Article
Multidisciplinary Sciences
Paul Kemper, Grigorios M. Karageorgos, Daniella Fodera, Nicole Lee, Nirvedh Meshram, Rachel A. Weber, Pierre Nauleau, Nima Mobadersany, Nancy Kwon, Kristin Myers, Elisa E. Konofagou
Summary: Non-invasive monitoring of atherosclerosis remains challenging. Pulse Wave Imaging (PW) is an effective technique to measure the stiffness of carotid arteries, analyze hemodynamics, and monitor changes over time. This study used hypercholesterolemic swine models to investigate the capabilities of PWI in assessing progressive changes in local stiffness, homogeneity of the carotid artery, and monitoring hemodynamics. The results showed that PWI can detect changes in wall shear stress and differentiate between distinct progression pathways leading to different compliances.
SCIENTIFIC REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Giuseppe C. A. Caridi, Elena Torta, Valentina Mazzi, Claudio Chiastra, Alberto L. L. Audenino, Umberto Morbiducci, Diego Gallo
Summary: This study presents an experimental set-up for characterizing the fluid dynamics in healthy and stenosed coronary arteries. The proposed smart-PIV approach, using a smartphone camera and low-power laser, provides both qualitative flow visualizations and quantitative results. Comparisons with conventional PIV measurements show good agreement, making smart-PIV a promising and low-cost methodology for cardiovascular flow characterization.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Francesca D'Errico, Francesca Ricci, Alessandra Luciano, Francesco Paolo Sbordone, Mario Laudazi, Daniele Mecchia, Maria Volpe, Flavia Briganti, Alessio Di Landro, Saverio Muscoli, Luca Pugliese, Vincenzo De Stasio, Carlo Di Donna, Francesco Romeo, Francesco Garaci, Roberto Floris, Marcello Chiocchi
Summary: This study aimed to evaluate the influence of nitroglycerin on the agreement between radiologists and cardiologists in the evaluation of vessel stenosis. The use of nitroglycerin before coronary computed tomography (CCT) may lead to a radiological overestimation of calcific stenosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Joseph Kamtchum-Tatuene, Luca Saba, Mirjam R. Heldner, Michiel H. F. Poorthuis, Gert J. de Borst, Tatjana Rundek, Stavros K. Kakkos, Seemant Chaturvedi, Raffi Topakian, Joseph F. Polak, Glen C. Jickling
Summary: This study demonstrates that circulating IL-6 levels predict carotid plaque severity, vulnerability, and progression. A cutoff of 2.0 pg/mL for IL-6 levels could facilitate the selection of individuals that would benefit from anti-IL-6 drugs for stroke prevention.
CIRCULATION RESEARCH
(2022)
Article
Ophthalmology
Le Cao, Hang Wang, William Robert Kwapong, Ruilin Wang, Junfeng Liu, Bo Wu
Summary: This study explored the retinal microvascular changes in carotid artery stenosis patients and their relationship with carotid plaque morphology. The results showed that patients with ipsilateral stenosis had reduced retinal microvascular densities, and these densities correlated with the length of the plaque. However, they did not correlate with the degree of plaque, except in patients with severe stenosis.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Article
Neuroimaging
Ran Xu, Bin Yang, Long Li, Tao Wang, Xia Lu, Jichang Luo, Xiao Zhang, Jia Dong, Yabing Wang, Yang Hua, Yan Ma, Liqun Jiao
Summary: The study utilized OCT to evaluate calcified lesions in the vertebral artery and found a potential relationship between macrocalcifications and the risk of in-stent restenosis. These findings need to be confirmed through larger prospective studies.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Surgery
Eva Karlof, Andrew Buckler, Moritz L. Liljeqvist, Mariette Lengquist, Malin Kronqvist, Mawaddah A. Toonsi, Lars Maegdefessel, Ljubica P. Matic, Ulf Hedin
Summary: The study demonstrates that CTA image analysis of carotid plaque morphology reflects prevalent biological processes relevant for assessment of plaque phenotype. The results support the use of CTA image analysis of plaque morphology for risk stratification and management of patients with carotid stenosis.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Multidisciplinary Sciences
Judith J. de Vries, Anouchska S. A. Autar, Dianne H. K. Van Dam-Nolen, Samantha J. Donkel, Mohamed Kassem, Anja G. van der Kolk, Twan J. van Velzen, M. Eline Kooi, Jeroen Hendrikse, Paul J. Nederkoorn, Daniel Bos, Aad van der Lugt, Moniek P. M. de Maat, Heleen M. M. van Beusekom
Summary: This study found a positive correlation between plaque vulnerability and levels of neutrophil extracellular traps (NETs) in patients who had not received statins or antithrombotic medication prior to the index event. Further analysis revealed that this association was mainly driven by intraplaque hemorrhage, lipid-rich necrotic core, and ulceration.
