Article
Clinical Neurology
Mohamed Mohsen Amen, Ahmed Zaher, Hatem Ibraheem Badr, Mohammad Fekry Elshirbiny, Ahmed Mahmoud Elnaggar, Amr Farid Khalil
Summary: VSGS as a temporary CSF diversion procedure for PIH patients is safe and effective, reducing hospital stay and economic burden. The study found a high proportion of cases needing permanent diversion, with complications including scalp infection and CSF leakage.
CHILDS NERVOUS SYSTEM
(2022)
Article
Clinical Neurology
Tong Sun, Wenyao Cui, Siyang Chen, Yikai Yuan, Jingguo Yang, Yicheng Zhou, Xuepei Li, Hang Yu, Chao You, Junwen Guan
Summary: This study revealed the association between the presence of red blood cells in preoperative CSF and early shunt obstruction in patients with post-hemorrhagic hydrocephalus treated by LPS. Elevated RBC count was identified as a dependent risk factor for early shunt obstruction, highlighting the importance of monitoring CSF parameters in predicting shunt performance.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Paolo Frassanito, Francesca Serrao, Francesca Gallini, Federico Bianchi, Luca Massimi, Giovanni Vento, Gianpiero Tamburrini
Summary: For neonatal post-hemorrhagic hydrocephalus (PHH), ventriculosubgaleal shunt (VSgS) and neuroendoscopic lavage (NEL) have been proposed as effective treatment options to reduce the risk of infection and multiloculated hydrocephalus.
CHILDS NERVOUS SYSTEM
(2021)
Review
Neurosciences
Sandip Chatterjee
Summary: Ventriculosubgaleal shunts are used for treating hydrocephalus in low-birth-weight neonates, while ventriculocholecystal shunts are a last resort when all else fails.
Article
Clinical Neurology
Miss Cristina Bleil, Francesca Vitulli, Mr Asfand Baig Mirza, Timothy Martyn Boardman, Qusai Al Banna, Wisam AlFaiadh, Mr Bassel Zebian
Summary: In this study, a modified surgical approach for ventriculosubgaleal shunt (VSGS) was found to be effective in reducing the risk of infection by reducing the risk of CSF leak from the surgical wound.
CHILDS NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Zhao Li, Hao Wang, Han Zhang, Jiqi Yang, Xiaofeng Yang, Liang Wen
Summary: This study retrospectively analyzed the application of continuous two-stage lumboperitoneal shunt (LPS) in the treatment of communicating hydrocephalus. The results showed that this surgical method simplified the procedure and had a low revision rate and shunt infection rate in clinical practice.
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
Amir El Rahal, Debora Cipriani, Christian Fung, Marc Hohenhaus, Lukas Sveikata, Jakob Straehle, Mukesch Johannes Shah, Henrik Dieter Heiland, Juergen Beck, Oliver Schnell
Summary: This study investigated risk factors, treatment options, and outcomes for tumor-associated hydrocephalus in glioblastoma patients over a 10-year period. Ventricular system opening during a previous tumor resection was identified as a risk factor for communicating hydrocephalus. Ventricular shunting improved hydrocephalus symptoms in 95% of patients and led to restoration of Karnofsky Performance Score.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pediatrics
Grace Y. Lai, William Chu-Kwan, Annie B. Westcott, Abhaya Kulkarni, James M. Drake, Sandi K. Lam
Summary: The timing of initiation of temporizing neurosurgical treatment is associated with rates of VPS conversion and neurodevelopmental impairment in premature infants with PHVD. However, there is significant heterogeneity in study inclusion criteria and definitions of timing across institutions, indicating a need for more comprehensive outcome reporting.
JOURNAL OF PEDIATRICS
(2021)
Article
Clinical Neurology
Raffaele Falsaperla, Manuela Lo Bianco, Antonio Palmeri, Pasqua Betta, Roberto Altieri, Giuseppe Maria Barbagallo, Martino Ruggieri
Summary: This retrospective cohort study compared the short-term efficacy of external ventricular drains (EVDs) and ventriculosubgaleal (VSG) shunt in managing posthemorrhagic hydrocephalus in preterm newborns. The study found that EVD had a higher risk of infection and reintervention rate compared to VSG shunt, and there was a significant delay in conversion to a definitive ventriculoperitoneal (VP) shunt.
