Koen van Zomeren, Teelkien van Veen, Aldona Mzyk, Yue Zhang, Xiaoling Zhou, Torsten Plosch, Uwe J. F. Tietge, Astrid Cantineau, Annemieke Hoek, Romana Schirhagl
Summary: Cumulus granulosa cells (cGCs) and mural granulosa cells (mGCs) are anatomically and functionally heterogeneous, but play critical roles in female fertility. Investigating the role of free radicals in these cells has been challenging due to limited temporal and spatial resolution. However, a quantum sensing approach using fluorescent nanodiamonds (FNDs) revealed that mitochondria are sites of free radical generation, and cGCs may be more resistant to oxidative stress compared to mGCs.
ACS CENTRAL SCIENCE
(2023)
Article
Chemistry, Analytical
Devon S. Jakob, Andrea Centrone
Summary: Photothermal induced resonance (PTIR) is an atomic force microscopy method that offers nanoscale lateral resolution and is widely used in biology and materials science. This study demonstrates the expansion of the PTIR setup to the visible and near-IR spectral ranges, allowing for improved resolution and light-polarization-dependent experiments.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Wenxin Zhu, Jinrun Dong, Guoxiang Ruan, Yuan Zhou, Jiandong Feng
Summary: A single-molecule electrochemiluminescence bioassay is developed for imaging and direct quantification of single biomolecules. This assay localizes the electrochemiluminescence events and allows mapping of biomolecule distribution. By merging repeated reactions and counting clustered molecules, biomolecules can be quantified. The developed bioassay shows a detection limit of 67 attomole concentration and represents a new tool for specific bioimaging and ultrasensitive quantitative analysis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biophysics
Qianying Cao, Ding Jiang, Lingli Zheng, Fangmin Xu, Hiroshi Shiigi, Xueling Shan, Wenchang Wang, Zhidong Chen
Summary: A highly sensitive single-cathode dual electrochemiluminescence (ECL) signal aptasensor with self-checking function was designed using In-based metal-organic framework (MIL-68) as a stabilizer. The introduction of cooperative-binding split-aptamers (CBSAs) improved the specificity and detection efficiency. The aptasensor could quantify the concentration of MDPV between 1.0 x 10-12 g/L and 1.0 x 10-6 g/L with a limit of detection (LOD) of 1.4 x 10-13 g/L and 2.0 x 10-13 g/L, respectively.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Jian Zhang, Qiang Li, Chenjie Dai, Mingliang Cheng, Xin Hu, Hyun-Sik Kim, Heesun Yang, Daniel J. Preston, Zhongyang Li, Xuefeng Zhang, Won-Kyu Lee
Summary: This paper presents a general approach to developing tunable plasmonic metasurfaces with hydrogel meta-atoms at the subwavelength scale. The size of hydrogel nanodots can be reversibly controlled by absorbing or releasing water, resulting in humidity-responsive surface plasmon polaritons (SPPs) that generate plasmonic color rendering in the visible spectrum. The size variations of constituent hydrogel nanostructures enable broadband beam-steering on a phase modulator.
Article
Physics, Applied
Arman Rashidi, Robert Kealhofer, Alexander C. Lygo, Susanne Stemmer
Summary: In this study, we investigate the dephasing mechanisms in topological materials by fabricating gated nanoscale mesas on thin films of cadmium arsenide. We observe two independent types of conductance oscillations related to the applied magnetic field and gate voltage. Varying the nanostructure dimensions allows us to distinguish different scenarios of previously reported similar oscillations. Our conclusion is that these conductance oscillations are not a signature of topological boundary states, but rather universal conductance fluctuations. These findings provide valuable insights for interpreting electronic quantum interference in mesoscopic devices made from topological materials.
