Deficiency in ZMPSTE24 and resulting farnesyl–prelamin A accumulation only modestly affect mouse adipose tissue stores

Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome

(2018) Paul H. Kim et al.   Science Translational Medicine

Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24

(2016) Shahid Mehmood et al.   Nature Chemistry

Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations

(2013) Takuro Arimura et al.   CARDIOVASCULAR RESEARCH

Lessons on Conditional Gene Targeting in Mouse Adipose Tissue

(2013) K. Y. Lee et al.   DIABETES

Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPAR 

(2013) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structural Basis of ZMPSTE24-Dependent Laminopathies

(2013) A. Quigley et al.   SCIENCE

Human ZMPSTE24 disease mutations: residual proteolytic activity correlates with disease severity

(2012) Jemima Barrowman et al.   HUMAN MOLECULAR GENETICS

HIV Protease Inhibitors Do Not Cause the Accumulation of Prelamin A in PBMCs from Patients Receiving First Line Therapy: The ANRS EP45 “Aging” Study

(2012) Sophie Perrin et al.   PLoS One

A Resource for the Conditional Ablation of microRNAs in the Mouse

(2012) Chong Yon Park et al.   Cell Reports

An absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair

(2011) Shao H. Yang et al.   HUMAN MOLECULAR GENETICS

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

Investigating the purpose of prelamin A processing

(2011) Brandon S. J. Davies et al.   Nucleus

GPIHBP1 Is Responsible for the Entry of Lipoprotein Lipase into Capillaries

(2010) Brandon S.J. Davies et al.   Cell Metabolism

Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes

(2010) Roger Lee et al.   HUMAN MOLECULAR GENETICS

An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria

(2010) B. S. J. Davies et al.   HUMAN MOLECULAR GENETICS

Direct Synthesis of Lamin A, Bypassing Prelamin A Processing, Causes Misshapen Nuclei in Fibroblasts but No Detectable Pathology in Mice

(2010) Catherine Coffinier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role ofLMNAin adipose: a novel mouse model of lipodystrophy based on the Dunnigan-type familial partial lipodystrophy mutation

(2009) Kari M. Wojtanik et al.   JOURNAL OF LIPID RESEARCH

HIV-protease inhibitors block the enzymatic activity of purified Ste24p

(2008) Sarah E. Hudon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Potent HIV Protease Inhibitor, Darunavir, Does Not Inhibit ZMPSTE24 or Lead to an Accumulation of Farnesyl-prelamin A in Cells

(2008) Catherine Coffinier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY