Article
Radiology, Nuclear Medicine & Medical Imaging
Soren Klingenberg, Mads R. Jochumsen, Benedicte P. Ulhoi, Jacob Fredsoe, Karina D. Sorensen, Michael Borre, Kirsten Bouchelouche
Summary: In this high-risk PCa cohort, advanced disease was identified in about one third of patients at diagnosis. ISUP grade was found to be the superior predictor for advanced disease at diagnosis. A significant difference in frequency of advanced disease was observed between ISUP grades 2 and 3, supporting the Gleason score 7 subdivision. Interestingly, no significant differences in risk of advanced disease were found when comparing the different cT2 stages. The undetected LNMs were either PSMA-negative or micrometastases.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Health Care Sciences & Services
Barak Rosenzweig, Rennen Haramaty, Tima Davidson, Alon Lazarovich, Asaf Shvero, Miki Haifler, Jonathan Gal, Shay Golan, Sagi Shpitzer, Azik Hoffman, Omri Nativ, Yuval Freifeld, Rani Zreik, Zohar A. Dotan
Summary: This study evaluated a unique subpopulation of RP candidates with negative PSMA PET/CT scans and found that misleading results can occur. However, the study also discovered a correlation between PSMA uptake and disease aggressiveness.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Oncology
Samuel J. Galgano, Andrew M. McDonald, Janelle T. West, Soroush Rais-Bahrami
Summary: With the development and application of PSMA-PET imaging, we are able to detect oligometastatic prostate cancer more accurately. However, there is currently a lack of data guiding the best treatment course for these cases. Moreover, the definition of oligometastatic disease is facing problems and challenges due to advancements in imaging modalities.
Review
Urology & Nephrology
Vishnu Murthy, Ida Sonni, Namasvi Jariwala, Roxanna Juarez, Robert E. Reiter, Steven S. Raman, Thomas A. Hope
Summary: PSMA PET imaging shows promising performance in the initial staging of prostate cancer, with high sensitivity and specificity for detecting tumors and guiding treatment options. Further research is needed to evaluate its role in management changes and treatment of metastatic disease.
EUROPEAN UROLOGY FOCUS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kunal Ramesh Chandekar, Harmandeep Singh, Rajender Kumar, Santosh Kumar, Nandita Kakkar, Bhagwant Rai Mittal, Shrawan Kumar Singh
Summary: This study aimed to compare the performance of F-18-PSMA-1007 PET/CT and Ga-68-PSMA-11 PET/CT in the initial staging of intermediate- and high-risk prostate cancer patients. The results showed that F-18-PSMA-1007 PET/CT is comparable to Ga-68-PSMA-11 PET/CT in detecting primary and metastatic lesions of prostate cancer.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
V. E. Corona-Montes, E. Gonzalez-Cuenca, G. Fernandez-Noyola, M. A. Olarte-Casas, D. Bobadilla-Salazar, H. M. Medrano-Urtecho, A. D. Asimakopoulos
Summary: This study evaluates the diagnostic efficacy of 68Ga PSMA PET-CT in primary nodal staging of high-risk prostate cancer, showing a high negative predictive value for lymph node metastases. Further evaluation of its role in primary nodal staging of high-risk PCa patients is warranted.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Endocrinology & Metabolism
Yinzhao Wang, Yongxiang Tang, Xiaomei Gao, Yu Gan, Shuo Hu, Min-Feng Chen, Yi Cai
Summary: This study aims to explore approaches to improve the utility of Ga-68-PSMA-PET/CT in diagnosing lymph node metastasis by evaluating inflammatory hematological markers in prostate cancer patients.
Article
Biochemistry & Molecular Biology
Rie von Eyben, Manuela Andrea Hoffmann, Cigdem Soydal, Irene Virgolini, Murat Tuncel, Mathieu Gauthe, Daniel S. Kapp, Finn Edler von Eyben
Summary: A biochemical recurrence (BCR) risk model was created based on pretest prostate specific antigen (PSA) and restaging prostate specific membrane antigen (PSMA) PET/CT. Both pretest PSA and PSMA PET/CT were found to be important for the overall survival (OS) of BCR patients. Treatment center, International Society of Urologic Pathology (ISUP) grade, pretest PSA threshold, and the grouping of positive sites on the restaging PSMA PET/CT were significant predictors of OS.
