Article
Oncology
Peter Baumgarten, Mana Sarlak, Daniel Monden, Andrea Spyrantis, Simon Bernatz, Florian Gessler, Daniel Dubinski, Elke Hattingen, Gerhard Marquardt, Adam Strzelczyk, Felix Rosenow, Patrick N. Harter, Volker Seifert, Thomas M. Freiman
Summary: Seizures are common symptoms in meningioma patients, even after surgery, with distinct factors identifying high-risk patients. Late seizures, accounting for 43% of postoperative cases, pose greater danger. The modified STAMPE2 score can predict postoperative seizures at high scores but may not be universally applicable.
Article
Clinical Neurology
Angeliki Vakrinou, Ravishankara Bellampalli, Medine Gulcebi, Helena Martins Custodio, Simona Genomics England Res Consortium, Simona Balestrini, Sanjay M. Sisodiya
Summary: Whole genome sequencing data was used to screen for pharmacogenomic risk factors related to antiseizure medication-induced cutaneous adverse drug reactions (cADRs). The study identified HLA-B*15:02 and HLA-A*31:01 carriers and found a high prevalence of cADRs in these carriers. The findings suggest that comprehensive utilization of genetic data can help identify pharmacogenomic biomarkers for personalized pharmacotherapy.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Seon-Jae Ahn, Jaeseong Oh, Do-Yong Kim, Hyoshin Son, Sungeun Hwang, Hye-Rim Shin, Eun Young Kim, Han Sang Lee, Woo-Jin Lee, Jangsup Moon, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, SeungHwan Lee, Kyung-Sang Yu, Kon Chu, Sang Kun Lee
Summary: This study explored the effect of genetic polymorphisms on serum LCM concentration in epilepsy patients, and found that genetic polymorphisms of the CYP2C19 gene significantly affect the serum LCM concentration.
Article
Clinical Neurology
Sung-Tae Kim, Sung Eun Kim, Dong Ah Lee, Ho-Joon Lee, Kang Min Park
Summary: This study aimed to evaluate the glymphatic system function in patients with focal epilepsy and its association with anti-seizure medication response. The results showed a greater reduction in glymphatic system function among poor responders, indicating a possible link between medication response and glymphatic system function.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Toshiya Nishi, Cameron S. Metcalf, Shinji Fujimoto, Shigeo Hasegawa, Maki Miyamoto, Eiji Sunahara, Sayuri Watanabe, Shinichi Kondo, H. Steve White
Summary: The study characterizes the anticonvulsive property of soticlestat in rodent models of epilepsy and suggests that it may be a novel class of antiseizure medications for the treatment of intractable epilepsy disorders.
Article
Clinical Neurology
Chia-Yu Hsu, Chun-Yu Cheng, Jiann-Der Lee, Meng Lee, Bruce Ovbiagele
Summary: Among patients with post-stroke epilepsy on first-line monotherapy, the use of phenytoin was associated with a higher risk of death in 5 years compared to new anti-seizure medications. However, all anti-seizure medication groups showed a similar risk of new ischemic stroke within 5 years.
Review
Clinical Neurology
Claudio Liguori, Manuel Toledo, Sanjeev Kothare
Summary: Anti-seizure medications (ASMs) can have varying effects on sleep, with some improving sleep while others worsening sleep. Clinicians should take into consideration the individual patient's condition and comorbid sleep disorders when making treatment decisions.
SLEEP MEDICINE REVIEWS
(2021)
Article
Pediatrics
Pietro Ferrara, Antonio Gatto, Valeria Blasi, Federica Di Ruscio, Domenica Battaglia
Summary: This study evaluated the weight gain in pediatric patients with epilepsy treated with VPA. The results showed a significant difference in weight and BMI percentile values at 36 and 48 months of follow-up, but not in height. The study suggests that nutritional support should be provided to pediatric patients starting VPA therapy.
MINERVA PEDIATRICS
(2022)
Article
Clinical Neurology
Sarah Holper, Emma Foster, Michael Lloyd, Genevieve Rayner, Maria Rychkova, Rashida Ali, Toby T. Winton-Brown, Dennis Velakoulis, Terence J. O'Brien, Patrick Kwan, Charles B. Malpas
Summary: This study aimed to identify factors predicting discordance between screening instruments and psychiatric diagnoses among patients with seizure disorders. Results showed that seven clinical factors were associated with discordance, and patients with a variety of psychiatric symptoms should be evaluated more thoroughly for depression and anxiety, especially those with psychogenic nonepileptic seizures.
