Article
Polymer Science
Fahad M. Aldakheel, Dalia Mohsen, Marwa M. El Sayed, Mohammed H. Fagir, Dalia K. El Dein
Summary: This study synthesized silver nanoparticles using curcumin and loaded them onto a hydrogel. The nanoparticles exhibited effective action against bacteria and promoted faster wound healing compared to the control hydrogel sample. The curcumin-silver nanoparticle-incorporated hydrogels show potential as antibacterial wound dressings that reduce scarring.
Article
Materials Science, Multidisciplinary
Huixing Liang, Maryam Sadat Mirinejad, Azadeh Asefnejad, Hadi Baharifar, Xiang Li, Saeed Saber-Samandari, Davood Toghraie, Amirsalar Khandan
Summary: Wound healing is a complex process that sometimes requires external stimuli. The use of biological agents in wound dressings can modify the healing process and promote better recovery. In this study, a bio-nanocomposite wound dressing containing different weight percentages of AgO-TiO2 nanoparticles was fabricated and characterized for its physical and chemical properties, as well as bioactivity and biodegradability.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Pharmacology & Pharmacy
Cinzia Pagano, Francesca Luzi, Maurizio Ricci, Alessandro Di Michele, Debora Puglia, Maria Rachele Ceccarini, Tommaso Beccari, Francesca Blasi, Lina Cossignani, Aurelie Schoubben, Sara Primavilla, Cesar Antonio Viseras Iborra, Luana Perioli
Summary: The combination of grape seed extract (GSE), acacia gum (AG), and polyvinylpyrrolidone (PVP) has resulted in the development of bioadhesive polymeric patches loaded with GSE and cyclic dextrin (CD). The patches are mechanically resistant and able to sustainably release GSE, providing antibacterial and antioxidant activities.
Article
Materials Science, Multidisciplinary
Armin Amirsadeghi, Arman Jafari, Seyyedeh-Sara Hashemi, Aboozar Kazemi, Younes Ghasemi, Amin Derakhshanfar, Mohammad-Ali Shahbazi, Seyyed Vahid Niknezhad
Summary: Novel sprayable antibacterial dressings were developed by in-situ formation of Ag-nanoparticles using Persian gum as a carbohydrate polymer. The dressings showed good sprayability, antibacterial activity, and biocompatibility, indicating high potential for wound repair.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Nanoscience & Nanotechnology
Changchang Kong, Shijunyin Chen, Wenhao Ge, Yang Zhao, Xiaodong Xu, Shiming Wang, Jianfa Zhang
Summary: In this study, an antibacterial and anti-inflammatory wound dressing based on riclin and silver nanoparticles was developed. The results showed that the dressing had sustained release of silver nanoparticles, effectively suppressed pathogen growth, and had negligible toxicity to human cells. In addition, it promoted faster and smoother wound healing while reducing the expression of inflammatory mediators.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Polymer Science
Harsh Gupta, Chetna Verma, Ankita Sharma, Pratibha Singh, Manali Somani, Samrat Mukhopadhyay, Ankit Shekhar, Bhuvanesh Gupta
Summary: In this study, wound dressings were prepared using polyethylene terephthalate fabric as the base material. The fabric was modified by alkaline hydrolysis to enhance its functionality, and silver was immobilized on the fabric as a bioactive component. The results showed that the developed material exhibited excellent antimicrobial properties and mechanical performance, making it suitable for use as wound dressings.
JOURNAL OF POLYMER RESEARCH
(2022)
Article
Chemistry, Applied
Xiangyan Chen, Hongjin Li, Xiaoni Qiao, Tianze Jiang, Xue Fu, Yue He, Xia Zhao
Summary: Marine agarose oligosaccharides and silver nanoparticles combined with antimicrobial peptides form a novel composite nanomaterial, which shows significant promoting effects on wound healing with strong antimicrobial activities and good biocompatibility.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Mohammed H. Alqarni, Ahmed Foudah, Aftab Alam, Mohammad A. Salkini, Magdy M. Muharram, Nikolaos E. Labrou, Piyush Kumar
Summary: This study aims to enhance the anti-fungal activity of rutin by encapsulating it in a nanocarrier system. The developed rutin-SNP gel showed significant activity against C. albicans skin candidiasis and was found to be biocompatible.
