Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 24, Issue 2, Pages 1428-1436Publisher
WILEY
DOI: 10.1111/jcmm.14822
Keywords
angiogenesis; microRNAs; retinal pigment epithelial cells
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Funding
- Universidad Catolica de Valencia San Vicente Martir research Fund [2018-128-001, 2019-128-001]
- Centro de Investigacion Traslacional San Alberto Magno, Universidad Catolica de Valencia San Vicente Martir [2018-128-001, 2019-128-001]
- Escuela de Doctorado Universidad Catolica de Valencia San Vicente Martir [EDUCV-PRE-2015-006, EDUCVPRE-2016-005]
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miR-205-5p is known to be involved in VEGF-related angiogenesis and seems to regulate associated cell signalling pathways, such as cell migration, proliferation and apoptosis. Therefore, several studies have focused on the potential role of miR-205-5p as an anti-angiogenic factor. Vascular proliferation is observed in diabetic retinopathy and the 'wet' form of age-related macular degeneration. Today, the most common treatments against these eye-related diseases are anti-VEGF therapies. In addition, both AMD and DR are typically associated with oxidative stress; hence, the use of antioxidant agents is accepted as a co-adjuvant therapy for these patients. According to previous data, ARPE-19 cells release pro-angiogenic factors when exposed to oxidative insult, leading to angiogenesis. Matching these data, results reported here, indicate that miR-205-5p is modulated by oxidative stress and regulates VEGFA-angiogenesis. Hence, miR-205-5p is proposed as a candidate against eye-related proliferative diseases.
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