Article
Biotechnology & Applied Microbiology
Fenting Lei, Fancai Zeng, Xin Yu, Yiping Deng, Zongquan Zhang, Maochang Xu, Nianhui Ding, Ji Tian, Chunhong Li
Summary: Due to the failure of oral nano-delivery systems to target the colon and achieve controlled drug release in the treatment of inflammatory bowel disease (IBD), there is an urgent need to develop a microenvironment responsive drug delivery system. In this study, a pH-responsive hydrogel-coated nanoemulsion was successfully developed for the co-delivery of curcumin and emodin. The prepared system showed promising therapeutic effects in IBD by alleviating inflammation, repairing mucosal damage, and clearing reactive oxygen species.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Food Science & Technology
Abir Ben Bacha, Norah Al-Orf, Mona Alonazi, Ramesa Shafi Bhat, Afaf El-Ansary
Summary: This study demonstrates that probiotics can reduce apoptosis and neuroinflammation induced by propionic acid (PPA) by modulating gut function. In a hamster model, probiotics significantly decreased levels of apoptotic markers and inflammation markers, providing protection against brain damage.
FOOD SCIENCE & NUTRITION
(2021)
Article
Dentistry, Oral Surgery & Medicine
X. Bao, J. Weiner, O. Meckes, H. Dommisch, A. S. Schaefer
Summary: Research showed that the protozoan Entamoeba gingivalis can invade oral mucosa and ingest fragments of live cells, demonstrating potential pathogenicity.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Immunology
Corinna L. L. Seidel, Elena Percivalle, Marco Tschaftari, Matthias Weider, Karin Strobel, Ines Willershausen, Christoph Unertl, Helga M. M. Schmetzer, Manuel Weber, Michael Schneider, Benjamin Frey, Udo S. S. Gaipl, Matthias W. W. Beckmann, Lina Goelz
Summary: The study found significantly increased levels of oral cytokines in neonates with orofacial clefts, especially at the first consultation after birth. Furthermore, a significant positive correlation was detected between cleft severity and specific pro-inflammatory mediators.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Heejin Kim, Yun-Seok Lee, Hye-Young Yu, Mijin Kwon, Ki-Kwang Kim, Gyo In, Soon-Ki Hong, Sang-Kyu Kim
Summary: This study investigated the potential probiotic properties of Limosilactobacillus fermentum KGC1601 isolated from Panax ginseng. The strain showed sensitivity to antibiotics, no production of biogenic amines, excellent bile salt tolerance, and anti-inflammatory effects, making it a safe and potential functional probiotic agent.
Article
Engineering, Biomedical
Zijun Zhang, Qiuyang Zhang, Shuna Gao, Hui Xu, Jiangna Guo, Feng Yan
Summary: Oral aphthous ulcers are common inflammatory lesions of the oral mucosa that cause pain and damage. The moist and dynamic environment of the oral cavity makes local treatment challenging. A buccal tissue adhesive patch loaded with diclofenac sodium was developed, which had antimicrobial and anti-inflammatory properties. The patch adhered to wet tissues and efficiently delivered the drug, showing promising potential for oral aphthous ulcer treatment.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Gang Tian, Xiaoqun Gu, Kaifan Bao, Xuerui Yu, Yuheng Zhang, Yifan Xu, Jie Zheng, Min Hong
Summary: The study confirmed the anti-inflammatory effect of Pudilan antiphlogistic oral liquid (PDL) on various inflammatory models, predicted 45 ingredients interacting with 185 targets, and suggested its involvement in multiple inflammation-related signaling pathways for its anti-inflammatory mechanisms.
Article
Biotechnology & Applied Microbiology
Deni Kostelac, Marko Geric, Goran Gajski, Jadranka Frece
Summary: This study investigated the antioxidant and anti-inflammatory potential of probiotic bacteria isolated from fermented whey and proposed a new probiotic model for reducing oxidative and inflammatory stress in the gut.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yoshitaka Hosokawa, Ikuko Hosokawa, Masahiro Shimoyama, Ayumi Fujii, Juri Sato, Kimitake Kadena, Kazumi Ozaki, Keiichi Hosaka
Summary: Iberin has been shown to inhibit inflammatory mediator expression and activate antioxidant signaling pathways in human oral epithelial cells.
