Relaxin’ the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders

Radiosynthesis and in Vivo Evaluation of Neuropeptide Y5 Receptor (NPY5R) PET Tracers

(2016) J. S. Dileep Kumar et al.   ACS Chemical Neuroscience

Stress activates the nucleus incertus and modulates plasticity in the hippocampo-medial prefrontal cortical pathway

(2016) Ramamoorthy Rajkumar et al.   BRAIN RESEARCH BULLETIN

Development of a Single-Chain Peptide Agonist of the Relaxin-3 Receptor Using Hydrocarbon Stapling

(2016) Keiko Hojo et al.   JOURNAL OF MEDICINAL CHEMISTRY

The serotonergic system in the neurobiology of depression: Relevance for novel antidepressants

(2016) Stephan Köhler et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Programming of stress pathways: A transgenerational perspective

(2016) Andrea Constantinof et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Inactivation of nucleus incertus impairs passive avoidance learning and long term potentiation of the population spike in the perforant path-dentate gyrus evoked field potentials in rats

(2016) Mohsen Nategh et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

DREADDs for Neuroscientists

(2016) Bryan L. Roth   NEURON

Potential of neuropeptide Y for preventing or treating post-traumatic stress disorder

(2016) Esther L. Sabban et al.   NEUROPEPTIDES

Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity

(2016) Tharindunee Jayakody et al.   PEPTIDES

Electrical microstimulation of the nucleus incertus induces forward locomotion and rotation in rats

(2016) Usman Farooq et al.   PHYSIOLOGY & BEHAVIOR

Animal models of major depression and their clinical implications

(2016) Boldizsár Czéh et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Comparative Distribution of Relaxin-3 Inputs and Calcium-Binding Protein-Positive Neurons in Rat Amygdala

(2016) Fabio N. Santos et al.   Frontiers in Neuroanatomy

Stress Response and Perinatal Reprogramming: Unraveling (Mal)adaptive Strategies

(2016) Laura Musazzi et al.   NEURAL PLASTICITY

Central relaxin-3 receptor (RXFP3) activation reduces elevated, but not basal, anxiety-like behaviour in C57BL/6J mice

(2015) Cary Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Stress In Utero: Prenatal Programming of Brain Plasticity and Cognition

(2015) Joerg Bock et al.   BIOLOGICAL PSYCHIATRY

The Concise Guide to PHARMACOLOGY 2015/16: Nuclear hormone receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sex-Specific Effects of Relaxin-3 on Food Intake and Brain Expression of Corticotropin-Releasing Factor in Rats

(2015) Christophe Lenglos et al.   ENDOCRINOLOGY

Regular theta-firing neurons in the nucleus incertus during sustained hippocampal activation

(2015) Sergio Martínez-Bellver et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Differential effects of central administration of relaxin-3 on food intake and hypothalamic neuropeptides in male and female rats

(2015) J. Calvez et al.   GENES BRAIN AND BEHAVIOR

Ascending Control of Arousal and Motivation: Role of Nucleus Incertus and its Peptide Neuromodulators in Behavioural Responses to Stress

(2015) S. Ma et al.   JOURNAL OF NEUROENDOCRINOLOGY

Neighborhood matters: divergent patterns of stress-induced plasticity across the brain

(2015) Sumantra Chattarji et al.   NATURE NEUROSCIENCE

Anxiogenic drug administration and elevated plus-maze exposure in rats activate populations of relaxin-3 neurons in the nucleus incertus and serotonergic neurons in the dorsal raphe nucleus

(2015) A.J. Lawther et al.   NEUROSCIENCE

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

(2015) Christopher Southan et al.   NUCLEIC ACIDS RESEARCH

Evidence of D2 receptor expression in the nucleus incertus of the rat

(2015) Jigna Rajesh Kumar et al.   PHYSIOLOGY & BEHAVIOR

Altered relaxin family receptors RXFP1 and RXFP3 in the neocortex of depressed Alzheimer’s disease patients

