Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 161, Issue 4, Pages 501-504Publisher
SPRINGER
DOI: 10.1007/s10517-016-3447-6
Keywords
type 2 diabetes mellitus; diabetic nephropathy; linagliptin
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Funding
- Ministry of Education and Science of Russian Federation [RFME-FI62114X0010, RFMEFI61914X0005]
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Effect of the dipeptidyl peptidase-4 inhibitor linagliptin on structural manifestations of diabetic nephropathy was studied in BKS.Cg-Dock7m+/+Leprdb/J mice (experimental model of type 2 diabetes mellitus). Linagliptin (10 mg/kg per day) or vehicle was administered by gavage over 8 weeks. Mesangial expansion, thickening of the basement membrane in glomerular capillaries and proximal tubules, and retraction of cytopodia were less pronounced in mice receiving linagliptin. The protective effect of linagliptin on the kidney structure was not associated with its hypoglycemic action.
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