Article
Chemistry, Physical
Ioannis Tsichlis, Athanasia-Paraskevi Manou, Vasiliki Manolopoulou, Konstantina Matskou, Maria Chountoulesi, Vasiliki Pletsa, Aristotelis Xenakis, Costas Demetzos
Summary: The aim of this study was to develop, characterize, and evaluate the cytotoxicity of liposomes and liquid crystalline nanoparticles loaded with quercetin. The addition of non-ionic surfactants successfully stabilized and improved the physicochemical stability of the nanoparticles. Additionally, the encapsulation efficiency of quercetin was increased with the combination of appropriate biosafety in vitro profile.
Article
Biochemistry & Molecular Biology
Meenu Mehta, Vamshikrishna Malyla, Keshav R. Paudel, Dinesh Kumar Chellappan, Philip M. Hansbro, Brian G. Oliver, Kamal Dua
Summary: Berberine, an isoquinoline alkaloid extracted from plants of the Papaveraceae family, exhibits anti-inflammatory, anticancer, and antidiabetic properties. This study shows that Berberine-loaded liquid crystalline nanoparticles significantly reduce the expression of CXCL-8, CCL-20, and HO-1, suggesting a potential therapeutic alternative for lung cancer management.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Keshav Raj Paudel, Nisha Panth, Bikash Manandhar, Sachin Kumar Singh, Gaurav Gupta, Peter R. Wich, Srinivas Nammi, Ronan MacLoughlin, Jon Adams, Majid Ebrahimi Warkiani, Dinesh Kumar Chellappan, Brian G. Oliver, Philip M. Hansbro, Kamal Dua
Summary: This study explored the effects of berberine-loaded liquid crystalline nanoparticles on oxidative stress, inflammation, and senescence induced by cigarette smoke. The results showed that berberine-LCNs exhibited potent antioxidant activity and could inhibit oxidative stress and inflammation caused by cigarette smoke, as well as delay the aging process.
Article
Materials Science, Biomaterials
Yinghan Chan, Sin Wi Ng, Dinesh Kumar Chellappan, Thiagarajan Madheswaran, Farrukh Zeeshan, Pradeep Kumar, Viness Pillay, Gaurav Gupta, Ridhima Wadhwa, Meenu Mehta, Peter Wark, Alan Hsu, Nicole G. Hansbro, Philip Michael Hansbro, Kamal Dua, Jithendra Panneerselvam
Summary: This study successfully formulated celastrol into liquid crystalline nanoparticles, with in-vitro release studies and molecular simulations confirming its potential therapeutic efficacy in treating asthma, demonstrating significant therapeutic effects.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2021)
Article
Chemistry, Physical
Artur Bukowczan, Konstantinos N. Raftopoulos, Maciej Czajkowski, Ewa Szefer, Edyta Hebda, Krzysztof Pielichowski
Summary: A series of liquid crystalline polyurethanes modified by TRIS-POSS were synthesized and characterized. The addition of POSS moieties led to the formation of liquid crystalline phases and higher melting and crystallization temperatures. POSS particles influenced thermal stability, glass transition, and mechanical properties in the polyurethanes, with no agglomerates observed.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Anna Poryvai, Michal Smahel, Marie Svecova, Ahlam Nemati, Sasan Shadpour, Pavel Ulbrich, Timothy Ogolla, Jiao Liu, Vladimira Novotna, Miroslav Veverka, Jana Vejpravova, Torsten Hegmann, Michal Kohout
Summary: Combining cobalt ferrite nanocrystals with organic ligands featuring a robust photosensitive unit and a source of chirality, nanoparticles are developed to serve as a multifunctional and multiaddressable dopant to modify the properties of liquid crystalline matrices. These nanoparticles, when dispersed in achiral liquid crystals, form chiral supramolecular structures that can respond to UV-light illumination and possess strong magnetic response.
Article
Chemistry, Multidisciplinary
Jose Antonio Ulloa, Joaquin Barbera, Jose Luis Serrano
Summary: A series of polybenzylic dendrons with an alkynyl focal point were synthesized and successfully incorporated onto gold nanoparticles. Five of the compounds showed columnar mesomorphism over a wide range of temperatures. The dendrons were functionalized onto the nanoparticles by 1,3-dipolar cycloaddition, resulting in stable dendron-coated nanoparticles. The subsequent growth of the nanoparticles after thermal treatment was influenced by the size and shape of the dendron. TEM, DSC, TGA, NMR, and UV-Vis spectroscopy were used to characterize the structures of the final nanoparticles.