Review
Clinical Neurology
George W. Koutsouras, Tatyana Koustov, Stephanie Zyck, Satish Krishnamurthy
Summary: This article systematically reviews the pathophysiology of post-hemorrhagic hydrocephalus of prematurity, finding that its development is multifactorial and prediction of who will develop the condition is still challenging.
CHILDS NERVOUS SYSTEM
(2022)
Article
Clinical Neurology
Sandeep Muram, Albert M. Isaacs, Nicholas Sader, Richard Holubkov, Annie Fong, John Conly, Mark G. Hamilton
Summary: This study aimed to create a standardized infection prevention bundle to reduce the rate of shunt infections. The implementation of Calgary Adult Shunt Infection Prevention Protocol (CASIPP) significantly reduced the infection rate, and the introduction of chlorhexidine/alcohol further decreased the rate to 0%. Multivariable logistic regression analysis showed that the use of chlorhexidine/alcohol with CASIPP was associated with a significant reduction in the odds of developing a shunt infection.
JOURNAL OF NEUROSURGERY
(2023)
Article
Medicine, General & Internal
Sokol Trungu, Antonio Scollato, Luca Ricciardi, Stefano Forcato, Filippo Maria Polli, Massimo Miscusi, Antonino Raco
Summary: This study aims to evaluate the clinical outcomes of shunting in normal pressure hydrocephalus following a new standardized protocol. The results showed that surgical treatment by VPS improves symptoms in most patients with normal pressure hydrocephalus. However, the study also found complications and reoperation rates.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Nina Rostgaard, Markus Harboe Olsen, Tenna Capion, Nanna MacAulay, Marianne Juhler
Summary: This study aimed to identify inflammatory biomarkers in cerebrospinal fluid (CSF) that can predict the development of post-hemorrhagic hydrocephalus (PHH) and shunt-dependency, as well as functional outcome in patients with subarachnoid hemorrhage (SAH). Proximity extension assay (PEA) was used to analyze CSF samples from 31 SAH patients, and 7 markers were identified as predictors of shunt dependency and 4 markers as predictors of functional outcome. These inflammatory biomarkers hold potential as predictive tools in the clinic.
Article
Infectious Diseases
Xiao Zhang, Pengtao Li, Junxian Wen, Jianbo Chang, Yihao Chen, Rui Yin, Houshi Xu, Xiaoyu Liu, Lang Yang, Junji Wei
Summary: VPS is effective in treating TBM-associated hydrocephalus with good short-term outcomes, but long-term prognosis and management of shunt-related complications are crucial. Complications include catheter obstruction and infection.
BMC INFECTIOUS DISEASES
(2023)
Review
Neurosciences
Yi-Jen Ho, Wen-Chun Chiang, Hsin-Yi Huang, Shinn-Zong Lin, Sheng-Tzung Tsai
Summary: This meta-analysis evaluates the safety and effectiveness of lumboperitoneal shunt (LPS) compared to ventriculoperitoneal shunt (VPS) for treating communicating hydrocephalus. The results show that LPS has lower complication and obstruction rates, and improves radiological outcomes.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Editorial Material
Clinical Neurology
Jeffrey P. Blount
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2023)
Article
Clinical Neurology
Pedram Maleknia, Timothy D. McWilliams, Ariana Barkley, Dagoberto Estevez-Ordonez, Curtis Rozzelle, Jeffrey P. Blount
Summary: This study reviewed the longer-term safety and efficacy of vagus nerve stimulator (VNS) placement in children younger than 6 years with generalized medically refractory epilepsy. The results showed that seizure reduction rate >= 50% was observed in both patients younger than 4 years and patients aged 4-6 years at multiple follow-up periods. The study suggests that VNS implantation is feasible and effective for children younger than 6 years of age.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2023)
Review
Clinical Neurology
Nathan A. Shlobin, Jordan T. Roach, Vijaya Kancherla, Adrian Caceres, Eylem Ocal, Kemel A. Ghotme, Sandi Lam, Kee B. Park, Gail Rosseau, Jeffrey P. Blount, Frederick A. Boop
