Emerging therapies for PBC

Therapeutic trials of biologics in primary biliary cholangitis: An open label study of abatacept and review of the literature

(2019) Christopher L. Bowlus et al.   JOURNAL OF AUTOIMMUNITY

Ursodeoxycholic acid therapy and liver transplant-free survival in patients with primary biliary cholangitis

(2019) Maren H. Harms et al.   JOURNAL OF HEPATOLOGY

Long-term efficacy and safety of obeticholic acid for patients with primary biliary cholangitis: 3-year results of an international open-label extension study

(2019) Michael Trauner et al.   Lancet Gastroenterology & Hepatology

Liver Injury in Patients with Cholestatic Liver Disease Treated with Obeticholic Acid

(2019) John E Eaton et al.   HEPATOLOGY

Bile acid receptors in the biliary tree: TGR5 in physiology and disease

(2018) Kathleen Deutschmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Antimitochondrial Antibody–Negative Primary Biliary Cholangitis

(2018) David M. Chascsa et al.   Clinics in Liver Disease

Rituximab is Ineffective for Treatment of Fatigue in Primary Biliary Cholangitis: A phase-2 Randomised Controlled Trial

(2018) Amardeep Khanna et al.   HEPATOLOGY

A Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis

(2018) Christophe Corpechot et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serum Autotaxin Is a Useful Disease Progression Marker in Patients with Primary Biliary Cholangitis

(2018) Satoru Joshita et al.   Scientific Reports

Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy

(2017) Ruqi Tang et al.   GUT

The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice

(2017) Yongqing Wang et al.   HEPATOLOGY

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

(2016) Frederik Nevens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-term outcomes in antimitochondrial antibody negative primary biliary cirrhosis

(2016) Gunnar Juliusson et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

The diagnosis of antimitochondrial antibody-negative primary biliary cholangitis

(2016) Ersan Ozaslan et al.   Clinics and Research in Hepatology and Gastroenterology

Combined ursodeoxycholic acid (UDCA) and fenofibrate in primary biliary cholangitis patients with incomplete UDCA response may improve outcomes

(2015) A. C. Cheung et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Pharmacological inhibition of apical sodium-dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice

(2015) Alexander G. Miethke et al.   HEPATOLOGY

The UK-PBC risk scores: Derivation and validation of a scoring system for long-term prediction of end-stage liver disease in primary biliary cholangitis

(2015) Marco Carbone et al.   HEPATOLOGY

Changing nomenclature for PBC: From ‘cirrhosis’ to ‘cholangitis’

(2015) Ulrich Beuers et al.   Clinics and Research in Hepatology and Gastroenterology

Levels of Alkaline Phosphatase and Bilirubin Are Surrogate End Points of Outcomes of Patients With Primary Biliary Cirrhosis: An International Follow-up Study

(2014) Willem J. Lammers et al.   GASTROENTEROLOGY

Case–Control Study on Prednisolone Combined With Ursodeoxycholic Acid and Azathioprine in Pure Primary Biliary Cirrhosis With High Levels of Immunoglobulin G and Transaminases

(2014) Yu-Qing Fang et al.   MEDICINE

B-Cell Depletion With Rituximab in Patients With Primary Biliary Cirrhosis Refractory to Ursodeoxycholic Acid

(2013) Robert P Myers et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Diagnostic and clinical utility of antibodies against the nuclear body promyelocytic leukaemia and Sp100 antigens in patients with primary biliary cirrhosis

(2012) Maria G. Mytilinaiou et al.   CLINICA CHIMICA ACTA

Clinical significance and prevalence of anti-Saccharomyces cerevisiae antibody in Chinese patients with primary biliary cirrhosis

(2012) Chaojun Hu et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Colchicine or Methotrexate, With Ursodiol, Are Effective After 20 Years in a Subset of Patients With Primary Biliary Cirrhosis

(2011) John Leung et al.   Clinical Gastroenterology and Hepatology

Inflammatory disease of the bile ducts-cholangiopathies: liver biopsy challenge and clinicopathological correlation

(2011) Bernard Portmann et al.   HISTOPATHOLOGY

Cytotoxic T-lymphocyte antigen 4 gene +49A/G polymorphism significantly associated with susceptibility to primary biliary cirrhosis: A meta-analysis

(2011) Rui Rui CHEN et al.   Journal of Digestive Diseases

Early primary biliary cirrhosis: Biochemical response to treatment and prediction of long-term outcome

(2011) Christophe Corpechot et al.   JOURNAL OF HEPATOLOGY

Optimizing biochemical markers as endpoints for clinical trials in primary biliary cirrhosis

(2011) Njideka Momah et al.   LIVER INTERNATIONAL

Pilot study: fenofibrate for patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid

(2010) C. Levy et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Baseline Ductopenia and Treatment Response Predict Long-Term Histological Progression in Primary Biliary Cirrhosis

(2010) Teru Kumagi et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Triple therapy with ursodeoxycholic acid, budesonide and mycophenolate mofetil in patients with features of severe primary biliary cirrhosis not responding to ursodeoxycholic acid alone

(2010) N. Rabahi et al.   GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE

American association for the study of liver diseases endpoints conference: Design and endpoints for clinical trials in primary biliary cirrhosis

(2010) Marina G. Silveira et al.   HEPATOLOGY

Primary biliary cirrhosis: A 2010 update

(2010) Raoul Poupon   JOURNAL OF HEPATOLOGY

Improved Prognosis of Patients With Primary Biliary Cirrhosis That Have a Biochemical Response to Ursodeoxycholic Acid

(2009) Edith M.M. Kuiper et al.   GASTROENTEROLOGY

High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis

(2009) Keith D. Lindor et al.   HEPATOLOGY

Primary biliary cirrhosis

(2009) Keith D. Lindor et al.   HEPATOLOGY

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

Is there a role for tetrathiomolybdate in the treatment of primary biliary cirrhosis?

(2009) Marina G. Silveira et al.   Translational Research

Treatment of primary biliary cirrhosis with tetrathiomolybdate: results of a double-blind trial

(2009) Fred Askari et al.   Translational Research

Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis

(2008) Christophe Corpechot et al.   HEPATOLOGY