Article
Oncology
Wenxiao Yu, Ming Zhao, Yingjun Deng, Shengjing Liu, Guanchao Du, Bin Yan, Ziwei Zhao, Ning Sun, Jun Guo
Summary: This study compared the diagnostic value of (18) F-PSMA-1007 PET/CT, (18) F-FDG PET/CT, and Ga-68-PSMA PET/CT in prostate cancer. The results showed that both (18) F-PSMA-1007 PET/CT and Ga-68 PSMA PET/CT demonstrated higher diagnostic efficacy compared to (18) F-FDG PET/CT.
Article
Radiology, Nuclear Medicine & Medical Imaging
Louise Emmett, Nathan Papa, James Buteau, Bao Ho, Victor Liu, Matthew Roberts, James Thompson, Dan Moon, Gemma Sheehan-Dare, Omar Alghazo, Shikha Agrawal, Declan Murphy, Phillip Stricker, Thomas A. Hope, Michael S. Hofman
Summary: This study analyzed the clinical significance of Ga-68-PSMA PET/CT in a low-prevalence population and proposed a 5-point PRIMARY score to improve the accuracy of diagnosing csPCa. The results showed that the PRIMARY score had high sensitivity and specificity in distinguishing high-risk and low-risk patterns.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jun Wen, Yinjie Zhu, Lianghua Li, Jianjun Liu, Yumei Chen, Ruohua Chen
Summary: Dynamic total-body PET imaging in patients with prostate cancer showed that 6 minutes post-injection was the optimal time for imaging, avoiding interference from bladder activity and detecting lesions with relatively low PSMA uptake. Additionally, imaging at 35-59 minutes post-injection could also yield similar results to imaging at 60 minutes post-injection.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aysegul Aksu, Nazli Pinar Karahan Sen, Emine Burcin Tuna, Guven Aslan, Gamze Capa Kaya
Summary: The study found that volumetric data obtained from Ga-68-PSMA PET/CT can provide unique information for clinical decision-making in patients with adenocarcinoma of the prostate.
NUCLEAR MEDICINE COMMUNICATIONS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Florian Rosar, Fadi Khreish, Robert J. Marlowe, Andrea Schaefer-Schuler, Caroline Burgard, Stephan Maus, Sven Petto, Mark Bartholomae, Samer Ezziddin
Summary: Preliminary data suggest that using Zr-89-labeled PSMA ligand radiotracers may be more effective than using tracers with short-lived radionuclides in detecting suspicious lesions in patients with biochemical recurrence of prostate cancer. In this study, 78% of patients had suspicious lesions detected on 24-h and 48-h scans, with higher detection rates on the 48-h scans. This suggests that imaging at a later time may be preferable.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Kilian Schiller, Lucia Stoehrer, Mathias Duesberg, Kai Borm, Michal Devecka, Marco M. E. Vogel, Robert Tauber, Matthias M. Heck, Isabel Rauscher, Matthias Eiber, Juergen E. Gschwend, Marciana Nona Duma, Stephanie E. Combs
Summary: This study visualized typical patterns of lymph node involvement in prostate cancer patients after surgery using Ga-68-PSMA PET imaging. Results showed that the standard RTOG CTV only covered 31.0% of LN metastases, with the majority of uncovered LNs located in specific regions.
EUROPEAN UROLOGY ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Clemens Mingels, Karl Peter Bohn, Axel Rominger, Ali Afshar-Oromieh, Ian Alberts
Summary: This study investigated the diagnostic accuracy of [F-18]PSMA-1007 PET/CT in biochemically recurrent prostate cancer. The results showed good performance in terms of regional sensitivity and negative predictive value, but limited positive predictive value, especially for bone lesions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Oncology
Carolin Kitzberger, Rebekka Spellerberg, Yang Han, Kathrin A. Schmohl, Christina Stauss, Christian Zach, Roland E. Kaelin, Gabriele Multhoff, Matthias Eiber, Franz Schilling, Rainer Glass, Wolfgang A. Weber, Ernst Wagner, Peter J. Nelson, Christine Spitzweg
Summary: In this study, genetically engineered MSCs carrying the NIS gene were injected into mice to treat experimental glioblastoma. The results showed that NIS-MSCs successfully homed to the tumor and expressed the NIS gene, and subsequent treatment with therapeutically effective radioiodide (131I) significantly delayed tumor growth and prolonged mouse survival.
