Article
Optics
Feng Huang, He Ren, Xianyu Wu, Pengfei Wang
Summary: The paper proposes a method for foveated imaging by collecting multiple partially overlapping sub-fields of view, using a high-efficiency algorithm based on the characteristics of the field of view deflected by the Risley-prism to solve prism rotation angles. The reliability of the proposed algorithm is proven through cross-validation with the particle swarm optimization algorithm, and experimental results demonstrate flexible foveated imaging using a single Risley-prism imaging system.
Article
Ophthalmology
Maurizio Battaglia Parodi, Alessandro Arrigo, Alessandro Calamuneri, Emanuela Aragona, Francesco Bandello
Summary: The subclinical stage of BVMD is characterized by significant alterations of the outer retinal bands and the choriocapillaris, suggesting functional impairment of the outer retinal structures in subclinical BVMD.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Gerardo Ledesma-Gil, Juliet Essilfie, Alex Onishi, Kenneth J. Wald, Yale L. Fisher, Amani A. Fawzi, Carol L. Shields, K. Bailey Freund, Jay Chhablani
Summary: This study describes retinal lesions that resemble retinal astrocytic hamartomas (RAHs) clinically but have unique characteristics, suggesting a novel variant. The lesions show distinctive features on fundus photography and OCT imaging, indicating the need for a separate designation and naming for these lesions.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Yong Li, Li-Lian Foo, Chee Wai Wong, Jonathan Li, Quan Hoang, Leopold Schmetterer, Daniel S. W. Ting, Marcus Ang
Summary: Pathologic myopia is a severe form of myopia that can cause permanent visual impairment. Recent advancements in imaging techniques, such as optical coherence tomography (OCT) and artificial intelligence (AI) analysis, have improved the early detection of pathological changes and the prediction of myopia progression. These advances have the potential to enhance disease monitoring and guide treatments for pathologic myopia.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Optics
Jie Cao, Dong Zhou, Yingqiang Zhang, Huan Cui, Fanghua Zhang, Kaiyu Zhang, Qun Hao
Summary: Retina-like patterns enhance imaging quality in the region of interest, optimizing ROI pattern design for high-quality ghost imaging technology.
Article
Optics
Egidijus Auksorius
Summary: Fourier-domain full-field optical coherence tomography is a fast imaging technique that can solve the problem of lost backscattered light from samples through spatial splitting of illumination pupil plane, enabling real-time imaging of the human cornea.
Article
Ophthalmology
Federico Zicarelli, Chiara Preziosa, Giovanni Staurenghi, Marco Pellegrini
Summary: This study investigated widefield imaging features, risk factors, and treatment modalities of peripheral exudative haemorrhagic chorioretinopathy (PEHCR). Peripheral subretinal fluid and neovascular networks were identified as risk factors for macular involvement in eyes with PEHCR, highlighting the importance of active treatment in high-risk patients.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Alessandro Marchese, Aniruddha Kishandutt Agarwal, Stefano Erba, Antonio Scialdone, Elisabetta Miserocchi, Francesco Bandello, Ugo Introini, Lee M. Jampol, Giuseppe Casalino
Summary: Placoid lesions of the retina can be caused by various inflammatory conditions, making clinical diagnosis and treatment challenging. A systematic approach to differentiate between infectious and non-infectious etiologies, along with in-depth imaging and investigations, is crucial in reaching a correct diagnosis.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Xuenan Zhuang, Ruoyu Chen, Anyi Liang, Jie Yao, Zicheng Wang, Yesheng Chen, Kangyan Zheng, Peiyao Lu, Liang Zhang, Dan Cao
