Article
Biotechnology & Applied Microbiology
Meng-Ying Cui, An-Rui Lu, Jian-Xu Li, Jie Liu, Yu-Min Fang, Tian-Lin Pei, Xin Zhong, Yu-Kun Wei, Yu Kong, Wen-Qing Qiu, Yong-Hong Hu, Jun Yang, Xiao-Ya Chen, Cathie Martin, Qing Zhao
Summary: The study found that methoxylated flavones have strong ability to induce apoptosis and enhance bioactivity, with methoxylation not causing side effects on healthy cells. Both type I and type II OMT enzymes are involved in the biosynthesis of methoxylated flavones in S. baicalensis.
PLANT BIOTECHNOLOGY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Wentao Wang, Suying Hu, Jing Yang, Caijuan Zhang, Tong Zhang, Donghao Wang, Xiaoyan Cao, Zhezhi Wang
Summary: This study identified a novel S20 R2R3-MYB regulator, SbMYB12, which positively regulates the biosynthesis of baicalin and wogonoside in Scutellaria baicalensis. These findings enhance our understanding of the transcriptional and regulatory mechanisms of baicalin biosynthesis and provide new insights for metabolic engineering in S. baicalensis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Li Xiang, Yue Gao, Shiyu Chen, Jiayi Sun, Jiasi Wu, Xianli Meng
Summary: This review summarizes the pharmacological effects and molecular mechanisms of Scutellaria baicalensis in lung cancer therapy. Scutellaria baicalensis and its constituents exhibit multiple anti-cancer mechanisms against lung cancer and show high antitumor efficacy and safety in animal models.
Article
Integrative & Complementary Medicine
Peng Yu, Jingyang Li, Yanqing Luo, Jiayi Sun, Yingfan Hu, Bo Lin, Xianli Meng, Li Xiang
Summary: Breast cancer is a common and deadly malignancy in women. Traditional Chinese medicine, especially Scutellaria baicalensis, has shown promising activity against breast cancer through multiple mechanisms, including proliferation inhibition, apoptosis induction, and modulation of signaling pathways.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Plant Sciences
Hyeon-Ji Yeo, Chang-Ha Park, Soo-Yun Park, Sun-Ok Chung, Jae-Kwang Kim, Sang-Un Park
Summary: This study found that white LED light and a 2-week growing period are the most effective conditions for producing baicalin, baicalein, and wogonin, with the highest concentrations found in the roots. As the duration of LED illumination increased, the concentrations of primary and secondary metabolites in the roots, stems, and leaves of S. baicalensis seedlings generally decreased.
Article
Agronomy
Ping He, Longfei Guo, Yuzhe Liu, Fanyun Meng, Cheng Peng
Summary: This study examined the importance of environmental variables in phenological phases for plant niches and quality. It found that environmental variables contributed more than 30% to species distribution modeling and that some populations were lost when specific phenological stages were considered. The study also highlighted the impact of environmental variables on quality and identified six key variables in secondary metabolite formation. These findings emphasize the importance of phenological phases and provide an integrative approach for resource allocation in obtaining medicinal plants.
EUROPEAN JOURNAL OF AGRONOMY
(2023)
Article
Biochemistry & Molecular Biology
Wentao Wang, Suying Hu, Caijuan Zhang, Jing Yang, Tong Zhang, Donghao Wang, Xiaoyan Cao, Zhezhi Wang
Summary: R2R3-MYB transcription factors play important roles in various biological processes, particularly in the regulation of secondary metabolites. This study focused on the R2R3-MYB gene family in Scutellaria baicalensis and identified 95 genes. These genes were categorized into 34 subgroups based on their exon-intron structures and conserved motifs. The study also revealed that segmental duplications drove the evolution and expansion of the R2R3-MYB gene family. Additionally, the expression patterns of these genes varied in different tissues and under different conditions. Some genes exhibited specific expression profiles in response to hormone stimuli and abiotic stresses. Furthermore, certain genes were found to be localized in the nucleus and possessed transcriptional activation activity. This study provides a comprehensive understanding of the R2R3-MYB gene family in S. baicalensis and serves as a foundation for further investigation of their biological function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Heping Hui, Weijun Gao
Summary: In this study, an arabinogalactoglucan SBP-1 was purified from Scutellaria baicalensis and its structure was characterized. SBP-1 showed antioxidant and hypoglycemic activities, indicating its potential therapeutic value.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Agricultural Engineering
Jingyuan Xu, Ruoyun Shi, Yijie Cheng, Guoyong Xie, Yan Zhu, Minjian Qin
Summary: Interactions between Scutellaria baicalensis and endophytic Pseudomonas sp. 2B can alter the secondary metabolism of S. baicalensis, which has potential applications in biocontrol for cultivation of S. baicalensis.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Engineering, Chemical
Aleksandra I. Solov'eva, Anna Y. Stepanova, Yury M. Panov, Evgeny A. Gladkov
Summary: Ten lines of hairy roots of Scutellaria pycnoclada, a poorly studied endemic species, were obtained through Agrobacterium rhizogenes A4. HPLC MS/MS analysis detected 14 flavonoids in S. pycnoclada and 17 in S. baicalensis. S. pycnoclada had lower diversity of methylated flavones and no tenaxin I in agar medium.
