Article
Immunology
Michael C. Scott, Karthik S. Prabhakara, Andrew J. Walters, Scott D. Olson, Charles S. Cox
Summary: In a rodent model of traumatic brain injury, sex-based differences in pathology and neuroinflammation are limited, and only noted in one specific analysis of BBB permeability.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Pinghui Zhao, Pingyi Zhu, Danbin Zhang, Bo Yin, Yu Wang, Nimo Mohamed Hussein, Zhihan Yan, Xiaozheng Liu, Guanghui Bai
Summary: This study explored sex differences in cerebral blood flow (CBF) and serum inflammatory cytokines in patients with acute-stage mild traumatic brain injury (mTBI). The results showed that both male and female patients had increased levels of IL-1L and IL-6. Female patients also exhibited higher levels of IL-8 and lower levels of IL-4. In terms of CBF levels, male patients had increased activity in three brain regions, while female patients had decreased activity in three brain regions. These findings suggest that females may be more susceptible to cognitive impairment following mTBI.
FRONTIERS IN NEUROLOGY
(2022)
Article
Critical Care Medicine
Karen M. Barlow, Kartik Iyer, Tingting Yan, Alex Scurfield, Helen Carlson, Yang Wang
Summary: Persistent post-concussion symptoms (PPCS) following pediatric mild traumatic brain injury (mTBI) are associated with differential changes in cerebral blood flow (CBF). Our study found that CBF levels were higher in participants with poor recovery and decreased over time, with a greater decrease observed in those with good recovery. These changes in CBF levels predicted outcomes in 77% of children with PPCS, highlighting its potential as a useful predictive biomarker in this population.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Critical Care Medicine
Taylor M. Yeates, H. Gerry Taylor, Erin D. Bigler, Nori M. Minich, Ken Tang, Daniel M. Cohen, Ann Bacevice, Leslie K. Mihalov, Barbara Bangert, Nicholas A. Zumberge, Keith Owen Yeates
Summary: This study investigated sex differences in outcomes among children and adolescents presenting to the Emergency Department for mild traumatic brain injury or orthopedic injury. The results indicated that sex did not moderate cognitive ability or symptom presentation, but girls reported more somatic symptoms. The mild TBI group showed lower cognitive ability and higher symptoms compared to the orthopedic injury group in the acute phase.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Neurosciences
Nathan W. Churchill, Michael G. Hutchison, Simon J. Graham, Tom A. Schweizer
Summary: This study found significant sex differences in brain recovery after concussion, with males showing greater reductions in occipital-parietal blood flow and increases in callosal mean diffusivity, while females had greater reductions in corona radiata fractional anisotropy. These findings provide new insights into how the brain recovers after a concussion, showing sex differences in both the acute and chronic phases of injury.
HUMAN BRAIN MAPPING
(2021)
Article
Rehabilitation
Eunkyung Kim, Han Gil Seo, Hyun Haeng Lee, Seung Hak Lee, Seung Hong Choi, Roh-Eul Yoo, Won-Sang Cho, Seo Jung Yun, Min-Gu Kang, Byung-Mo Oh
Summary: The study aimed to investigate changes in regional brain volume after mild traumatic brain injury and their relationship with cognitive deficits. The results showed that individuals with mild traumatic brain injury had reduced brainstem volume and this reduction was significantly associated with cognitive function, especially performance on tests like executive card sorting, forward digit span, and verbal learning.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Clinical Neurology
Jeroen Hermanides, Young T. Hong, Monica Trivedi, Joanne Outtrim, Franklin Aigbirhio, Peter J. Nestor, Matthew Guilfoyle, Stefan Winzeck, Virginia F. J. Newcombe, Tilak Das, Marta M. Correia, Keri L. H. Carpenter, Peter J. A. Hutchinson, Arun K. Gupta, Tim D. Fryer, John D. Pickard, David K. Menon, Jonathan P. Coles
Summary: Metabolic derangements following traumatic brain injury were comprehensively characterized using a combination of PET techniques, revealing reduced glucose utilization in the brain of patients, with regional increases associated with reductions in glucose availability, blood flow, and oxygen metabolism in the absence of ischemia.