Article
Chemistry, Multidisciplinary
Abdullah M. Alnuqaydan, Abdulmajeed G. Almutary, Mohd Azam, Bikash Manandhar, Gabriele De Rubis, Thiagarajan Madheswaran, Keshav Raj Paudel, Philip M. Hansbro, Dinesh Kumar Chellappan, Kamal Dua
Summary: Inflammation and oxidative stress are underlying causes of chronic inflammatory diseases, and macrophages play a key role in the inflammatory process. Berberine, a natural compound with anti-inflammatory and antioxidant properties, could be a potential therapeutic agent for chronic inflammatory diseases when encapsulated in liquid crystalline nanoparticles.
Article
Pharmacology & Pharmacy
Vivek P. Chavda, Sathish Dyawanapelly, Shilpa Dawre, Ines Ferreira-Faria, Rajashri Bezbaruah, Niva Rani Gogoi, Praveen Kolimi, Divyang J. Dave, Ana Claudia Paiva-Santos, Lalitkumar K. Vora
Summary: Liquid crystal-based nanoformulations are efficient in delivering drugs and therapeutics to specific biological sites. Lyotropic liquid crystalline phases (LLCPs) have unique characteristics that make them promising drug delivery systems, offering improved drug loading, stability, and controlled release. Factors such as molecule shape, microsegregation, and chirality play important roles in the formation of these liquid crystalline phases. Additionally, due to their similarity to biological membranes, liquid crystals demonstrate higher bioadhesivity and biocompatibility, making them more effective for targeted drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Infectious Diseases
Muhammed Awad, Timothy J. Barnes, Clive A. Prestidge
Summary: Lipid liquid crystalline nanoparticles (LCNPs) are effective nanocarriers for delivering antimicrobials, but they are not stable in aqueous dispersions. In this study, lyophilization was used to produce dry LCNPs loaded with a hydrophobic antimicrobial compound. The rehydrated LCNPs retained their structure and antimicrobial activity. This research demonstrates the potential of lyophilization to enhance the application of LCNPs as an antimicrobial delivery system.
Article
Polymer Science
Hongdeok Kim, Joonmyung Choi
Summary: Synthesizing surface-grafted Au nanoparticles and incorporating them into a liquid crystalline elastomer matrix disrupts the mesogen arrangement, forming a highly entangled network on the LCE matrix side and a ductile grafted layer on the AuNP side. The curvature of the inserted AuNPs plays a crucial role in changing the mechanical and structural properties of the LCE matrix phase.
Article
Pharmacology & Pharmacy
Muhammed Awad, Timothy J. Barnes, Nicky Thomas, Paul Joyce, Clive A. Prestidge
Summary: This study investigated the use of gallium protoporphyrin liquid crystalline lipid nanoparticles (GaPP-LCNP) as a photosensitizer in antimicrobial photodynamic therapy (aPDT). The results showed that GaPP-LCNP significantly enhanced the antibacterial activity and effectively reduced the viability of both planktonic and biofilm forms of P. aeruginosa. The findings suggest that GaPP-LCNP is a promising platform for the photodynamic inactivation of antibiotic resistant bacterial infections.
Article
Chemistry, Applied
Giulia Simonetti, Francesca Buiarelli, Flaminia Bernardini, Patrizia Di Filippo, Carmela Riccardi, Donatella Pomata
Summary: This study analyzed the content of quercetin and its derivatives in wines from different varieties in Italy using HPLC-ESIMS/MS. Wines produced from Sangiovese and Nero d'Avola grapes were found to be richest in quercetin compounds.
Article
Medicine, Research & Experimental
Keshav Raj Paudel, Ridhima Wadhwa, Xin Nee Tew, Natalie Jia Xin Lau, Thiagarajan Madheswaran, Jithendra Panneerselvam, Farrukh Zeeshan, Pradeep Kumar, Gaurav Gupta, Krishnan Anand, Sachin K. Singh, Niraj Kumar Jha, Ronan MacLoughlin, Nicole G. Hansbro, Gang Liu, Shakti D. Shukla, Meenu Mehta, Philip M. Hansbro, Dinesh Kumar Chellappan, Kamal Dua
Summary: This study explored the anti-cancer activity of Rutin-loaded liquid crystalline nanoparticles (LCNs) in non-small cell lung cancer cell line, showing promising anti-proliferative and anti-migratory activities, induction of apoptosis, and inhibition of colony formation. These findings provide important insights for further mechanistic studies of Rutin-LCNs as a potential therapeutic option for NSCLC.
Article
Chemistry, Multidisciplinary
Pei-Xi Wang
Summary: A simple method was developed to transform layered organic-inorganic metal halide perovskites into colloidal lyotropic liquid crystalline dispersions with microscopic structural orderliness, semiconducting properties, and photoluminescence. These materials can be used for polarized light emission or detection, combining the ordered structures of liquid crystals and the adjustable semiconductivity of hybrid perovskites.