(2015) Jasinda H. Lee et al.   PSYCHOPHARMACOLOGY

Serotonergic Therapies for Cognitive Symptoms in Alzheimer’s Disease: Rationale and Current Status

(2014) Maria J. Ramirez et al.   DRUGS

Relaxin-3 stimulates the neuro-endocrine stress axis via corticotrophin-releasing hormone

(2014) B M McGowan et al.   JOURNAL OF ENDOCRINOLOGY

Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress

(2014) Loren D. Walensky et al.   JOURNAL OF MEDICINAL CHEMISTRY

The organization of the stress system and its dysregulation in depressive illness

(2014) P W Gold   MOLECULAR PSYCHIATRY

Regulation of expression of relaxin-3 and its receptor RXFP3 in the brain of diet-induced obese rats

(2014) Christophe Lenglos et al.   NEUROPEPTIDES

PACAP receptor gene polymorphism impacts fear responses in the amygdala and hippocampus

(2014) J. S. Stevens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animal models as tools to study the pathophysiology of depression

(2014) Helena M. Abelaira et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuropsychiatric diseases?

(2014) Craig M. Smith et al.   Frontiers in Pharmacology

Neuropathology of stress

(2013) Paul J. Lucassen et al.   ACTA NEUROPATHOLOGICA

Chemical synthesis and orexigenic activity of rat/mouse relaxin-3

(2013) Mohammed Akhter Hossain et al.   AMINO ACIDS

Central relaxin-3 receptor (RXFP3) activation decreases anxiety- and depressive-like behaviours in the rat

(2013) Philip J. Ryan et al.   BEHAVIOURAL BRAIN RESEARCH

Electrolytic lesion of the nucleus incertus retards extinction of auditory conditioned fear

(2013) C.W. Pereira et al.   BEHAVIOURAL BRAIN RESEARCH

Neuropeptide S receptor gene is associated with cortisol responses to social stress in humans

(2013) Robert Kumsta et al.   BIOLOGICAL PSYCHOLOGY

Acute antipsychotic treatments induce distinct c-Fos expression patterns in appetite-related neuronal structures of the rat brain

(2013) Ramamoorthy Rajkumar et al.   BRAIN RESEARCH

Selective lesioning of nucleus incertus with corticotropin releasing factor-saporin conjugate

(2013) Liying Corinne Lee et al.   BRAIN RESEARCH

The plasma levels of relaxin-2 and relaxin-3 in patients with diabetes

(2013) Xiaohui Zhang et al.   CLINICAL BIOCHEMISTRY

Hypercortisolemia and Glucocorticoid Receptor-Signaling Insufficiency in Alzheimer’ s Disease Initiation and Development

(2013) Elena Notarianni   Current Alzheimer Research

Protein–protein interactions as druggable targets: recent technological advances

(2013) Alicia P Higueruelo et al.   CURRENT OPINION IN PHARMACOLOGY

Corticotropin-releasing factor infusion into nucleus incertus suppresses medial prefrontal cortical activity and hippocampo-medial prefrontal cortical long-term potentiation

(2013) Usman Farooq et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Sex differences in the effects of chronic stress and food restriction on body weight gain and brain expression of CRF and relaxin-3 in rats

(2013) C. Lenglos et al.   GENES BRAIN AND BEHAVIOR

CRF system and mood disorders

(2013) Jean-Michel Aubry   JOURNAL OF CHEMICAL NEUROANATOMY

Heterogeneous responses of nucleus incertus neurons to corticotrophin-releasing factor and coherent activity with hippocampal theta rhythm in the rat

(2013) Sherie Ma et al.   JOURNAL OF PHYSIOLOGY-LONDON

Prediction of relaxin-3-induced downstream pathway resulting in anxiolytic-like behaviors in rats based on a microarray and peptidome analysis

