Thermal, SEM, AFM, BET and biological analysis of newly synthesized Fe2+/Fe3+ based MOIFs

Herein we report the thermal, morphological, topographical, gas adsorption and biological activities of newly synthesized [Fe(CN)(6)](4-)/[Fe(CN)(6)](3-) based MOIFs using Differential Scanning Colorimetry (DSC), Scanning Electron Microscope (SEM), BET (Brunauer, Emmett and Teller) and spectrophotometric methods. Thermal analysis revealed an effect of MOIFs alkyl chain on their heat holding capacity as a function of temperature. Nitrogen adsorption method was applied for surface and apparent cross-sectional area determination within MOIF ionic assembly. The DNA binding activity (DBA) of as prepared MOIFs was found in 40% order, computed using Ameta-Hyper-Hypochromic model. The increments and decrements in DNA helix axial length were conferred by hydrophobic (Hb)/hydrophilic (Hp) interactions, attributing for corresponding hyper/hypo chromic effect. Considerable anticancer activities of +2 and +3 Fe oxidation states (evaluated on MCF-7 cell line) for the DTAB stabilized MOIFs, were noticed. Apart from this, the free radical antioxidant activity of MOIF has also been investigated, found as directly varying with the alkyl chain lengths. A free radical trapping mechanism is suggested on the basis of H-b-H-b and Hp-Hp interactions. (C) 2019 Published by Elsevier B.V.