Article
Oncology
Anela Blazevic, Tessa Brabander, Wouter T. Zandee, Johannes Hofland, Gaston J. H. Franssen, Marie-Louise F. van Velthuysen, Richard A. Feelders, Wouter W. De Herder
Summary: Around two-thirds of patients with small intestinal neuroendocrine tumours present with a metastatic mesenteric mass, which exhibits a static growth behavior over time. This site-specific growth behavior should be taken into consideration when selecting target lesions and assessing disease progression and therapeutic response, with peptide receptor radionuclide therapy showing limited effectiveness for size reduction of the mesenteric mass.
Article
Oncology
Oddry Folkestad, Oyvind Hauso, Patricia Mjones, Reidun Fougner, Hans H. Wasmuth, Reidar Fossmark
Summary: This study compared the clinical data and survival rates of patients with small intestinal neuroendocrine tumors (SI-NETs) in two periods: 2005 to 2012 and 2012 to 2021. The results showed that the survival rate was higher in the later period, which may be attributed to improved surgical quality and earlier diagnosis.
Article
Surgery
Jonathan Koea
Summary: Three subtypes of small bowel neuroendocrine tumours have been described: Type A is resectable without involving the mesenteric root, Type B is borderline resectable with mesenteric nodal metastases adjacent to the main vessels, and Type C is locally advanced or irresectable with encasement of the vessels. Type C, although rare, presents with symptoms of intestinal ischemia or obstruction and requires symptom management as the primary focus of treatment.
WORLD JOURNAL OF SURGERY
(2021)
Article
Endocrinology & Metabolism
Anela Blazevic, Anand M. Iyer, Marie-Louise F. Van Velthuysen, Johannes Hofland, Lindsey Oudijk, Wouter W. de Herder, Leo J. Hofland, Richard A. Feelders
Summary: Small-intestinal neuroendocrine tumors (SI-NETs) have a higher prevalence and worse prognosis in male patients. This study found that mesenteric metastasis and fibrosis were more common in men than women. The risk of mesenteric metastasis in women increased around menopause. The expression of estrogen receptor alpha and androgen receptor was observed in primary tumors and mesenteric metastases.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Oncology
Gowri M. Ratnayake, Faidon-Marios Laskaratos, Dalvinder Mandair, Martyn E. Caplin, Krista Rombouts, Christos Toumpanakis
Summary: The development of mesenteric desmoplasia in small intestinal neuroendocrine neoplasms (SINENs) involves interactions between neoplastic cells and the microenvironment, resulting in fibrotic reactions. These reactions can be localized to the tumor or occur at distant sites. Key profibrotic molecules involved in desmoplasia include serotonin, TGF beta, and CTGF. However, further research is needed to fully understand these mechanisms and develop targeted therapies to minimize desmoplasia.
CURRENT ONCOLOGY REPORTS
(2022)
Article
Oncology
Tobias Hofving, Frank Liang, Joakim Karlsson, Ulf Yrlid, Jonas A. Nilsson, Ola Nilsson, Lisa M. Nilsson
Summary: This study characterized the immune cells of small-intestinal neuroendocrine tumors (SINETs) and found that tumor-infiltrating lymphocytes (TILs) could be activated in the lab, suggesting a potential treatment option for patients.
Article
Surgery
Janice L. Pasieka
Summary: In contemporary surgical series, the incidence of multifocal tumours (MFT) in small bowel neuroendocrine tumours (SBNET) is high, posing challenges and questions for operating surgeons. The etiology of these multiple tumours may be multifactorial, involving local metastases, genetic mutations, or genetic and epigenetic events within the bowel. Contrary to historical series, recent data suggest that MFT are not associated with a poorer prognosis, highlighting the need for long-term surveillance of these unique tumours.
WORLD JOURNAL OF SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Mervi Aavikko, Eevi Kaasinen, Noora Andersson, Nalle Pentinmikko, Paivi Sulo, Iikki Donner, Paivi Pihlajamaa, Anna Kuosmanen, Simona Bramante, Riku Katainen, Lauri J. Sipila, Samantha Martin, Johanna Arola, Olli Carpen, Ilkka Heiskanen, Jukka-Pekka Mecklin, Jussi Taipale, Ari Ristimaki, Kaisa Lehti, Erika Gucciardo, Pekka Katajisto, Camilla Schalin-Jantti, Pia Vahteristo, Lauri A. Aaltonen
Summary: This study identified a novel genetic susceptibility associated with intestinal tumors in a family, with a heterozygous deletion at the cystic fibrosis locus perfectly segregating with the predisposition. Multiple molecular methods were used to understand the mechanism, revealing the tumorigenic effects of aberrant WNT activation in the human intestine.