CLINICAL CANCER RESEARCH
(2023)
Article
Education & Educational Research
Hannah P. K. Rubisch, Anna-Lena Blaschke, Pascal O. Berberat, Cornelia S. Fuetterer, Bernhard Haller, Martin Gartmeier
Summary: We analysed interactions between teachers and students during video-recorded bedside teaching sessions in internal medicine, orthopaedics and neurology. Our research focused on the types of student mistakes, clinical teachers' reactions to them and if they use different strategies to address different types of mistakes. The most common student mistakes were reproduction mistakes, which were associated with the highest level of rejection and the lowest level of elaboration. Students were allowed more time to correct mistakes in the areas of analysis or application of skills and knowledge. There was a decrease in the rate of making mistakes for neurology and orthopaedics compared to internal medicine.
ADVANCES IN HEALTH SCIENCES EDUCATION
(2023)
Article
Computer Science, Interdisciplinary Applications
Alexander Hapfelmeier, Roman Hornung, Bernhard Haller
Summary: Hypothesis testing of variable importance measures (VIMPs) is an ongoing research topic. Different approaches have been proposed to address the computational costs associated with these tests, including heuristic approaches, formal tests, and non-parametric permutation tests. The use of sequential permutation tests and sequential p-value estimation can significantly reduce the computational costs of conventional permutation tests. Simulation studies and application studies confirm the theoretical properties and numerical stability of these methods.
COMPUTATIONAL STATISTICS & DATA ANALYSIS
(2023)
Article
Medicine, Research & Experimental
Volker Morath, Corinna Brandt, Friedrich-Christian Deuschle, Claudia T. Mendler, Birgit Blechert, Dominik Summer, Cyril Barinka, Clemens Decristoforo, Wolfgang A. Weber, Markus Schwaiger, Arne Skerra
Summary: Anticalin proteins targeting PSMA with tailored plasma half-life using PASylation technology are promising radioligands for PET imaging of xenograft tumors in mice. PET imaging using the FsC radiochelator is superior to Dfo radiochelator and adjusting the plasma half-life of Anticalin radioligands using PASylation technology can increase radioisotope accumulation within the tumor.
MOLECULAR PHARMACEUTICS
(2023)
Article
Physiology
Julia Schoenfeld, Astrid Roeh, Stefan Holdenrieder, Pia von Korn, Bernhard Haller, Kimberly Krueger, Peter Falkai, Martin Halle, Alkomiet Hasan, Johannes Scherr
Summary: This study investigated the impact of prolonged and strenuous exercise on markers of immunogenic cell damage. The findings revealed that HMGB1, sRAGE, nucleosomes, hs-TnT, and hs-CRP significantly increased immediately after the race and returned to baseline within 24-72 hours.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Oncology
Lukas Lunger, Lisa Steinhelfer, Philipp Korn, Matthias Eiber, Tobias Maurer, Jakob Buechler, Thomas Horn, Jurgen E. Gschwend, Matthias M. Heck
Summary: This study investigated the use of prostate-specific membrane antigen (PSMA)-radioguided surgery (RGS) to remove locoregional lymph node metastases (LNMs) identified on preoperative PSMA positron emission tomography (PET) during open radical prostatectomy (RP) with extended pelvic lymph node dissection (ePLND). The results showed a high success rate (94%) of resecting PSMA-positive LNMs using RGS, with 40% of LNMs located outside the ePLND template. Patients with a lower metastatic burden on preoperative PSMA PET had better postoperative outcomes. The study has limitations including a retrospective analysis and a small sample size.
EUROPEAN UROLOGY ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
Johanna Knoke, Roxana Raab, Kristina Geyer, Monika Spies, Bernhard Haller, Hans Hauner
Summary: Antibiotic therapies during pregnancy and breastfeeding pose challenges, and the frequency of antibiotic use is not well-known in Germany. The GeliS study reveals that approximately one in five women receive at least one antibiotic treatment during this phase.
GEBURTSHILFE UND FRAUENHEILKUNDE
(2023)
Article
Oncology
Carolin Kitzberger, Khuram Shehzad, Volker Morath, Rebekka Spellerberg, Julius Ranke, Katja Steiger, Roland E. Kaelin, Gabriele Multhoff, Matthias Eiber, Franz Schilling, Rainer Glass, Wolfgang A. Weber, Ernst Wagner, Peter J. Nelson, Christine Spitzweg
Summary: New treatment strategies are urgently needed for glioblastoma (GBM) due to its resistance to standard treatment and poor prognosis. In this study, mesenchymal stem cells (MSCs) were engineered to express the sodium/iodide symporter (NIS) in response to interleukin-6 (IL-6) activation, and were successfully used to deliver NIS deep into the GBM tumor microenvironment. This novel tumor-targeted gene therapy approach resulted in enhanced radiotracer uptake, delayed tumor growth, and improved survival in mice with GBM.