Summary: The global neurosurgery movement aims to address the global burden of neurosurgical disease by focusing on public health intervention in addition to individual treatment. The Global Alliance for the Prevention of Spina Bifida-F (GAPSBiF) advocates for folic acid fortification (FAF) of staple foods worldwide. This paper reviews the work of GAPSBiF in promoting universal FAF to prevent spina bifida caused by folic acid insufficiency.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2023)
Article
Health Care Sciences & Services
Betsy Hopson, Madeline Eckenrode, Brandon G. Rocque, Jeffrey Blount, Emily Hooker, Virginia Rediker, Emma Cao, Nancy Tofil, Yung Lau, Carlie Stein Somerville
Summary: This article describes the development of the STEP program and the innovative use of Individualized Transition Plans (ITP) in the clinic setting. The STEP program improves the transition from pediatric to adult healthcare by conducting a provider needs' assessment, creating a transition policy, and establishing an interdisciplinary medical home. The ITP focuses on 5 individualized goals and has been implemented through interdisciplinary patient visits in collaboration with adult healthcare departments.
DISABILITY AND HEALTH JOURNAL
(2023)
Letter
Clinical Neurology
Adrian Caceres, Jeffrey Parker Blount
CHILDS NERVOUS SYSTEM
(2023)
Review
Clinical Neurology
Homero Martinez, Adriana Benavides-Lara, Anastasia Arynchyna-Smith, Kemel. A. A. Ghotme, Mandana Arabi, Alexander Arynchyn
Summary: Neural tube defects are a global public health problem, especially in countries without effective prevention strategies. The global prevalence is estimated to be 18.6/10,000 live births, with 75% of cases resulting in under-five mortality. Insufficient folate levels in women of reproductive age are the main risk factor. Strategies to improve folate status, such as dietary diversification, supplementation, education, and fortification, can effectively reduce the prevalence of neural tube defects.
CHILDS NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Jeffrey P. Blount, Betsy D. Hopson, James M. Johnston, Brandon G. Rocque, Curtis J. Rozzelle, Jerry W. Oakes
Summary: Spina bifida (SB) is the most serious and common congenital anomaly of the human nervous system, which requires multi-disciplinary care. In utero myelomeningocele closure (IUMC) has revolutionized initial care for SB, but hydrocephalus remains a major concern. The development of a holistic and transitional care approach is crucial for the overall health and well-being of SB patients.
CHILDS NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Kemel A. Ghotme, Anastasia Arynchyna-Smith, Pedram Maleknia, Vijaya Kancherla, Helena Pachon, Philip J. van der Wees, Joseph M. Bocchino, Gail L. Rosseau
Summary: This article discusses the main barriers and facilitators for implementing mandatory food fortification as an evidence-based policy to prevent neural tube defects worldwide. The study found that lack of knowledge and awareness, difficulties in policy implementation, and external factors all impact the implementation of food fortification. Science-driven advocacy and partnerships with essential stakeholders can help overcome the barriers and leverage the facilitators for safe and effective food fortification.
CHILDS NERVOUS SYSTEM
(2023)
Article
Oncology
Michael Dewan, Albert Isaacs, Michael J. Cools, Aaron Yengo-Kahn, Robert Naftel, Hailey Jensen, Ron W. Reeder, Richard Holubkov, Joseline Haizel-Cobbina, Jay Riva-Cambrin, Ryan J. Jafrani, Jonathan A. Pindrik, Eric Jackson, Brendan F. Judy, Elena Kurudza, Ian Pollack, Michael Mcdowell, Todd Hankinson, Susan Staulcup, Jason Hauptman, Koko Hall, Mandeep S. Tamber, Alex Cheong, Nebras Warsi, Brandon Rocque, Benjamin W. Saccomano, Rita Snyder, Abhaya Kulkarni, John R. W. Kestle, John Wellons III, Hydrocephalus Clinical Res Network
Summary: This study compared the treatment outcomes of VPS and ETV for persistent hydrocephalus following posterior fossa brain tumor resection. The overall success rates were similar between the two methods, but ETV had earlier failure time while VPS had persistent risk of failure beyond 5 years.