HUMAN MOLECULAR GENETICS
(2021)
Article
Gastroenterology & Hepatology
Sarah O'Neill, Amyn Haji, Suzanne Ryan, Dominique Clement, Konstantinos Sarras, Bu Hayee, Nicola Mulholland, John K. Ramage, Rajaventhan Srirajaskanthan
Summary: This study aimed to determine if MRI and nuclear medicine imaging can alter tumor staging in patients with rectal NETs <= 10 mm. The results demonstrated that even small rectal NETs can develop nodal metastases, highlighting the importance of accurate staging for these tumors.
COLORECTAL DISEASE
(2021)
Article
Oncology
Tobias Hofving, Erik Elias, Anna Rehammar, Linda Inge, Gulay Altiparmak, Marta Persson, Erik Kristiansson, Martin E. Johansson, Ola Nilsson, Yvonne Arvidsson
Summary: Patients with small intestinal neuroendocrine tumors (SINETs) often have lymph node and liver metastases at diagnosis, with hemizygous loss of chromosome 18q and the SMAD4 gene being the most common genetic event. Reduced SMAD4 protein expression in primary tumors is associated with a higher likelihood of metastatic disease. Functional consequences of reduced SMAD4 protein levels may play a role in the clonal selection of these genetic aberrations in SINETs.
Article
Oncology
Anela Blazevic, Anand M. Iyer, Marie-Louise F. van Velthuysen, Johannes Hofland, Gaston J. H. Franssen, Richard A. Feelders, Marina Zajec, Theo M. Luider, Wouter W. de Herder, Leo J. Hofland
Summary: Mesenteric metastases in small intestinal neuroendocrine tumors (SI-NETs) are associated with mesenteric fibrosis (MF). Proteomics-based analysis found differential protein abundance primarily in the stromal compartment of mesenteric metastases of SI-NET patients with MF. The differentially abundant proteins included collagen and proteoglycans associated with profibrotic extracellular matrix dysregulation and signaling pathways. COL12A1 and C9 were confirmed to have significantly higher expression in MF mesenteric metastases. This study provides insights into new signaling pathways involved in MF development.
ENDOCRINE-RELATED CANCER
(2023)
Article
Oncology
Man Liu, Faidon-Marios Laskaratos, Jose Bennell, Jie Chen, Christos Toumpanakis, Dalvinder Mandair, Martyn Caplin
Summary: Home TPN may be a treatment option for highly selected advanced SI-NEN patients, associated with long-term survival and acceptable complication rates.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2021)
Article
Endocrinology & Metabolism
Maria J. Klomp, Julie Refardt, Peter M. van Koetsveld, Claudia Campana, Simone U. Dalm, Fadime Dogan, Marie-Louise F. van Velthuysen, Richard A. Feelders, Wouter W. de Herder, Johannes Hofland, Leo J. Hofland
Summary: This study found that DNA methylation and histone modifications are associated with SST2 expression in SI-NETs. DNA methylation levels and H3K27me3 levels were lower in SI-NETs compared to normal tissue, and there was a negative correlation between SST2 mRNA expression level and DNA methylation. However, the role of histone modifications in SI-NETs remains unclear.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Anela Blazevic, Martijn P. A. Starmans, Tessa Brabander, Roy S. Dwarkasing, Renza A. H. van Gils, Johannes Hofland, Gaston J. H. Franssen, Richard A. Feelders, Wiro J. Niessen, Stefan Klein, Wouter W. de Herder
Summary: By combining CT scans with clinical criteria and radiomics, it is possible to identify the risk of intestinal complications in patients with small intestinal neuroendocrine tumors. Both clinicians and radiomics models showed similar performance in predicting complications, but with poor inter-observer agreement among clinicians.
ENDOCRINE-RELATED CANCER
(2021)
Article
Endocrinology & Metabolism
Scott Waterfield, Paul Yousefi, Amy Webster, Caroline Relton, Chrissie Thirlwell, Matt Suderman
Summary: This study examines the genetic characteristics and clinical features of different subtypes of small intestinal neuroendocrine tumors (siNETs) and identifies potential genes and CD14 infiltration associated with the 18LOH subtype and poorer prognosis. The findings highlight the importance of the 18LOH subtype and provide potential clues about the underlying mechanisms.
