Journal
JOURNAL OF APPLIED POLYMER SCIENCE
Volume 137, Issue 36, Pages -Publisher
WILEY
DOI: 10.1002/app.49056
Keywords
gels; porous materials; radical polymerization; structure-property relationships
Categories
Funding
- Fundac~ao de Amparo a Pesquisa do Estado de S~ao Paulo [2016/02414-5]
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Changing the pore morphology of hydrogels can be an effective strategy to modulate their drug release profiles. Herein, Pluronic F127 was used to change the three-dimensional pore morphology of crosslinked poly(N-isopropylacrylamide-co-acrylic acid) (P[NIPAm-co-AAc]) hydrogels. F127 reduced the pore diameters from 20 +/- 4 to 2.9 +/- 0.4 mu m and from 11 +/- 1 to 1.4 +/- 0.4 mu m in hydrogels synthesized at 8 and 30 degrees C, respectively. Small-angle X-ray scattering indicates that the segregation of the F127 during the polymerization process induces F127 phase transitions from unimers (at 8 degrees C) or cubic-packed micelles (at 30 degrees C) to a lamellar structure. P(NIPAm-co-AAc) hydrogels charged with S-nitrosoglutathione (GSNO), released nitric oxide (NO) spontaneously during hydration. The decrease in the pore diameter led to a twofold to threefold increase in the rate of water absorption and a fourfold to sixfold increase in the rate of NO release of the hydrogels. F127 can be used to change the pore morphology of P(NIPAm-co-AAc) hydrogels, with concomitant changes in their rate of hydration and NO release from GSNO, opening a new perspective for their use in topical NO delivery.
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