MOLECULAR THERAPY-ONCOLYTICS
(2023)
Article
Oncology
Fabian Falkenbach, Francesca Ambrosini, Pierre Tennstedt, Matthias Eiber, Matthias M. Heck, Felix Preisser, Markus Graefen, Lars Budaeus, Daniel Koehler, Sophie Knipper, Tobias Maurer
Summary: This study found that both BCR risk groups and PSA kinetics are not predictive factors for the success of PSMA-RGS performed at low absolute PSA values. Additionally, indolent low-risk BCR is rarely treated with PSMA-RGS.
Article
Gastroenterology & Hepatology
Joerg D. Ulrich, Paul Rechberger, Jeannine Bachmann, Alexander Herner, Guido V. Figura, Tobias Lahmer, Veit Phillip, Ulrich Mayr, Bernhard Haller, Moritz Jesinghaus, Roland M. Schmid, Mohamed Abdelhafez, Christoph Schlag
Summary: This study evaluated the efficacy and safety of cold snare polypectomy (CSP) for polyps sized between 10 and 15 mm. Results showed that CSP was efficient and safe for removing colorectal polyps of this size. If CSP failed in larger polyps, immediate conversion to hot snare polypectomy (HSP) was successful for resection.
Article
Mathematical & Computational Biology
Hannah Schuster, Bernhard Haller, Sengul Sancak, Johanna Erber, Roland M. Schmid, Tobias Lahmer, Sebastian Rasch
Summary: The purpose of this study is to evaluate the efficacy of the currently implemented correction function and improve it further. The results show that the new correction formula has better performance in reducing bias, improving correlation, and reliability compared to the currently implemented formula.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2023)
Article
Urology & Nephrology
Gisa Mehring, Derya Tilki, Hans Heinzer, Thomas Steuber, Randi M. Pose, Imke Thederan, Lars Budaeus, Georg Salomon, Alexander Haese, Uwe Michl, Tobias Maurer, Hartwig Huland, Markus Graefen, Hendrik Isbarn
Summary: Prostate cancer detection is usually achieved by PSA measurement and further diagnostics. However, some men might harbor significant PCa at a younger age. This study evaluated the histopathological results of men treated with RP in their 40s.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Sport Sciences
Melanie Heitkamp, Bianca Spanier, Pia von Korn, Sebastian Knapp, Claudia Gross, Bernhard Haller, Martin Halle
Summary: The F-PROTECT study aimed to evaluate the feasibility of introducing a high volume and long duration of physical activity in colorectal cancer patients. The results showed that although 50 patients were recruited, the training attendance rate was only 64%. Therefore, strategies specifically designed for this patient group need to be developed and investigated to improve long-term physical activity.
TRANSLATIONAL SPORTS MEDICINE
(2023)
Article
Urology & Nephrology
Elena Herms, Gregor Weirich, Tobias Maurer, Stefan Wagenpfeil, Stephanie Preuss, Andreas Sauter, Matthias Heck, Anita Gaertner, Katharina Hauner, Michael Autenrieth, Hubert P. Kubler, Konstantin Holzapfel, Ulrike Schwarz-Boeger, Uwe Heemann, Julia Slotta-Huspenina, Konrad Friedrich Stock
Summary: This study examines the benefits of using combined contrast-enhanced ultrasound (CEUS) and CT/MRI evaluation in diagnosing and monitoring renal cystic lesions. The results show that the CEUS-Bosniak classification is an essential tool in clinical practice for differentiating and monitoring renal cysts, and it enhances diagnostic work-up and patient care.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Medicine, Research & Experimental
Christian Klenk, Johanna Erber, David Fresacher, Stefan Roehrl, Manuel Lengl, Dominik Heim, Hedwig Irl, Martin Schlegel, Bernhard Haller, Tobias Lahmer, Klaus Diepold, Sebastian Rasch, Oliver Hayden
Summary: The study presents a point-of-care compatible method for quantitatively analyzing blood cell aggregates in COVID-19 patients. The severity of COVID-19 is found to be significantly associated with the amount of platelet and platelet-leukocyte aggregates. The study highlights the potential of the method in supporting risk stratification and preventing complications in severe COVID-19 patients and other medical disorders involving immune cell aggregation.
COMMUNICATIONS MEDICINE
(2023)