Journal
JOURNAL OF MAGNETIC RESONANCE
Volume 311, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2019.106668
Keywords
Dipolar relaxation time; T-1D; Inhomogeneous magnetization transfer; ihMT; MRI contrast; Jeener-Broekaert; Myelin; Myelin Imaging
Funding
- European Union [713750]
- Regional Council of Provence-Alpes-Cote d'Azur
- A/MIDEX - Investissements d'Avenir project [ANR-11-IDEX-0001-02]
- French Government
- national research agency ANR, VERISMO project [ANR-17-CE18-0030]
- ARSEP 2017 grant (Association pour la Recherche sur la Sclerose en Plaques)
- Agence Nationale de la Recherche (ANR) [ANR-17-CE18-0030] Funding Source: Agence Nationale de la Recherche (ANR)
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T-1D, the relaxation time of dipolar order, is sensitive to slow motional processes. Thus T-1D is a probe for membrane dynamics and organization that could be used to characterize myelin, the lipid-rich membrane of axonal fibers. A mono-component T-1D model associated with a modified ihMT sequence was previously proposed for in vivo evaluation of T-1D with MRI. However, experiments have suggested that myelinated tissues exhibit multiple T-1D components probably due to a heterogeneous molecular mobility. A bi-component T-1D model is proposed and implemented. ihMT images of ex-vivo, fixed rat spinal cord were acquired with multiple frequency alternation rate. Fits to data yielded two T(1D)s of about 500 mu s and 10 ms. The proposed model seems to further explore the complexity of myelin organization compared to the previously reported mono-component T-1D model. (C) 2019 Elsevier Inc. All rights reserved.
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