Article
Hematology
Marios K. Georgakis, Sander W. van der Laan, Yaw Asare, Joost M. Mekke, Saskia Haitjema, Arjan H. Schoneveld, Saskia C. A. de Jager, Nick S. Nurmohamed, Jeffrey Kroon, Erik S. G. Stroes, Dominique P. de Kleijn, Gert J. de Borst, Lars Maegdefessel, Oliver Soehnlein, Gerard Pasterkamp, Martin Dichgans
Summary: The study revealed that MCP-1 levels in human atherosclerotic plaques are associated with vulnerability features, clinical manifestations, and increased risk of adverse vascular events. Higher levels of MCP-1 are linked to histopathologic and molecular markers of plaque vulnerability, clinical plaque instability, and risks of major adverse vascular events post plaque removal.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Medicine, General & Internal
Carolina Giordano, Alberto Morello, Nicola Corcione, Salvatore Giordano, Simona Gaudino, Cesare Colosimo
Summary: Carotid artery disease is a cause of ischemic stroke and cognitive decline. Evaluating the morphology of atherosclerotic plaques is crucial for accurate diagnosis and decision-making. Noninvasive imaging methods such as ultrasound, angiography, computed tomography, and magnetic resonance angiography are commonly used.
Review
Clinical Neurology
Jean Jacques Noubiap, Joseph Kamtchum-Tatuene, John L. Fitzgerald, Prashanthan Sanders
Summary: The study found that carotid stenosis was not associated with ischemic stroke, but was linked to thromboembolism. There was more consistent evidence suggesting that carotid plaque predicts stroke or transient ischemic attack in AF patients. Including carotid plaque and carotid intima-media thickness may improve stroke prediction and prevention in AF patients.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniele Fresilli, Nicola Di Leo, Ombretta Martinelli, Luca Di Marzo, Patrizia Pacini, Vincenzo Dolcetti, Giovanni Del Gaudio, Fabrizio Canni, Ludovica Isabella Ricci, Corrado De Vito, Corrado Caiazzo, Raffaella Carletti, Cira Di Gioia, Iacopo Carbone, Steven B. Feinstein, Carlo Catalano, Vito Cantisani
Summary: The study aimed to assess the efficacy of Multiparametric Ultrasound (MPUS) in evaluating carotid plaque vulnerability and carotid stenosis degree. The results showed that the combination of Contrast-Enhanced Ultrasound (CEUS) and 3D Arterial Analysis can be a powerful clinical tool to identify and stratify at-risk patients with atherosclerotic carotid artery disease.
Article
Clinical Neurology
John Joseph McCabe, Pol Camps-Renom, Nicola Giannotti, Jonathan P. McNulty, Sarah Coveney, Sean Murphy, Mary Barry, Joseph Harbison, Simon Cronin, David Williams, Gillian Horgan, Eamon Dolan, Tim Cassidy, Ciaran McDonnell, Eoin Kavanagh, Shane Foley, Sean Collins, Martin O'Connell, Alejandro Fernandez-Leon, Raquel Delgado-Mederos, Michael Marnane, Joan Marti-Fabregas, Peter J. Kelly
Summary: The study aimed to determine the association between carotid plaque inflammation detected by F-18-fluorodeoxyglucose (18)FDG-PET and late (5-year) recurrent stroke. Results showed that baseline plaque SUVmax and SCAIL score independently predicted 5-year ipsilateral recurrent stroke. This suggests that plaque inflammation-related (18)FDG uptake could improve identification of recurrent ipsilateral stroke over a 5-year period.
Article
Neuroimaging
Ivan Lylyk, Carlos Bleise, Pedro N. Lylyk, Nicolas Perez, Javier Lundquist, Esteban Scrivano, Anibal A. Francone, Martin Charles, Tamara Zompa, Pedro Lylyk
Summary: The study aims to investigate the correlation between AMD and compromised blood flow in the eye, as well as to demonstrate the potential of OA angioplasty as a treatment for late-stage AMD. Results showed the feasibility and safety of OA angioplasty, with perceived benefits in patients with profound vision loss. Further clinical trials are needed to confirm these findings.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Neuroimaging
Tianhua Li, Ran Xu, Yan Ma, Tao Wang, Bin Yang, Liqun Jiao
Summary: This study aimed to explore the relationship between intracranial calcification and in-stent restenosis (ISR) with a larger sample size. The follow-up assessments were performed using ultrasonography. The results revealed a significant association between calcification and intracranial ISR, with a higher likelihood in patients with macrocalcification. These findings have important implications for individualized treatment and optimizing stent design.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Review
Endocrinology & Metabolism
Khalid M. Saqr, Sherif Rashad, Simon Tupin, Kuniyasu Niizuma, Tamer Hassan, Teiji Tominaga, Makoto Ohta
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2020)
Article
Cell Biology
Sherif Rashad, Xiaobo Han, Khalid Saqr, Simon Tupin, Makoto Ohta, Kuniyasu Niizuma, Teiji Tominaga
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
Yasutomo Shimizu, Simon Tupin, Chihaya Kiyomitsu, Ko Kitamura, Kazuto Takashima, Makoto Ohta
