Article
Pathology
Junyang Song, Fangcheng Xu, Lingbo An, Yuxin Yin, Jin Liu, Jia Chai, Yanru Yang, Mingyang Li, Qingge Jia, Zhe Wang
Summary: This study found that BTG2 is downregulated in cervical squamous cell carcinoma (CESC) and high expression of BTG2 is associated with better survival in CESC patients. Cellular assays and mouse model experiments confirmed that overexpression of BTG2 inhibits CESC cell proliferation, migration, and metastasis, and high BTG2 expression inhibits tumor growth in vivo.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemical Research Methods
Wei Wei, Changyong Wang, Jianfeng Zhang, Lele Wang, Lei Wei, Hairong Huang
Summary: This study aims to explore the regulatory mechanism of lncRNA LINC01234 in non-small cell lung cancer (NSCLC). The results showed that LINC01234 was abundantly expressed in NSCLC cells. LINC01234 competitively bound to miR-433-3p and promoted GRB2 transcription to augment NSCLC cell malignant proliferation.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2023)
Article
Oncology
Changchun Zhu, Songling Zhang, Aiying Xue, Guoxing Feng, Saijun Fan
Summary: The study identified BTG2 as a radio-responsive gene in non-small cell lung cancer (NSCLC). Overexpression of BTG2 inhibited cell growth, promoted DNA damage, and increased apoptosis in irradiated cancer cells.
Article
Oncology
Qingxi Luo, Wenwen Shi, Bo Dou, Jun Wang, Wei Peng, Xianyu Liu, Deze Zhao, Faqing Tang, Yingfang Wu, Xizhe Li, Jiajia Li, Siqi Wen, Chunfang Zhang, Chaojun Duan
Summary: XBP1s protein is significantly overexpressed in NSCLC and promotes cell invasion and metastasis, making it a potential therapeutic target for NSCLC.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, Research & Experimental
Minyu Kong, Xiao Yu, Qingyuan Zheng, Shuijun Zhang, Wenzhi Guo
Summary: Abnormal expression of lncRNA LINC01234 is associated with various cancers and may serve as a potential biomarker for cancer diagnosis, treatment, and prognosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biology
Mirna Jovanovic, Tijana Stankovic, Sonja Stojkovic Buric, Jasna Bankovic, Jelena Dinic, Mila Ljujic, Milica Pesic, Miodrag Dragoj
Summary: Tspan14, a member of the tetraspanin protein family, plays an important role in non-small cell lung cancer (NSCLC) progression. The inactivation of TSPAN14 gene is associated with low survival rate and aggressive tumor types in NSCLC patients.
Review
Pharmacology & Pharmacy
Zdenek Kejik, Robert Kaplanek, Petr Dytrych, Michal Masarik, Katerina Vesela, Nikita Abramenko, David Hoskovec, Martina Vasakova, Jarmila Kralova, Pavel Martasek, Milan Jakubek
Summary: Designing optimal adjuvant therapy is crucial in treating non-small-cell lung carcinoma. Standard methods may not be effective in cases with high level of CTCs, thus alternative therapeutic strategies like low-toxicity natural agents may be considered when standard methods fail. This review discusses NSCLC therapy strategies and potential options for treatment beyond standard methods.
Article
Radiology, Nuclear Medicine & Medical Imaging
Shaoping Hou, Ying Fan, Xiaoyu Wang, Juan Su, Meihong Ren, Yujiao Wu, Jie Zhou, Minghui Qu, Yahong Luo, Wenyan Jiang
Summary: The study aims to investigate the use of MRI radiomics on hepatic metastasis from primary NSCLC to differentiate patients with EGFR mutations from those with EGFR wild-type and develop a prediction model. Radiomics features were extracted from the primary tumor and metastasis, and a radiomics signature was developed to predict the EGFR mutation status. The study concludes that radiomics based on hepatic metastasis can be used to detect EGFR mutation, and a multiorgan combined radiomics signature may guide individual treatment strategies for patients with metastatic NSCLC.