Review
Pharmacology & Pharmacy
Sibusiso Alven, Buhle Buyana, Zizo Feketshane, Blessing Atim Aderibigbe
Summary: Nanofibrous scaffolds loaded with silver nanoparticles show promising biological and mechanical outcomes in wound healing, with good antibacterial and bioactive properties.
Article
Materials Science, Multidisciplinary
Huan Fang, Dongrun Li, Longquan Xu, Yi Wang, Xu Fei, Jing Tian, Yao Li
Summary: A novel antibacterial cotton gauze wound dressing was developed through grafting ionic liquid for antibacterial properties, which was evaluated in terms of biocompatibility, antibacterial ability, and wound healing properties. The results showed potential advantages for biomedical applications.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Polymer Science
Irina Popescu, Marieta Constantin, Gheorghe Solcan, Daniela Luminita Ichim, Delia Mihaela Rata, Loredana Horodincu, Carmen Solcan
Summary: In this study, a composite hydrogel based on chitosan (CS) and polyvinyl alcohol (PVA) embedding silver nanoparticles (AgNPs) with antibacterial properties and ibuprofen (Ib) as an anti-inflammatory agent was developed. The hydrogel displayed good mechanical properties, high swelling degree, sustained drug delivery, and showed strong antibacterial activity. In vivo experiments demonstrated that the hydrogel accelerated wound healing process by activating downstream cascades and supporting the healing process of inflammation and promoting cell migration and proliferation.
Review
Polymer Science
Zizo Feketshane, Sibusiso Alven, Blessing Atim Aderibigbe
Summary: Factors such as bacterial infections, underlying conditions, malnutrition, obesity, aging, and smoking contribute to delayed wound healing. Gellan gum, a biopolymer with excellent properties, can be utilized for the development of wound dressings that promote accelerated wound healing.
Article
Chemistry, Physical
Kanchan Mehta, Virendra Kumar, Bhuvaneshwar Rai, Meenu Talwar, Gulshan Kumar
Summary: This study developed an antibacterial and hydrophilic non-woven polypropylene fabric with excellent breathability through a two-step process. Acrylic acid was introduced onto the fabric using simultaneous irradiation graft polymerization and pre-irradiation graft polymerization methods. The fabric was then immobilized with silver nanoparticles. The resulting fabric samples exhibited desired properties and demonstrated excellent antibacterial efficacy.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Mohammad Javed Ansari, Najeeb Ur Rehman, Elmoatasim Ibnouf, Ahmed Alalaiwe, Majid Ahmad Ganaie, Ameeduzzafar Zafar
Summary: This research article presents the development, characterization, stability, antimicrobial activity, antispasmodic activity, and antidiarrheal activity of silver nanoparticles synthesized and stabilized by a polymeric coating of gum tragacanth solution. The study found that the silver nanoparticles exhibited good stability and significant antimicrobial, antispasmodic, and antidiarrheal activities.
Article
Chemistry, Applied
M. R. El-Aassar, Omar M. Ibrahim, Moustafa M. G. Fouda, Hala Fakhry, Jamaan Ajarem, Saleh N. Maodaa, Ahmed A. Allam, Elsayed E. Hafez
Summary: The wound dressing made of chitosan, gelatin, polyvinyl pyrmlidone, and embedded silver nanoparticles showed strong antibacterial activity against pathogenic bacteria and reduced the expression of antibiotic resistance genes. This cost-effective membrane has a promising application in treating severe diabetic and burn wound infections.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Analytical
Mehrez E. El-Naggar, Ola A. Abu Ali, Dalia Saleh, M. A. Abu-Saied, M. K. Ahmed, E. Abdel-Fattah, S. F. Mansour
Summary: By combining hydroxyapatite (HAP), graphene oxide, and vivianite in a ternary nanocomposite with three phases and shapes, the cell viability of osteoblast cells was increased to 97.6% +/- 4 in vitro. The nanocomposite showed decreased crystal size, increased roughness peak height, and exhibited antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), making it suitable for various medical applications.
