Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 121, Issue 5-6, Pages 3235-3247Publisher
WILEY
DOI: 10.1002/jcb.29591
Keywords
biomarker; epithelial-mesenchymal transformation; HOTAIR; immune signaling; nasopharyngeal carcinoma
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Funding
- National Natural Science Foundation of China [81872200, 31900558, 81372816]
- Fundamental Research Funds for the Central Universities [2042018kf0091]
- Natural Science Foundation of Hubei Province [2018CFB510]
- Zhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund [CXPY2017029]
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Long noncoding RNA HOX antisense intergenic RNA (HOTAIR) is overexpressed in many types of cancers, and substantial evidence has suggested a link between cancers and HOTAIR. In the present study, we reviewed the structure and the corresponding biologic function of HOTAIR to clarify its molecular mechanism in cancer progression. HOTAIR promotes proliferation, invasion, and migration, and inhibits apoptosis in cancer cells. HOTAIR also participates in the pathogenesis and progression of cancer by regulating inflammation and immune signaling. These findings suggested that HOTAIR is a novel biomarker in human cancers.
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