Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 85, Issue 5, Pages 3383-3392Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b03169
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Funding
- JSPS KAKENHI [16 K08164, 15 J06024, JP19am0101084]
- Research Foundation for Pharmaceutical Sciences
- Kobayashi International Scholarship Foundation
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We developed a one-pot method for the generation of benzynes from a range of readily available 2-hydroxyphenylboronic acids. This method features the in situ activation of both boronic acid and hydroxyl groups of the substrate to enhance benzyne generation at 60 degrees C. Such mild conditions facilitate the generation of functionalized benzynes that immediately react with diverse arynophiles to produce multisubstituted fused benzenes.
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