Article
Chemistry, Analytical
Mohamed H. El-Newehy, Hak Yong Kim, Tawfik A. Khattab, Mehrez E. El-Naggar
Summary: A photochromic and long-lasting photoluminescent transparent, rigid, UV-protective, and superhydrophobic poly(methyl methacrylate) (PMMA) plastic has been developed, capable of switching colors under UV irradiation. The PMMA plastic, prepared through a simple polymerization process immobilizing alkaline earth aluminate nanoparticles, exhibited enhanced UV shielding and superhydrophobicity, with demonstrated photoluminescence properties.
Article
Materials Science, Multidisciplinary
Sarah Alharthi, Mehrez E. El-Naggar, M. A. Abu-Saied, Tawfik A. Khattab, Dalia Saleh
Summary: A microporous cellulose acetate biopolymer test dipstick was constructed for colorimetric detection of urea, with proton transfer from hydrolysis of urea/urease reaction. Integration of TAM probe led to ratiometric changes in absorption spectra as a function of urea total content in the aqueous medium.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Ibrahim El-Tantawy El Sayed, Sami Ullah, Omar A. Al-Hartomy, Asmaa Mohammed Hasanein, Abdullah A. S. Ahmed, Khaled A. Kahilo, Mehrez E. El-Naggar
Summary: This study demonstrates the potential of using mesoporous silica oxide nanoemulsion to improve the solubility and pharmacological properties of neocryptolepine and its analogs, leading to increased safety and cell viability as an effective anticancer drug nanosystem.
Article
Polymer Science
M. Afifi, Mehrez E. El-Naggar, Shabbir Muhammad, Noweir Alghamdi, S. Wageh, Manal F. Abou Taleb, Mervat S. Mostafa, Salem Salem, Ibrahim El-Tantawy
Summary: Hydroxyapatite, niobium pentoxide, and graphene oxide were combined into a ternary nanocomposite with multifunctionality including antibacterial activity and biocompatible properties. The structure and surface morphology of the composite were analyzed using X-ray diffraction, scanning electron microscope, and transmittance electron microscope. The dimensions of the nanorods and spherical particles as well as the surface roughness were measured. In vitro experiments on osteoblast cell lines showed increased cell viability and inhibition zones for E. coli and S. aureus bacteria. These findings suggest that the composite has potential for biomedical applications.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2022)
Article
Chemistry, Analytical
Mehrez E. El-Naggar, Sahar Shaarawy, Mohamed S. Abdel-Aziz, Hazem Abd El Moneim Katry, Ahmed M. Youssef
Summary: The aim of this study was to prepare titanium oxide doped silver nanoparticles (Ag/TiO(2)NPs) and investigate their impact on the functionalization of cotton fabrics. The findings suggested that Ag/TiO(2)NPs-treated cotton fabrics exhibited superior antimicrobial and UPF properties, as well as enhanced tensile strength and elongation features.
Article
Materials Science, Paper & Wood
M. Rostamitabar, A. Ghahramani, G. Seide, S. Jockenhoevel, S. Ghazanfari
Summary: Cellulose and chitosan are promising materials for wound dressing due to their biocompatibility, biodegradability, and other characteristics. This study focuses on transforming these biopolymers into fibrous bioaerogels, which can greatly enhance their functional and structural properties. Wet spun chitosan-cellulose aerogel microfibers (CHCLAFs) were successfully produced using supercritical CO2 drying, and loaded with ibuprofen for wound dressing application. The CHCLAFs exhibited favorable characteristics, such as low density, high porosity, large specific surface area, water absorbability, antibacterial properties, cytotoxicity, and sustained drug release. These findings indicate that CHCLAFs have the potential to be used as effective wound dressing materials.
Article
Biology
Soheila Zare, Mahnaz Mohammadpour, Zhila Izadi, Samaneh Ghazanfari, Samad Nadri, Hadi Samadian
Summary: A porous, non-toxic, and degradable scaffold has been designed and produced to mimic bone tissue and provide a suitable environment for cell and tissue growth, which has been demonstrated to be used for treating bone defects and reconstructing damaged bone.
