Journal
JOURNAL OF APPLIED POLYMER SCIENCE
Volume 137, Issue 37, Pages -Publisher
WILEY
DOI: 10.1002/app.49098
Keywords
biodegradable; electrospinning; fibers; morphology; nanostructured polymers
Categories
Funding
- Directorate-General for Research and Innovation
Ask authors/readers for more resources
Ungeremine (UNG) is an alkaloid typically isolated from Pancratium maritimum or synthesized by the oxidation of lycorine. This antifungal alkaloid was incorporated into electrospun nanofibers based on blends of poly(lactic acid) (PLA) and poly(ethylene glycol) (PEG). The effect of the UNG on the structure, morphology, and thermal properties of the fibers was evaluated, and the release of the alkaloid from the fibers was quantified. Studies on the release of the UNG for the nanofibers show that the release rate is related to the amount and distribution of the PEG in the nanofiber matrix. Initial burst release of the antifungal alkaloid is related to the PEG in the nanofibers, where after a sustained release occurs indicating that the UNG is present in both the PLA and PEG domains in the nanofibers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available