Article
Public, Environmental & Occupational Health
Junquan Chen, Yunpeng Bai, Hong Liu, Mingzhen Qin, Zhigang Guo
Summary: The study aimed to create a prediction model for in-hospital death in Chinese patients with acute type A aortic dissection (ATAAD). A retrospective derivation cohort of 340 patients from Tianjin and a retrospective validation cohort of 153 patients from Nanjing were used. Variable selection was done using least absolute shrinkage and selection operator analysis, and risk scoring was done using logistic regression coefficients. A risk classifier was established based on independent baseline data using a multivariable logistic model. The prediction performance was evaluated using the receiver operating characteristic curve (ROC). Individualized clinical decision-making was conducted using decision curve analysis (DCA). The risk prediction model showed good performance in predicting in-hospital death in ATAAD patients.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Weiqi Feng, Huili Li, Qiuji Wang, Chenxi Li, Jinlin Wu, Jue Yang, Ruixin Fan
Summary: This study aimed to assess the impact of neutrophil count on patients with acute type A aortic dissection (ATAAD). The results showed that elevated neutrophil count was significantly associated with higher in-hospital mortality. Therefore, neutrophil count is an independent risk factor for in-hospital mortality in ATAAD patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Hong Liu, Ying-yuan Zhang, Xiao-hang Ding, Si-chong Qian, Ming-yu Sun, Al-Wajih Hamzah, Ya-nan Gao, Yong-feng Shao, Hai-yang Li, Kai Wang, Bu-qing Ni, Hong-jia Zhang
Summary: This study evaluated the impact of proximal vs extensive repair on mortality in patients with acute type A aortic dissection and examined how patient characteristics influence this impact. The results showed that extensive repair had a higher operative mortality compared to proximal repair, indicating a higher risk. The choice of surgery should be based on individualized risk prediction and treatment effectiveness.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Yanjuan Lin, Qiong Chen, Yanchun Peng, Yiping Chen, Xizhen Huang, Lingyu Lin, Xu Zhang, Liang-Wan Chen
Summary: This retrospective study on AAAD patients found that lower PNI may be independently associated with in-hospital mortality, along with factors like hypertension and operation time. It suggests that PNI could serve as a predictive marker for postoperative outcomes in AAAD patients.
Article
Medicine, General & Internal
Guifang Yang, Wen Peng, Yang Zhou, Huaping He, Xiaogao Pan, Xizhao Li, Xiangping Chai
Summary: The study revealed a negative correlation between admission systolic blood pressure (SBP) and in-hospital deaths in acute type A aortic dissection (AAD) patients, showing a non-linear relationship where SBP was negatively correlated with in-hospital mortality when <= 120 mmHg. Subgroup analysis indicated a more pronounced effect in the male population and non-diabetic individuals.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Zhiwei Tang, Yongfeng Shao
Summary: This study aims to investigate whether postoperative thrombocytopenia following open aortic surgery with a median sternotomy can predict morbidity and mortality. The results indicate a significant association between postoperative thrombocytopenia and early-term mortality and acute renal injury.
ANNALS OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Shulun Ma, Qian Xu, Qinghua Hu, Lingjin Huang, Dongkai Wu, Guoqiang Lin, Xuliang Chen, Wanjun Luo
Summary: This study found that pre- and post-operative hyperuricemia may be associated with worsened outcomes in patients undergoing surgery for acute type A aortic dissection (AAAD). The post-operative day 1 (POD1) serum uric acid (UA) level has a predictive role in 30-day mortality in AAAD repair patients.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Cardiac & Cardiovascular Systems
Zhao An, Keng Zhong, Yangyong Sun, Lin Han, Zhiyun Xu, Bailing Li
Summary: This study aimed to investigate the risk factors for in-hospital mortality in acute type A aortic dissection (ATAAD) patients who underwent the total arch procedure. The results showed that older age, preoperative renal dysfunction, long cardiopulmonary bypass (CPB) time, and massive intraoperative transfusion were independent risk factors for in-hospital mortality in ATAAD patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Yu-Ting Cheng, Kuang-Tso Lee, Chih-Hsiang Chang, Victor Chien-Chia Wu, Yi-Shin Chan, Dong-Yi Chen, Pao-Hsien Chu, An-Hsun Chou, Kuo-Sheng Liu, Shao-Wei Chen
Summary: This study evaluated the effectiveness of dexmedetomidine in patients who received surgery for type A aortic dissection. The results showed that post-operative dexmedetomidine infusion significantly reduced the risk of severe acute kidney injury and newly-onset dialysis in these patients.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Weiqi Feng, Qiuji Wang, Chenxi Li, Jinlin Wu, Juntao Kuang, Jue Yang, Ruixin Fan
Summary: This study explores the relationship between admission D-dimer levels and in-hospital major adverse events (MAE) in patients with acute type A aortic dissection (ATAAD). The results indicate that increasing D-dimer levels are independently associated with MAE during hospitalization, suggesting that D-dimer can be used as a useful prognostic biomarker before surgery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Kevin R. An, Charles de Mestral, Derrick Y. Tam, Feng Qiu, Maral Ouzounian, Thomas F. Lindsay, Harindra C. Wijeysundera, Jennifer C-Y Chung
Summary: This study found poor adherence to guideline-directed imaging surveillance following ATAAD repair, while long-term mortality and reinterventions rates remained high. Further research is needed to determine if guidelines should be modified.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Toshiyuki Takahashi, Hideaki Yoshino, Koichi Akutsu, Tomoki Shimokawa, Hitoshi Ogino, Takashi Kunihara, Michio Usui, Kazuhiro Watanabe, Mitsuhiro Kawata, Hiroshi Masuhara, Manabu Yamasaki, Takeshi Yamamoto, Ken Nagao, Morimasa Takayama
Summary: This study found that female patients with type B acute aortic dissection are typically older, have more intramural hematoma cases, less end-organ malperfusion, and higher in-hospital mortality compared to male patients. However, after multivariable adjustment, gender was not associated with in-hospital mortality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Meng-meng Wang, Min-Tao Gai, Bao-zhu Wang, Gulinazi Yesitayi, Yi-Tong Ma, Xiang Ma
Summary: A prediction model was constructed to predict the risk of in-hospital death in patients with acute type B aortic dissection. The model included white blood cell count, hemoglobin level, lactate dehydrogenase, procalcitonin, and left ventricular ejection fraction as independent risk factors for in-hospital deaths. The model showed good predictive ability and consistency.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Manabu Yamasaki, Hideaki Yoshino, Takashi Kunihara, Koichi Akutsu, Tomoki Shimokawa, Hitoshi Ogino, Mitsuhiro Kawata, Toshiyuki Takahashi, Michio Usui, Kazuhiro Watanabe, Hiroshi Masuhara, Takeshi Yamamoto, Ken Nagao, Morimasa Takayama
Summary: This study found that male sex, use of percutaneous circulatory assist devices, shock, cardiac and cerebral ischemia are independent preoperative risk factors for early mortality after acute type A aortic dissection repair, while cardiac tamponade, cerebral and mesenteric ischemia are independent postoperative risk factors.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Tuo Guo, Zhuo Fang, Guifang Yang, Yang Zhou, Ning Ding, Wen Peng, Xun Gong, Huaping He, Xiaogao Pan, Xiangping Chai
Summary: Acute aortic dissection is a potentially fatal cardiovascular disorder with high mortality rates. This study utilized machine learning algorithms to predict in-hospital mortality, finding that the extreme gradient boost model was the most effective and identified treatment, type of acute aortic dissection, and ischemia-modified albumin levels as significant predictors of mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)