Review
Pharmacology & Pharmacy
Jun Wang, Shanshan Chen, Jizhou Zhang, Jiasi Wu
Summary: Autoimmune diseases are caused by lymphocytes self-tolerance failure. Scutellaria baicalensis Georgi and its bioactive contents have the potential to be used in the treatment of these diseases, but further research is needed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Hyeon Ji Yeo, Chang Ha Park, Jae Kwang Kim, Ramaraj Sathasivam, Jae Cheol Jeong, Cha Young Kim, Sang Un Park
Summary: Plants adjust their nutrient balance by regulating primary and secondary metabolisms when exposed to stressful conditions; chilling stress can increase the concentrations of sugars, amino acids, salicylic acid, flavones, and phenolic acids in Scutellaria baicalensis roots.
Article
Food Science & Technology
Xiaoqiang Chen, Yu Han, Tiefeng Zhou, Yang Liu, Ni Zhang, Jing Wang, Chunpeng Wang, Yayuan Luo, Zhengqi Wu, Yong Cheng, Yundong Shao
Summary: The O/W emulsions prepared using SBPC as an emulsifier showed smaller particle size and increased stability compared to emulsions with other emulsifiers. The emulsions exhibited tolerance to metal ions and thermal treatment, and also demonstrated antioxidant properties by inhibiting the polymerization of EGC, with an average retention rate of 88.28% on the 10th day. This research provides insights into the potential use of SBPC as an emulsifier in various applications.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Guanghui Sun, Yongkang Dang, Yanke Lin, Wanying Zeng, Zongjian Wu, Xingwang Zhang, Dong Dong, Baojian Wu
Summary: The study reveals that Scutellaria baicalensis Georgi (SBG) can counteract skin aging by antagonizing REV-ERB alpha and increasing BMAL1 expression. This leads to reduced skin wrinkles, increased levels of antioxidant enzymes and collagen, and improved skin structure and function.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Yaqian Zhou, Qianqian Xue, Miaomiao Wang, Liyan Mu, Danni Chen, Qiao Liu, Xun Liu, Wu Yin, Fangzhou Yin
Summary: This study established an integrated strategy of biosynthetic pathway - plant metabolomics - bioactivity evaluation to evaluate the quality differences between Scutellaria baicalensis (SG) and Scutellaria rehderiana (SD). The study found differences in chemical components between SG and SD, and identified chemical markers for quality analysis. Moreover, both SG and SD exhibited prominent anti-inflammatory activity, but SD was less effective.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Biochemical Research Methods
Chenglong Sun, Fukai Wang, Xiao Wang, Yanling Geng, Shubin Song, Zhiyong Yu, Wei Liu
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Analytical
Chenglong Sun, Wei Liu, Yanling Geng, Xiao Wang
ANALYTICAL CHEMISTRY
(2020)
Article
Biochemical Research Methods
Jinqian Yu, Lei Zhao, Xiaowei Sun, Chenglong Sun, Xiao Wang
Summary: This study aimed to develop an efficient method for the extraction and separation of flavonoids from Gleditsia sinensis thorns using choline chloride deep eutectic solvents (DES) and high-speed counter-current chromatography (HSCCC). Five flavonoids were successfully obtained using this method, demonstrating that the combination of DES and HSCCC is a powerful technique for extracting and isolating flavonoids compared to traditional methods.
PHYTOCHEMICAL ANALYSIS
(2021)
Article
Chemistry, Analytical
Qingce Zang, Chenglong Sun, Xiaoping Chu, Limei Li, Wenqiang Gan, Zitong Zhao, Yongmei Song, Jiuming He, Ruiping Zhang, Zeper Abliz
Summary: Spatially resolved metabolomics combined with multicellular tumor spheroid model offers a powerful approach to discover cancer tissue relevant metabolic signatures and reveals metabolic heterogeneity of cancer cells under different proliferative states.
