Article
Biochemistry & Molecular Biology
Huan Yang, Sam J. George, Dane A. Thompson, Harold A. Silverman, Tea Tsaava, Aisling Tynan, Valentin A. Pavlov, Eric H. Chang, Ulf Andersson, Michael Brines, Sangeeta S. Chavan, Kevin J. Tracey
Summary: Recent studies have shown that famotidine has anti-inflammatory effects and can attenuate the clinical course of COVID-19 by preventing cytokine storm. The mechanism of action involves activation of the inflammatory reflex, which inhibits inflammation and is mediated by alpha 7 nicotinic acetylcholine receptors (alpha 7nAChR).
MOLECULAR MEDICINE
(2022)
Article
Geriatrics & Gerontology
Jianhua Wu, Zhuoze Wu, Aodi He, Tongmei Zhang, Ping Zhang, Jing Jin, Sisi Li, Gaigai Li, Xinyan Li, Shiqi Liang, Lei Pei, Rong Liu, Qing Tian, Ximiao He, Youming Lu, Zhouping Tang, Hao Li
Summary: Our study identifies Hmgb2 and Ctss as major mediators of microglial inflammatory response in stroke, inhibition of which can protect against brain damage and improve neurological functions in stroke mice. These findings suggest Hmgb2 and Ctss as promising targets for stroke therapies.
Article
Biochemistry & Molecular Biology
Madlen Reinicke, Judith Leyh, Silke Zimmermann, Soroth Chey, Ilijana Begcevic Brkovic, Christin Wassermann, Julia Landmann, Dieter Luetjohann, Berend Isermann, Ingo Bechmann, Uta Ceglarek
Summary: Plant sterols (PSs) must be obtained through diet as mammals cannot synthesize them. Obesity induced by a high-fat diet leads to decreased levels of PSs in the blood and brain, which have anti-neuroinflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rania Elsayed, Salwa Fayez, Laila Ahmed Rashed, Marwa Farghali, Marwa AbdelHamid, Marwa Alkaffas
Summary: This study aimed to investigate the plasma level of miRNA-155 in RRMS patients and its relationship with inflammatory and anti-inflammatory mediators. The results showed no significant difference in miRNA-155 expression between MS patients and controls, but there was a significant increase in TNF-alpha, INF-gamma, and TGF-beta levels. IL-10 levels did not differ significantly between the two groups. Furthermore, miRNA-155 had a positive correlation with TNF-alpha, INF-gamma, and iNOS, and an inverse correlation with IL-10, TGF-beta, and SMAD2.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Cell Biology
Ewelina Honkisz-Orzechowska, Katarzyna Popiolek-Barczyk, Zuzanna Linart, Jadwiga Filipek-Gorzala, Anna Rudnicka, Agata Siwek, Tobias Werner, Holger Stark, Jakub Chwastek, Katarzyna Starowicz, Katarzyna Kiec-Kononowicz, Dorota Lazewska
Summary: This study demonstrates the strong anti-inflammatory effect of new human H3R ligands with flavonoid structure in murine microglial cells. Further research is needed to understand the mechanism of action of flavonoids in reducing inflammation.
INFLAMMATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Samantha Minh Thy Nguyen, Chase Preston Rupprecht, Aaisha Haque, Debendra Pattanaik, Joseph Yusin, Guha Krishnaswamy
Summary: Anaphylaxis is a severe, acute, life-threatening allergic reaction that can be triggered by medications, foods, latex, etc., causing respiratory, cardiovascular, and skin symptoms. The condition is characterized by a variety of symptoms and can have diverse causes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Irene Tsilioni, Theoharis C. C. Theoharides
Summary: SARS-CoV-2 infection leads to acute symptoms especially in the lungs known as COVID-19, primarily through the binding of its spike protein to ACE2 receptor. However, there is increasing evidence suggesting that SARS-CoV-2 infection also causes neuroinflammation, resulting in neurological, neuropsychiatric, and cognitive symptoms that persist even after the resolution of the infection, known as post-COVID-19 sequalae or long-COVID. The specific neuroimmune mechanisms involved in long-COVID have not been well characterized.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Immunology
Nathan Calzadilla, Shane M. M. Comiskey, Pradeep K. K. Dudeja, Seema Saksena, Ravinder K. K. Gill, Waddah A. A. Alrefai
Summary: Bile acids play a critical role in lipid and fat-soluble vitamin digestion and absorption, but they also act as signaling molecules. Disturbances in bile acid homeostasis can contribute to the development of Inflammatory Bowel Diseases (IBD). Studies have shown that different bile acids have different effects on the inflammatory response and intestinal permeability, suggesting a potential link between bile acid changes and the development of IBD.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Linh Pham, Leonardo Baiocchi, Lindsey Kennedy, Keisaku Sato, Vik Meadows, Fanyin Meng, Chiung-Kuei Huang, Debjyoti Kundu, Tianhao Zhou, Lixian Chen, Gianfranco Alpini, Heather Francis
Summary: The daily rhythmicity in our body is controlled by a circadian clock in the suprachiasmatic nucleus in the hypothalamus. Mast cells play a protective role against pathogens and inflammation and are associated with the circadian rhythm. Melatonin and histamine modulate circadian rhythms by regulating NF-kappa B, offering a promising therapeutic strategy for MC-mediated inflammatory diseases.
JOURNAL OF PINEAL RESEARCH
(2021)
Editorial Material
Oncology
Song Chen, Andrew D. Luster
Summary: The study identifies that histamine released during allergic reactions and from tumor cells weakens the response to immunotherapy. Histamine H-1-receptor signaling induces a suppressive phenotype in tumor-associated macrophages and increases VISTA expression, thereby suppressing CD8(+) T cell function. Anti-histamines can reverse these effects and improve the efficacy of immunotherapy.
Review
Biochemistry & Molecular Biology
Cassia de Faveri, Paula M. Poeta Fermino, Anna P. Piovezan, Lia K. Volpato
Summary: The pathogenesis of endometriosis is still controversial, with the inflammatory immune response playing a critical role. Pro-resolving mediators (PRMs) in endometriosis are not well understood, but research shows their potential in inhibiting disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Vittoria Borgonetti, Nicoletta Galeotti
Summary: Growing evidence suggests that the histamine system could be a promising target for the management of neuropathic pain. This study investigated the role of H4R in the anti-hyperalgesic action of the H3R antagonist GSK189254 in a mouse model of spared nerve injury (SNI). The results demonstrate the selective contribution of H4R to the attenuation of hypernociceptive behavior induced by the H3R antagonist, which could help identify innovative therapeutic interventions for neuropathic pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Kristina A. Dvornikova, Olga N. Platonova, Elena Y. Bystrova
Summary: Inflammatory bowel disease (IBD) is a serious global public health concern, with various factors involved in its pathogenesis. Histamine and its receptors may play a significant role in the gut due to the high immunomodulatory activity of histamine and the immune-mediated nature of IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anesthesiology
Robert C. Alexander, Karen Raudibaugh, Egilius L. H. Spierings, Nathaniel Katz
Summary: The study found no evidence of clinical efficacy for AZD5213 combined with pregabalin in treating painful diabetic neuropathy. Training patients in pain reporting and enriching with good pain reporters did not enable robust detection of pregabalin's efficacy relative to placebo in a small sample size, suggesting further work is needed before recommending the use of connoisseur patients in future neuropathic pain studies.
CLINICAL JOURNAL OF PAIN
(2021)
Article
Multidisciplinary Sciences
Chuan Hong, Noel J. Byrne, Beata Zamlynny, Srivanya Tummala, Li Xiao, Jennifer M. Shipman, Andrea T. Partridge, Christina Minnick, Michael J. Breslin, Michael T. Rudd, Shawn J. Stachel, Vanessa L. Rada, Jeffrey C. Kern, Kira A. Armacost, Scott A. Hollingsworth, Julie A. O'Brien, Dawn L. Hall, Terrence P. McDonald, Corey Strickland, Alexei Brooun, Stephen M. Soisson, Kaspar Hollenstein
Summary: NT1 is a chronic neurological disorder with limited treatment options, while OX2R agonists show promise in providing novel therapeutic approaches. Cryo-EM structures of OX2R bound to agonists suggest a molecular mechanism for receptor activation and inhibition.
NATURE COMMUNICATIONS
(2021)