Article
Environmental Sciences
Tatiana Fernandes Araujo Almeida, Sicilia Rezende Oliveira, Janine Mayra da Silva, Ana Laura Fernandes de Oliveira, Zenilda de Lourdes Cardeal, Helvecio Costa Menezes, Jose Messias Gomes, Gabriel Henrique Campolina-Silva, Cleida Aparecida Oliveira, Soraia Macari, Gustavo Pompermaier Garlet, Ivana Marcia Alves Diniz, Andreia Machado Leopoldino, Tarcilia Aparecida Silva
Summary: BPA poses harmful effects on oral mucosa and both tumorigenic and non-tumorigenic cells, leading to increased proliferative activity in oral tissues, disruption of keratinocytes function, and induction of proliferative, invasive, pro-angiogenic, and epigenetic pathways in tumor cells.
ENVIRONMENTAL POLLUTION
(2021)
Article
Medicine, General & Internal
P. G. Vaughan-Shaw, G. Grimes, J. P. Blackmur, M. Timofeeva, M. Walker, L. Y. Ooi, Victoria Svinti, Kevin Donnelly, F. V. N. Din, S. M. Farrington, M. G. Dunlop
Summary: This study found that oral vitamin D supplementation can induce beneficial gene expression effects in human rectal epithelium, leading to anti-tumour effects. However, only a minority of participants showed significant responses to vitamin D supplementation. Changes in HIPK2 and PPP1CC expression serve as blood biomarkers of mucosal transcriptomic response.
Article
Dentistry, Oral Surgery & Medicine
Koya Nakamura, Toshiro Yamamoto, Ryo Ema, Kei Nakai, Yoshiki Sato, Kenta Yamamoto, Keiji Adachi, Fumishige Oseko, Yoshiaki Yamamoto, Narisato Kanamura
Summary: The study found that mechanical stress applied through dentures increases the production of inflammatory cytokines from oral mucosal epithelial cells and fibroblasts, likely through the p38 MAPK cascade, leading to inflammation. On the other hand, up-regulation of growth factors may be a biological defense mechanism against excessive mechanical stress.
Article
Biotechnology & Applied Microbiology
Jin Xu, Mubasher Hussain, Wenfeng Su, Qian Yao, Guandong Yang, Yu Zhong, Lin Zhou, Xiaoting Huang, Zhixiang Wang, Quliang Gu, Yifei Ren, He Li
Summary: This study developed a functional vine tea fermentation broth using microbial fermentation and cellulase degradation. The fermented tea showed strong antioxidant, anti-melanoma, and anti-inflammatory effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Boonyarut Ladda, Chittapon Jantararussamee, Wisuit Pradidarcheep, Anongnard Kasorn, Udomlak Matsathit, Malai Taweechotipatr
Summary: This study examined the properties of three probiotic strains in colorectal adenocarcinoma cells. It was found that the probiotic L. paracasei strain MSMC39-1 significantly suppressed TNF-a secretion in the cells. Further experiments showed that this strain reduced liver enzyme levels, inhibited TNF-a secretion in colon and liver tissues, alleviated colon and liver histopathology, and increased beneficial bacteria in the gut.
Review
Immunology
Nadia Peyravian, Sapna Deo, Sylvia Daunert, Joaquin J. Jimenez
Summary: Acne, a common skin condition, can be treated with conventional therapies such as retinoids and antibiotics, but these treatments may have side effects and risks of antibiotic resistance. Therefore, the use of natural plant-derived treatments like CBD as an alternative or adjunct therapy is attractive to patients due to their anti-inflammatory properties and minimal side effects.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
