A novel peptide exerts potent immunosuppression by blocking the two-site interaction of NFAT with calcineurin

Dendritic cell MST1 inhibits Th17 differentiation

(2017) Chunxiao Li et al.   Nature Communications

RCAN-11R peptide provides immunosuppression for fully mismatched islet allografts in mice

(2017) Hirofumi Noguchi et al.   Scientific Reports

Quercetin targets the interaction of calcineurin with LxVP-type motifs in immunosuppression

(2016) Yane Zhao et al.   BIOCHIMIE

Enzymatic and thermodynamic analysis of calcineurin inhibition by RCAN1

(2015) Yipeng Ma et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Poly(inosinic-cytidylic) Acid–Triggered Exacerbation of Experimental Asthma Depends on IL-17A Produced by NK Cells

(2015) Lars P. Lunding et al.   JOURNAL OF IMMUNOLOGY

Toll-Like Receptors Promote Mitochondrial Translocation of Nuclear Transcription Factor Nuclear Factor of Activated T-Cells in Prolonged Microglial Activation

(2015) B. Ma et al.   JOURNAL OF NEUROSCIENCE

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

A calcineurin- and NFAT-dependent pathway is involved in  -synuclein-induced degeneration of midbrain dopaminergic neurons

(2014) J. Luo et al.   HUMAN MOLECULAR GENETICS

A Calcineurin Docking Motif (LXVP) in Dynamin-related Protein 1 Contributes to Mitochondrial Fragmentation and Ischemic Neuronal Injury

(2013) Andrew M. Slupe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of Calcineurin

(2013) Simina Grigoriu et al.   PLOS BIOLOGY

Cell permeable NFAT inhibitory peptide Sim-2-VIVIT inhibits T-cell activation and alleviates allergic airway inflammation and hyper-responsiveness

(2012) Je-Min Choi et al.   IMMUNOLOGY LETTERS

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

(2012) Susanne A.I. Seidel et al.   METHODS

A fluorescent polarization-based assay for the identification of disruptors of the RCAN1–calcineurin A protein complex

(2009) M. Carme Mulero et al.   ANALYTICAL BIOCHEMISTRY

Inhibiting the Calcineurin-NFAT (Nuclear Factor of Activated T Cells) Signaling Pathway with a Regulator of Calcineurin-derived Peptide without Affecting General Calcineurin Phosphatase Activity

(2009) Ma Carme Mulero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Domain Architecture of the Regulators of Calcineurin (RCANs) and Identification of a Divergent RCAN in Yeast

(2009) S. Mehta et al.   MOLECULAR AND CELLULAR BIOLOGY

A Conserved Docking Surface on Calcineurin Mediates Interaction with Substrates and Immunosuppressants

(2009) Antonio Rodríguez et al.   MOLECULAR CELL

The RCAN carboxyl end mediates calcineurin docking-dependent inhibition via a site that dictates binding to substrates and regulators

(2009) S. Martinez-Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infusion of FK506, a specific inhibitor of calcineurin, induces potent tau hyperphosphorylation in mouse brain

(2008) Jing Luo et al.   BRAIN RESEARCH BULLETIN

Effects of Radix Adenophorae and Cyclosporine A on an OVA-Induced Murine Model of Asthma by Suppressing to T Cells Activity, Eosinophilia, and Bronchial Hyperresponsiveness

(2008) Seong-Soo Roh et al.   MEDIATORS OF INFLAMMATION

Signaling to gene expression: calcium, calcineurin and NFAT

(2008) Anjana Rao   NATURE IMMUNOLOGY

Domains involved in calcineurin phosphatase inhibition and nuclear localisation in the African swine fever virus A238L protein

(2008) Charles C. Abrams et al.   VIROLOGY