Summary: This study suggests that diabetic eyes with peripheral lesions (PLs) have worse retinal function. These findings challenge the conventional ETDRS protocols that ignore the importance of the peripheral retina in determining diabetic retinopathy (DR) severity. Combining ultrawide field imaging with the RETeval system may be useful in detecting more retinal abnormalities in DR management.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Beatrice Gallo, Samantha R. de Silva, Omar A. Mahroo, Zubin Saihan, Praveen J. Patel, Jonathan G. Dowler, Carlos Pavesio, Pearse A. Keane, Adnan Tufail, Mandeep S. Sagoo
Summary: Choroidal macrovessels exhibit diverse features on various imaging modalities, which can aid in accurate diagnosis and prevent underdiagnosis.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Yu Fujinami-Yokokawa, Hideki Ninomiya, Xiao Liu, Lizhu Yang, Nikolas Pontikos, Kazutoshi Yoshitake, Takeshi Iwata, Yasunori Sato, Takeshi Hashimoto, Kazushige Tsunoda, Hiroaki Miyata, Kaoru Fujinami
Summary: This study investigated the utility of a data-driven deep learning approach in predicting causative genes in patients with inherited retinal disorders, achieving a high accuracy rate of over 80% for fundus photographs and FAF images. The research involved reviewing clinical and genetic data from 1302 subjects in Japan and successfully predicting prevalent causative genes, demonstrating the potential for early diagnosis and improved medical care in IRD patients.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Pharmacology & Pharmacy
Amir Sadeghi, Marika Ruponen, Jooseppi Puranen, Shoupeng Cao, Roxane Ridolfo, Shirin Tavakoli, Elisa Toropainen, Tatu Lajunen, Veli-Pekka Ranta, Jan van Hest, Arto Urtti
Summary: This study investigates the pharmacokinetics of nanomaterials in the eyes of rats and rabbits. The impact of particle size and shape on ocular distribution and elimination was examined using various imaging techniques. The results show that differently sized particles have different retention times and elimination rates, suggesting that factors other than size also play a role in their kinetics. The study also demonstrates the importance of synchronized particle retention and drug release rate for efficient drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Ophthalmology
Raul F. Membreno, Tharindu De Silva, Elvira Agron, Tiarnan D. L. Keenan, Catherine A. Cukras
Summary: Quantitative measures derived from OCT images can effectively discriminate between eyes unaffected by hydroxychloroquine and those with different severities of toxicity, providing valuable insights for assessing the severity of hydroxychloroquine toxicity.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
C. Ellis Wisely, Dong Wang, Ricardo Henao, Dilraj S. Grewal, Atalie C. Thompson, Cason B. Robbins, Stephen P. Yoon, Srinath Soundararajan, Bryce W. Polascik, James R. Burke, Andy Liu, Lawrence Carin, Sharon Fekrat
Summary: This study developed a convolutional neural network (CNN) that successfully predicted the diagnosis of symptomatic Alzheimer's disease using multimodal retinal images and patient data. The results showed that GC-IPL maps were the most useful single input for prediction, and models that only used images performed similarly to those that also included quantitative data and patient data.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Clinical Neurology
Peter J. Snyder, Jessica Alber, Clemens Alt, Lisa J. Bain, Brett E. Bouma, Femke H. Bouwman, Delia Cabrera DeBuc, Melanie C. W. Campbell, Maria C. Carrillo, Emily Y. Chew, M. Francesca Cordeiro, Michael R. Duenas, Brian M. Fernandez, Maya Koronyo-Hamaoui, Chiara La Morgia, Roxana O' Carare, Srinivas R. Sadda, Peter van Wijngaarden, Heather M. Snyder
Summary: Research on retinal imaging as potential biomarkers for Alzheimer's disease and other neurodegenerative diseases has significantly increased over the past 20 years. Discussions have focused on the different modalities of retinal imaging, their strengths and weaknesses, and the importance of defining the context of use to guide the development of retinal biomarkers.