Article
Medicine, General & Internal
Sophia Wagberg, Britt-Marie Stalnacke, Beatrice M. M. Magnusson
Summary: This study evaluates post-TBI symptoms and disabilities seven to eight years after mild TBI (mTBI), showing that women and individuals with repeated TBI experience more severe symptoms and functional decline. These findings have implications for clinical practice and research, and should be considered in rehabilitation and follow-up plans.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Min Duan, Yin Liu, Fengfang Li, Liyan Lu, Yu-Chen Chen
Summary: This study confirms the sex differences in cerebral blood flow and connectivity in patients with mild traumatic brain injury (mTBI) in the acute stage, and their association with cognitive outcomes.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Neurosciences
Emily L. Dennis, David Baron, Brenda Bartnik-Olson, Karen Caeyenberghs, Carrie Esopenko, Frank G. Hillary, Kimbra Kenney, Inga K. Koerte, Alexander P. Lin, Andrew R. Mayer, Stefania Mondello, Alexander Olsen, Paul M. Thompson, David F. Tate, Elisabeth A. Wilde
Summary: Traumatic brain injury (TBI) is a leading cause of global disability, but predicting patient outcomes is challenging due to the heterogeneous nature of TBI in terms of injury severity and other factors. Neuroimaging research has been limited by small sample sizes, and the development of reliable biomarkers for mild TBI or repeated subconcussive impacts has been slow.
HUMAN BRAIN MAPPING
(2022)
Article
Endocrinology & Metabolism
Margalit Haber, Franck Amyot, Cillian E. Lynch, Danielle K. Sandsmark, Kimbra Kenney, John K. Werner, Carol Moore, Kelley Flesher, Sarah Woodson, Erika Silverman, Yiyu Chou, Dzung Pham, Ramon Diaz-Arrastia
Summary: The study indicates that diffuse axonal injury (DAI) and diffuse vascular injury (DVI) in traumatic brain injury (TBI) represent two distinct endophenotypes that are spatially independent.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Sean O. Mahoney, Nahian F. Chowdhury, Van Ngo, Phoebe Imms, Andrei Irimia
Summary: This study reveals that intracortical demyelination after mild traumatic brain injury is significantly more severe than in typical aging, with different regions of the brain affected differently. Occipital regions may be more susceptible to primary injury, while temporal, cingulate, and insular regions are more vulnerable to later manifestations of injury sequelae.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Shaorui Zheng, Shuwen Mu, Jun Li, Shangming Zhang, Liangfeng Wei, Mingyue Wang, Yongjun Xu, Shousen Wang
Summary: This study examined the changes in venous blood flow after traumatic brain injury (TBI) using a TBI mouse model. The results showed a significant negative correlation between venous blood flow and intracranial pressure (ICP), indicating that venous blood flow can be used as an indicator of the progression of secondary brain injury.
Article
Neurosciences
Meaghan K. Race, Amanda E. Hahn-Ketter, Lisa A. A. Spielman, Enna Selmanovic, Karla L. Therese Sy, Robin Wellington, Kristen Dams-O'Connor
Summary: The study aimed to test the hypothesis that individuals with a history of traumatic brain injury (TBI) before the collegiate pre-season are at a higher risk for re-injury. The findings revealed that collegiate athletes with a lifetime history of TBI had a significantly higher risk of sustaining a subsequent concussion.
Review
Critical Care Medicine
Gustavo C. Medeiros, Claire Twose, Alexandra Weller, John W. Dougherty, Fernando S. Goes, Haris I. Sair, Gwenn S. Smith, Durga Roy
Summary: Depression after traumatic brain injury (TBI) is associated with neuroimaging measures such as lower gray matter and greater white matter damage. However, there is currently no clear neuroimaging biomarker for diagnosing and treating depression after TBI. Further research is needed in this area.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Psychology, Clinical
Wael K. Karameh, Ines Kortebi, Sanjeev Kumar, Damien Gallagher, Angela Golas, Krista L. Lanctot, Meryl A. Butters, Christopher R. Bowie, Alastair Flint, Tarek Rajji, Nathan Herrmann, Bruce G. Pollock, Benoit Mulsant, Linda Mah, David G. Munoz, Tom A. Schweizer, Corinne E. Fischer
Summary: This study compared the prevalence of cardiovascular risk factors in patients with mild cognitive impairment, major depression disorder, and a normal comparison group. The results showed an association between hypertension and cognitive performance in patients with MCI or MDD, highlighting the importance of treating modifiable CVRFs to mitigate cognitive decline.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Neurosciences
Sheeba Arnold Anteraper, Xavier Guell, Yoon Ji Lee, Jovicarole Raya, Ilya Demchenko, Nathan W. Churchill, Benicio N. Frey, Stefanie Hassel, Raymond W. Lam, Glenda M. MacQueen, Roumen Milev, Tom A. Schweizer, Stephen C. Strother, Susan Whitfield-Gabrieli, Sidney H. Kennedy, Venkat Bhat
Summary: Neuroimaging studies have shown abnormal structure and function of the cognitive-affective cerebellum in major depressive disorder (MDD). This study aims to investigate the role of cerebellar functional networks in depression. The results suggest that the cerebello-cerebral default mode network (DMN) is involved in MDD, and highlight the potential of using these functional and anatomical locations as biomarkers and targets for neuromodulation therapies.