ANALYTICA CHIMICA ACTA
(2021)
Article
Plant Sciences
Chenglong Sun, Shuangshuang Ma, Lili Li, Daijie Wang, Wei Liu, Feng Liu, Lanping Guo, Xiao Wang
Summary: A highly sensitive MALDI-MS imaging method was developed to visualize the spatial distributions and spatiotemporal changes of metabolites in different botanical parts of Panax notoginseng. Metabolites that changed during the steaming of Panax notoginseng were successfully screened and imaged, enhancing our understanding of its metabolic networks.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Chenglong Sun, Chunxia Ma, Lili Li, Yuhao Han, Daijie Wang, Xiao Wan
Summary: The application of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to investigate the changes of lipids in biological tissues has yielded significant results. However, the presence of structural isomers with varying C=C double bond (DB) locations calls for the development of isomer-resolved MSI. In this study, a new light-driven on-tissue [2 + 2] cycloaddition reaction coupled with MALDI-MS/MS imaging was introduced to identify lipid DB position isomers and their spatial signatures in biological tissues.
CHINESE CHEMICAL LETTERS
(2022)
Article
Agriculture, Multidisciplinary
Lili Li, Daijie Wang, Chenglong Sun, Yue Li, Heng Lu, Xiao Wang
Summary: The study optimized lipidome and metabolome extraction methods for Panax quinquefolius and identified 497 metabolites, including 365 lipids and 76 ginsenosides. Differences in metabolomic profiles were observed in two growing regions of China, providing insights into the metabolic regulation mechanisms of P. quinquefolius.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Chenglong Sun, Li Cui, Bingqian Zhou, Xiao Wang, Lanping Guo, Wei Liu
Summary: This study investigated the spatial location and variation of endogenous metabolites in continuously cropped Salvia miltiorrhiza Bge (SMB) roots using matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). The results showed that continuous cropping led to lower expression levels of tanshinones, salvianolic acids, polyamines, and oligosaccharides in SMB roots. However, there was little difference in the expressions of caffeic acid and salvianolic acid A. Ferulic acid was more widely distributed in continuously cropped SMB.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Article
Biochemical Research Methods
Yuhao Han, Panpan Chen, Zhichao Li, Xiao Wang, Chenglong Sun
Summary: A novel visible-light induced [2+2] cycloaddition reaction combined with mass spectrometry techniques was proposed to identify lipid C=C position isomers. The new cycloaddition reagents achieved high conversion efficiency under compact fluorescent lamp light, offering new insights into photocatalytic reagent development for visible-light induced cycloaddition and structural lipidomic studies.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Engineering, Environmental
Lingyu Li, Zhichang Qiu, Yuanfeng Qi, Dantong Zhao, Iftikhar Ali, Chenglong Sun, Longhua Xu, Zhenjia Zheng, Chunxia Ma
Summary: The hybrid nanocomposite of gold nanoparticles and nickel/iron-layered double hydroxides can improve the performance of laser desorption/ionization mass spectrometry for low-molecular-weight samples, demonstrating high peak intensity, low background noise, salt and protein tolerance, good repeatability, and quantification. This nanocomposite also shows potential for detecting a variety of small molecules, providing rapid and accurate analysis in water samples.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Analytical
Zhigang Luo, Weixin Wang, Xuechao Pang, Jin Zhang, Chenglong Sun, Xia Zhou, Jiuming He, Ruiping Zhang, Xin Li, Zhe Lian, Zeper Abliz
Summary: The study developed a method combining mass spectrometry imaging and chemometric analysis to determine the writing sequence of seals and signatures in documents, providing a convenient, objective, and quasi-nondestructive approach. By analyzing 28 prepared samples with known sequences and two blind test samples, the effectiveness of the method was confirmed.
Article
Chemistry, Analytical
Yuhao Han, Yisheng Zhao, Panpan Chen, Lei Wang, Qiongzheng Hu, Xiao Wang, Chenglong Sun
Summary: In this study, a method based on MALDI-MS was developed for on-tissue derivatization, imaging, and quantification of aldose and ketose isomers of monosaccharides in biological tissues. The use of the newly synthesized derivatization reagent NAH significantly enhanced the imaging sensitivity of monosaccharides and allowed for isomer-specific MS imaging through the generation of isomer-specific diagnostic ions.
