Article
Biochemistry & Molecular Biology
Fengli Li, Shuyuan Mo, Jie Yin, Sitian Zhang, Saisai Gu, Zi Ye, Jianping Wang, Zhengxi Hu, Yonghui Zhang
Summary: Several novel secondary metabolites were isolated from the fungus Aspergillus calidoustus obtained from wetland soil in Dianchi Lake, Yunnan Province. One of these compounds showed significant cytotoxicity against certain tumor cells.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Wei-Mao Zhong, Xiao-Yi Wei, Yu-Chan Chen, Qi Zeng, Jun-Feng Wang, Xue-Feng Shi, Xin-Peng Tian, Wei-Min Zhang, Fa-Zuo Wang, Si Zhang
Summary: Through large-scale fermentation with modified culture, new salicylaldehyde derivative enantiomers were isolated from Eurotium sp. SCSIO F452, showing significant inhibitory activity against alpha-glucosidase and moderate cytotoxic activities against various cell lines.
Article
Chemistry, Medicinal
Jinwei Ren, Ruiyun Huo, Gaoran Liu, Ling Liu
Summary: Three new andrastin-type meroterpenoids, penimeroterpenoids A-C (1-3), along with two known analogs, were isolated from the cultures of marine-derived Penicillium species. The structures of the new compounds were identified through NMR and mass spectrometry, while the absolute configurations were determined using experimental and calculated ECD spectra. Compound 1 exhibited moderate cytotoxicity against A549, HCT116, and SW480 cell lines.
Article
Plant Sciences
Meng Bai, Cai-Juan Zheng, Guang-Ying Chen
Summary: Three unusual austins-type meroterpenoids were isolated from a mangrove-derived fungus, each with unique structural features. These compounds showed inhibitory effects on the growth of Helicoverpa armigera larvae.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Xin Qi, Weihao Chen, Liurong Chen, Yiwei Hu, Xueni Wang, Wenrong Han, Jiao Xiao, Xiaoyan Pang, Xingang Yao, Shuwen Liu, Yong Li, Jie Yang, Junfeng Wang, Yonghong Liu
Summary: Guided by Global Natural Products Social molecular networking, 14 new p-terphenyl derivatives, asperterphenyls A-N (1-14), together with 20 known p-terphenyl derivatives (15-34), were obtained from a sponge derived fungus Aspergillus sp. SCSIO41315. Among them, new compounds 2-8 and 15-17 were ten pairs of enantiomers. Comprehensive methods such as chiral-phase HPLC analysis, ECD calculations and X-ray diffraction analysis were applied to determine the absolute configurations. Asperterphenyls B (2) and C (3) represented the first reported natural p-terphenyl derivatives possessing a dicarboxylic acid system. Asperterphenyl A (1) displayed neuraminidase inhibitory activity with an IC50 value of 1.77 +/- 0.53 mu M and could efficiently inhibit infection of multiple strains of H1N1 with IC50 values from 0.67 +/- 0.28 to 1.48 +/- 0.60 mu M through decreasing viral plaque formation in a dose-dependent manner, which suggested that asperterphenyl A (1) might be exploited as a potential antiviral compound in the pharmaceutical fields.
BIOORGANIC CHEMISTRY
(2023)
Article
Infectious Diseases
Fuhang Song, Rui Lin, Na Yang, Jia Jia, Shangzhu Wei, Jiahui Han, Jiangpeng Li, Hongkai Bi, Xiuli Xu
Summary: Four new secondary metabolites and four known compounds were isolated from the marine-derived fungus Aspergillus sp. IMCASMF180035. Compound 1 exhibited a unique carbon skeleton and significant inhibitory effects against S. aureus and MRSA. Compounds 2 and 6 showed potent antibacterial activities against H. pylori.
Article
Chemistry, Applied
Huiling Wen, Yi Zang, Qianheng Zhu, Sheng Ouyang, Juanjuan Luo, Nianhua Luo, Hucheng Zhu, Yonghui Zhang
Summary: This article reports the isolation and structural elucidation of two new compounds from a marine-derived fungus, as well as the evaluation of their biological activity.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Fei Zhang, Li Yang, Qing-Yi Xie, Jiao-Cen Guo, Qing-Yun Ma, Lu-Ting Dai, Li-Man Zhou, Hao-Fu Dai, Fan-Dong Kong, Du-Qiang Luo, You-Xing Zhao
Summary: Eight previously undescribed indole-diterpenoids were isolated from the marine soft coral-derived fungus Aspergillus sp. ZF-104, along with seven known analogues. Their structures and absolute configurations were determined through spectroscopic data, ECD analysis, and quantum ECD and NMR calculations. Several of these compounds showed comparable protein tyrosine phosphatase 1B inhibitory activity to the positive control.
