Review
Immunology
Curtis J. Pritzl, Mark A. Daniels, Emma Teixeiro
Summary: CD8 positive, tissue resident memory T cells are a specialized subset of T cells that provide critical protection against tumors and pathogen re-infection. The development and maintenance of these cells involve a myriad of signals, including tissue-derived signals and antigenic/pro-inflammatory cytokines. Recent research suggests additional roles for antigenic and pro-inflammatory signals in the establishment of resident memory T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Gurupreet S. Sethi, Donald Gracias, Michael Croft
Summary: This study investigated the role of circulatory T cells in asthma relapse and the population of lung Trm cells. They found that circulatory cells contribute to the accumulation and expansion of Trm phenotype cells, but are not required to maintain this population once lung-localized Trm cells develop. However, circulatory cells still contribute to the overall asthmatic lung inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Peter-Paul A. Unger, Anna E. Oja, Tamana Khemai-Mehraban, Werner J. D. Ouwendijk, Pleun Hombrink, Georges M. G. M. Verjans
Summary: This study revealed that the human trigeminal ganglia (TG) is an immunocompetent environment where both CD4 and CD8 tissue-resident memory T-cells (T-RM) are established and retained. These findings provide support for T-RM-targeted vaccine strategies.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Cell Biology
Young Min Son, Jie Sun
Summary: This article discusses the importance of memory CD8 T and B cells in protecting respiratory mucosa from secondary microbial invasion, with a focus on the role of tissue-resident helper T cell populations in this process.
Article
Multidisciplinary Sciences
Spela Konjar, Cristina Ferreira, Filipa Sofia Carvalho, Patricia Figueiredo-Campos, Julia Fanczal, Sofia Ribeiro, Vanessa Alexandra Morais, Marc Veldhoen
Summary: The metabolic capacity of tissue-resident memory CD8(+) T cells can adapt to changes in the tissue environment, and their activation is dependent on rapid access to metabolites and glucose levels.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Immunology
Rut Mora-Buch, Shannon K. Bromley
Summary: Resident memory CD8(+) T cells provide rapid local protection and control tumor growth, but dysregulation may contribute to autoimmune diseases. Intrinsic mechanisms and extrinsic stimuli regulate T-RM differentiation and response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Nicholas N. Jarjour, Kelsey M. Wanhainen, Changwei Peng, Noah V. Gavil, Nicholas J. Maurice, Henrique Borges da Silva, Ryan J. Martinez, Talia S. Dalzell, Matthew A. Huggins, David Masopust, Sara E. Hamilton, Stephen C. Jameson
Summary: Interleukin-15 (IL-15) is a central regulator of memory CD8+ T cells and can stimulate their proliferation and expansion. IL-15 sensitivity is an important feature of memory CD8+ T cell populations, with therapeutic potential.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Immunology
Pauline Ginsberg, Ulf Panzer, Nariaki Asada
Summary: The discovery of tissue-resident memory T cells has brought new understanding to human tissue-specific immunity. These cells remain in peripheral tissues after activation and clonal expansion, providing quick immunological responses upon re-encounter with antigens. However, recent studies have shown that tissue-resident memory T cells might worsen autoimmune diseases like lupus nephritis and ANCA-associated glomerulonephritis. Understanding renal tissue-resident memory T cells could lead to new therapeutic targets for autoimmune kidney diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Peter A. Szabo
Summary: Tissue-resident memory T cells (TRM) are a specialized localized immune memory layer in the human body, present in almost every organ. They exhibit remarkable heterogeneity in form and function, shaped by various site-specific influences. This review discusses the surface phenotypes, transcriptional programming, and tissue-specific adaptations of TRM, as well as the mechanisms and models for TRM generation. Understanding the differentiation, function, and maintenance of different subpopulations within the TRM lineage could unlock the full potential of TRM in promoting localized tissue immunity throughout the body.
IMMUNOLOGICAL REVIEWS
(2023)
Review
Cell Biology
Juliana Barreto de Albuquerque, Christoph Mueller, Bilgi Gungor
Summary: Tissue-resident memory T (T-RM) cells play a crucial role in rapid immune protection and chronic inflammatory disorders, with potential for immunopathological reactions. Researchers focus on the role of T-RM cells in the intestine and discuss potential therapeutic strategies to interfere with diseases mediated by these cells.
Review
Cell Biology
Anoushka Ashok Kumar Samat, Jolijn van der Geest, Sebastiaan J. Vastert, Jorg van Loosdregt, Femke van Wijk
Summary: The article summarizes the role of tissue-resident memory T cells (T-RM) in chronic inflammatory diseases, highlighting the presence of T-RM in both non-lymphoid tissue and circulation, and their potential significance in disease progression and treatment.