ANALYTICA CHIMICA ACTA
(2022)
Article
Oncology
Fukai Wang, Shuangshuang Ma, Panpan Chen, Yuhao Han, Zhaoyun Liu, Xinzhao Wang, Chenglong Sun, Zhiyong Yu
Summary: Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was used to characterize the expressions of fatty acids in breast cancer tissues, revealing that most fatty acids are up-regulated compared to adjacent normal tissues. Up-regulation of fatty acid synthase (FASN) and acetyl CoA carboxylase (ACC) was found in breast cancer, which can be targeted to limit cancer cell growth, proliferation, and metastasis.
CANCER CELL INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Chenglong Sun, Anqiang Wang, Yanhe Zhou, Panpan Chen, Xiangyi Wang, Jianpeng Huang, Jiamin Gao, Xiao Wang, Liebo Shu, Jiawei Lu, Wentao Dai, Zhaode Bu, Jiafu Ji, Jiuming He
Summary: This study explores the spatial signature of metabolic remodeling in gastric cancer by integrating mass spectrometry imaging-based spatial metabolomics and lipidomics with microarray-based spatial transcriptomics, allowing for the visualization of metabolic heterogeneity. Mapping tumor metabolic remodeling and its interaction with non-tumor cells improves our understanding of tumor biology and helps in designing advanced therapeutic strategies.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Panpan Chen, Yuhao Han, Lei Wang, Yurong Zheng, Zihan Zhu, Yuan Zhao, Mingqi Zhang, Xiangfeng Chen, Xiao Wang, Chenglong Sun
Summary: In this study, a 3D tumor-immune cell coculture spheroid model combined with mass spectrometry imaging was developed to visualize the metabolic interactions between tumor and immune cells during immune response. The transport and catabolism of glutamine were found to be significantly reprogrammed during the antitumor immune response, indicating their important roles in energy metabolism and new biomass building. This integrated approach provides insights into the immunometabolic alterations in tumor immunotherapy.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Bingbing Liu, Jie Cao, Lu Liu, Min Zeng, Hongli Yu, Hao Wu
Summary: This study investigated the effect of processing with Chebulae Fructus on the chemical composition of Euphorbia pekinensis (EP) and found that it could alter the composition and reduce toxicity, providing a scientific basis for optimizing processing technology and handling other ethnomedicines with toxic properties.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Renuka P. Rathnasekara, Abu M. Rustum
Summary: A simple and robust HPLC method was developed for simultaneous determination of four active pharmaceutical ingredients and their degradation products. The method successfully separated the peaks of interest and demonstrated stability-indicating capability by separating the degradation products in stressed samples.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Bryan Lee, Gita Kharal, Benjamin Sreenan, Claire Lin, Ruosheng Zeng, Colin A. Fox, Patricia Ellison, Robert O. Ryan, Paul J. Brett, David Aucoin, Xiaoshan Zhu
Summary: In this study, a new type of Mn-doped nanocrystals was developed for detecting a biomarker of a fatal disease. The sensitivity of the detection was enhanced by surface treatment and time-resolved reading, achieving a detection limit comparable to enzyme-based immunoassay.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xiaoling Liu, Ting Yang, Lu Chen, Lili Lan, Guoxiang Sun, Ping Guo
Summary: In this study, the quality of Yiqing tablet was comprehensively evaluated using multi-component quantification, multi-dimensional fingerprint construction, and antioxidant activity analysis. The results showed that the sample had 25 components with antioxidant activity according to the HPLC fingerprint and most bands of FTIR also showed antioxidant activity. Based on the evaluation results of HPLC and FTIR fingerprint, all samples were classified as first level, demonstrating the consistency of sample quality. This study provides a new idea for achieving comprehensive quality evaluation of traditional Chinese medicines.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Siqi Li, Hao Guo, Yan Gao, Wen Tian, Shan Wang, Chen Shen, Lili Xu, Hailong Liu, Jinliang Zhang, Yingwu Wang
Summary: Using competitive ELISA to detect free cytokines is limited in accurately determining their real state and quantity. In this study, a novel cytokine immunoassay was developed using Rosetta molecular docking prediction technique to establish a method that can detect the true concentration of free cytokines without disrupting the dynamic equilibrium.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Changqing Yu, Tiantian Xie, Haiyan Liu, Ligai Bai
Summary: A phenyl-hybrid monolithic adsorbent with porous structure and multiple functional groups was prepared. It was used for the online extraction and quantification of coumarins in mouse plasma, showing good removal ability and selectivity.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Joao B. Pereira Jr, Vanessa S. Carvalho, William Q. Ferreira, Rennan G. O. Araujo, Sergio L. C. Ferreira