ALZHEIMERS & DEMENTIA
(2021)
Article
Ophthalmology
C. Ellis Wisely, Dong Wang, Ricardo Henao, Dilraj S. Grewal, Atalie C. Thompson, Cason B. Robbins, Stephen P. Yoon, Srinath Soundararajan, Bryce W. Polascik, James R. Burke, Andy Liu, Lawrence Carin, Sharon Fekrat
Summary: This study developed a convolutional neural network (CNN) that successfully predicted the diagnosis of symptomatic Alzheimer's disease using multimodal retinal images and patient data. The results showed that GC-IPL maps were the most useful single input for prediction, and models that only used images performed similarly to those that also included quantitative data and patient data.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Bjorn Kaijun Betzler, Jianbin Ding, Xin Wei, Jia Min Lee, Dilraj S. Grewal, Sharon Fekrat, Srinivas R. Sadda, Marco A. Zarbin, Aniruddha Agarwal, Vishali Gupta, Leopold Schmetterer, Rupesh Agrawal
Summary: CVI is a new parameter calculated from OCT images for quantitative evaluation of choroid vascularity. Studies have shown promising results in using CVI for disease prognostication and progression monitoring, filling the limitations of previous choroidal parameters.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Sushant Wagley, Peter J. Belin, James J. Dollar, J. William Harbour, Amanda C. Maltry, Prithvi Mruthyunjaya, A. M. Y. C. Schefler, Peter H. Tang
Summary: Unilateral multifocal uveal melanomas in the setting of ocular melanosis may result from the development of genetically independent primary tumors, as indicated by the mutation profiles of each tumor.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Tatiana R. Rosenblatt, Nadim Rayess, Ahmad Al-Moujahed, Rahul N. Khurana, Prithvi Mruthyunjaya
Summary: Discontinuation rates in major intravitreal anti-VEGF clinical trials were highly variable, indicating that even trials struggle with overall patient retention. While trial LTFU rates were low, real-world outcomes may differ due to higher reported LTFU rates, which should be taken into consideration when extrapolating trial results to clinical practice.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Francesco Pichi, Ester Carreno Salas, Carlos Pavesio, Alastair K. Denniston, Dilraj S. Grewal, Gabor Deak, Moncef Khairallah, Matilde Ruiz-Cruz, Joao Rafael de Oliveira Dias, Alfredo Adan, Tomas Burke, Alessandro Invernizzi, Ariel Schlaen, Meng Tian, Aniruddha Kishandutt Agarwal, William R. Tucker, H. Nida Sen, Phoebe Lin, Lyndell L. Lim, Kathryn L. Pepple, Marion R. Munk
Summary: This study establishes consensus recommendations for reporting OCTA findings in uveitis, which can serve as guidance for routine clinical care and clinical trials.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Amee D. Azad, Kapil Mishra, Eric B. Lee, Evan Chen, Alexander Nguyen, Ravi Parikh, Prithvi Mruthyunjaya
Summary: The COVID-19 pandemic had a significant impact on the utilization of ophthalmic procedures, with most procedures experiencing a decline, but the majority returning to pre-pandemic levels by June 2020.
OPHTHALMIC EPIDEMIOLOGY
(2022)
Review
Ophthalmology
Abhilasha Baharani, Marie-Helene Errera, Mahima Jhingan, Anindya Samanta, Aniruddha Agarwal, Sumit Randhir Singh, P. Raja Rami Reddy, Dilraj S. Grewal, Jay Chhablani
Summary: Advancements in ocular imaging algorithms and devices aim to improve image acquisition and resolution of deeper ocular tissues, leading to a better understanding and monitoring of ocular inflammatory conditions.
SURVEY OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Thomas A. Ciulla, Barry Kapik, Mark R. Barakat, Rahul N. Khurana, Quan Dong Nguyen, Dilraj S. Grewal, Thomas Albini, Emmett T. Cunningham, Debra A. Goldstein
Summary: This study assessed the relationship between BCVA and OCT features in NIU-related macular edema. The results showed that baseline EZ integrity and the presence of central subfield cystoid spaces or subretinal fluid predicted improved therapeutic response. Modeling analysis indicated that CST improvement preceded BCVA improvement in eyes treated with CLS-TA.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Ruobing Qian, Kevin C. Zhou, Jingkai Zhang, Christian Viehland, Al-Hafeez Dhalla, Joseph A. Izatt
Summary: This paper presents a high-speed FMCW-based 3D imaging system that combines grating beam steering with compressed time-frequency analysis for depth retrieval. The system achieves real-time densely sampled 3D imaging of moving objects with submillimeter localization accuracy.
