Article
Environmental Sciences
Guilherme Ramos Pereira, Renata Pereira Lopes, Wenjuan Wang, Tiago Guimaraes, Robson Ricardo Teixeira, Didier Astruc
Summary: In this study, hydrochar functionalized with a triazole group was used as a support for palladium nanoparticles, and it showed excellent catalytic performance in the Ullmann coupling reaction. The catalyst exhibited high selectivity, conversion, and recyclability at a low temperature.
Article
Pharmacology & Pharmacy
Diego F. Rodriguez, Francisca Duran-Osorio, Yorley Duarte, Pedro Olivares, Yanina Moglie, Kamal Dua, Flavia C. Zacconi
Summary: Implementation of green chemistry has shown promising results in waste reduction in the pharmaceutical industry. However, sustainable development of pharmaceutically active compounds and ingredients remains challenging. In this study, a green synthesis method was used to produce pharmaceutically active peptide triazoles as potent factor Xa inhibitors, important drug targets for cardiovascular diseases. The synthesis involved cycloaddition reactions with high atom economy, microwave-assisted organic synthesis for energy efficiency, and copper nanoparticle catalysis with Earth-abundant metals. The synthesized molecules demonstrated FXa inhibition with low IC50 values and no cytotoxicity in HEK293 and HeLa cells, highlighting the environmental potential and chemical implications of the applied methodologies for new molecule development.
Article
Chemistry, Organic
Jeremy R. Tuck, Robert J. Tombari, Noah Yardeny, David E. Olson
Summary: In this study, arylazo-1,2,3-triazoles were successfully synthesized using azide-alkyne click chemistry, showcasing high thermal stabilities and near-quantitative bidirectional photoconversion.
Article
Chemistry, Organic
Cong Guan, Jiabin Yin, Jian Ji, Jinhua Liu, Xiang Wu, Tong Zhu, Shunying Liu
Summary: A regioselective electrochemical C-H amination method using easily accessible ethers has been developed to synthesize N (2)-substituted 1,2,3-triazole. Multiple substituents, including heterocycles, were well-tolerated, and 24 examples were obtained in moderate to good yields. Control experiments and DFT calculations revealed that the electrochemical synthesis occurs through a N-tosyl 1,2,3-triazole radical cation process, promoted by single-electron transfer from the lone pair electrons of the aromatic N-heterocycle, and the desulfonation is responsible for the high N (2)-regioselectivity.
Review
Chemistry, Applied
Farid Ahmed, Hai Xiong
Summary: This review summarizes the latest developments in chemosensors based on click generated triazoles for a range of metal cations, anions, and neutral analytes, highlighting the need for continuous research accumulation in this rapidly growing field to meet demand.
Article
Chemistry, Inorganic & Nuclear
Nasrin Moeini-Eghbali, Hossein Eshghi
Summary: In this study, a new and selective nanocatalyst (Fe3O4@S-TiO2/Cu) was synthesized by incorporating sulfur heteroatoms onto Fe3O4@TiO2 substrate as a ligand to stabilize copper nanoparticles. The Fe3O4@S-TiO2/Cu nanorods were characterized using various techniques and showed high catalytic activity in preparing triazole derivatives. The nanocatalyst exhibited advantages such as high regioselectivity, short reaction times, easy separation, and recyclability.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Organic
Jose Laxio Arenas, Pascal Retailleau, Jean-Michel Gillet, Nour-Eddine Ghermani, Sandrine Ongeri, Benoit Crousse
Summary: The 5-fluoro triazole amino acid scaffold prepared by halogen exchange was successfully incorporated into peptides. The X-ray diffraction results revealed an important localization of the 5-fluoro triazole motif on one side of the negative potential surface, with the fluorine atom showing a cylindrical shape in its electron density deformation.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Applied
Andreii S. Kritchenkov, Anton R. Egorov, Rimma A. Abramovich, Aleh Kurliuk, Tatsiana Shakola, Ekaterina K. Kultyshkina, Moises J. Ballesteros Meza, Anastasia Pavlova, Elena P. Suchkova, Giang Le Nhat Thuy, Nguyen Van Tuyen, Victor N. Khrustalev
Summary: In this study, novel water-soluble triazole chitin derivatives were synthesized with high antibacterial activity, non-toxicity, and efficient catalytic properties. They can be easily reused in water as green catalysts.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Physical
Neha Sharma, Monika Gupta, Bushra Chowhan, Antonio Frontera
Summary: The study involved the synthesis and characterization of a novel heterogeneous magnetic nanocatalyst IL@CuFe2O4L Tyr-TiO2/TiTCIL, which demonstrated excellent performance in the synthesis of 1,4-disubstituted-1,2,3-triazoles and degradation of methylene blue dye. The catalyst also showed recyclability and good photocatalytic activity.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Physical
Kai Zhang, Yuan Xie, Michael J. Monteiro, Zhongfan Jia
Summary: Researchers have synthesized redox-active organic compounds with very low solubility nitroxide radicals, which show potential for application in solid-state energy storage. These new structures demonstrate the importance of lower solubility and the ability to maintain good properties even at high content, while preventing shuttle effects.