Summary: This work presents a simple, cost-effective, and environmentally friendly method for determining the content of multiple elements in medicinal herbs using ICP OES. The optimized experimental parameters result in low dissolved organic carbon content and residual acidity concentration. The accuracy of the method is confirmed through the analysis of certified reference materials, and its environmental friendliness is validated using the AGREE metric. Principal component analysis is used to classify the medicinal herbs based on their inorganic constituent concentrations.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Orwa Siddig, Chenxi Liu, Mohamed Abdulbagi, Min Song, Yu-ting Lu, Tai-jun Hang
Summary: In this study, a reliable LC-QTOF-MS method was developed to separate and characterize process-related substances and degradation products of Lurasidone hydrochloride. The results showed that Lurasidone hydrochloride exhibited instability under certain stress conditions, and several previously unidentified compounds were discovered. The study emphasizes the importance of monitoring and controlling related substances in the manufacturing processes to optimize the process and ensure quality control.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Jiaxi Fang, Luping Wang, Di Zhang, Yan Liang, Shouxin Li, Jingkui Tian, Qiang He, Juan Jin, Wei Zhu
Summary: This study reports that a novel compound called CPS-A exhibits therapeutic effects on cisplatin-induced acute kidney injury (AKI) and explores its potential mechanisms through transcriptomics and metabolomics. CPS-A improves cell viability, reduces inflammatory markers, and attenuates cisplatin-induced kidney injury. The study also identifies potential targets related to amino acid metabolism.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ricardo Conde, Nadia Oliveira, Elisabete Morais, Ana Paula Amaral, Adriana Sousa, Goncalo Graca, Ignacio Verde
Summary: Decreased levels of tyrosine, glutamate, valine, leucine, and isoleucine are associated with worsening pathological cognitive decline. Decreased levels of isobutyrate, histidine, acetone, and unknown-1 metabolite are potential biomarkers with neuroprotective and antioxidant actions for cognitive decline.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
A. L. Santunione, F. Palazzoli, P. Verri, D. Vandelli, V. Castagnetti, C. Profeta, E. Silingardi
Summary: This study describes two fatal suicide cases involving four cardiovascular drugs, and presents the concentrations and distribution of these drugs in different post-mortem specimens. The study developed a fast, sensitive, and simple method for drug detection suitable for forensic purposes.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Meiyun Shi, Xinyue Zheng, Yuncheng Ge, Ning Zhang, Luyao Yu, Xujian Duan, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin
Summary: This study investigated the cellular uptake of low, medium and high molecular weight polyethylene glycol (PEG) in MCF-7 cells using UPLC-MS/MS and CID techniques. The results showed that PEG600, PEG2K, PEG4K and PEG10K exhibited low toxicity and had limited cellular entry at concentrations of 5-1200 μg/mL. Additionally, the environmental friendliness of the developed analytical methods was evaluated.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ruijin Geng, Mengjie Yu, Jinbiao Xu, Yuanwang Wei, Qiong Wang, Junguo Chen, Fei Sun, Kun Xu, Han Xu, Xiaohui Liu, Juhua Xiao, Xianchao Zhang, Baogang Xie
Summary: This study validated serum methionine as a potential biomarker for Kawasaki disease (KD), and found that its alteration is associated with the activation of DNMT1 in KD patients.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Eman Shawky, Rasha A. Nassra, Aliaa M. T. El-Alkamy, Shaimaa M. Sallam, Samah M. El Sohafy
Summary: This study employed network pharmacology-based analysis and reverse molecular docking to investigate the molecular targets and pathways associated with gynecological disorders and the potential therapeutic effects of fenugreek constituents. The results highlighted the potential of steroidal saponins, isoflavones, and flavones as active constituents of fenugreek with implications for lactation, reproductive processes, and estrogenic activity. Animal model study further supported the presence of these bioactive compounds and their effects on body weight, serum prolactin levels, serum estradiol levels, and ovarian histological structure.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xuelong Zhao, Ruixue Dai, Jing Wang, Liangliang Cao, Peidong Chen, Weifeng Yao, Fangfang Cheng, Beihua Bao, Li Zhang
Summary: This study identified the skin-permeable and skin-retainable components of Cayratia japonica ointment and found that flavonoids are the main active components that play a crucial role in the inflammatory and proliferative phases of wound healing.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