Review
Nutrition & Dietetics
Cristina Diez-Arroyo, Monica Garcia-Garcia, Maria Jose Soto-Mendez, Esther Molina-Montes, Mercedes Gil-Campos, Angel Gil, Miriam Gutierrez-Jimeno, Angela Hernandez-Ruiz
Summary: Epilepsy is a common neurological disorder in childhood, and despite antiepileptic drugs being the preferred treatment, a significant number of children continue to experience seizures. This review examines the use of a ketogenic diet (KD) as an alternative treatment for refractory epilepsy in children.
Review
Biochemistry & Molecular Biology
Walaa Hamada Abd-Allah, Mostafa Abd El-Mohsen Anwar, Eman R. Mohammed, Samir M. El Moghazy
Summary: Epilepsy is a common neurological disorder requiring long-term treatment. Despite the availability of new drugs, a significant number of patients are still drug-resistant. Therefore, there is an urgent need for new anticonvulsants with lower toxicity and better efficacy. However, target-based studies for discovering these drugs are uncommon due to insufficient knowledge of the molecular pathway of epilepsy and the complex mode of action of existing drugs.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Adam J. Noble, Sara Haddad, Niamh Coleman, Anthony G. Marson
Summary: This study is the first independent and comprehensive examination of ASM PILs. It found that the majority of PILs fail to meet recommendations and regulatory requirements, and may not be understandable to users. Additionally, there are marked differences in comprehension of PILs between epilepsy patients and students, highlighting the importance of user testing with the target population.
Review
Biochemistry & Molecular Biology
Mohammad Qneibi, Sosana Bdir, Celine Maayeh, Mohammad Bdair, Dana Sandouka, Diana Basit, Mira Hallak
Summary: Essential oils have diverse chemical compositions and pharmacological properties, which can be used to relieve anxiety, pain, and insomnia. Integrating essential oils into conventional therapies can enhance the effectiveness of comprehensive treatment regimens for neurodegenerative diseases, providing a holistic approach to address these conditions.
NEUROCHEMICAL RESEARCH
(2023)
Article
Anatomy & Morphology
Sisi Jiang, Hechun Li, Haonan Pei, Linli Liu, Zhiliang Li, Yan Chen, Xiangkui Li, Qifu Li, Dezhong Yao, Cheng Luo
Summary: This study characterized the connective profiles and coupling relationship between dynamic and static functional connectivity in large-scale brain networks in patients with generalized epilepsy. The findings showed hypervariability and enhancement of functional connectivity, notably decreased structural connectivity in subcortical networks, as well as increased dynamic functional connectivity in default mode network of GE patients. Additionally, decreased antagonism between dFC and sFC was observed in core epileptic networks of GE patients compared to healthy controls.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Biochemistry & Molecular Biology
Stefan Rampp, Martin Kaltenhaeuser, Nadia Mueller-Voggel, Arnd Doerfler, Burkhard S. Kasper, Hajo M. Hamer, Sebastian Brandner, Michael Buchfelder
Summary: Epilepsy surgery is an effective treatment option for patients with drug-resistant focal epilepsies, and accurate localization of the epileptogenic zone is essential. This study investigates the relationship between node degree (ND) and the seizure onset zone (SOZ) in resting state magnetoencephalography (MEG) data. The findings suggest that ND in certain frequency bands is significantly related to the SOZ, indicating its potential as a new tool for presurgical evaluation of epilepsy surgery.
Article
Neurosciences
Inja Cho, Kyoung Hoon Jeong, Jing Zhu, Yun Ho Choi, Kyoo Ho Cho, Kyoung Heo, Won-Joo Kim
MOLECULAR NEUROBIOLOGY
(2019)
Article
Multidisciplinary Sciences
Ji-Yong Jang, Shinje Moon, Sungsoo Cho, Kyoo Ho Cho, Chang-Myung Oh
SCIENTIFIC REPORTS
(2019)
Article
Clinical Neurology
Soo Hwan Yim, Yun Ho Choi, Kyoung Heo, Kyoo Ho Chotk
Article
Clinical Neurology
Han Kyu Na, Ho-Joon Lee, Seok-Jun Hong, Dong Hyun Lee, Kyung Min Kim, Hyung Woo Lee, Kyoung Heo, Kyoo Ho Cho
Article
Critical Care Medicine
Minyoul Baik, Kyung Min Kim, Chang-Myung Oh, Dongbeom Song, Ji Hoe Heo, Yoo Seok Park, Jin Wi, Young Sam Kim, Jeongmin Kim, Sung Soo Ahn, Kyoo Ho Cho, Yang-Je Cho
Summary: A pilot study was conducted on unconscious out-of-hospital cardiac arrest survivors to assess the characteristics and risk factors of cerebral infarction following MRI imaging. Approximately one-fifth of the patients had procedure-unrelated cerebral infarction, with older age and atrial fibrillation potentially being associated with its occurrence. It was found that cerebral infarction was not linked with poor clinical outcomes at discharge, while hypoxic-ischemic encephalopathy was strongly correlated with unfavorable outcomes. Further research is needed to confirm these findings due to the small sample size of the pilot study.