APPLIED PHYSICS LETTERS
(2023)
Article
Biophysics
Lin Cai, Haiyang Wang, Yichuan Cao, Wen Hao, Guozhen Fang, Shuo Wang
Summary: A molecularly imprinted electrochemiluminescence sensor (MIECLS) is developed using boron nitride quantum dots@gold nanoflowers/silver nanowires (BNQDs@AuNFs/AgNWs) to selectively detect clenbuterol (CLB). The sensor utilizes an electrostatic self-assembly effect between BNQDs and AuNFs to create a novel nanoscale co-reaction accelerator (NCRA) with high activity. The NCRA, along with the network structure of AgNW luminophores, enhances the electrochemiluminescence (ECL) signal through catalysis and electron acceleration. The MIECLS also utilizes molecularly imprinted polymers (MIPs) to recognize and block CLB, resulting in ECL signal quenching. The MIECLS demonstrates high sensitivity and accuracy in CLB detection.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Xuemei Wang, Chuantao Hou, Feifei Zhang, Jianfei Xia, Zonghua Wang
Summary: In this study, a self-enhanced electrochemiluminescence (ECL) strategy was employed by generating a coreaction accelerator in situ during the synthesis of luminophores. A composite material integrating a luminophore (Zn-TCPP) and a coreaction accelerator (TiO2 NPs) was synthesized. The ECL signal was greatly improved by immobilizing a probe on the composite material, which increased the concentration of the coreactant and shortened the electron transport distance. This work not only developed a simple and ultrasensitive exosome detection system but also demonstrated a potential application of porphyrin-based metal-organic frameworks (Por-MOFs) in biological analysis.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Qinglong Qiao, Wenjuan Liu, Yinchan Zhang, Jie Chen, Guangying Wang, Yi Tao, Lu Miao, Wenchao Jiang, Kai An, Zhaochao Xu
Summary: By using single-molecule localization microscopy, we visualized the dynamic process of benzyl-naphthalimide dyes in real time and examined their internal structure. We found that the growth process of these assemblies exhibited highly heterogeneous dynamics, with different growth rates at different locations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Hao Ding, Bin Su, Dechen Jiang
Summary: Understanding cellular mechanisms is a major goal in biology, and single cell measurements are more accurate than population-averaged assays for studying cellular systems. Electrochemiluminescence (ECL) is an emerging method for single cell analysis, which involves light emission triggered by electrochemical reactions. This review provides an overview of recent research progress on ECL principles and systems for analyzing single cells, including various analytes and their impact on cellular functions.
Article
Biophysics
Xin Li, Jingying Pan, Yue Wu, Huan Xing, Zijian An, Zhenghan Shi, Jingjiang Lv, Fenni Zhang, Jing Jiang, Di Wang, Ray P. S. Han, Bin Su, Yanli Lu, Qingjun Liu
Summary: A wireless facemask based on Ti3C2Tx MXene is developed for the noninvasive monitoring of breath acetone (BrAC) and real-time tracking of lipid metabolism. The facemask can not only detect acetone but also filter out breath interference. It is integrated with a miniaturized flexible detection tag for easy BrAC detection and wireless data transmission. The system enables detection of BrAC down to 0.31 ppm in breath.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Ping Zhou, Lurong Ding, Yajuan Yan, Yafeng Wang, Bin Su
Summary: Cell-matrix adhesions, mediated by integrins, play a crucial role in biological processes by connecting intracellular environments with the extracellular matrix. Advanced imaging techniques have facilitated the understanding of the molecular composition and dynamics of cell-matrix adhesions, including label-free imaging methods. This article provides an overview of recent developments in label-free imaging of cell-matrix adhesions, introducing electrochemiluminescence microscopy and surface plasmon resonance microscopy and discussing their applications. Furthermore, the advances in mapping cell-matrix adhesion force using molecular tension probes and fluorescence microscopy are highlighted.
CHEMICAL COMMUNICATIONS
(2023)
Article
Fisheries
Haikuo Zhao, Yong Zhou, Yuding Fan, Nan Jiang, Yan Meng, Yiqun Li, Mingyang Xue, Chen Xu, Weiliang Guo, Wenzhi Liu
Summary: In this study, a sensitive ddPCR-based method was developed and applied to rapidly detect and quantify Tilapia parvovirus (TiPV). The results showed that the ddPCR method was effective at detecting TiPV in samples with low viral loads.
JOURNAL OF FISH DISEASES
(2023)
Article
Chemistry, Multidisciplinary
Yafeng Wang, Jialian Ding, Ping Zhou, Jilin Liu, Zhiyuan Qiao, Kai Yu, Jie Jiang, Bin Su
Summary: In this study, the electrochemiluminescence (ECL) generation by Ru(bpy)(3)(2+) and five tertiary amine coreactants was investigated. The ECL distance and reactivity of the coreactants were measured, and the integrated ECL intensity was used to quantitatively evaluate the reactivity. Statistical analysis of ECL images of labeled microbeads showed that the ECL distance and reactivity of the coreactant determine the emission intensity and sensitivity of immunoassay. BIS-TRIS was found to balance the trade-off between ECL distance and reactivity, resulting in a 236% increase in sensitivity compared to TPrA in the bead-based immunoassay of carcinoembryonic antigen.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Agriculture, Dairy & Animal Science
Li Zhu, Shaoqun Wang, Yan Cai, Huizhong Shi, Yongcan Zhou, Dongdong Zhang, Weiliang Guo, Shifeng Wang
Summary: This study examined the effects of five prebiotics on the growth, antioxidant activities, non-specific immunity, stress resistance, and disease resistance of juvenile hybrid grouper. Mannan oligosaccharides and xylooligosaccharides were found to have the best overall effects in improving these parameters. These findings provide a theoretical basis for the application of prebiotics in aquaculture.
