Journal
JOURNAL OF DERMATOLOGY
Volume 47, Issue 2, Pages 104-113Publisher
WILEY
DOI: 10.1111/1346-8138.15184
Keywords
alpha-interferon; dendritic cells; interleukin-23; Langerhans cells; psoriasis
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Psoriasis is a chronic skin inflammatory disorder, the immune mechanism of which has been profoundly elucidated in the past few years. The dominance of the interleukin (IL)-23/IL-17 axis is a significant breakthrough in the understanding of the pathogenesis of psoriasis, and treatment targeting IL-23 and IL-17 has successfully benefited patients with the disease. The skin contains a complex network of dendritic cells (DC) mainly composed of epidermal Langerhans cells, bone marrow-derived dermal conventional DC, plasmacytoid DC and inflammatory DC. As the prominent cellular source of alpha-interferon, tumor necrosis factor-alpha, IL-12 and IL-23, DC play a pivotal role in psoriasis. Thus, targeting pathogenic DC subsets is a valid strategy for alleviating and preventing psoriasis and other DC-derived diseases. In this review, we survey the known role of DC in this disease.
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