Correction
Materials Science, Paper & Wood
Mehrez E. El-Naggar, Tawfik A. Khattab, Meram S. Abdelrahman, Ali Aldalbahi, Mohammad Rafe Hatshan
Article
Biochemistry & Molecular Biology
Dalia A. Elsherbiny, Abdelrahman M. Abdelgawad, Tharwat I. Shaheen, Nayera A. M. Abdelwahed, Stefan Jockenhoevel, Samaneh Ghazanfari
Summary: Long-term application of antibiotics on wounds has led to drug-resistant bacterial infections. In this study, a series of antimicrobial compounds were synthesized and incorporated into thermoresponsive wound dressing patches. The dressings showed improved properties and had clear antimicrobial effects against tested microorganisms. This approach of synthesizing new antimicrobial molecules and incorporating them into nanofibers shows great potential for smart and innovative dressings.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Celien A. M. Jacobs, Abdelrahman M. Abdelgawad, Stefan Jockenhoevel, Keita Ito, Samaneh Ghazanfari
Summary: In this study, a novel biomimetic artificial intervertebral disc replacement (bioAID) with a swelling hydrogel core as nucleus pulposus, a fiber jacket as annulus fibrosus, and metal endplates was developed. Various warp-knitted textile structures were evaluated to ensure structural integrity, swelling constraint, and integration similar to a natural IVD. The 2 x 1 and 2 x 1 with pillar stitch stitch patterns showed the most suitable pore size range for cell infiltration and had the highest strength under compression loading.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Engineering, Biomedical
Celien A. M. Jacobs, S. Amir Kamali, Abdelrahman M. Abdelgawad, Bjorn P. Meij, Samaneh Ghazanfari, Marianna A. Tryfonidou, Stefan Jockenhoevel, Keita Ito
Summary: A novel biomimetic artificial intervertebral disc (bioAID) replacement implant has been developed and evaluated for its design safety based on biomechanical parameters. The results indicate that the implant can withstand shear-compression loads and mimic the behavior of natural disc under a diurnal loading pattern.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Orthopedics
Celien A. M. Jacobs, Remco J. P. Doodkorte, S. Amir Kamali, Abdelrahman M. Abdelgawad, Samaneh Ghazanfari, Stefan Jockenhoevel, J. J. Chris Arts, Marianna A. Tryfonidou, Bjorn P. Meij, Keita Ito
Summary: The study shows that biomimetic artificial intervertebral disc replacement can mimic the kinematics of the replaced disc and better protect the adjacent discs compared to fusion surgery. Therefore, using the new biomimetic artificial disc replacement is a promising treatment alternative for severely degenerated discs.
Article
Pharmacology & Pharmacy
Maryam Asadi, Zeinab Salehi, Mohammad Akrami, Mohammadreza Hosseinpour, Stefan Jockenhoevel, Samaneh Ghazanfari
Summary: This study aimed to design and produce pH-responsive drug release 3D printed tablet shells for colon-specific oral drug administration. By investigating the effects of polymer blending ratios and MC concentrations on the physical, thermal, and material properties of the tablets, as well as the in vitro drug release kinetics, the optimal combination was identified, which exhibited good printability, processability, and drug release kinetics, as well as non-cytotoxicity. This innovative pharmaceutical approach holds the potential for personalized medicine.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Materials Science, Biomaterials
Dalia A. Elsherbiny, Abdelrahman M. Abdelgawad, Bahaa A. Hemdan, Ahmed S. Montaser, Ibrahim El-Tantawy El-Sayed, Stefan Jockenhoevel, Samaneh Ghazanfari
Summary: Microbial infection is a common obstacle in wound healing, but existing antibiotics are becoming less effective due to drug resistance. In this study, a new approach using α-aminophosphonate derivatives as antimicrobial agents incorporated into cryogels was proposed. The most effective derivative, cinnamaldehyde-based derivative (Cinnam), was loaded into the cryogels, which showed superior physical properties and sustained drug release. The Cinnam-loaded cryogel demonstrated high efficacy against both Gram-negative and Gram-positive bacteria, making it a promising solution for managing wound infection.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