Article
Plant Sciences
Xiang Guo, Qinyu Meng, Jie Liu, Jingshuai Wu, Hongli Jia, Dong Liu, Yucheng Gu, Jianrong Liu, Jian Huang, Aili Fan, Wenhan Lin
Summary: Bioassay-guided fractionation, combined with LC-MS and NMR detection, led to the discovery of six new alkaloids from a marine gorgonian-derived fungus. Among them, sclerotiamides C and F showed significant inhibition against tumor cell lines, and sclerotiamide C induced apoptosis in cervical cancer cells.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Applied
Mengyi Deng, Xiaosheng Tan, Yuben Qiao, Weiguang Sun, Shuangshuang Xie, Zhengyi Shi, Yuanyuan Lu, Gang Chen, Changxing Qi, Yonghui Zhang
Summary: In this study, a new DMOA-based meroterpenoid and other compounds were isolated from the endophytic fungus Aspergillus sp. The structures and absolute configurations were determined using various techniques. Compound 1 showed a rare cis-fused C/D ring system, while compound 2 contained an unusual (E)-oxime group. Additionally, lovastatin analogues 5, 6, 9, and 10 exhibited potential immunosuppressive activity.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Medicinal
Sheng-Tao Fang, Zhen-Zhen Shi, Yin-Ping Song, Xiu-Li Yin, Nai-Yun Ji
Summary: Further investigation of secondary metabolites from a marine-alga-derived fungus led to the discovery of new compounds with inhibitory effects on marine harmful microalgae.
Article
Biochemistry & Molecular Biology
Hong-Lei Li, Sui-Qun Yang, Xiao-Ming Li, Xin Li, Bin-Gui Wang
Summary: Thirteen alkaloids, including three new diketopiperazines and ten known derivatives, were isolated from the marine red algal-derived fungus Aspergillus creber EN-602. Some of these compounds showed inhibitory activity against ACE and aquatic bacteria, with further investigation on their interactions through molecular docking simulations with ACE.
BIOORGANIC CHEMISTRY
(2021)
Article
Microbiology
Sha-Sha Liu, Li Yang, Fan-Dong Kong, Jia-Hui Zhao, Li Yao, Zhi-Guang Yuchi, Qing-Yun Ma, Qing-Yi Xie, Li-Man Zhou, Meng-Fei Guo, Hao-Fu Dai, You-Xing Zhao, Du-Qiang Luo
Summary: By feeding tryptophan to the marine-derived fungus Aspergillus sp. HNMF114 from the bivalve mollusk Sanguinolaria chinensis, 3 new quinazoline-containing indole alkaloids were obtained, with compound 3 showing a unique structure and promising bioactivities.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yu-Yue Qin, Wan-Shan Li, Xuan Zhang, Zhang-Xin Yu, Xiao-Bao Li, Han-Yi Chen, Yan-Ru Lv, Chang-Ri Han, Guang-Ying Chen
Summary: Fifteen new meroterpenoids, including three rearranged skeleton meroterpenoids, were isolated from the mangrove-derived fungus Penicillium sp. HLLG-122. The structures and absolute configurations of the new compounds were determined using various analytical techniques. Compounds 6 and 11 exhibited anti-inflammatory effects.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Huawei Lv, Jinkun Zhang, Yaxin Xue, Songwei Li, Xiaoyu Sun, Jia Jia, Hongkai Bi, Shoubao Wang, Haibo Su, Mengdi Zhu, Hong Wang, Kui Hong, Xingnuo Li
Summary: Two new austocystin analogs, austocystin P (1) and austocystin Q (2), were isolated from the fermentation extract of Aspergillus sp. WHUF05236, along with fourteen known compounds. Compounds 3, 11, and 12 exhibited antimicrobial activities against Helicobacter pylori, while compounds 3, 6, and 7 showed cytotoxicities against human colon cancer cell lines Hct-116.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Organic
Yi Zang, Yihua Gong, Jiaojiao Gong, Junjun Liu, Chunmei Chen, Lianghu Gu, Yuan Zhou, Jianping Wang, Hucheng Zhu, Yonghui Zhang
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Chong Dai, Chunmei Chen, Danyingzi Guan, Hailun Chen, Fuxin Wang, Wenjing Wang, Yi Zang, Qin Li, Mengsha Wei, Xiaoxin Li, Xiaotian Zhang, Jianping Wang, Qun Zhou, Hucheng Zhu, Yonghui Zhang
Article
Chemistry, Applied
Huiling Wen, Yi Zang, Qianheng Zhu, Sheng Ouyang, Juanjuan Luo, Nianhua Luo, Hucheng Zhu, Yonghui Zhang
Summary: This article reports the isolation and structural elucidation of two new compounds from a marine-derived fungus, as well as the evaluation of their biological activity.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Chong Dai, Xiaoxin Li, Kailin Zhang, Xiao-Nian Li, Wenjing Wang, Yi Zang, Xia Chen, Qin Li, Mengsha Wei, Chunmei Chen, Hucheng Zhu, Yonghui Zhang
Summary: Eleven undescribed quinolone alkaloids, pesimquinolones I-S, as well as eleven known congeners were isolated from the fungus Penicillium simplicissimum. Pesimquinolones I-K are the first examples of natural occurring quinolone alkaloids possessing a 6/6/6/6 tetracyclic ring system. Some compounds showed suppressive effects on LPS-induced NO production, indicating potential anti-inflammatory activities.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Peng Zhou, Meijia Zheng, Xiao-Nian Li, Mengsha Wei, Mi Zhang, Qin Li, Yi Zang, Weiguang Sun, Jianping Wang, Hucheng Zhu, Chunmei Chen, Yonghui Zhang
Summary: Seven new isopimarane diterpene glycosides (hypoxylonoids A-G) were isolated from the fungus Xylaria hypoxylon, along with five known analogues. Extensive spectroscopic and single crystal X-ray diffraction analyses were used to confirm the structures and absolute configurations of these compounds. Among them, hypoxylonoid A has a unique gamma-lactone moiety, while hypoxylonoids B and E exhibit a 1,2-methyl shift and hypoxylonoid E undergoes decarboxylation, distinguishing them within the isopimarane family. Single crystal X-ray diffraction analyses were also performed on hypoxylonoids A, C, F, and 15-hydroxy 16-alpha-D-mannopyranosyloxyisopimar-7-en-19-oic acid to determine their absolute structural configuration.
