Article
Endocrinology & Metabolism
Yang Xu, Li Shen, Lianyong Liu, Zhenlin Zhang, Weiwei Hu
Summary: This study investigated the profile of serum undercarboxylated osteocalcin (ucOC) levels and their associations with bone mineral density (BMD), bone turnover markers (BTMs), and prevalence of osteopenia and osteoporosis in the Chinese population. The results showed that ucOC levels were higher in men than women and decreased with age until the age of 50, after which they increased. Higher ucOC levels were correlated with lower BMD values and higher levels of BTMs in both men and women. Furthermore, an increase in ucOC levels was associated with an increased risk of osteopenia and osteoporosis in both genders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Juan J. Lopez-Gomez, Jose L. Perez-Castrillon, Isabel Garcia de Santos, Maria Perez-Alonso, Olatz Izaola-Jauregui, David Primo-Martin, Daniel A. De Luis-Roman
Summary: This study examined the differences in bone metabolism between postmenopausal women with and without obesity, and compared the risk of fracture at five years between these groups.
Article
Endocrinology & Metabolism
Christian Meier, Richard Eastell, Dominique D. Pierroz, Nancy E. Lane, Nasser Al-Daghri, Atsushi Suzuki, Nicola Napoli, Ambrish Mithal, Marlene Chakhtoura, Ghada El-Hajj Fuleihan, Serge Ferrari
Summary: This review provides a summary of current data on biochemical markers in relation to bone fragility and fracture risk in diabetes. The results show that although bone resorption and bone formation markers are not effective predictors of fracture risk in diabetes, osteoporosis drugs have similar effects on bone turnover markers in both diabetics and nondiabetics, resulting in reduced fracture risk. Other biochemical markers related to bone and glucose metabolism, such as sclerostin, glycated hemoglobin A(1c), and inflammatory markers, as well as hormones like insulin-like growth factor-1 and calciotropic hormones, are also associated with bone mineral density and fracture risk in diabetes. HbA(1c) levels appear to be the most reliable estimate of fracture risk, while bone turnover markers can be used to monitor the effects of antiosteoporosis therapy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Mingwei Hu, Yifan Zhang, Jianjun Guo, Cuicui Guo, Xue Yang, Xue Ma, Hao Xu, Shuai Xiang
Summary: This study evaluated the changes in bone mineral density and bone turnover markers after denosumab and romosozumab therapies in patients with osteoporosis. The results showed that the romosozumab group exhibited greater changes in lumbar BMD and bone turnover markers at 3 months of treatment, while changes in BMD of total hip and femoral neck were relatively delayed. From 6 to 12 months of treatment, romosozumab showed greater changes in bone mineral density and markers of bone turnover.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Julie Abildgaard, Thorkil Ploug, Anette Tonnes Pedersen, Pia Eiken, Bente Klarlund Pedersen, Jens Juul Holst, Bolette Hartmann, Birgitte Lindegaard
Summary: Despite higher fasting levels, postmenopausal women exhibit comparable postprandial suppression of bone turnover markers to premenopausal women. None of the postprandial gut hormone increases predict postprandial bone turnover suppression.
Article
Nutrition & Dietetics
Sara Quattrini, Barbara Pampaloni, Giorgio Gronchi, Francesca Giusti, Maria Luisa Brandi
Summary: Osteoporosis is a widespread public health issue, and the key to management and prevention lies in the correct lifestyle and proper nutrition. Research has shown that the Mediterranean diet is beneficial for reducing the incidence of chronic diseases and lowering the risk of fractures. Nutritional improvement and dietary surveys can help increase adherence to the Mediterranean diet, which is advantageous for osteoporosis prevention.
Article
Pediatrics
Tanju Celik, Ozlem Sangun, Sule Unal, Ali Balci, Sedat Motor
Summary: The study suggests that serum OPG concentration can be used as a biochemical marker for screening the development of osteoporosis in patients with beta-thalassemia major.