NEUROCRITICAL CARE
(2021)
Article
Clinical Neurology
Kyoung Heo, Kyung Min Kim, Seung Min Han, Kyoo Ho Cho, Min Kyung Chu
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2020)
Article
Clinical Neurology
Soo Hwan Yim, Kyoo Ho Cho, Yun Ho Choi, Hye Ihn Kim, Yang-Je Cho, Kyoung Heo
Summary: Comparing EEG recordings with NPEs and ATEs to those with only ATEs, it was found that NPE recordings had higher sensitivity and agreement in detecting IEDs, especially in patients with mesial and non-lesional TLE. The use of NPE recordings may be recommended for patients with suspected TLE for better diagnostic yield.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Seok Jong Chung, Kyoo Ho Cho, Yang Hyun Lee, Han Soo Yoo, KyoungWon Baik, Jin Ho Jung, Byoung Seok Ye, Young H. Sohn, Jungho Cha, Phil Hyu Lee
Summary: This study investigated the diagnostic value of measuring pontine damage using DTI in patients with synucleinopathies. The results suggest that MD values in the pons may be a useful marker of brain stem neurodegeneration in these patients.ROC analyses showed that MD values had a fair discriminatory power to differentiate healthy controls from patients with PD, iRBD, and MSA.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Clinical Neurology
Ravnoor Singh Gill, Hyo-Min Lee, Benoit Caldairou, Seok-Jun Hong, Carmen Barba, Francesco Deleo, Ludovico D'Incerti, Vanessa Cristina Mendes Coelho, Matteo Lenge, Mira Semmelroch, Dewi Victoria Schrader, Fabrice Bartolomei, Maxime Guye, Andreas Schulze-Bonhage, Horst Urbach, Kyoo Ho Cho, Fernando Cendes, Renzo Guerrini, Graeme Jackson, R. Edward Hogan, Neda Bernasconi, Andrea Bernasconi
Summary: The study successfully tested a multicenter-validated deep learning algorithm that accurately detects MRI-negative focal cortical dysplasia, demonstrating high sensitivity and confidence in risk stratification. This approach shows potential to assist clinicians in adjusting hypotheses and increasing diagnostic confidence in patients with epilepsy.
Article
Clinical Neurology
Kyoo Ho Cho, Ho-Joon Lee, Kyoung Heo, Sung Eun Kim, Dong Ah Lee, Kang Min Park
Summary: The study aimed to identify differences in intrinsic amygdala, hippocampal, or thalamic networks according to surgical outcomes in temporal lobe epilepsy patients with hippocampal sclerosis. The results revealed significant differences in intrinsic thalamic network between patients with poor and good surgical outcomes, suggesting a potential correlation between pre-operative intrinsic thalamic network and surgical outcomes in this patient population.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Kyoo Ho Cho, Kang Min Park, Ho-Joon Lee, Hojin Cho, Dong Ah Lee, Kyoung Heo, Sung Eun Kim
Summary: This study investigated metabolic network differences based on preoperative FDG-PET in TLE patients with HS, comparing those with complete seizure-free and noncomplete seizure-free outcomes after anterior temporal lobectomy. Significant differences in global and regional metabolic networks were found between the two groups, suggesting that metabolic network analysis may be a potential tool for predicting surgical outcomes in these patients.
JOURNAL OF NEUROIMAGING
(2022)
Article
Clinical Neurology
Kyoo Ho Cho, Ho-Joon Lee, Dong Ah Lee, Kang Min Park
Summary: This study investigated the frequency and clinical significance of mammillary body (MB) atrophy in patients with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS), as well as its association with volume changes in other subcortical limbic structures. The results showed that about one-quarter of the patients had ipsilateral MB atrophy, which was associated with older age at seizure onset and shorter duration of epilepsy. However, MB atrophy had minimal impact on volume changes in other subcortical limbic structures.
JOURNAL OF CLINICAL NEUROLOGY
(2022)
Letter
Clinical Neurology
Ki Hoon Kim, Jinhyuk Cho, Kyoo Ho Cho, Ha Young Shin, Seung Woo Kim
JOURNAL OF CLINICAL NEUROLOGY
(2021)
Article
Neuroimaging
Hyo M. Lee, Ravnoor S. Gill, Fatemeh Fadaie, Kyoo H. Cho, Marie C. Guiot, Seok-Jun Hong, Neda Bernasconi, Andrea Bernasconi
NEUROIMAGE-CLINICAL
(2020)