Article
Engineering, Electrical & Electronic
Zhuhao Li, Changgui Yang, Yunshan Zhang, Ting-Hsun Wang, Ziyi Chang, Boyu Zhu, Lin Zhou, Yuxuan Luo, Bin Su, Bo Zhao
Summary: Diabetes has become a major cause of death and disability worldwide. Continuous glucose monitoring (CGM) based on wireless power transfer (WPT) and backscatter communication allows for real-time wireless telemetry to control glycemic levels in the long term. This study proposes a delta sigma backscatter technique for CGM, which achieves high-precision glucose monitoring over a wide range of concentrations using a small on-chip antenna.
IEEE JOURNAL OF SOLID-STATE CIRCUITS
(2023)
Article
Chemistry, Multidisciplinary
Lin Zhou, Rongjie Yang, Xinru Li, Nuo Dong, Boyu Zhu, Jingjing Wang, Xingyu Lin, Bin Su
Summary: This study reports the development of a covalent organic framework (COF)-modified carbon fiber microelectrode that allows real-time detection of dopamine in the mouse brain. The COF modification provides outstanding antibiofouling and antichemical fouling ability, as well as excellent analytical selectivity and sensitivity. It has been combined with levodopa administration to devise a closed-loop feedback mode for Parkinson's disease diagnosis and therapy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Xinrui Yang, Junmeng Hang, Weiyu Qu, Yulan Wang, Lei Wang, Ping Zhou, Hao Ding, Bin Su, Jianping Lei, Weiliang Guo, Zhihui Dai
Summary: Developing highly sensitive multipleximmunoassays is urgently needed to guide medical research and improve clinical diagnosis. In this study, proximity electrochemiluminescence (ECL) generation enabled by gold microbeads (GMBs) was used to enhance the sensitivity and multiplexing capacity of ECL immunoassays. By employing GMBs as solid carriers, the ECL generation through proximity low oxidation potential (LOP) route significantly increased the turnover frequency compared to conventional non-conductive microbeads. Moreover, the proximity ECL generation allowed for the simultaneous detection of multiple acute myocardial infarction biomarkers using size-encoded GMB-based multiplex ECLIAs. This work provides new insights into ECL mechanisms and advances the practical use of multiplex ECLIAs.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Hao Ding, Kang Liu, Xinlu Zhao, Bin Su, Dechen Jiang
Summary: A nanopipet electric thermometer (NET) is established for real-time intracellular temperature measurement, providing high sensitivity, excellent resolution, stability, and the ability to monitor thermal heterogeneities in cancer cells during immunotherapy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Materials Science, Multidisciplinary
Shanshan Liu, Xingyu Lin, Bin Su
Summary: This study proposes a unique concept of thermopiles by fabricating two types of hydrogels with carriers moving in different thermal motion directions. One hydrogel shows a positive Seebeck coefficient, while the other shows a negative Seebeck coefficient. The Seebeck coefficient of the latter is increased by 50 times compared to the original component, and the thermopile exhibits excellent flexibility and stability.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Zhiyuan Cao, Chuyue Li, Yufei Shu, Meiyi Zhu, Bin Su, Haiyan Qin, Xiaogang Peng
Summary: Using CdSe/CdS/ZnS core/shell/shell quantum dots as a model system, time- and potential-resolved spectroelectrochemical measurements were successfully applied to study the mechanisms and kinetics of electrochemiluminescence (ECL) generation. The rate constant of electron injection into a negatively charged quantum dot increased with increasing potential, and the key intermediate for ECL generation was found to be structurally stable and possess slow deionization channels.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yajuan Yan, Ping Zhou, Lurong Ding, Wei Hu, Wei Chen, Bin Su
Summary: This study presents a label-free electrochemiluminescence microscopy approach for imaging immune synapses of T cells, allowing discrimination of specific T cell receptor (TCR)/peptide-loaded major histocompatibility complex (pMHC) recognition and the role of auxiliary molecules. The method can be used to assess TCR-antigen specificity and screen for potential immunotherapies.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Boyu Zhu, Xinru Li, Lihang Zhu, Min Qi, Jiayi Cao, Lin Zhou, Bin Su
Summary: This study investigates the changes in brain glucose levels of early diabetic mice using in vivo electrochemical measurement. The research suggests that diabetes may downregulate the activity of glucose transporter in the brain, leading to a decrease in brain glucose uptake.