Article
Neurosciences
Adrienne L. Atayde, Corinne E. Fischer, Tom A. Schweizer, David G. Munoz
Summary: This study found that sleep disturbances assessed by the NPI-Q significantly contribute to the rapid cognitive decline in Alzheimer's disease patients who carry the APOE epsilon 4 gene or show cerebral amyloid angiopathy (CAA).
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Marc A. Khoury, Mohamad-Ali Bahsoun, Ayad Fadhel, Shukrullah Shunbuli, Saanika Venkatesh, Abdollah Ghazvanchahi, Samir Mitha, Karissa Chan, Luis R. Fornazzari, Nathan W. Churchill, Zahinoor Ismail, David G. Munoz, Tom A. Schweizer, Alan R. Moody, Corinne E. Fischer, April Khademi
Summary: This study investigates the relationship between delusional severity and volume and texture biomarkers in cognitively impaired adults using FLAIR MRI. The results suggest that patients with more severe delusions have greater tissue degeneration in the NABM region (gray matter and white matter combined), which is significantly associated with CSF tau.
Article
Neurosciences
Jimmy K. Y. Wong, Nathan W. Churchill, Simon J. Graham, Andrew J. Baker, Tom A. Schweizer
Summary: This study aims to investigate the roles of the default mode network (DMN) and executive control network (ECN) in prolonged recovery after mild traumatic brain injury (mTBI), as well as their relationships with indices of white matter microstructural injury. The results showed that patients with mTBI had increased functional connectivity of the DMN and ECN to brain regions implicated in salience and frontoparietal networks, as well as increased white matter diffusivity within the cerebrum and brainstem. These findings suggest that hyper-connectivity may represent a compensatory response in female mTBI patients with prolonged symptoms.
Editorial Material
Clinical Neurology
Jennifer Dawson, Sharon Johnston, Shawn Marshall, Tom A. Schweizer, Nick Reed, Hannes Devos, Julianne Schmidt, Alexander Lithopoulos, Roger Zemek
JOURNAL OF HEAD TRAUMA REHABILITATION
(2023)
Correction
Neurosciences
Mila Valcic, Marc A. A. Khoury, Julia Kim, Luis Fornazzari, Nathan W. W. Churchill, Zahinoor Ismail, Vincenzo De Luca, Debby Tsuang, Tom A. A. Schweizer, David G. G. Munoz, Corinne E. E. Fischer
Article
Neurosciences
Nick Teller, Jordan A. Chad, Alexander Wong, Hayden Gunraj, Xiang Ji, Maged Goubran, Asaf Gilboa, Eugenie Roudaia, Allison Sekuler, Nathan Churchill, Tom Schweizer, Fuqiang Gao, Mario Masellis, Benjamin Lam, Chris Heyn, Ivy Cheng, Robert Fowler, Sandra E. Black, Bradley J. MacIntosh, Simon J. Graham, J. Jean Chen
Summary: By comparing simulation and experimental data, it is found that correlated diffusion imaging method performs better in detecting the effect of COVID-19, which reveals less restricted diffusion in the frontal lobe and more restricted diffusion in the cerebellar white matter in patients, consistent with existing studies.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Shijing Wang, Sidney H. Kennedy, Tim V. Salomons, Amanda K. Ceniti, Shane J. McInerney, Yvonne Bergmans, Diego A. Pizzagalli, Norman Farb, Gustavo Turecki, Tom A. Schweizer, Nathan Churchill, Mark Sinyor, Sakina J. Rizvi
Summary: This study aims to explore the relationship between suicide capability and pain in patients with Major Depressive Disorder (MDD) and identify the neural network associated with pain processing. The results reveal a positive correlation between suicide capability and pain endurance, and a negative correlation with pain threshold intensity. Additionally, suicide capability is associated with the functional connectivity strength of four brain regions in MDD patients, and this correlation is weaker in healthy controls. Pain threshold intensity serves as a mediator between suicide capability and connectivity strength.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Nathan W. Churchill, Simon J. Graham, Tom A. Schweizer
NEUROIMAGING CLINICS OF NORTH AMERICA
(2023)
Article
Clinical Neurology
Nathan W. W. Churchill, Eugenie Roudaia, J. Jean Chen, Asaf Gilboa, Allison Sekuler, Xiang Ji, Fuqiang Gao, Zhongmin Lin, Aravinthan Jegatheesan, Mario Masellis, Maged Goubran, Jennifer S. S. Rabin, Benjamin Lam, Ivy Cheng, Robert Fowler, Chris Heyn, Sandra E. E. Black, Bradley J. J. MacIntosh, Simon J. J. Graham, Tom A. A. Schweizer
Summary: This cross-sectional observational study aimed to determine if there are significant alterations in resting brain function among non-hospitalized individuals with PACS. The results showed that COVID-19 patients had lower functional connectivity in the brain, and the severity of symptoms was associated with altered functional connectivity.
