PTPRD-inactivation-induced CXCL8 promotes angiogenesis and metastasis in gastric cancer and is inhibited by metformin

Metformin inhibits metastatic breast cancer progression and improves chemosensitivity by inducing vessel normalization via PDGF-B downregulation

(2019) Ji-Chang Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Effects of hyperglycemia on the progression of tumor diseases

(2019) Wenjie Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Metformin targets a YAP1-TEAD4 complex via AMPKα to regulate CCNE1/2 in bladder cancer cells

(2019) Yanju Wu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PTPRT and PTPRD Deleterious Mutations and Deletion Predict Bevacizumab Resistance in Metastatic Colorectal Cancer Patients

(2018) Hung-Chih Hsu et al.   Cancers

The Contribution of Angiogenesis to the Process of Metastasis

(2015) Diane R. Bielenberg et al.   CANCER JOURNAL

CXCL8, overexpressed in colorectal cancer, enhances the resistance of colorectal cancer cells to anoikis

(2015) You-Chuan Xiao et al.   CANCER LETTERS

Loss of RACK1 Promotes Metastasis of Gastric Cancer by Inducing a miR-302c/IL8 Signaling Loop

(2015) Ling Chen et al.   CANCER RESEARCH

FDA Approval Summary: Ramucirumab for Gastric Cancer

(2015) S. J. Casak et al.   CLINICAL CANCER RESEARCH

Metformin Reverts the Secretion of CXCL8 Induced by TNF-α in Primary Cultures of Human Thyroid Cells: An Additional Indirect Anti-Tumor Effect of the Drug

(2015) Mario Rotondi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes

(2015) Razvan Cristescu et al.   NATURE MEDICINE

Interleukin-8: A potent promoter of angiogenesis in gastric cancer

(2015) JUN SHI et al.   Oncology Letters

STAT3 and ERK1/2 Cross-talk in Leukaemia Inhibitory Factor Mediated Trophoblastic JEG-3 Cell Invasion and Expression of Mucin 1 and Fos

(2014) Pankaj Suman et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

(2014) Rakesh K. Jain   CANCER CELL

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Comprehensive molecular characterization of gastric adenocarcinoma

(2014) Adam J. Bass et al.   NATURE

Reduced Expression of PTPRD Correlates with Poor Prognosis in Gastric Adenocarcinoma

(2014) Dandan Wang et al.   PLoS One

Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis

(2014) B. Ortiz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Model-based patterns in stomach cancer mortality worldwide

(2013) Bárbara Peleteiro et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

PPAR-γ2 and PTPRD gene polymorphisms influence type 2 diabetes patients' response to pioglitazone in China

(2012) Qi Pei et al.   ACTA PHARMACOLOGICA SINICA

Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers

(2012) Xin-Sheng Deng et al.   CELL CYCLE

Replication of genome-wide association signals of type 2 diabetes in Han Chinese in a prospective cohort

(2011) Yi-Cheng Chang et al.   CLINICAL ENDOCRINOLOGY

Phase III Trial Comparing Capecitabine Plus Cisplatin Versus Capecitabine Plus Cisplatin With Concurrent Capecitabine Radiotherapy in Completely Resected Gastric Cancer With D2 Lymph Node Dissection: The ARTIST Trial

(2011) Jeeyun Lee et al.   JOURNAL OF CLINICAL ONCOLOGY

Tyrosine phosphatase PTPRD suppresses colon cancer cell migration in coordination with CD44

(2011) KOSUKE FUNATO et al.   Experimental and Therapeutic Medicine

Protein kinase signaling networks in cancer

(2010) John Brognard et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Pioglitazone in chemically induced mammary carcinogenesis in rats

(2010) Bianka Bojková et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

High resolution ArrayCGH and expression profiling identifies PTPRD and PCDH17/PCH68 as tumor suppressor gene candidates in laryngeal squamous cell carcinoma

(2010) Maciej Giefing et al.   GENES CHROMOSOMES & CANCER

Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

(2010) Yung-Jue Bang et al.   LANCET

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Metformin Inhibits Aromatase via an Extracellular Signal-Regulated Kinase-Mediated Pathway

(2009) Suman Rice et al.   ENDOCRINOLOGY

The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers

(2009) S. Veeriah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational Inactivation of PTPRD in Glioblastoma Multiforme and Malignant Melanoma

(2008) D. A. Solomon et al.   CANCER RESEARCH

Deregulation of a STAT3-Interleukin 8 Signaling Pathway Promotes Human Glioblastoma Cell Proliferation and Invasiveness

(2008) N. de la Iglesia et al.   JOURNAL OF NEUROSCIENCE