Article
Biochemistry & Molecular Biology
Yi Zang, Yihua Gong, Xia Chen, Huiling Wen, Changxing Qi, Chunmei Chen, Junjun Liu, Zengwei Luo, Jianping Wang, Hucheng Zhu, Yonghui Zhang
Summary: Four new compounds, including janthinolides and trichopyrone, were isolated from the extract of Penicillium griseofulvwn. Janthinolide C and D demonstrated potential immunosuppressive activity against murine splenocytes.
Article
Biochemistry & Molecular Biology
Yi Zang, Yihua Gong, Zhengyi Shi, Changxing Qi, Chunmei Chen, Qingyi Tong, Junjun Liu, Jianping Wang, Hucheng Zhu, Yonghui Zhang
Summary: The OSMAC strategy led to the discovery of seven unreported multioxidized aromatic polyketides from a soil-derived fungus Penicillium canescens. Among them, (-)-penicanesin A showed potential cytotoxicity against human cancer cell lines, while its enantiomer (+)-penicanesin A was less active.
Article
Microbiology
Yang Zhou, Shuoxing Yi, Yi Zang, Qing Yao, Honghui Zhu
Summary: The study identified a novel genus and species, Citreicoccus inhibens gen. nov. sp. nov., from a myxobacterium strain M34 isolated from subtropical forest soil in South China, which has the potential to be developed into a versatile biocontrol agent against both fungal and bacterial phytopathogens. The strain exhibited antifungal activity against phytopathogenic fungi and predatory activity against phytopathogenic bacteria due to the presence of pyrrolnitrin and extracellular proteins with lytic activity.
Article
Chemistry, Applied
Beiping Zhou, Qingyi Tong, Yi Zang, Honghui Zhu
Summary: Two new polyketide derivatives, aurovertins V and W, and a known analogue were isolated from the fungus Aspergillus aureoterreus. Their structures and configurations were determined using spectroscopic methods and theoretical calculations. These compounds showed no cytotoxicity against human cancer cell lines.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yi Zang, Muyuan Yu, Zhengyi Shi, Chunmei Chen, Junjun Liu, Jianping Wang, Hucheng Zhu, Yonghui Zhang
Summary: In this study, two pairs of undescribed enantiomers were isolated from the crude extract of Penicillium griseofulvum and one of them showed potential weak inhibitory activity against α-glucosidase.
Article
Biochemistry & Molecular Biology
Yi Zang, Beiping Zhou, Mengsha Wei, Zhengyi Shi, Guangda Feng, Mingrong Deng, Hucheng Zhu, Yonghui Zhang, Honghui Zhu
Summary: Twelve undescribed sesquiterpenoids, named aureoterrolides B-M, were discovered through genome sequence analyses and isolated from the culture broth of fungus Aspergillus aureoterreus. These compounds possess unusual structures and exhibit cytotoxic activity, with aureoterrolide A showing good activity and apoptotic effect on HL-60 cells.
Article
Chemistry, Organic
Mi Zhang, Shan Yan, Yu Liang, Meijia Zheng, Zhaodi Wu, Yi Zang, Muyuan Yu, Weiguang Sun, Junjun Liu, Ying Ye, Jianping Wang, Chunmei Chen, Hucheng Zhu, Yonghui Zhang
ORGANIC CHEMISTRY FRONTIERS
(2020)
Article
Chemistry, Organic
Yi Zang, Yi-Hua Gong, Xu-Wen Li, Xiao-Nian Li, Jun-Jun Liu, Chun-Mei Chen, Yuan Zhou, Liang-Hu Gu, Zeng-Wei Luo, Jian-Ping Wang, Wei-Guang Sun, Hu-Cheng Zhu, Yong-Hui Zhang
ORGANIC CHEMISTRY FRONTIERS
(2019)
Article
Chemistry, Organic
Jiaojiao Gong, Chunmei Chen, Shuyuan Mo, Junjun Liu, Wenjing Wang, Yi Zang, Huaqiang Li, Chenwei Chai, Hucheng Zhu, Zhengxi Hu, Jianping Wang, Yonghui Zhang
ORGANIC & BIOMOLECULAR CHEMISTRY
(2019)