(2013) Chihiro Miyamoto Nakazawa et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Memory, navigation and theta rhythm in the hippocampal-entorhinal system

(2013) György Buzsáki et al.   NATURE NEUROSCIENCE

Role of neuropeptides in anxiety, stress, and depression: From animals to humans

(2013) Viktória Kormos et al.   NEUROPEPTIDES

Single intranasal neuropeptide Y infusion attenuates development of PTSD-like symptoms to traumatic stress in rats

(2013) L.I. Serova et al.   NEUROSCIENCE

Relaxin-3/RXFP3 system regulates alcohol-seeking

(2013) P. J. Ryan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroendocrine regulation of appetitive ingestive behavior

(2013) Erin Keen-Rhinehart et al.   Frontiers in Neuroscience

Relaxin-3 is associated with metabolic syndrome and its component traits in women

(2012) Maivel H. Ghattas et al.   CLINICAL BIOCHEMISTRY

Neuronal correlates of appetite regulation in patients with schizophrenia: Is there a basis for future appetite dysfunction?

(2012) O. Lungu et al.   EUROPEAN PSYCHIATRY

Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus

(2012) D E Ganella et al.   GENE THERAPY

Anti-anxiety drugs reduce conflict-specific “theta”—A possible human anxiety-specific biomarker

(2012) Neil McNaughton et al.   JOURNAL OF AFFECTIVE DISORDERS

Minimization of Human Relaxin-3 Leading to High-Affinity Analogues with Increased Selectivity for Relaxin-Family Peptide 3 Receptor (RXFP3) over RXFP1

(2012) Fazel Shabanpoor et al.   JOURNAL OF MEDICINAL CHEMISTRY

Non-Monoaminergic Targets for the Development of Antidepressants: Focus on Neuropeptides

(2012) Mario Catena-Dell'Osso et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Drug discovery: In defence of the animal model

(2012) Richard M. Baldarelli   NATURE

Neuroreceptor imaging in depression

(2012) Jonathan B. Savitz et al.   NEUROBIOLOGY OF DISEASE

Neuronal Dynamics and Neuropsychiatric Disorders: Toward a Translational Paradigm for Dysfunctional Large-Scale Networks

(2012) Peter J. Uhlhaas et al.   NEURON

Effects of chronic plus acute prolonged stress on measures of coping style, anxiety, and evoked HPA-axis reactivity

(2012) Megan K. Roth et al.   NEUROPHARMACOLOGY

Glutamatergic projection from the nucleus incertus to the septohippocampal system

(2012) Ana Cervera-Ferri et al.   NEUROSCIENCE LETTERS

Structural biology and drug discovery for protein–protein interactions

(2012) Harry Jubb et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Relaxin-3 systems in the brain—The first 10 years

(2011) Craig M. Smith et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Relaxin polymorphisms associated with metabolic disturbance in patients treated with antipsychotics

(2011) Janet Munro et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Design, Synthesis, and Characterization of a Single-Chain Peptide Antagonist for the Relaxin-3 Receptor RXFP3

(2011) Linda M. Haugaard-Kedström et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor

(2011) Kerry J. Ressler et al.   NATURE

A pathophysiological framework of hippocampal dysfunction in ageing and disease

(2011) Scott A. Small et al.   NATURE REVIEWS NEUROSCIENCE

Prenatal stress induces long term stress vulnerability, compromising stress response systems in the brain and impairing extinction of conditioned fear after adult stress

(2011) M.K. Green et al.   NEUROSCIENCE

Nucleus incertus—An emerging modulatory role in arousal, stress and memory

(2011) Philip J. Ryan et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Relaxin-3-Deficient Mice Showed Slight Alteration in Anxiety-Related Behavior

(2011) Yoshihisa Watanabe et al.   Frontiers in Behavioral Neuroscience

Theta synchronization between the hippocampus and the nucleus incertus in urethane-anesthetized rats