SCIENTIFIC REPORTS
(2020)
Article
Clinical Neurology
Masaaki Shojima, Yoshihiro Okamoto, Makoto Ohta, Kuniyasu Niizuma, Nobuyuki Sakai, Teiji Tominaga
WORLD NEUROSURGERY
(2020)
Article
Mathematics, Interdisciplinary Applications
Haoran Wang, Hitomi Anzai, Youjun Liu, Aike Qiao, Jinsheng Xie, Makoto Ohta
Article
Engineering, Mechanical
Simon Tupin, Khalid M. Saqr, Makoto Ohta
EXPERIMENTS IN FLUIDS
(2020)
Editorial Material
Chemistry, Physical
Simon Tupin, Makoto Ohta
Article
Mathematics, Interdisciplinary Applications
Haoran Wang, Hitomi Anzai, Youjun Liu, Aike Qiao, Jinsheng Xie, Makoto Ohta
Article
Cardiac & Cardiovascular Systems
Simon Tupin, Kei Takase, Makoto Ohta
Summary: The experimental study on the multilayer flow modulator (MFM) device showed that it effectively decreases intra-aneurysmal flow while preserving branch flow, reducing the risk of type II endoleak. The developed experimental system was effective in simulating endovascular procedures and assessing the safety and effectiveness of endovascular devices.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Engineering, Biomedical
Mingzi Zhang, Yujie Li, Shin-ichiro Sugiyama, David I. Verrelli, Yasushi Matsumoto, Teiji Tominaga, Yi Qian, Simon Tupin, Hitomi Anzai, Makoto Ohta
Summary: Incomplete stent expansion (IncSE) in flow-diversion (FD) treatment of intracranial aneurysms may lead to variable haemodynamic consequences, with significant reductions in aneurysm flow-reduction performance observed when central or distal IncSE occurs, while a slight reduction in aneurysm inflow was associated with proximal IncSE. The effects of IncSE vary greatly with the location of occurrence, emphasizing the importance of individualized, patient-specific risk assessment before treatment.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2021)
Article
Acoustics
Muhammad Shiddiq Sayyid Hashuro, Simon Tupin, Narendra Kurnia Putra, Kotaro Daibo, Kosuke Inoue, Takuro Ishii, Hiroyuki Kosukegawa, Kenichi Funamoto, Toshiyuki Hayase, Makoto Ohta
Summary: A transparent ultrasound flow phantom material composed of poly(vinyl alcohol) hydrogel (PVA-H) with dimethyl sulfoxide (DMSO) and water solution was proposed for visualizing and measuring flow inside ultrasound systems. The material's refractive index was modified to match that of glass for transparency. Feasibility tests were conducted, and an ultrasound flow phantom was fabricated for B-mode visualization and Doppler-PIV comparison. The results showed promising accuracy in velocity measurement and similarity to real tissue visualization, with some limitations regarding sound velocity and Doppler measurements.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Meghane Decroocq, Carole Frindel, Pierre Rouge, Makoto Ohta, Guillaume Lavoue
Summary: This paper proposes an automatic method to generate a structured hexahedral mesh suitable for CFD directly from centerlines, which offers better robustness and mesh quality compared to existing methods. It allows for easy editing of vascular models to study the impact of vascular geometry and topology on hemodynamics.
MEDICAL IMAGE ANALYSIS
(2023)
Review
Engineering, Biomedical
Makoto Ohta, Naoya Sakamoto, Kenichi Funamoto, Zi Wang, Yukiko Kojima, Hitomi Anzai
Summary: Vascular endothelial cells are exposed to mechanical stress from blood flow and their functions can be studied using specific chamber designs. The functions of these cells are closely connected to the outer layers of arteries and organs, and the interaction between smooth muscle cells in the middle layer and endothelial cells can be investigated using coculture chambers. Additionally, microfabrication technology in microfluidic devices allows for mechanical and chemical stimulation of cells to study their dynamics in vivo microenvironments.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Physics, Fluids & Plasmas
Simon Tupin, Kei Takase, Makoto Ohta
Summary: This study investigated the ability of a porous stent called the Multilayer Flow Modulator (MFM) to maintain renal perfusion in vascular surgery. The results showed that the MFM device was able to preserve renal perfusion thanks to its highly porous microstructure. However, overlapping MFM devices led to a decrease in certain 2D metrics, but did not affect branch perfusion.
Article
Engineering, Biomedical
Kohei Mitsuzuka, Yujie Li, Toshio Nakayama, Hitomi Anzai, Daisuke Goanno, Simon Tupin, Mingzi Zhang, Haoran Wang, Kazunori Horie, Makoto Ohta
Summary: This study aimed to improve the visibility of angioscopy operations. Through computational fluid dynamics simulations under different values for the parameters of the injection waveform, endoscope position, and catheter angle, the study found that using a stepped waveform, bottom endoscope, and three-degree-angle catheter resulted in the highest visibility, improving the success rate of angioscopy operations.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)