☆ 4.7 Article

Arterial Wall Inflammation and Increased Hematopoietic Activity in Patients With Primary Aldosteronism

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

Journal

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Volume 105, Issue 5, Pages -

Publisher

ENDOCRINE SOC

DOI: 10.1210/clinem/dgz306

Keywords

primary aldosteronism; inflammation; atherosclerosis; immune system; mineralocorticoid; F-18-FDG PET-CT

Funding

European Union Horizon 2020 research and innovation program REPROGRAM [667837]
Netherlands Organization for Scientific Research Spinoza Grant [NWO SPI 94-212]
Competitiveness Operational Programme grant of the Romanian Ministry of European Funds [P_37_762, MySMIS 103587]
Dutch Heart Foundation [JTC2018, 2018T093, CVON2012-03, CVON2018-27]
Deutsche Forschungsgemeinschaft [CRC/TRR 205]

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Abstract

Context: Primary aldosteronism (PA) confers an increased risk of cardiovascular disease (CVD), independent of blood pressure. Animal models have shown that aldosterone accelerates atherosclerosis through proinflammatory changes in innate immune cells; human data are scarce. Objective: The objective of this article is to explore whether patients with PA have increased arterial wall inflammation, systemic inflammation, and reprogramming of monocytes. Design: A cross-sectional cohort study compared vascular inflammation on 2'-deoxy-2'-(F-18) fluoro-D-glucose; (F-18-FDG) positron emission tomography-computed tomography, systemic inflammation, and monocyte phenotypes and transcriptome between PA patients and controls. Setting: This study took place at Radboudumc and Rijnstate Hospital, the Netherlands. Patients: Fifteen patients with PA and 15 age-, sex-, and blood pressure-matched controls with essential hypertension (EHT) participated. Main Outcome Measures and Results: PA patients displayed a higher arterial F-18-FDG uptake in the descending and abdominal aorta (P <.01, P <.05) and carotid and iliac arteries (both P <.01). In addition, bone marrow uptake was higher in PA patients (P <.05). Although PA patients had a higher monocyte-to-lymphocyte ratio (P <.05), systemic inflammatory markers, cytokine production capacity, and transcriptome of circulating monocytes did not differ. Monocyte-derived macrophages from PA patients expressed more TNFA; monocyte-derived macrophages of healthy donors cultured in PA serum displayed increased interleukin-6 and tumor necrosis factor-a production. Conclusions: Because increased arterial wall inflammation is associated with accelerated atherogenesis and unstable plaques, this might importantly contribute to the increased CVD risk in PA patients. We did not observe inflammatory reprogramming of circulating monocytes. However, subtle inflammatory changes are present in the peripheral blood cell composition and monocyte transcriptome of PA patients, and in their monocyte-derived macrophages. Most likely, arterial inflammation in PA requires interaction between various cell types.

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7

Not enough ratings

Secondary Ratings

Novelty

Significance

Scientific rigor

Rate this paper

Omental Hibernoma Revealed by F-18-FDG PET/CT

Jin Qi, Elizabeth Kurian, Orhan K. oez

Summary: Hibernomas are rare benign tumors originating from fetal brown adipose tissue. They can occur in various parts of the body, with thigh, shoulder, back, and neck being the most common locations, and are rarely found in the abdominal cavity, retroperitoneum, breast, bones, scrotum, and perirectum. We present a case of a 58-year-old woman with a mediastinal mass, who was incidentally found to have an FDG-avid fat-containing lesion in the omentum abutting the stomach.

CLINICAL NUCLEAR MEDICINE (2023)