ACADEMIC RADIOLOGY
(2023)
Article
Oncology
Chunyuan Tang, Ying Zhou, Wen Sun, Haihong Hu, Yuxi Liu, Lu Chen, Fengting Ou, Su Zeng, Nengming Lin, Lushan Yu
Summary: This study reports the identification and characterization of a peptide called MEK1-binding oncopeptide (MBOP) encoded by LINC01234, which is highly expressed in colorectal cancer (CRC) and plays an oncogenic role in tumorigenesis. MBOP interacts with MEK1 and activates the MEK1/pERK/MMP2/MMP9 signaling pathway. The degradation of MBOP is mediated by the E3 ubiquitin-protein transferases MAEA and RMND5A. These findings suggest that MBOP could serve as a potential target and prognostic indicator for clinical therapy of CRC.
Article
Biochemistry & Molecular Biology
Chunmiao Deng, Xiaohui Liu, Cuiqiong Zhang, Lu Li, Shiyuan Wen, Xuejuan Gao, Langxia Liu
Summary: This study reveals the important roles of ANXA1 and GSK3 beta in NSCLC metastasis, where ANXA1 negatively regulates the phosphorylation of GSK3 beta to inhibit EMT and migration and invasion of NSCLC cells.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Sol Min, Chungyoul Choe, Sangho Roh
Summary: Studies have shown that cell surface protrusions play a crucial role in facilitating the aggregation of floating cells, especially in non-small cell lung cancers, affecting cell migration ability through the regulation of AQP3 levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Muhua Chen, Chunfeng Zhang, Wei Liu, Xiaojuan Du, Xiaofeng Liu, Baocai Xing
Summary: In hepatocellular carcinoma, the long noncoding RNA LINC01234 promotes cell proliferation, migration, and drug resistance by orchestrating aspartate metabolic reprogramming. LINC01234 downregulates the expression of argininosuccinate synthase 1 (ASS1), leading to activation of the mammalian target of rapamycin pathway and promoting HCC progression.
Article
Medicine, General & Internal
Cuiping Tang, Si Qin, Qian Li, Yusheng Huang
Summary: This study evaluated the effectiveness and safety of local radiotherapy followed by immune checkpoint inhibitors (ICIs) in driver gene-negative non-small cell lung cancer (NSCLC) patients with symptomatic local metastasis in the brain and bone. The results showed that sequential ICIs with local radiotherapy significantly improved both tumor response and symptom control in these patients.
Review
Oncology
Qinfeng Zhou, Lianfang Liu, Jing Zhou, Yuanyuan Chen, Dacheng Xie, Yinan Yao, Dawei Cui
Summary: The long non-coding RNA MALAT1 is overexpressed in NSCLC and is associated with tumor size, stage, metastasis, and invasion, making it a potential biomarker for early diagnosis and prognosis evaluation of the disease.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ji Li, Min Wang, Shuhui Xu, Yuying Li, Jiatong Li, Jinming Yu, Hui Zhu
Summary: Brain metastases are becoming more common among NSCLC patients. Targeted therapy has shown ideal outcomes for patients with specific mutations, but wild-type patients have poor survival due to lack of effective treatments. ICIs have changed the management of NSCLC, but their efficacy in patients with brain metastases is still uncertain. Studies have suggested that ICIs may be effective in the central nervous system in select patients with high PD-L1 expression and low CNS disease burden.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Xin Chen, Zhenyao Chen, Shanxun Yu, Fengqi Nie, Shuai Yan, Pei Ma, Qinnan Chen, Chenchen Wei, Hangjiang Fu, Tianwei Xu, Shengnan Ren, Ming Sun, Zhaoxia Wang