ENERGY STORAGE MATERIALS
(2021)
Article
Multidisciplinary Sciences
Ye Xin, Shuo Liu, Yan Liu, Zhen Qian, Hongyue Liu, Bingjie Zhang, Taijie Guo, Garth J. Thompson, Raymond C. Stevens, K. Barry Sharpless, Jiajia Dong, Wenqing Shui
Summary: The recently developed double-click reaction sequence is promising in expanding the number and diversity of 1,2,3-triazole derivatives. This study focused on the design, synthesis, and screening of double-click triazole libraries for drug discovery, using the glucagon-like-peptide-1 receptor as a challenging drug target. The streamlined synthesis of customized triazole libraries on an unprecedented scale led to the identification of positive allosteric modulators with unreported scaffolds. The unexpected binding mode of these modulators could provide insights into their mechanism of action.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Physical
Loic Habert, Matthieu Daniel, Pascal Palmas, Eric Pasquinet
Summary: This study describes the synthesis of 5-hydrazino-3-nitro-1,2,4-triazole (HNT) from 5-bromo-3-nitro-1,2,4-triazole (BNT) in three steps. HNT demonstrates excellent thermal stability and powerful energetic properties. Various salts of HNT were synthesized to demonstrate its amphoteric nature. Compounds derived from HNT, particularly perchlorate 7 and fused triazolo[4,3-b]triazole 4, exhibit remarkable performance and potential as high-density and heat-resistant explosives.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Biochemistry & Molecular Biology
Amit Kumar Sharma, Drishty Satpati, Rohit Sharma, Amit Das, Haladhar Dev Sarma, Archana Mukherjee
Summary: In this study, a click reaction catalyzed by on-resin Cu(I) was performed to synthesize triazole-stapled cyclic peptide mimetic, DOTA-c[TZ]A9, targeting HER2 receptor expression in breast cancers. Spectroscopic and docking analysis showed that the triazole-stapled peptide exhibited enhanced helicity, secondary structure stabilization, and improved HER2 affinity compared to the linear peptide, DOTA-[Pra1, Aza7]A9. Biodistribution studies in tumor-bearing mice demonstrated higher radioactivity levels and prolonged retention of the cyclic peptide in the tumor compared to the linear peptide.
BIOORGANIC CHEMISTRY
(2023)
Article
Biology
Sabera Bijani, Danish Iqbal, Sheefa Mirza, Vicky Jain, Sadaf Jahan, Mohammed Alsaweed, Yahya Madkhali, Suliman A. Alsagaby, Saeed Banawas, Abdulrahman Algarni, Faris Alrumaihi, Rakesh M. Rawal, Wael Alturaiki, Anamik Shah
Summary: A library of 1,4-dihydropyridine-based 1,2,3-triazol derivatives was designed, synthesized, and evaluated for their cytotoxic potential against colorectal adenocarcinoma cells. Most of the compounds exhibited significant antiproliferative activity and some were found to induce apoptosis and cell cycle arrest.