FRONTIERS IN NEUROLOGY
(2023)
Article
Behavioral Sciences
Nathan W. Churchill, Eugenie Roudaia, J. Jean Chen, Asaf Gilboa, Allison Sekuler, Xiang Ji, Fuqiang Gao, Zhongmin Lin, Mario Masellis, Maged Goubran, Jennifer S. Rabin, Benjamin Lam, Ivy Cheng, Robert Fowler, Chris Heyn, Sandra E. Black, Bradley J. Macintosh, Simon J. Graham, Tom A. Schweizer
Summary: This study investigates the neurophysiological mechanisms underlying post-COVID headache, finding suppressed scaling properties in the brain activity of individuals with persistent headache compared to those without headache. This finding suggests a potential biomarker specific to post-COVID headache.
BRAIN AND BEHAVIOR
(2023)
Meeting Abstract
Clinical Neurology
L. Lee, I. Vavasour, E. Hernandez-Torres, A. Traboulsee, R. Tam, S. Kolind, T. Schweizer, J. Oh
MULTIPLE SCLEROSIS JOURNAL
(2022)
Meeting Abstract
Geriatrics & Gerontology
Mila Valcic, Sandra Black, Morris Freedman, Michael Borrie, Andrew Frank, Sanjeev Kumar, Stephen Pasternak, Bruce Pollock, Tarek Rajji, Dallas Seitz, David Tang-Wai, Carmela Tartaglia, Mario Masellis, Anthony Lang, David Breen, David Grimes, Mandar Jog, Connie Marras, Rick Swartz, Gustavo Saposnik, Donna Kwan, Brian Tan, Rob Hegele, Allison A. Dilliott, John Robinson, Ekaterina Rogaeva, Sali Farhan, Paula McLaughlin, Stephen Strother, Malcolm Binns, Thomas Steeves, Pawel Kostyrko, Komal Talib, Luis Fornazzari, Nathan Churchill, Tom A. Schweizer, David G. Munoz, Corinne E. Fischer
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Clinical Neurology
Michael L. Martini, Sean N. Neifert, William H. Shuman, Emily K. Chapman, Alexander J. Schupper, Eric K. Oermann, J. Mocco, Michael Todd, James C. Torner, Andrew Molyneux, Stephan Mayer, Peter Le Roux, Mervyn D. Vergouwen, Gabriel J. E. Rinkel, George K. C. Wong, Peter Kirkpatrick, Audrey Quinn, Daniel Hanggi, Nima Etminan, Walter M. van den Bergh, Blessing N. R. Jaja, Michael Cusimano, Tom A. Schweizer, Jose Suarez, Hitoshi Fukuda, Sen Yamagata, Benjamin Lo, Airton Leonardo de Oliveira Manoel, Hieronymus D. Boogaarts, R. Loch Macdonald
Summary: This study used machine learning and propensity score matching methods to analyze the clinical outcome of patients with angiographic vasospasm and delayed cerebral ischemia receiving rescue therapy. The results showed that rescue therapy might increase the odds of good outcome, and interventions targeting the prevention or treatment of cerebral ischemia may improve clinical outcomes.
JOURNAL OF NEUROSURGERY
(2022)