CHEMICAL COMMUNICATIONS
(2021)
Article
Cell Biology
Mohamed El-Tanani, Arwa Omar Al Khatib, Belal O. Al-Najjar, Ashok K. Shakya, Yahia El-Tanani, Yin-Fai Lee, Angel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Alaa A. Aljabali, Rohit Goyal, Poonam Negi, Marzieh Ramezani Farani, Maryam Moradi Binabaj, Amir Gholami, Maryam Moradi Binabaj, Nitin B. Charbe, Murtaza M. Tambuwala
Summary: There has been extensive research on breast cancer in recent decades, resulting in important breakthroughs in the treatment of both primary and metastatic breast cancers. Despite the availability of advanced treatment options, treating breast cancer remains a challenge, requiring a combination of traditional chemotherapeutic drugs and surgical options. Recent developments have led to a wide range of treatment options including chemotherapeutic drugs, endocrine system-based treatments, biological therapies, gene therapy, and innovative techniques.
CELLULAR SIGNALLING
(2023)
Article
Respiratory System
Hannelore P. Van Eeckhoutte, Chantal Donovan, Richard Y. Kim, Thomas M. Conlon, Meshal Ansari, Haroon Khan, Ranjith Jayaraman, Nicole G. Hansbro, Yves Dondelinger, Tom Delanghe, Allison M. Beal, Brad Geddes, John Bertin, Tom Vanden Berghe, Joyceline De Volder, Tania Maes, Peter Vandenabeele, Bart M. Vanaudenaerde, Dieter Deforce, Sonja Skevin, Filip Van Nieuwerburgh, Fien M. Verhamme, Guy F. Joos, Sobia Idrees, Herbert B. Schiller, Ali Oender Yildirim, Alen Faiz, Mathieu J. M. Bertrand', Guy G. Brusselle, Philip M. Hansbro, Ken R. Bracke
Summary: RIPK1 plays a key role in COPD pathogenesis by mediating cell death and inflammation. Inhibition of RIPK1 kinase activity can alleviate airway inflammation and cell death caused by COPD, making it a potential therapeutic approach.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Vancha Harish, Waleed Hassan Almalki, Ahmed Alshehri, Abdulaziz Alzahrani, Madan Mohan Gupta, Sami I. Alzarea, Imran Kazmi, Monica Gulati, Devesh Tewari, Gaurav Gupta, Kamal Dua, Sachin Kumar Singh
Summary: The analytical quality by design (AQbD) approach is used to develop a simple, sensitive, and cost-effective reverse-phase high-performance liquid chromatographic method for estimating xanthohumol (XH) in bulk and nanoformulations. The Box-Behnken design (BBD) is utilized for method optimization, and the optimized conditions result in predicted values of retention time, peak area, peak height, tailing factor, and theoretical plates. The validation of the method satisfies the requirements specified by ICH Q2(R1) recommendations, indicating that the developed and validated AQbD method can be applied for estimating XH in bulk and various nanoformulations.
Review
Chemistry, Multidisciplinary
Akshansh Sharma, Devanshi Shambhwani, Sadanand Pandey, Jay Singh, Hauzel Lalhlenmawia, Murali Kumarasamy, Sachin Kumar Singh, Dinesh Kumar Chellappan, Gaurav Gupta, Parteek Prasher, Kamal Dua, Deepak Kumar
Summary: Carcinoma of the lungs is a deadly form of cancer with low survival rates. Nanotechnology offers potential solutions, through nanoscale theranostic agents, to improve drug delivery, enhance therapeutic efficacy, and enable early detection and targeted therapy. Various types of nanoparticles, such as liposomes, dendrimers, and gold nanoparticles, have been successfully studied for therapeutic applications in lung carcinoma. This review provides a comprehensive overview of the overexpressed receptors in lung cancer and the targeting approaches of nanoparticles.
Article
Physiology
Punnam Chander Veerati, Andrew T. Reid, Kristy S. Nichol, Peter A. B. Wark, Darryl A. Knight, Nathan W. Bartlett, Christopher L. Grainge
Summary: Bronchoconstriction in asthma patients can suppress antiviral immune responses, while virus infection is the main cause of exacerbations.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Richard Y. Kim, Brian Oliver
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Vinod Kumar Kannaujiya, Gabriele De Rubis, Keshav Raj Paudel, Bikash Manandhar, Dinesh Kumar Chellappan, Sachin Kumar Singh, Ronan MacLoughlin, Gaurav Gupta, Dikaia Xenaki, Pradeep Kumar, Philip Michael Hansbro, Brian Gregory George Oliver, Peter Richard Wich, Kamal Dua
Summary: Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide, and current treatment options are limited. Inhibition of NF kappa B, a master regulator of NSCLC, shows promise as an innovative therapeutic strategy. This study demonstrates the encapsulation of a hydrophilic NF kappa B decoy ODN into a dextran-based nanoparticle system, which effectively inhibits NF kappa B activity and exhibits promising anticancer activity against NSCLC.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Mohamed El-Tanani, Hamdi Nsairat, Alaa A. Aljabali, Angel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Gowhar A. Naikoo, Walhan Alshaer, Murtaza M. Tambuwala
Summary: The mammalian target of rapamycin (mTOR), a signalling system, is necessary for various cell proliferation activities. It recognizes PI3KAKT stress signals as a serine-threonine kinase. The abnormal regulation of mTOR pathway has been proven to be crucial in cancer growth and advancement. This review primarily discusses the normal functions of mTOR as well as its abnormal roles in cancer development.