ITALIAN JOURNAL OF PEDIATRICS
(2022)
Article
Pharmacology & Pharmacy
Zhi Yang, Shu Xuan, Weihong Li, Wan Hu, Ping Tu, Peng Duan
Summary: This study compared the risk of osteoporotic fractures between urban and urban-rural fringe populations in southern China and explored the impact of bone turnover markers on fracture risk. The results showed that the urban-rural fringe populations had lower femoral neck bone mineral density and higher FRAX values compared to urban populations, especially among women. Combining FRAX with bone mineral density and bone turnover markers may provide a better prediction of fracture risk.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Xiaowen Zhang, Suhas Krishnamoorthy, Casey Tze-Lam Tang, Warrington Wen-Qiang Hsu, Gloria Hoi-Yee Li, Chor-Wing Sing, Kathryn Choon-Beng Tan, Bernard Man-Yung Cheung, Ian Chi-Kei Wong, Annie Wai-Chee Kung, Ching-Lung Cheung
Summary: This study investigated the association between bone health and incident type-2 diabetes mellitus (T2DM). The results showed that higher bone density is associated with an increased risk of T2DM.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Yinghao Wu, Shengting Wu, Erzhu Yang, Guowang Zhang, Qiang Shi, Jiaming Liang, XiaoFeng Lian, JianGuang Xu
Summary: Recent studies have investigated the association between PFN1 gene and bone-related diseases in Chinese subjects. The study found that certain SNPs in the PFN1 gene were associated with Bone Mineral Density (BMD), bone turnover markers, and osteoporotic fractures. These associations were observed in both males and females. The findings confirm the importance of PFN1 gene polymorphisms in bone health and fracture risk in the Chinese population.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Stefano Ciardullo, Emanuele Muraca, Francesca Zerbini, Giuseppina Manzoni, Gianluca Perseghin
Summary: The study investigated the association between liver steatosis and fibrosis with reduced bone mineral density in the US population aged 50 and above. Results showed a high prevalence of steatosis and significant fibrosis in the study population, but after adjustment, liver steatosis and fibrosis were not found to be associated with reduced BMD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
B. Hanusch, M. Prediger, S. P. Tuck, J. Walker, R. McNally, H. K. Datta
Summary: Men with low-trauma wrist fractures have higher bone turnover markers and lower bone mineral density compared to healthy controls. Bone turnover markers are negative predictors of bone mineral density and fracture risk in these men.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Chemistry, Medicinal
Naheed Aryaeian, Fatemehsadat Amiri, Seyedeh Tayebeh Rahideh, Jamileh Abolghasemi, Shima Jazayeri, Afsaneh Gholamrezayi, Manijeh Motevalian, Masoud Solaymani-Dodaran, Mohsen Taghizadeh, Elaheh Heshmati, Shahnaz Rimaz
Summary: The study suggests that C. mas extract may decrease BAP, PTH, and hsCRP levels in postmenopausal women, but has no beneficial effect on OC and TC.
PHYTOTHERAPY RESEARCH
(2021)
Article
Medical Laboratory Technology
Gregory A. Kline, Daniel T. Holmes
Summary: Bone turnover markers (BTM) are important for understanding the effect of anti-resorptives on osteoclast activity. Post-hoc trial data suggests that a 40% reduction in BTM may represent an appropriate response to therapy. However, applying this target threshold in individual patients is problematic due to measurement uncertainty and natural variation.
CLINICAL BIOCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Mitsuru Doi, Ko Chiba, Narihiro Okazaki, Choko Kondo, Shuta Yamada, Kazuaki Yokota, Akihiko Yonekura, Masato Tomita, Makoto Osaki
Summary: The study found that age-related changes in bone microstructure in men involve decreases in trabecular and cortical volumetric bone density, decreased trabecular number, cavitation of the trabecular structure, and increased cortical porosity. Femoral aBMD was strongly correlated with bone microstructure in the tibia, while biochemical markers showed almost no relationships with bone microstructure.