NATURE COMMUNICATIONS
(2022)
Article
Robotics
William Edwards, Gao Tang, Yuan Tian, Mark Draelos, Joseph Izatt, Anthony Kuo, Kris Hauser
Summary: Deep anterior lamellar keratoplasty (DALK) is a technique for cornea transplantation that reduces patient morbidity. Robot microsurgery has been explored as a potential application for DALK due to its challenging nature for human surgeons. In this study, we have developed a data-driven autoregressive dynamic model and a model predictive controller to improve the accuracy of needle insertion during the surgery. Our experiments show that our controller significantly improves needle positioning accuracy compared to previous methods.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2022)
Article
Ophthalmology
Saman S. Ahmadian, Ian J. Dryden, Andrea Naranjo, Angus Toland, Romain A. Cayrol, Donald E. Born, Peter S. Egbert, Ryanne A. Brown, Prithvi Mruthyunjaya, Jonathan H. Lin
Summary: In this study, we evaluated the expression of PRAME in UM patients using both RT-PCR and IHC techniques. The results showed that PRAME IHC can distinguish PRAME-positive and PRAME-negative UM tumor cells, and also revealed intratumoral heterogeneity in PRAME expression. The concordance between PRAME RT-PCR and IHC results was observed in the majority of cases.
OCULAR ONCOLOGY AND PATHOLOGY
(2022)
Article
Ophthalmology
Dennis Y. Akrobetu, Cason B. Robbins, Justin P. Ma, Snnath Soundararajan, Michael S. Quist, Sandra S. Stinnett, Kathryn P. L. Moore, Kim G. Johnson, Andy J. Liu, Dilraj S. Grewal, Sharon Fekrat
Summary: The purpose of this study was to assess the intrasession repeatability of macular OCTA parameters in AD, MCI, PD, and NC patients. The results showed that the repeatability of macular OCTA metrics was similar and moderate to good in both NC and neurodegenerative disease groups.
OPHTHALMOLOGY SCIENCE
(2023)
Review
Allergy
Richmond Woodward, Sri Meghana Konda, Dilraj S. Grewal
Summary: The purpose of this review is to provide a framework for identifying key symptoms and clinical findings in patients with autoimmune inflammatory eye disease. The most common manifestations of this disease include episcleritis, scleritis, uveitis (anterior, intermediate, posterior, and panuveitis), and keratoconjunctivitis sicca. The etiologies can be idiopathic or associated with a systemic autoimmune condition. Referral of patients with potential scleritis or uveitis is crucial, and infectious causes should be ruled out in all cases.
CURRENT ALLERGY AND ASTHMA REPORTS
(2023)
Letter
Ophthalmology
Richmond Woodward, Andrew Gross, Grant A. Justin, Glenn J. Jaffe, Dilraj S. Grewal
Summary: A case of bilateral panuveitis in an 11-year-old girl with autoimmune lymphoproliferative syndrome (ALPS) due to CTLA4 haploinsufficiency is described. The patient developed cervical adenopathy, autoimmune hemolytic anemia, and thrombocytopenia consistent with Evan's Syndrome at the age of 5. Ocular symptoms appeared 6 years later and were partially responsive to corticosteroids.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Amee D. Azad, Evan M. Chen, John Hinkle, Nadim Rayess, David Wu, Dean Eliott, Prithvi Mruthyunjaya, Ravi Parikh
Summary: This study characterized the usage rates of PRP and anti-VEGF medications before and after the publication of Protocol S. It was found that PRP rates decreased while anti-VEGF rates increased following the publication.
OPHTHALMOLOGY RETINA
(2021)