JOURNAL OF NEURO-ONCOLOGY
(2023)
News Item
Clinical Neurology
Nathan A. Shlobin, Kemel Ghotme, Adrian Caceres, Eylem Ocal, Jogi V. Pattisapu, Gail Rosseau, Jeffrey P. Blount, Frederick A. Boop
WORLD NEUROSURGERY
(2023)
Review
Clinical Neurology
Pedram D. Maleknia, Andrew T. Hale, Cody Savage, Jeffrey P. Blount, Brandon G. Rocque, Curtis J. Rozzelle, James M. Johnston, Jesse G. A. Jones
Summary: This systematic review summarizes the published cases of pediatric dAVFs and reveals a lack of information in this field, with publication bias and difficulty in determining detailed complications.
CHILDS NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Jonathan Roth, Lottem Bergman, Alexander G. Weil, Tristan Brunette-Clement, Howard L. Weiner, Jeffrey M. Treiber, Ben Shofty, Arthur Cukiert, Cristine Mella Cukiert, Manjari Tripathi, Poodipedi Sarat Chandra, Robert J. Bollo, Helio Rubens Machado, Marcelo Volpon Santos, William D. Gaillard, Chima O. Oluigbo, George M. Ibrahim, George I. Jallo, Nir Shimony, Brent R. O'Neill, Marcelo Budke, Maria Angeles Perez-Jimenez, Francesco T. Mangano, Masaki Iwasaki, Keiya Iijima, Jorge Gonzalez-Martinez, Kensuke Kawai, Yohei Ishishita, Samer K. Elbabaa, Luis Bello-Espinosa, Aria Fallah, Cassia A. B. Maniquis, Ido Ben-Zvi, Martin Tisdall, Manas Panigrahi, Sita Jayalakshmi, Jeffrey P. Blount, Georg Dorfmuller, Christine Bulteau, Scellig S. Stone, Jeffrey Bolton, Shimrit Uliel-Sibony
Summary: CC is vital in seizure control in children with LGS in whom VNS has failed. Surgical risks are low. A complete CC has a tendency toward better effectiveness than anterior CC for some seizure types.
Article
Clinical Neurology
Andrew T. Hale, Dagoberto Estevez-Ordonez, Jana Badrani, Wen Sha, Anastasia Arynchyna-Smith, Monisha Goyal, Ismail Mohamed, Pongkiat Kankirawatana, Curtis J. Rozzelle, Jeffrey P. Blount
Summary: The study aimed to validate the Hemispherectomy Outcome Prediction Scale (HOPS) through a 20-year retrospective study on 60 patients, but found that the HOPS score was not statistically significant in predicting seizure outcomes postoperatively. More rigorous testing is needed for seizure outcome prediction tools, with prospective, standardized, and longitudinal evaluations of patients undergoing hemispherectomy.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2023)
Article
Clinical Neurology
Jonathan Roth, Howard L. Weiner, P. Sarat Chandra, Helio Rubens Machado, Jeffrey P. Blount, Georg Dorfmueller, Christian Dorfer, Manas Panigrahi, Shimrit Uliel-Sibony, Shlomi Constantini
Summary: There are significant disparities in access to epilepsy surgery technologies across countries and continents, highlighting the importance of collaboration between neurologists and neurosurgeons worldwide to enhance medical education, training, and increase technological availability.
CHILDS NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Mark S. Dias, Ming Wang, Menglu Liang, Elias B. Rizk, Robin Bowman, Michael D. Partington, Jeffrey P. Blount, Brandon G. Rocque, Betsy Hopson, Amy Lee, William O. Walker
Summary: The authors analyzed the National Spina Bifida Patient Registry to determine the ongoing risk for tethered cord release among adults with myelomeningocele who had not previously undergone the surgery during childhood. They also identified the impact of lesion level, ambulation status, and prior treatments on the surgery rates.
JOURNAL OF NEUROSURGERY-SPINE
(2023)