Review
Psychiatry
Hui Chen, Yang Yang, Diana Odisho, Siqi Wu, Chenju Yi, Brian G. Oliver
Summary: Currently, the diagnosis of ADHD relies on behavioral tests. However, this review aims to identify potential biomarkers for ADHD which can provide more objective and accurate diagnosis and evaluation of treatment efficacy.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Pharmacology & Pharmacy
Poonam Negi, Akriti Singh, Swati Pundir, Arun Parashar, Navneet Upadhyay, Shweta Agarwal, Raveen Chauhan, Murtaza M. Tambuwala
Summary: The vagina can be infected by a fungus called Candida albicans, causing a common sickness known as thrush. Over 75% of women will experience this infection at some point, with a high recurrence rate. While there are medicines available, scientists are studying the use of plants to create nanosized carriers for powerful medicine that can effectively treat the infection. This review focuses on nanocarrier-based approaches and essential oil-based formulations for vaginal candidiasis.
THERAPEUTIC DELIVERY
(2023)
Review
Engineering, Biomedical
Martin Birkett, Abdul Wasy Zia, Dinesh Kumar Devarajan, Soni Mihalis I. Panayiotidis, Thomas J. Joyce, Murtaza M. Tambuwala, Angel Serrano-Aroca
Summary: Diamond-like carbon (DLC) coatings doped with bioactive elements of silver (Ag) and copper (Cu) have attracted increasing attention in recent years, as they have the potential to enhance antimicrobial and mechanical performance. These multi-functional coatings offer great potential to improve wear resistance and antimicrobial properties of load-bearing medical implants.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Fareeha Arshad, Gowhar A. Naikoo, Israr U. Hassan, Sai Raghuveer Chava, Mohamed El-Tanani, Alaa A. Aljabali, Murtaza M. Tambuwala
Summary: Silver nanoparticles (AgNPs) possess unique properties as antimicrobial, antifungal, antiviral, and anticancer agents. The green synthesis method of AgNPs has advantages such as low cost and eco-friendly production, which attract attention.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Swati Saini, Nisha Gulati, Rajendra Awasthi, Vimal Arora, Sachin Kumar Singh, Shobhit Kumar, Gaurav Gupta, Kamal Dua, Rakesh Pahwa, Harish Dureja
Summary: Breast cancer refers to the uncontrollable division and multiplication of breast cells. Symptoms include the formation of lumps, changes in breast texture or color, and nipple discharge. Local or systemic therapies, such as surgery and radiation, are commonly used. Monoclonal antibodies (mAbs) have shown significant progress in treating breast cancer by destroying cancer cells, blocking immune inhibitors, and preventing the formation of new blood vessels. This review focuses on the therapeutic applications, characteristics, and safety aspects of mAbs in breast cancer treatment, highlighting the need for novel technologies utilizing modified antibodies.
CURRENT DRUG DELIVERY
(2023)
Meeting Abstract
Respiratory System
Olivia Carroll, Alexandra Brown, Jemma Mayall, Henry Gomez, Richard Kim, Chantal Donovan, Evan Williams, Bronwyn Berthon, James Pinkerton, Philip Hansbro, Paul Foster, Katie Wynne, Hayley Scott, Lisa Wood, Jay Horvat
Article
Cell Biology
Hamid A. Bakshi, Michella Mkhael, Hakkim L. Faruck, Asad Ullah Khan, Alaa A. A. Aljabali, Vijay Mishra, Mohamed El-Tanani, Nitin B. Charbe, Murtaza M. Tambuwala
Summary: The rewiring of cellular metabolism is a defining characteristic of cancer, as tumor cells adapt to acquire essential nutrients from a nutrient-poor environment to sustain their viability and biomass. Recent studies have shown that hypoxic cancer cells, which heavily rely on glucose, can utilize alternative energy sources such as mannose and maltose. This review comprehensively examines the hypoxic cancer microenvironment, its association with drug resistance, and potential therapeutic strategies for targeting this unique niche.
CELLULAR SIGNALLING
(2024)