Article
Chemistry, Multidisciplinary
Keshav Taruneshwar Jha, Pooja A. Chawla
Summary: In recent years, there has been considerable interest in finding efficient and sustainable catalysts for click chemistry. The copper-catalyzed azide-alkyne cycloaddition (CuAAC) process has diverse applications in medicinal chemistry and chemical biology. This review focuses on the properties, synthetic approaches, and recent advancements in nanometal catalyzed azide-alkyne cycloaddition (nMAAC) using various metals (Ir, Zn, La, Ag, Au, Ru). The article discusses the synthesis and characterization of nanometals as click catalysts, optimization of reaction conditions, and potential applications in various fields.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Review
Biochemistry & Molecular Biology
Majid M. Heravi, Pourya Mohammadi
Summary: Layered double hydroxides (LDHs) are utilized as efficient and eco-friendly catalysts in Suzuki, Heck, Sonogashira, and Ullmann cross-coupling reactions, leading to carbon-carbon bond formations.
MOLECULAR DIVERSITY
(2022)
Article
Engineering, Chemical
Ghazaleh Jahani, Masoume Malmir, Majid M. Heravi
Summary: A novel nitrogen- and sulfur-doped graphene carbon dot-modified magnetic nanocomposite was synthesized and characterized. The catalyst, Fe3O4/g-CSNCDs, showed excellent catalytic activity and selectivity in alcohol oxidation. The carbonation of reagents and magnetic nanoparticles were found to have an impact on the catalytic performance. The Fe3O4/g-CSNCDs catalyst not only exhibited recyclability and magnetic recovery, but also showed improved catalytic activity compared to the bare g-CSNCDs.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Heshmatollah Sepahvand, Majid M. Heravi, Mahyar Saber, Seyyed Emad Hooshmand
Summary: Enzymes play a key role in chemical industries as biological catalysts. Immobilization of enzymes using techniques like the Ugi multicomponent reaction can enhance their stability and activity, leading to a more robust catalyst system. Immobilized enzymes through Ugi MCR show good stability and activity, with the potential for synergistic effects on enzyme activities.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Majid M. Heravi, Reihaneh Malakooti, Kosar Kafshdarzadeh, Zahra Amiri, Vahideh Zadsirjan, Hassan Atashin
Summary: An eco-friendly method for the synthesis of substituted dihydropyrano[2,3-c]pyrazole and benzylpyrazolyl coumarin derivatives has been developed through a multicomponent reaction. The method offers wide scope, high yields, short reaction times, and simple workup procedure. Furthermore, the nanocatalyst used in this method can be easily recovered and reused multiple times without significant loss in catalytic activity and performance.
RESEARCH ON CHEMICAL INTERMEDIATES
(2022)
Review
Chemistry, Applied
Yalda Rangraz, Majid M. Heravi
Summary: The development of methodologies for carbon-nitrogen bond formation is crucial in organic synthesis, as the resulting products are widely used in pharmaceuticals, biologically active compounds, and natural products. Recently, nanosized metal catalysts have gained significant attention for their excellent catalytic performance, high product yields, mild reaction conditions, and environmental sustainability. This review provides an overview of the latest progress in the fabrication of nanocatalysts and their applications in constructing carbon-nitrogen bonds via cross-coupling reactions.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Leyla Mohammadkhani, Majid M. Heravi, Farhad Panahi
Summary: This paper reports the efficient conversion of nitroarenes to anilines using immobilized palladium nanoparticles on a silica-starch substrate. The catalyst system exhibited high efficiency and could be reused multiple times.
MONATSHEFTE FUR CHEMIE
(2022)
Article
Chemistry, Multidisciplinary
Reihaneh Malakooti, Majid M. Heravi, Zahra Amiri, Kosar Kafshdarzadeh, Vahideh Zadsirjan, Zeynab Parsaee
Summary: In this study, [Cu(bpdo)(2)center dot 2H(2)O](2+)/montmorillonite nanocomposite was successfully prepared and characterized. It exhibited efficient catalytic activity in the synthesis of 2-amino-4H-chromene and 2-amino-4H-benzopyran derivatives, as well as spirochromene and spiroacenaphthylene derivatives via multicomponent reactions. The method demonstrated advantages such as efficiency, rapidness, easy operation, high yields, recyclable catalyst, and environmentally friendly conditions.
