Neuronal Regulation of Cutaneous Immunity

Nppb Neurons Are Sensors of Mast Cell-Induced Itch

(2019) Hans Jürgen Solinski et al.   Cell Reports

Immunoregulatory Effects of Neuropeptides on Endothelial Cells: Relevance to Dermatological Disorders

(2019) Devina Mehta et al.   DERMATOLOGY

The Neuroimmune Axis in Skin Sensation, Inflammation, and Immunity

(2019) Anna M. Trier et al.   JOURNAL OF IMMUNOLOGY

Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity

(2019) Jonathan A. Cohen et al.   CELL

Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation

(2019) Hiroyuki Nagashima et al.   IMMUNITY

Neuronal Regulation of Immunity in the Skin and Lungs

(2019) Kimbria J. Blake et al.   TRENDS IN NEUROSCIENCES

Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection

(2018) Felipe A. Pinho-Ribeiro et al.   CELL

LPS-induced neuronal activation and TRPA1 sensitization in trigeminal sensory neurons is dependent to TLR4 receptor

(2018) B. Michot et al.   JOURNAL OF PAIN

Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia

(2018) Pankaj Baral et al.   NATURE MEDICINE

Circuit dissection of the role of somatostatin in itch and pain

(2018) Jing Huang et al.   NATURE NEUROSCIENCE

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Neuromodulatory treatment of recalcitrant plaque psoriasis with onabotulinumtoxinA

(2018) Kelly A. Aschenbeck et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Overview of Neuropeptides: Awakening the Senses?

(2017) Andrew F. Russo   HEADACHE

The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies

(2017) Patrick M. Brunner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

(2017) Antonia Wallrapp et al.   NATURE

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

(2017) Christoph S. N. Klose et al.   NATURE

Neuronal regulation of type 2 innate lymphoid cells via neuromedin U

(2017) Vânia Cardoso et al.   NATURE

Distinct behavioral responses evoked by selective optogenetic stimulation of the major TRPV1+ and MrgD+ subsets of C-fibers

(2017) Hélène Beaudry et al.   PAIN

Sensory TRP channels contribute differentially to skin inflammation and persistent itch

(2017) Jing Feng et al.   Nature Communications

Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis

(2017) Kenta Maruyama et al.   Cell Reports

TRPA1 mediated aggravation of allergic contact dermatitis induced by DINP and regulated by NF-κB activation

(2017) Jun Kang et al.   Scientific Reports

TRPC3 Is Dispensable for β-Alanine Triggered Acute Itch

(2017) Peter Dong et al.   Scientific Reports

The Role of the Nervous System in the Pathophysiology of Psoriasis: A Review of Cases of Psoriasis Remission or Improvement Following Denervation Injury

(2016) Tian Hao Zhu et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Mycolactone-mediated neurite degeneration and functional effects in cultured human and rat DRG neurons

(2016) U Anand et al.   Molecular Pain

IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy

(2016) Boyi Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and neuroinflammation

(2016) Xing-Jun Liu et al.   Scientific Reports

Calcitonin gene-related peptide: key regulator of cutaneous immunity

(2015) R. D. Granstein et al.   Acta Physiologica

Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?

(2015) Nicholas K. Mollanazar et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal Dendritic Cells and Drive Protective Cutaneous Immunity

(2015) Sakeen W. Kashem et al.   IMMUNITY

Candida albicans Morphology and Dendritic Cell Subsets Determine T Helper Cell Differentiation

(2015) Sakeen W. Kashem et al.   IMMUNITY

TRPV1 expression level in isolectin B4-positive neurons contributes to mouse strain difference in cutaneous thermal nociceptive sensitivity

(2015) Kentaro Ono et al.   JOURNAL OF NEUROPHYSIOLOGY

Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade

(2015) Zhen-Zhong Xu et al.   NATURE MEDICINE

The Multi-Modal Immune Pathogenesis of Atopic Eczema

(2015) Kilian Eyerich et al.   TRENDS IN IMMUNOLOGY

Immunology of Psoriasis

(2014) Michelle A. Lowes et al.   Annual Review of Immunology

Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain

(2014) Lintao Qu et al.   BRAIN

Itch and nerve fibers with special reference to atopic dermatitis: Therapeutic implications

(2014) Mitsutoshi Tominaga et al.   JOURNAL OF DERMATOLOGY

Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation

(2014) Lorena Riol-Blanco et al.   NATURE

The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells

(2014) Samuel Bertin et al.   NATURE IMMUNOLOGY

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis

(2014) Lisa A. Beck et al.   NEW ENGLAND JOURNAL OF MEDICINE

Calcitonin gene-related peptide is a key neurotransmitter in the neuro-immune axis

(2014) Bakri M. Assas et al.   Frontiers in Neuroscience

TRP Channels and Pain

(2013) David Julius   Annual Review of Cell and Developmental Biology

The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch

(2013) Sarah R. Wilson et al.   CELL

A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1

(2013) Ferda Cevikbas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Neurturin Overexpression in Skin Enhances Expression of TRPM8 in Cutaneous Sensory Neurons and Leads to Behavioral Sensitivity to Cool and Menthol

(2013) T. Wang et al.   JOURNAL OF NEUROSCIENCE

Bacteria activate sensory neurons that modulate pain and inflammation

(2013) Isaac M. Chiu et al.   NATURE

TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice

(2012) Tong Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Botulinum Neurotoxin A Decreases Infiltrating Cutaneous Lymphocytes and Improves Acanthosis in the KC-Tie2 Mouse Model

(2012) Nicole L. Ward et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mechanisms of Itch Evoked by  -Alanine

(2012) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology

(2012) Isaac M Chiu et al.   NATURE NEUROSCIENCE

CGRPα-Expressing Sensory Neurons Respond to Stimuli that Evoke Sensations of Pain and Itch

(2012) Eric S. McCoy et al.   PLoS One

The Development and Application of Optogenetics

(2011) Lief Fenno et al.   Annual Review of Neuroscience

Painful Pathways Induced by TLR Stimulation of Dorsal Root Ganglion Neurons

(2011) J. Qi et al.   JOURNAL OF IMMUNOLOGY

Cutaneous Denervation of Psoriasiform Mouse Skin Improves Acanthosis and Inflammation in a Sensory Neuropeptide-Dependent Manner

(2011) Stephen M. Ostrowski et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Restriction of Transient Receptor Potential Vanilloid-1 to the Peptidergic Subset of Primary Afferent Neurons Follows Its Developmental Downregulation in Nonpeptidergic Neurons

(2011) D. J. Cavanaugh et al.   JOURNAL OF NEUROSCIENCE

Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons

(2011) S.-J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune and Nervous Systems: More Than Just a Superficial Similarity?

(2009) Dimitris Kioussis et al.   IMMUNITY

Involvement of capsaicin-sensitive afferents and the Transient Receptor Potential Vanilloid 1 Receptor in xylene-induced nocifensive behaviour and inflammation in the mouse

(2009) Katalin Sándor et al.   NEUROSCIENCE LETTERS