PPARα serves as a new receptor of aspirin for neuroprotection

Aspirin induces Lysosomal biogenesis and attenuates Amyloid plaque pathology in a mouse model of Alzheimer's disease via PPARα

(2018) Sujyoti Chandra et al.   JOURNAL OF NEUROSCIENCE

Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory

(2018) Dhruv Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cinnamic acid activates PPARα to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer's disease mouse model

(2018) Sujyoti Chandra et al.   NEUROBIOLOGY OF DISEASE

Low-Dose Aspirin Use and Cognitive Function in Older Age: A Systematic Review and Meta-analysis

(2017) Nicola Veronese et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease

(2016) Dheeraj S. Roy et al.   NATURE

Identification and characterization of PPARα ligands in the hippocampus

(2016) Avik Roy et al.   Nature Chemical Biology

The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

(2016) Heidi Martini-Stoica et al.   TRENDS IN NEUROSCIENCES

Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons

(2016) Ernest Palomer et al.   Nature Communications

Mean Daily Dosage of Aspirin and the Risk of Incident Alzheimer’s Dementia in Patients with Type 2 Diabetes Mellitus: A Nationwide Retrospective Cohort Study in Taiwan

(2016) Cheng-Wei Chang et al.   Journal of Diabetes Research

Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer’s disease

(2016) S-S Jiao et al.   Translational Psychiatry

HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice

(2015) Avik Roy et al.   Cell Metabolism

PPARα Signaling in the Hippocampus: Crosstalk Between Fat and Memory

(2015) Avik Roy et al.   Journal of Neuroimmune Pharmacology

Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing A  Generation and Amyloid Plaque Pathogenesis

(2015) Q. Xiao et al.   JOURNAL OF NEUROSCIENCE

Regular Aspirin Use Does Not Reduce Risk of Cognitive Decline

(2015) Brendan J. Kelley et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Neurodegenerative lysosomal disorders: A continuum from development to late age

(2014) Ralph A. Nixon et al.   Autophagy

Enhancing Astrocytic Lysosome Biogenesis Facilitates A  Clearance and Attenuates Amyloid Plaque Pathogenesis

(2014) Q. Xiao et al.   JOURNAL OF NEUROSCIENCE

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

Regulation of Cyclic AMP Response Element Binding and Hippocampal Plasticity-Related Genes by Peroxisome Proliferator-Activated Receptor α

(2013) Avik Roy et al.   Cell Reports

Is Statin-Associated Cognitive Impairment Clinically Relevant? A Narrative Review and Clinical Recommendations

(2012) Carlos H Rojas-Fernandez et al.   ANNALS OF PHARMACOTHERAPY

Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials

(2012) Peter M Rothwell et al.   LANCET

Dysregulation of Calcium Homeostasis in Alzheimer’s Disease

(2009) David H. Small   NEUROCHEMICAL RESEARCH

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Multiple Roles of Calcium Ions in the Regulation of Neurotransmitter Release

(2008) Erwin Neher et al.   NEURON