(2011) Ana Cervera-Ferri et al.   EXPERIMENTAL BRAIN RESEARCH

REVIEW: Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy

(2010) Cedric Viero et al.   CNS Neuroscience & Therapeutics

Relaxin-3/INSL7 Regulates the Stress-response System in the Rat Hypothalamus

(2010) Yoshihisa Watanabe et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Animal models of neuropsychiatric disorders

(2010) Eric J Nestler et al.   NATURE NEUROSCIENCE

Synthesis, characterization, and monkey positron emission tomography (PET) studies of [18F]Y1-973, a PET tracer for the neuropeptide Y Y1 receptor

(2010) Eric D. Hostetler et al.   NEUROIMAGE

Neurochemical basis for symptomatic treatment of Alzheimer's disease

(2010) Paul T. Francis et al.   NEUROPHARMACOLOGY

Behavioral Phenotyping of Mixed Background (129S5:B6) Relaxin-3 Knockout Mice

(2009) Craig M. Smith et al.   Annals of the New York Academy of Sciences

Probing the Functional Domains of Relaxin-3 and the Creation of a Selective Antagonist for RXFP3/GPCR135 over Relaxin Receptor RXFP1/LGR7

(2009) Changlu Liu et al.   Annals of the New York Academy of Sciences

Metabolic and Neuroendocrine Responses to RXFP3 Modulation in the Central Nervous System

(2009) Steven W. Sutton et al.   Annals of the New York Academy of Sciences

Low Cerebrospinal Fluid Neuropeptide Y Concentrations in Posttraumatic Stress Disorder

(2009) Renu Sah et al.   BIOLOGICAL PSYCHIATRY

Sustained Conditioned Responses in Prelimbic Prefrontal Neurons Are Correlated with Fear Expression and Extinction Failure

(2009) A. Burgos-Robles et al.   JOURNAL OF NEUROSCIENCE

Modulation of hippocampal theta oscillations and spatial memory by relaxin-3 neurons of the nucleus incertus

(2009) S. Ma et al.   LEARNING & MEMORY

Chronic icv oxytocin attenuates the pathological high anxiety state of selectively bred Wistar rats

(2009) D.A. Slattery et al.   NEUROPHARMACOLOGY

Swim stress excitation of nucleus incertus and rapid induction of relaxin-3 expression via CRF1 activation

(2009) Avantika Banerjee et al.   NEUROPHARMACOLOGY

Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety

(2009) Michael Davis et al.   NEUROPSYCHOPHARMACOLOGY

Behavioral effects of neuropeptides in rodent models of depression and anxiety

(2009) Susan Rotzinger et al.   PEPTIDES

Relaxin-3 stimulates the hypothalamic-pituitary-gonadal axis

(2008) B. M. McGowan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sensory Gating Endophenotype Based on Its Neural Oscillatory Pattern and Heritability Estimate

(2008) L. Elliot Hong et al.   ARCHIVES OF GENERAL PSYCHIATRY

Structure of the R3/I5 Chimeric Relaxin Peptide, a Selective GPCR135 and GPCR142 Agonist

(2008) Linda M. Haugaard-Jönsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neural Circuitry of Stress-Induced Insomnia in Rats

(2008) G. Cano et al.   JOURNAL OF NEUROSCIENCE

Removing Obstacles in Neuroscience Drug Discovery: The Future Path for Animal Models

(2008) Athina Markou et al.   NEUROPSYCHOPHARMACOLOGY

Central and Peripheral Regulation of Food Intake and Physical Activity: Pathways and Genes

(2008) Natalie R. Lenard et al.   Obesity

The HPA axis in major depression: classical theories and new developments

(2008) Carmine M. Pariante et al.   TRENDS IN NEUROSCIENCES

Developmental expression and serotonergic regulation of relaxin 3/INSL7 in the nucleus incertus of rat brain

(2007) Yasumasa Miyamoto et al.   REGULATORY PEPTIDES