Article
Multidisciplinary Sciences
Tabea Bertram, Daniel Reimers, Niels C. Lory, Constantin Schmidt, Joanna Schmid, Lisa C. Heinig, Peter Bradtke, Guido Rattay, Stephanie Zielinski, Malte Hellmig, Patricia Bartsch, Holger Rohde, Sarah Nunez, Mariana V. Rosemblatt, Maria Rosa Bono, Nicola Gagliani, Inga Sandrock, Ulf Panzer, Christian F. Krebs, Catherine Meyer-Schwesinger, Immo Prinz, Hans-Willi Mittruecker
Summary: γδ T cells are involved in the control of Staphylococcus aureus infection, but their importance compared to other T cells in protection is unclear. Research shows that kidney-resident γδ T cells play a nonredundant role in limiting the growth of Staphylococcus aureus during chronic infection and provide enhanced protection against reinfection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Thomas Emmanuel, Josephine Mistegard, Anne Bregnhoj, Claus Johansen, Lars Iversen
Summary: TRMs play crucial roles in skin diseases, especially in infectious skin diseases with existing studies. Future research should explore biomarkers of TRMs in skin diseases and understand their relationship with the local skin microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Claire E. Depew, Jordan A. Rixon, Stephen J. McSorley
Summary: Hepatic CD4 tissue-resident memory T cells (TRM) are crucial for protection against Salmonella infection, and a study has found that local inflammation in the liver enhances the formation of CD4 TRM. The researchers developed a system to directly visualize the formation of hepatic TRM and found that liver inflammation also boosts the effectiveness of a subunit Salmonella vaccine. Surprisingly, IL-2 and IL-1 were found to play a role in enhancing CD4 TRM formation. This knowledge is important for developing a more effective vaccine against invasive nontyphoidal salmonellosis (iNTS).
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Immunology
Nariaki Asada, Pauline Ginsberg, Nicola Gagliani, Hans-Willi Mittruecker, Ulf Panzer
Summary: The presence of T-RM cells in the kidneys and their role in kidney diseases is discussed in this review, highlighting their potential therapeutic implications.
SEMINARS IN IMMUNOPATHOLOGY
(2022)
Article
Nutrition & Dietetics
Alda J. Leonel, Lilian G. Teixeira, Rafael P. Oliveira, Andrezza F. Santiago, Nathalia V. Batista, Talita R. Ferreira, Rosana C. Santos, Valbert N. Cardoso, Denise C. Cara, Ana M. C. Faria, Jacqueline Alvarez-Leite
BRITISH JOURNAL OF NUTRITION
(2013)
Article
Cell Biology
Luana Pereira Antunes Dourado, Maria de Lourdes Meirelles Noviello, Debora Moreira Alvarenga, Zelia Menezes, Denise Alves Perez, Nathalia Vieira Batista, Gustavo Batista Menezes, Adaliene Versiani Matos Ferreira, Danielle da Gloria de Souza, Denise Carmona Cara
CELLULAR IMMUNOLOGY
(2011)
Article
Biochemistry & Molecular Biology
Fabiola Lacerda Pires Soares, Rafael de Oliveira Matoso, Lilian Goncalves Teixeira, Zelia Menezes, Solange Silveira Pereira, Andrea Catao Alves, Nathalia Vieira Batista, Ana Maria Caetano de Faria, Denise Carmona Cara, Adaliene Versiani Matos Ferreira, Jacqueline Isaura Alvarez-Leite
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Lilian G. Teixeira, Alda J. Leonel, Edenil C. Aguilar, Nathalia V. Batista, Andrea C. Alves, Candido C. Coimbra, Adaliene V. M. Ferreira, Ana Maria C. de Faria, Denise C. Cara, Jacqueline I. Alvarez Leite
LIPIDS IN HEALTH AND DISEASE
(2011)
Article
Immunology
Angela C. Zhou, Nathalia Batista, Tania H. Watts
JOURNAL OF IMMUNOLOGY
(2019)
Article
Immunology
Nathalia Batista, Marialuisa Barbagallo, Vivian L. S. Oliveira, Thiago Castro-Gomes, Rene D. R. Oliveira, Paulo Louzada-Junior, Geraldo R. C. Pinheiro, Alberto Mantovani, Mauro M. Teixeira, Cecilia Garlanda, Flavio A. Amaral
JOURNAL OF IMMUNOLOGY
(2019)