CLINICAL CANCER RESEARCH
(2018)
Review
Biotechnology & Applied Microbiology
Tianwei Xu, Lihua Jiang, Zhaoxia Wang
ONCOTARGETS AND THERAPY
(2019)
Article
Oncology
Shanxun Yu, Daolu Yang, Yunyao Ye, Pei Liu, Zhenyao Chen, Tianyao Lei, Jiaze Pu, Longfa Liu, Zhaoxia Wang
Article
Medicine, Research & Experimental
Tianwei Xu, Shuai Yan, Lihua Jiang, Shanxun Yu, Tianyao Lei, Daolu Yang, Binbin Lu, Chenchen Wei, Erbao Zhang, Zhaoxia Wang
MOLECULAR THERAPY-NUCLEIC ACIDS
(2019)
Review
Medical Laboratory Technology
Zhenyao Chen, Tianyao Lei, Xin Chen, Jingyao Gu, Jiali Huang, Binbin Lu, Zhaoxia Wang
CLINICA CHIMICA ACTA
(2020)
Review
Medicine, Research & Experimental
Jiali Huang, Zhenyao Chen, Xin Chen, Jun Chen, Zhixiang Cheng, Zhaoxia Wang
Summary: m(6)A is a modification of eukaryotic RNA that is dynamically regulated during cell metabolism and embryo development, mainly involved in various aspects of RNA metabolism, and closely related to the occurrence and development of cancer. Methyltransferases, as key elements in the dynamic regulation of m(6)A, play a crucial role in these processes.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Biotechnology & Applied Microbiology
Mengwei Wang, Tianwei Xu, Wenyan Feng, Junxia Liu, Zhaoxia Wang
Summary: Long noncoding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that do not encode proteins. Dysregulation of lncRNAs and their involvement in key cancer-related signaling pathways, such as the Hippo signaling pathway, play a crucial role in cancer development and progression. Understanding the role of lncRNAs in modulating the Hippo signaling pathway provides valuable insights for the development of novel strategies for early detection and treatment of cancer.
ONCOTARGETS AND THERAPY
(2021)
Article
Biophysics
Lei Wang, Ying Deng, Juan Wei, Yue Huang, Zhaoxia Wang, Genxi Li
Summary: This study introduces a cascade signal amplification strategy based on SNAs for the detection of exosomes, demonstrating high sensitivity and potential clinical applications.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Oncology
Li Ma, Jin Gao, Niu Zhang, Jiawei Wang, Tianwei Xu, Tianyao Lei, Xiaoteng Zou, Chenchen Wei, Zhaoxia Wang
Summary: This review summarizes the studies on SNHG17 in recent years, highlighting its high expression in various tumors and its potential impact on the biological function and clinical applications of tumor cells.
CANCER CELL INTERNATIONAL
(2022)
Review
Medicine, Research & Experimental
Junxia Liu, Qinqiu Zhang, Daolu Yang, Fei Xie, Zhaoxia Wang
Summary: Long non-coding RNAs (lncRNAs) play a crucial role in tumor angiogenesis and resistance to anti-angiogenic therapy. Understanding their functions and potential clinical applications is important for improving tumor treatment.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Retraction
Biotechnology & Applied Microbiology
[Anonymous]
ONCOTARGETS AND THERAPY
(2023)
Article
Oncology
Jin Gao, Yadong Li, Xiaoteng Zou, Tianyao Lei, Tianwei Xu, Yijiang Chen, Zhaoxia Wang
Summary: HEY1 was found to regulate cisplatin resistance in lung adenocarcinoma by modulating the epithelial-mesenchymal transition (EMT) process. High expression of HEY1 was associated with poor prognosis after cisplatin therapy.
Article
Chemistry, Multidisciplinary
Zhaoxia Wang, Xinming Li, Zhixing Shao, ZhengFang, Yueping Zhai
Article
Chemistry, Multidisciplinary
Yucai Yang, Chao Li, Xiaolu Hu, Yi Yang, Yongmei Yin, Zhaoxia Wang
CHEMICAL COMMUNICATIONS
(2017)