RESEARCH ON CHEMICAL INTERMEDIATES
(2022)
Article
Multidisciplinary Sciences
Mansoureh Daraie, Masoud Mirzaei, Maryam Bazargan, Vadjiheh Sadat Amiri, Bita Abdolahi Sanati, Majid M. Heravi
Summary: A series of nanocatalysts containing different lanthanide elements were synthesized and evaluated for their catalytic performance in the synthesis of bioactive isatin derivatives, with nano-Gd-B2W22 showing superior catalytic activity.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Masoume Malmir, Majid M. Heravi, Zahra Yekke-Ghasemi, Masoud Mirzaei
Summary: Polyoxometalates (POMs) are efficient catalysts that can be used for a wide range of chemical transformations. In this study, two hybrid and heterogeneous Keggin catalysts, TBA-PW11 and TBA-SiW11, were reported. The catalytic performance of these catalysts was tested in the cyanosilylation reaction under solvent-free conditions. TBA-PW11 showed better catalytic efficiency than TBA-SiW11, possibly due to its higher Lewis acidity and easier accessibility of metal centers. The recyclability and heterogeneity of both catalysts were also examined, and they remained active after at least three recycling procedures.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Organic
Majid M. Heravi, Batoul Alipour, Vahideh Zadsirjan, Masoume Malmir
Summary: The Robinson annulation is a significant reaction for the synthesis of alpha,beta-unsaturated ketone ring that involves the generation of two C-C bonds. It has been frequently used in the total synthesis of biologically active natural products. These products and their derivatives play a major role in pharmacotherapy, especially for cancer and infectious diseases.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Masoume Malmir, Majid M. Heravi, Zahra Yekke-Ghasemi, Satar Saberi, Masoud Mirzaei
Summary: A new heterogeneous catalyst, TBA8[Zr(W5O18)2]middot17H2O (Zr(W5)2), was synthesized and characterized. It was found that the catalyst had a sandwich-type structure consisting of zirconium ions and mono-lacunary Lindqvist [W5O18 ]4- anions, encapsulated by TBA+ cations. This catalyst exhibited hydrophobic properties and improved catalytic efficiency by trapping reactants on its surface. Using Zr(W5)2 as a catalyst, a series of 1,5-benzodiazepines were successfully synthesized via mild and solvent-free reactions.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Applied
Masoume Malmir, Majid M. Heravi, Ghazaleh Jahani
Summary: Metal-organic frameworks (MOFs) are viable and environmentally friendly alternatives to traditional catalysts, and the magnetic Ox-CN-Cu-MOF catalyst has shown remarkable catalytic performance due to its unique structure and Lewis acidic properties. It also exhibits excellent recyclability.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Masoumeh Bagheri Bisafar, Masoume Malmir, Majid M. Heravi
Summary: In this study, a novel magnetic MOFs-based catalyst was synthesized and showed good catalytic activity and stability for the reduction of nitroarenes and organic dyes. The catalyst can be easily separated and recovered by magnetic separation, and it can be reused for multiple cycles.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Zahra Yekke-Ghasemi, Majid M. Heravi, Masoume Malmir, Masoud Mirzaei
Summary: In this study, a tri-component composite Zr/SiW12/GO was prepared using an ultrasonic-assisted method. This composite, acting as a remarkable heterogeneous catalyst, showed exceptional catalytic performance in the oxidation reaction of sulfides to sulfoxides. The composite also demonstrated exceptional stability and could be reused up to four times without significant loss in its catalytic activity.
SCIENTIFIC REPORTS
(2023)
Review
Chemistry, Multidisciplinary
Majid M. Heravi, Azadeh Nazari
Summary: Natural product synthesis is a constantly evolving field that evaluates new synthetic methods and reagents to address the complexities of structures and functions. SmI2, a widely-used reagent in chemical synthesis, has been highlighted in this review for its recent advances and strategies used in the total synthesis of natural products since 2004.