NEUROENDOCRINOLOGY
(2023)
Article
Oncology
Achyut Ram Vyakaranam, Joakim Crona, Olov Norlen, Dan Granberg, Ulrike Garske-Roman, Mattias Sandstrom, Katarzyna Fross-Baron, Espen Thiis-Evensen, Per Hellman, Anders Sundin
Article
Gastroenterology & Hepatology
Harald Soderback, Ulf Gunnarsson, Anna Martling, Per Hellman, Gabriel Sandblom
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2019)
Article
Endocrinology & Metabolism
Elham Barazeghi, Per Hellman, Gunnar Westin, Peter Stalberg
ENDOCRINE CONNECTIONS
(2019)
Article
Endocrinology & Metabolism
Samuel Backman, Duska Bajic, Joakim Crona, Per Hellman, Britt Skogseid, Peter Stalberg
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Johan Botling, Angela Lamarca, Duska Bajic, Olov Norlen, Vincent Lonngren, Josefine Kjaer, Barbro Eriksson, Staffan Welin, Per Hellman, Guido Rindi, Britt Skogseid, Joakim Crona
NEUROENDOCRINOLOGY
(2020)
Article
Surgery
J. Eriksson, O. Norlen, M. Ogren, H. Garmo, C. Ihre-Lundgren, P. Hellman
Summary: The average annual incidence of small intestinal neuroendocrine tumors is 5.33 per 100,000 individuals, with an average annual prevalence of 581 per 100,000. Most patients with small intestinal neuroendocrine tumors ultimately die from other causes, and 48% of patients also have at least one other malignancy. Multiple primary tumors are common, suggesting that they may arise before metastatic disease, and there is a high rate of associated colorectal carcinoma.
SCANDINAVIAN JOURNAL OF SURGERY
(2021)
Article
Surgery
Fredrik Sellgren, Anna Koman, Erik Nordenstrom, Per Hellman, Joakim Hennings, Andreas Muth
WORLD JOURNAL OF SURGERY
(2020)
Article
Biochemistry & Molecular Biology
Karin Saljo, Anders Thornell, Chunsheng Jin, Peter Stalberg, Olov Norlen, Susann Teneberg
Summary: The glycosphingolipid patterns of the human parathyroid and thyroid glands were very similar, with the major acid glycosphingolipids being sulfatide and gangliosides. Complex glycosphingolipids with terminal blood group determinants were found in both tissues. The glycosylation of human thyroid and parathyroid glands is more complex than previously appreciated, providing a platform for further studies of alterations in cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Matilda Anneback, Edward McHale Sjodin, Per Hellman, Peter Stalberg, Olov Norlen
Summary: This retrospective cohort study investigated the potential benefit of preoperative active vitamin D supplementation on hypocalcaemia and its symptoms after thyroidectomy. The study found that preoperative alfacalcidol treatment was associated with reduced biochemical hypocalcaemia and duration of hospital stay.
Meeting Abstract
Endocrinology & Metabolism
A. R. Vyakaranam, J. Crona, E. Thiis-Evensen, P. Hellman, O. Norlen, D. Granberg, U. Garske-Roman, K. Fross-Baron, M. Sandstrom, A. Sundin
NEUROENDOCRINOLOGY
(2020)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
A. Vyakaranam, J. Crona, E. Thiis-Evensen, P. Hellman, O. Norlen, D. Granberg, U. Garske-Roman, K. Fross-Baron, M. Sandstrom, A. Sundin
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Meeting Abstract
Oncology
J. Botling, A. Lamarca, D. Bajic, O. Norlen, V. Lonngren, J. Kjaer, B. Eriksson, S. Welin, P. Hellman, G. Rindi, B. Skogseid, J. Crona
ANNALS OF ONCOLOGY
(2019)
Meeting Abstract
Biochemical Research Methods
Mahabuba Jahan, Isabella Silins, Per Hellman, Anders Sundin, Morris Brown, Mark Gurnell, Franklin Aigbirhio, Patrik Nordeman, Gunnar Antoni
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2019)
Meeting Abstract
Endocrinology & Metabolism
A. Sundin, A. R. Vyakaranam, J. Crona, P. Hellman
NEUROENDOCRINOLOGY
(2019)
Meeting Abstract
Endocrinology & Metabolism
J. Botling, A. Lamarca, D. Bajic, O. Norlen, V Lonngren, B. Eriksson, S. Welin, P. Hellman, G. Rindi, B. Skogseid, J. Crona
NEUROENDOCRINOLOGY
(2019)